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The map label for this gene is tlpA [H]

Identifier: 218231652

GI number: 218231652

Start: 1146829

End: 1148556

Strand: Direct

Name: tlpA [H]

Synonym: BCB4264_A1178

Alternate gene names: 218231652

Gene position: 1146829-1148556 (Clockwise)

Preceding gene: 218235019

Following gene: 218232108

Centisome position: 21.16

GC content: 34.09

Gene sequence:

>1728_bases
ATGTATTTTTTACAAAATTTAAAAGTGAAATATAAATTATTAGCGCTTATTTCATTAGCAGTTTTAGGTATGGTAATTAT
AAGCAGTGTAGCAATTAGTTCTATTAATAAGATTAAGCATGATACAGAGGTTGTAGTAGATGATTATCAATATTCTGCAA
TTTTATTAGAAGGAATGCTTCGCACACAAAATTCACTAGAATATAACCTACTAGAATTAATTACGGCATCACAAAATGAA
GTGGCAAATAAAGAGGGAATAATTGATAATATTGAAAAGGATCTTAAAAAATATGATTCTTTATTAAAAGAATATGATGA
TGGTTTTAATTTAAGTAAGCAAGAGGATGAACTGTTTCAGAAGATGAAGAAATCTTTGCCAAGTTATAAAGATACATATA
AAAAATTATTTGAAAAGGCAAAGGCAACAAACGAGCCACAAATGGTAAATGAATTTCAGAAGGAATTAAAACCGAAGGGA
ATAGAGTTAGCCGGTTATGCAGTGGATCTAGAATCGTATGTTTCAAATTTAGCTGACCAAGTATTTAAAGATTCTCAAAA
AATGATTGATCGTTCCGTTATTACCTTTATCATTCTTGTAGTAGTTACTACAATCGTTATATGTATAGTAAGTTATATTA
TTAGCAAGCTCATAGTTGCTCCTTTACAAACGGTTAGTCGTATGATGGAAAGAGCGAAAGAAGGAGATTTAACCGTACAT
GGTGATTATACTGCTAAGGATGAATTAGGTGTATTAGTAAGTAATTTTAACGAGATGATTGCAGGGCTAAGAACAAATAT
GCAAGAAGTAGAGAATAATATTCAGCTTTTATTCCAACATGCAGACGGAGTAGTATCTGCATCAGAAGTATCTAGTAGTG
CAGCGAAGAAAATCACTATGGATATTGAAGAAGTTGCAAATGGTGCAGAGAGTCAAATGCAAGCAATGGAACAAACTGCG
GGTGCGATGGAAGAGTTGACGCAAGGAATGCAGAGTATAGTCAATACATCATCCTCTGTAAATGAATTATCTGCTCAATC
AGCATTAGATGCAGAGAGTGGTAACAAATTAATGAAACAAATGATTCAACAGATGGATACAATCCAAAATTCGGTACATA
GCGGTGTGAAACAAGTAGAGACTATGAAAGAACAATCAGAAGAAATTGTTAAAATCATTGATGTTATGCAAGGTATTACC
TCCCAGATTAACTTATTAGCATTAAACGCCGCAATTGAGGCTGCACGTGCTGGTGAAAGTGGTAGAGGATTTGCAATTGT
GGCAGATGAAGTGCGGAAATTAGCAGAACAATCTAGTGATTCTGCAAAACAAATTGAGAATCTTATTACTCAAGTTATGG
GAACAACGAACCATACGGTACATATGATGGGGAAAGTAGATAATGAGGTACAGGCAGGTACACAAGTAGTAATGCATACA
GAAAAAGTATTTGGAACAATTACAGAAAAAGTACAGCAAGTATCTGAGCAAATTCAAACGGTATCTATGTCTACAGATGA
AATTGCAGCGAGTAGTGAGGAAATCTCGGCTTCTGCAGAAGACATGGCTCAAATTTCCCAAAGATCATCTGACCGAACTG
ATAGGGTAAAAGAGTCTATTCAACAGCAAGAAAAATCTGTTCAAGAGATTTCGGTTTCAATTGAACATATGCATAACGCA
GCAGGAAAATTAAAACAAATAGTTGCCCAATTTACTCTTCAAAAGTAG

Upstream 100 bases:

>100_bases
TTCATATTGGGAATATTTATCATTGCTTTTTATTGCGATTTTGTAAATAATAAGCTATAAAATTCTAAAAATCTATATAT
AAAGGAATAAAGGTGAAAAA

Downstream 100 bases:

>100_bases
TAGCATATTTGAGTGTTAATAAATATAAAAAAATCATCCTCTTTTAAGAAAAAAGGATGATTTTTTTATCCCGTTATTTG
CTGGGCAGTAAGACCCCCAC

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MYFLQNLKVKYKLLALISLAVLGMVIISSVAISSINKIKHDTEVVVDDYQYSAILLEGMLRTQNSLEYNLLELITASQNE
VANKEGIIDNIEKDLKKYDSLLKEYDDGFNLSKQEDELFQKMKKSLPSYKDTYKKLFEKAKATNEPQMVNEFQKELKPKG
IELAGYAVDLESYVSNLADQVFKDSQKMIDRSVITFIILVVVTTIVICIVSYIISKLIVAPLQTVSRMMERAKEGDLTVH
GDYTAKDELGVLVSNFNEMIAGLRTNMQEVENNIQLLFQHADGVVSASEVSSSAAKKITMDIEEVANGAESQMQAMEQTA
GAMEELTQGMQSIVNTSSSVNELSAQSALDAESGNKLMKQMIQQMDTIQNSVHSGVKQVETMKEQSEEIVKIIDVMQGIT
SQINLLALNAAIEAARAGESGRGFAIVADEVRKLAEQSSDSAKQIENLITQVMGTTNHTVHMMGKVDNEVQAGTQVVMHT
EKVFGTITEKVQQVSEQIQTVSMSTDEIAASSEEISASAEDMAQISQRSSDRTDRVKESIQQQEKSVQEISVSIEHMHNA
AGKLKQIVAQFTLQK

Sequences:

>Translated_575_residues
MYFLQNLKVKYKLLALISLAVLGMVIISSVAISSINKIKHDTEVVVDDYQYSAILLEGMLRTQNSLEYNLLELITASQNE
VANKEGIIDNIEKDLKKYDSLLKEYDDGFNLSKQEDELFQKMKKSLPSYKDTYKKLFEKAKATNEPQMVNEFQKELKPKG
IELAGYAVDLESYVSNLADQVFKDSQKMIDRSVITFIILVVVTTIVICIVSYIISKLIVAPLQTVSRMMERAKEGDLTVH
GDYTAKDELGVLVSNFNEMIAGLRTNMQEVENNIQLLFQHADGVVSASEVSSSAAKKITMDIEEVANGAESQMQAMEQTA
GAMEELTQGMQSIVNTSSSVNELSAQSALDAESGNKLMKQMIQQMDTIQNSVHSGVKQVETMKEQSEEIVKIIDVMQGIT
SQINLLALNAAIEAARAGESGRGFAIVADEVRKLAEQSSDSAKQIENLITQVMGTTNHTVHMMGKVDNEVQAGTQVVMHT
EKVFGTITEKVQQVSEQIQTVSMSTDEIAASSEEISASAEDMAQISQRSSDRTDRVKESIQQQEKSVQEISVSIEHMHNA
AGKLKQIVAQFTLQK
>Mature_575_residues
MYFLQNLKVKYKLLALISLAVLGMVIISSVAISSINKIKHDTEVVVDDYQYSAILLEGMLRTQNSLEYNLLELITASQNE
VANKEGIIDNIEKDLKKYDSLLKEYDDGFNLSKQEDELFQKMKKSLPSYKDTYKKLFEKAKATNEPQMVNEFQKELKPKG
IELAGYAVDLESYVSNLADQVFKDSQKMIDRSVITFIILVVVTTIVICIVSYIISKLIVAPLQTVSRMMERAKEGDLTVH
GDYTAKDELGVLVSNFNEMIAGLRTNMQEVENNIQLLFQHADGVVSASEVSSSAAKKITMDIEEVANGAESQMQAMEQTA
GAMEELTQGMQSIVNTSSSVNELSAQSALDAESGNKLMKQMIQQMDTIQNSVHSGVKQVETMKEQSEEIVKIIDVMQGIT
SQINLLALNAAIEAARAGESGRGFAIVADEVRKLAEQSSDSAKQIENLITQVMGTTNHTVHMMGKVDNEVQAGTQVVMHT
EKVFGTITEKVQQVSEQIQTVSMSTDEIAASSEEISASAEDMAQISQRSSDRTDRVKESIQQQEKSVQEISVSIEHMHNA
AGKLKQIVAQFTLQK

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=517, Percent_Identity=25.7253384912959, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1788194, Length=415, Percent_Identity=28.1927710843373, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI2367378, Length=543, Percent_Identity=24.4935543278085, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788195, Length=320, Percent_Identity=26.5625, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789453, Length=356, Percent_Identity=25.8426966292135, Blast_Score=95, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 63644; Mature: 63644

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYFLQNLKVKYKLLALISLAVLGMVIISSVAISSINKIKHDTEVVVDDYQYSAILLEGML
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEECCHHHHHHHHHHHH
RTQNSLEYNLLELITASQNEVANKEGIIDNIEKDLKKYDSLLKEYDDGFNLSKQEDELFQ
HHCCCCHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
KMKKSLPSYKDTYKKLFEKAKATNEPQMVNEFQKELKPKGIELAGYAVDLESYVSNLADQ
HHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEHHHCCHHHHHHHHHHH
VFKDSQKMIDRSVITFIILVVVTTIVICIVSYIISKLIVAPLQTVSRMMERAKEGDLTVH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
GDYTAKDELGVLVSNFNEMIAGLRTNMQEVENNIQLLFQHADGVVSASEVSSSAAKKITM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
DIEEVANGAESQMQAMEQTAGAMEELTQGMQSIVNTSSSVNELSAQSALDAESGNKLMKQ
CHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHH
MIQQMDTIQNSVHSGVKQVETMKEQSEEIVKIIDVMQGITSQINLLALNAAIEAARAGES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GRGFAIVADEVRKLAEQSSDSAKQIENLITQVMGTTNHTVHMMGKVDNEVQAGTQVVMHT
CCCEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHH
EKVFGTITEKVQQVSEQIQTVSMSTDEIAASSEEISASAEDMAQISQRSSDRTDRVKESI
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHCCHHHHHHHHHCCCCHHHHHHHHH
QQQEKSVQEISVSIEHMHNAAGKLKQIVAQFTLQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYFLQNLKVKYKLLALISLAVLGMVIISSVAISSINKIKHDTEVVVDDYQYSAILLEGML
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEECCHHHHHHHHHHHH
RTQNSLEYNLLELITASQNEVANKEGIIDNIEKDLKKYDSLLKEYDDGFNLSKQEDELFQ
HHCCCCHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
KMKKSLPSYKDTYKKLFEKAKATNEPQMVNEFQKELKPKGIELAGYAVDLESYVSNLADQ
HHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEHHHCCHHHHHHHHHHH
VFKDSQKMIDRSVITFIILVVVTTIVICIVSYIISKLIVAPLQTVSRMMERAKEGDLTVH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
GDYTAKDELGVLVSNFNEMIAGLRTNMQEVENNIQLLFQHADGVVSASEVSSSAAKKITM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
DIEEVANGAESQMQAMEQTAGAMEELTQGMQSIVNTSSSVNELSAQSALDAESGNKLMKQ
CHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHH
MIQQMDTIQNSVHSGVKQVETMKEQSEEIVKIIDVMQGITSQINLLALNAAIEAARAGES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GRGFAIVADEVRKLAEQSSDSAKQIENLITQVMGTTNHTVHMMGKVDNEVQAGTQVVMHT
CCCEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHH
EKVFGTITEKVQQVSEQIQTVSMSTDEIAASSEEISASAEDMAQISQRSSDRTDRVKESI
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHCCHHHHHHHHHCCCCHHHHHHHHH
QQQEKSVQEISVSIEHMHNAAGKLKQIVAQFTLQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]