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The map label for this gene is lctP [H]

Identifier: 218231686

GI number: 218231686

Start: 1259228

End: 1260727

Strand: Direct

Name: lctP [H]

Synonym: BCB4264_A1300

Alternate gene names: 218231686

Gene position: 1259228-1260727 (Clockwise)

Preceding gene: 218231065

Following gene: 218232141

Centisome position: 23.24

GC content: 37.27

Gene sequence:

>1500_bases
ATGGCCATATTGTTGGCACTTATCCCAATTATGATGATTTTCATTTGTTTATTTTTATTTAAACAAACGTCATTAAGGTC
CTCGTTAATTTCTTATGCTGTGTCTGTTGGAATCGTTTTACTCTCGCCAACGTTTCAATTAGGGATAAGTGAAACTGTGC
ACGCAACGATTAAAGGATGGTTAATTTGTTTTATTGTCGGGTACGTTTTATTTTTCGGTATTTTTTTATTTCACCTCATG
AACAAAATGGGGTACATCGATCAAGTAGCACGTTTTCTAGAAGCAGTTACTCAGGATCGCTTATTACAAATGCTGCTTAT
GTGTTTTGGCATTTGCCCGCTTATTGAATCAGTAAGTGGATTCGGTATCGGCTTCATGGTTGCAGCACCTATTTTTCTTT
CACTAGGATATAAACCATTTCAAGCTGTACTGCTCTCATTCATCGGCTTACTAGCTAGTTCATGGGGCGCAATGGCAACT
GGTACGATTATCGGTTCGCAGCTAATAAATATGCCTCTTACAACACTTGGTACAAATACAGCGCTATTAAGTATTCCGAT
GTTTGCTTACTTTGTTATTCTTTCTTTACACGTTGTTGGCGGCTGGCAAGCGGTTATAGAAAAGTGGAAAGAAGGAGTAG
GATTCTTTCTATTATTTTCTCTCGGAATCTATCTTTCTAATGCGTACGTAAGTGTTGAACTAGCCGGGATATTAAGTTCT
ATCGTTACGATTACATTTGGCTTTCTTATCATTAAATTAAAAGGAAAAAGTGGGCAAAATCTTATAACAGAACATGCGGC
GGCAACGGAAAGAGAAATATCCATTATAAAAATTATTAGCCCTTATATATTTCTAACAGTTTGTATTTTACTCTCCCGCC
TCGTTCCAGCATTACATGATTTGTTTAGATCATATGCGGTTCTTGATTTGAAATCATACTCTTACAAACTAGAGTTACTA
TATTCACCAGGATTTTGGCTCGGTATGACTTGCTTATTTACTATTATTTTCTTCCGCATCCCGTCTAATATTATGAAACA
ATCACTCTCACAAACGATAAAACAATGGATTCCTTTTGCGATTACGACGACAATGTTTATCGCCATTTCAGAACTAATGG
GTGCATCAGGCATGCATTCATTACTCGCAAAGACAGCTGGTGACACATTTGGAACGTTTTTCGTTTTCGTTGCTCCGTTT
ATTGGCGCTATTGGTGGATTTTTAACAGGTAGTAACGCAGGATCAAATGCAATGTTTATAAAACTACAAATGCAAACTGC
ACAAAACGTAGCACTCCCGTGGCAATATGTCACAACACTTCAAAACACCGCATCATCAGTAGCGACAATCGCTTGTCCAT
CACGGATTACATTAGGTGCTTACTTATGTAATATCCCTTACCGTGAAAATGAACTATTAAAGAAGACGACGTTAATGATC
TTTGGTGCGGTTTTACTTGTAGTGGTAGAGGTTATTGTTTGGTATATGTTGAGAAATTAA

Upstream 100 bases:

>100_bases
TTTGGTTCCTTTTTTGAATCTGTTGTAAAAACAATTGAAAATTATAGCATCTGTTATATAATAGTTAAAAATTGTATTTT
AAAAGAAATGAGATGATAAC

Downstream 100 bases:

>100_bases
AAATCCTCCTAACATAGGAGGATTTTTTTTATGAATGGATAATGATTTAAATATGAATAGCTGCTACTAAATGAATAGGA
GATGAAATGTATGCCCCTAA

Product: putative L-lactate permease

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MAILLALIPIMMIFICLFLFKQTSLRSSLISYAVSVGIVLLSPTFQLGISETVHATIKGWLICFIVGYVLFFGIFLFHLM
NKMGYIDQVARFLEAVTQDRLLQMLLMCFGICPLIESVSGFGIGFMVAAPIFLSLGYKPFQAVLLSFIGLLASSWGAMAT
GTIIGSQLINMPLTTLGTNTALLSIPMFAYFVILSLHVVGGWQAVIEKWKEGVGFFLLFSLGIYLSNAYVSVELAGILSS
IVTITFGFLIIKLKGKSGQNLITEHAAATEREISIIKIISPYIFLTVCILLSRLVPALHDLFRSYAVLDLKSYSYKLELL
YSPGFWLGMTCLFTIIFFRIPSNIMKQSLSQTIKQWIPFAITTTMFIAISELMGASGMHSLLAKTAGDTFGTFFVFVAPF
IGAIGGFLTGSNAGSNAMFIKLQMQTAQNVALPWQYVTTLQNTASSVATIACPSRITLGAYLCNIPYRENELLKKTTLMI
FGAVLLVVVEVIVWYMLRN

Sequences:

>Translated_499_residues
MAILLALIPIMMIFICLFLFKQTSLRSSLISYAVSVGIVLLSPTFQLGISETVHATIKGWLICFIVGYVLFFGIFLFHLM
NKMGYIDQVARFLEAVTQDRLLQMLLMCFGICPLIESVSGFGIGFMVAAPIFLSLGYKPFQAVLLSFIGLLASSWGAMAT
GTIIGSQLINMPLTTLGTNTALLSIPMFAYFVILSLHVVGGWQAVIEKWKEGVGFFLLFSLGIYLSNAYVSVELAGILSS
IVTITFGFLIIKLKGKSGQNLITEHAAATEREISIIKIISPYIFLTVCILLSRLVPALHDLFRSYAVLDLKSYSYKLELL
YSPGFWLGMTCLFTIIFFRIPSNIMKQSLSQTIKQWIPFAITTTMFIAISELMGASGMHSLLAKTAGDTFGTFFVFVAPF
IGAIGGFLTGSNAGSNAMFIKLQMQTAQNVALPWQYVTTLQNTASSVATIACPSRITLGAYLCNIPYRENELLKKTTLMI
FGAVLLVVVEVIVWYMLRN
>Mature_498_residues
AILLALIPIMMIFICLFLFKQTSLRSSLISYAVSVGIVLLSPTFQLGISETVHATIKGWLICFIVGYVLFFGIFLFHLMN
KMGYIDQVARFLEAVTQDRLLQMLLMCFGICPLIESVSGFGIGFMVAAPIFLSLGYKPFQAVLLSFIGLLASSWGAMATG
TIIGSQLINMPLTTLGTNTALLSIPMFAYFVILSLHVVGGWQAVIEKWKEGVGFFLLFSLGIYLSNAYVSVELAGILSSI
VTITFGFLIIKLKGKSGQNLITEHAAATEREISIIKIISPYIFLTVCILLSRLVPALHDLFRSYAVLDLKSYSYKLELLY
SPGFWLGMTCLFTIIFFRIPSNIMKQSLSQTIKQWIPFAITTTMFIAISELMGASGMHSLLAKTAGDTFGTFFVFVAPFI
GAIGGFLTGSNAGSNAMFIKLQMQTAQNVALPWQYVTTLQNTASSVATIACPSRITLGAYLCNIPYRENELLKKTTLMIF
GAVLLVVVEVIVWYMLRN

Specific function: Plays a role in L-lactate utilization [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1790031, Length=513, Percent_Identity=22.2222222222222, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1789347, Length=316, Percent_Identity=23.7341772151899, Blast_Score=72, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 54918; Mature: 54787

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILLALIPIMMIFICLFLFKQTSLRSSLISYAVSVGIVLLSPTFQLGISETVHATIKGW
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHH
LICFIVGYVLFFGIFLFHLMNKMGYIDQVARFLEAVTQDRLLQMLLMCFGICPLIESVSG
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FGIGFMVAAPIFLSLGYKPFQAVLLSFIGLLASSWGAMATGTIIGSQLINMPLTTLGTNT
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHCCCCH
ALLSIPMFAYFVILSLHVVGGWQAVIEKWKEGVGFFLLFSLGIYLSNAYVSVELAGILSS
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCHHHHHHHHHHHHHHCHHHEEHHHHHHHH
IVTITFGFLIIKLKGKSGQNLITEHAAATEREISIIKIISPYIFLTVCILLSRLVPALHD
HHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFRSYAVLDLKSYSYKLELLYSPGFWLGMTCLFTIIFFRIPSNIMKQSLSQTIKQWIPFA
HHHHHHHHEECCCCEEEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
ITTTMFIAISELMGASGMHSLLAKTAGDTFGTFFVFVAPFIGAIGGFLTGSNAGSNAMFI
HHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
KLQMQTAQNVALPWQYVTTLQNTASSVATIACPSRITLGAYLCNIPYRENELLKKTTLMI
EEEECCCCCCCCCHHHHHHHHHHHHHHEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHH
FGAVLLVVVEVIVWYMLRN
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AILLALIPIMMIFICLFLFKQTSLRSSLISYAVSVGIVLLSPTFQLGISETVHATIKGW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHH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HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10508058 [H]