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The map label for this gene is pdhA [H]

Identifier: 218232014

GI number: 218232014

Start: 3991107

End: 3992222

Strand: Reverse

Name: pdhA [H]

Synonym: BCB4264_A4075

Alternate gene names: 218232014

Gene position: 3992222-3991107 (Counterclockwise)

Preceding gene: 218233384

Following gene: 218235790

Centisome position: 73.67

GC content: 39.96

Gene sequence:

>1116_bases
ATGGGTACTAAAACAAAAAAGACCCTATTTAATGTTGATGAGCAAATGAAAGCTATCGCAGCTCAATTTGAAACATTACA
AATTTTAAATGAAAACGGTGAAGTTGTGAATGAAGCAGCTATGCCTGAATTATCTGATGATCAATTAAAAGAATTAATGC
GTCGTATGGTGTATACTCGCGTATTAGATCAACGTTCTATTTCTTTAAACCGTCAAGGACGTTTAGGTTTCTACGCACCT
ACAGCTGGACAAGAAGCTTCTCAATTAGCAAGTCATTTCGCACTTGAAGCAGAAGACTTCATCTTACCAGGATACCGTGA
TGTACCACAATTAGTATGGCACGGATTACCATTATACCAAGCATTCTTATTCTCTCGTGGACACTTCATGGGTAACCAAA
TGCCTGAGAATGTAAATGCATTAGCTCCACAGATCATTATCGGTGCGCAAATCATCCAAACTGCTGGTGTTGCGTTAGGT
ATGAAACTACGTGGTAAAAAATCTGTTGCAATTACTTACACTGGTGACGGTGGTGCTTCACAAGGTGACTTCTACGAAGG
TATGAACTTTGCAGGTGCATTCAAAGCTCCAGCAATCTTCGTTGTTCAAAACAACCGTTATGCAATCTCTACTCCAGTAG
AAAAGCAATCTGCAGCTAAAACTGTAGCACAAAAAGCAGTAGCAGCAGGTATTTACGGAATTCAAGTAGACGGTATGGAT
CCATTAGCTGTATACGCAGCAACTGCTTTCGCTCGTGAGCGCGCAGTAAATGGCGAAGGCCCTACTTTAATCGAGACTTT
AACATTCCGTTACGGTCCACATACAATGGCTGGTGATGACCCAACTCGTTACCGTACAAAAGATATCGAAAACGAATGGG
AACAAAAAGACCCAATCGTACGCTTCCGTAAGTTCTTAGAAGCTAAAGGCCTATGGTCTCAAGAAGTTGAAGAGACAGTA
ATCGAAGAAGCAAAAGAAGATATCAAACAAGCAATTGCTAAGGCTGACCAAGCTCCAAAACAAAAAGTAACTGATTTAAT
GGAAATCATGTACGAAAAAATGCCTTACAACTTAGCTGAACAATATGAAATCTACAAAGAAAAGGAGTCGAAGTAA

Upstream 100 bases:

>100_bases
CATACAAACATGTTGGTTTACATCGTTGCGCTTTTTAAACTGGAAAATAGCCAGTGAAAGCGTTTCAGAATATGGTTCAA
GAGAGGAAGAGGTGAACGGA

Downstream 100 bases:

>100_bases
GCCATGGCTCAAATGACAATGATTCAAGCAATCACTGATGCTTTACGCGTTGAAATGAAAAATGACCCTAACGTACTTGT
ATTTGGTGAAGACGTTGGTG

Product: pyruvate dehydrogenase complex E1 component, alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MGTKTKKTLFNVDEQMKAIAAQFETLQILNENGEVVNEAAMPELSDDQLKELMRRMVYTRVLDQRSISLNRQGRLGFYAP
TAGQEASQLASHFALEAEDFILPGYRDVPQLVWHGLPLYQAFLFSRGHFMGNQMPENVNALAPQIIIGAQIIQTAGVALG
MKLRGKKSVAITYTGDGGASQGDFYEGMNFAGAFKAPAIFVVQNNRYAISTPVEKQSAAKTVAQKAVAAGIYGIQVDGMD
PLAVYAATAFARERAVNGEGPTLIETLTFRYGPHTMAGDDPTRYRTKDIENEWEQKDPIVRFRKFLEAKGLWSQEVEETV
IEEAKEDIKQAIAKADQAPKQKVTDLMEIMYEKMPYNLAEQYEIYKEKESK

Sequences:

>Translated_371_residues
MGTKTKKTLFNVDEQMKAIAAQFETLQILNENGEVVNEAAMPELSDDQLKELMRRMVYTRVLDQRSISLNRQGRLGFYAP
TAGQEASQLASHFALEAEDFILPGYRDVPQLVWHGLPLYQAFLFSRGHFMGNQMPENVNALAPQIIIGAQIIQTAGVALG
MKLRGKKSVAITYTGDGGASQGDFYEGMNFAGAFKAPAIFVVQNNRYAISTPVEKQSAAKTVAQKAVAAGIYGIQVDGMD
PLAVYAATAFARERAVNGEGPTLIETLTFRYGPHTMAGDDPTRYRTKDIENEWEQKDPIVRFRKFLEAKGLWSQEVEETV
IEEAKEDIKQAIAKADQAPKQKVTDLMEIMYEKMPYNLAEQYEIYKEKESK
>Mature_370_residues
GTKTKKTLFNVDEQMKAIAAQFETLQILNENGEVVNEAAMPELSDDQLKELMRRMVYTRVLDQRSISLNRQGRLGFYAPT
AGQEASQLASHFALEAEDFILPGYRDVPQLVWHGLPLYQAFLFSRGHFMGNQMPENVNALAPQIIIGAQIIQTAGVALGM
KLRGKKSVAITYTGDGGASQGDFYEGMNFAGAFKAPAIFVVQNNRYAISTPVEKQSAAKTVAQKAVAAGIYGIQVDGMDP
LAVYAATAFARERAVNGEGPTLIETLTFRYGPHTMAGDDPTRYRTKDIENEWEQKDPIVRFRKFLEAKGLWSQEVEETVI
EEAKEDIKQAIAKADQAPKQKVTDLMEIMYEKMPYNLAEQYEIYKEKESK

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=347, Percent_Identity=32.8530259365994, Blast_Score=194, Evalue=7e-50,
Organism=Homo sapiens, GI258645172, Length=347, Percent_Identity=32.8530259365994, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI291084742, Length=331, Percent_Identity=30.5135951661631, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI4505685, Length=331, Percent_Identity=30.5135951661631, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI291084744, Length=211, Percent_Identity=36.0189573459716, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI4885543, Length=307, Percent_Identity=28.9902280130293, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI291084757, Length=313, Percent_Identity=28.7539936102236, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI86563357, Length=346, Percent_Identity=33.8150289017341, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI86563355, Length=346, Percent_Identity=33.8150289017341, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17536047, Length=304, Percent_Identity=31.9078947368421, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI32564172, Length=304, Percent_Identity=31.9078947368421, Blast_Score=131, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6321026, Length=334, Percent_Identity=28.7425149700599, Blast_Score=130, Evalue=4e-31,
Organism=Drosophila melanogaster, GI21355903, Length=347, Percent_Identity=31.4121037463977, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24639744, Length=323, Percent_Identity=30.9597523219814, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI28571106, Length=323, Percent_Identity=30.9597523219814, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24639740, Length=323, Percent_Identity=30.9597523219814, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24639746, Length=289, Percent_Identity=32.1799307958478, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24639748, Length=287, Percent_Identity=30.6620209059233, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 41415; Mature: 41283

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTKTKKTLFNVDEQMKAIAAQFETLQILNENGEVVNEAAMPELSDDQLKELMRRMVYTR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHH
VLDQRSISLNRQGRLGFYAPTAGQEASQLASHFALEAEDFILPGYRDVPQLVWHGLPLYQ
HHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCHHHH
AFLFSRGHFMGNQMPENVNALAPQIIIGAQIIQTAGVALGMKLRGKKSVAITYTGDGGAS
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEECCCCEEEEEEECCCCCC
QGDFYEGMNFAGAFKAPAIFVVQNNRYAISTPVEKQSAAKTVAQKAVAAGIYGIQVDGMD
CCCHHHCCCCCCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHCEEEEEECCCC
PLAVYAATAFARERAVNGEGPTLIETLTFRYGPHTMAGDDPTRYRTKDIENEWEQKDPIV
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCHHH
RFRKFLEAKGLWSQEVEETVIEEAKEDIKQAIAKADQAPKQKVTDLMEIMYEKMPYNLAE
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHH
QYEIYKEKESK
HHHHHHHHCCC
>Mature Secondary Structure 
GTKTKKTLFNVDEQMKAIAAQFETLQILNENGEVVNEAAMPELSDDQLKELMRRMVYTR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHH
VLDQRSISLNRQGRLGFYAPTAGQEASQLASHFALEAEDFILPGYRDVPQLVWHGLPLYQ
HHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCHHHH
AFLFSRGHFMGNQMPENVNALAPQIIIGAQIIQTAGVALGMKLRGKKSVAITYTGDGGAS
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEECCCCEEEEEEECCCCCC
QGDFYEGMNFAGAFKAPAIFVVQNNRYAISTPVEKQSAAKTVAQKAVAAGIYGIQVDGMD
CCCHHHCCCCCCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHCEEEEEECCCC
PLAVYAATAFARERAVNGEGPTLIETLTFRYGPHTMAGDDPTRYRTKDIENEWEQKDPIV
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCHHH
RFRKFLEAKGLWSQEVEETVIEEAKEDIKQAIAKADQAPKQKVTDLMEIMYEKMPYNLAE
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHH
QYEIYKEKESK
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA