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The map label for this gene is purC [H]

Identifier: 218231628

GI number: 218231628

Start: 312009

End: 312728

Strand: Direct

Name: purC [H]

Synonym: BCB4264_A0337

Alternate gene names: 218231628

Gene position: 312009-312728 (Clockwise)

Preceding gene: 218234739

Following gene: 218232164

Centisome position: 5.76

GC content: 35.14

Gene sequence:

>720_bases
ATGCAAAAGCTAGAATTGCTGTATGAAGGTAAGGCAAAAAGAATTTATCGTACAGAATCAGCAGATATGGTTTGGGTAGA
GTACAAAGATAGTGCGACTGCTTTCAATGGGGAGAAAAAAGAGACGATTACAGGAAAAGGTCGTTTGAACAATGAAATTA
CAACTTTATTGTTCAGAAAGTTACAAGAAGTGGGAATTAAAACACATTTTGTTGAGAAGTTATCTGAAACAGAACAACTT
GTTAAAAAAGTGAGTATTATTCCTTTAGAAGTTGTCACAAGAAATGTAATTGCAGGAAGTCTTTCAAAACGATTAGGAAT
GGAAGAGGGAACTGTACTTGCAGAACCAATCGTAGAATTTTACTTCAAAGATGATGATTTAGGAGATCCGCTTGTAACGG
AAGATCATATTCGTGTATTAAACGTTGCATCGCCAGAGCAAGTAAGTGTATTACGAGATATGGCTCTACAAATCAATCAA
GTGTTGATTGATCATTTCGCAAGCTGTCGTGTAAGATTAGTAGATTTCAAATTAGAGTTTGGTGTAACGGAAGAAGGAGA
AATCATTTTAGCGGATGAAATTTCACCAGATACTTGCCGTTTATGGGATGAAACGAGCAATGAAAAGTTTGATAAAGATG
TATTCCGTCGTGATCTTGGAAATTTAACAGATGCTTATGAAGAGATTTTAAAACGTTTAGGGGGAATTTCACATGTATAA

Upstream 100 bases:

>100_bases
AACGAAGCGTAAAATTTCATATGGCACAGAATAGAGTCATTCTGTGCCATTCTTTATAAAAATATTATTCACATTTTTCA
AACTACAGGGGGCTTGCGAA

Downstream 100 bases:

>100_bases
AGTTAAGGTATATGTAACATTAAGAGAAAGCGTATTAGATCCACAAGGAACAGCAGTAAAAGGAGCACTTCATAGTCTTT
CATTCACAGAAGTACAAGAC

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MQKLELLYEGKAKRIYRTESADMVWVEYKDSATAFNGEKKETITGKGRLNNEITTLLFRKLQEVGIKTHFVEKLSETEQL
VKKVSIIPLEVVTRNVIAGSLSKRLGMEEGTVLAEPIVEFYFKDDDLGDPLVTEDHIRVLNVASPEQVSVLRDMALQINQ
VLIDHFASCRVRLVDFKLEFGVTEEGEIILADEISPDTCRLWDETSNEKFDKDVFRRDLGNLTDAYEEILKRLGGISHV

Sequences:

>Translated_239_residues
MQKLELLYEGKAKRIYRTESADMVWVEYKDSATAFNGEKKETITGKGRLNNEITTLLFRKLQEVGIKTHFVEKLSETEQL
VKKVSIIPLEVVTRNVIAGSLSKRLGMEEGTVLAEPIVEFYFKDDDLGDPLVTEDHIRVLNVASPEQVSVLRDMALQINQ
VLIDHFASCRVRLVDFKLEFGVTEEGEIILADEISPDTCRLWDETSNEKFDKDVFRRDLGNLTDAYEEILKRLGGISHV
>Mature_239_residues
MQKLELLYEGKAKRIYRTESADMVWVEYKDSATAFNGEKKETITGKGRLNNEITTLLFRKLQEVGIKTHFVEKLSETEQL
VKKVSIIPLEVVTRNVIAGSLSKRLGMEEGTVLAEPIVEFYFKDDDLGDPLVTEDHIRVLNVASPEQVSVLRDMALQINQ
VLIDHFASCRVRLVDFKLEFGVTEEGEIILADEISPDTCRLWDETSNEKFDKDVFRRDLGNLTDAYEEILKRLGGISHV

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=236, Percent_Identity=34.7457627118644, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI5453539, Length=236, Percent_Identity=34.7457627118644, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI119220559, Length=243, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=2e-25,
Organism=Escherichia coli, GI1788820, Length=234, Percent_Identity=43.5897435897436, Blast_Score=199, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17531275, Length=228, Percent_Identity=38.1578947368421, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6319326, Length=257, Percent_Identity=26.0700389105058, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI18860083, Length=237, Percent_Identity=32.9113924050633, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24583917, Length=249, Percent_Identity=31.3253012048193, Blast_Score=114, Evalue=4e-26,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 27251; Mature: 27251

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLELLYEGKAKRIYRTESADMVWVEYKDSATAFNGEKKETITGKGRLNNEITTLLFRK
CCHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCEEECCCCCCHHHHHHHHHH
LQEVGIKTHFVEKLSETEQLVKKVSIIPLEVVTRNVIAGSLSKRLGMEEGTVLAEPIVEF
HHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
YFKDDDLGDPLVTEDHIRVLNVASPEQVSVLRDMALQINQVLIDHFASCRVRLVDFKLEF
HCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEEE
GVTEEGEIILADEISPDTCRLWDETSNEKFDKDVFRRDLGNLTDAYEEILKRLGGISHV
CCCCCCCEEEECCCCCCCEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQKLELLYEGKAKRIYRTESADMVWVEYKDSATAFNGEKKETITGKGRLNNEITTLLFRK
CCHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCEEECCCCCCHHHHHHHHHH
LQEVGIKTHFVEKLSETEQLVKKVSIIPLEVVTRNVIAGSLSKRLGMEEGTVLAEPIVEF
HHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
YFKDDDLGDPLVTEDHIRVLNVASPEQVSVLRDMALQINQVLIDHFASCRVRLVDFKLEF
HCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEEE
GVTEEGEIILADEISPDTCRLWDETSNEKFDKDVFRRDLGNLTDAYEEILKRLGGISHV
CCCCCCCEEEECCCCCCCEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA