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The map label for this gene is opuE [H]

Identifier: 218231602

GI number: 218231602

Start: 3665131

End: 3666609

Strand: Reverse

Name: opuE [H]

Synonym: BCB4264_A3752

Alternate gene names: 218231602

Gene position: 3666609-3665131 (Counterclockwise)

Preceding gene: 218231033

Following gene: 218234524

Centisome position: 67.66

GC content: 36.85

Gene sequence:

>1479_bases
GTGAAGATTGAAATTATGGTTTCGCTTGCTATTTATATGGCAGGTATGTTGTATATCGGATATTGGTCTTATAAGAAGAC
ATCCGATTTATCAGGTTATATGTTAGGCGGGAGGGGACTCGGCCCAGCAGTTACAGCTTTATCAGCTGGTGCTTCTGACA
TGAGTGGTTGGATGCTAATGGGATTACCTGGTGCGATGTATGCAACAGGATTATCAAGTGTATGGATTGCGATAGGTTTA
TTGATAGGTGCGTATGCAAACTATTTAATCATTGCCCCGCGTTTACGAACGTATACAGAAGTGGCAAATGATTCAATTAC
GATTCCAGACTTTTTAGAGAATCGGTTTAAAGATCGTACGAAAATACTTCGTTTTTTCTCCGCTATCGTCATTTTAGTAT
TTTTCACATTTTATGCGTCGGCTGGTTTAGTTTCAGGTGGACGTTTGTTTGAAAATTCTTTTAACCTTGATTATAAAATT
GGTTTATTTGTAACAGTAGGTGTTGTTGTTGCGTATACACTATTTGGTGGCTTTCTAGCCGTAAGTTGGACGGACTTTGT
GCAAGGTTGTATTATGTTTATTGCGCTTGTACTAGTGCCAATTGTTGCTGTTACGGATGTCGGTGGTGTAACAGAAACAT
TTAATACGATTAAGCAAGTCGATGCATCGCATTTAGATATGTTTAAAGGGACCACAATACTTGGTATTATTTCATTTTTA
GCATGGGGCCTTGGATATTTTGGTCAACCACATATTATTGTCCGCTTTATGGCAATTACCTCTATTAAAGATTTAAAAAC
TTCTCGTAGAATCGGTATCGGTTGGATGACGATTTCAATTATAGGTGCAATGCTTACTGGTCTAATTGGTATCGCCTATT
ATGCTAAAAATAATGCGACATTACAAGACCCAGAAATGGTCTTTGTAACATTCTCAAATATTTTATTCCATCCGTATATT
ACAGGATTTTTATTATCAGCTATTTTGGCTTCGATTATGAGTAGTATTTCCTCACAATTACTTGTTATTTCAAGTGCAGT
AACGGAAGACTTTTATAAAACATTTTTCCGTCGTAACGCAAGTGACAAAGAACTTGTATTTATCGGTAGATTGTCAGTAT
TAGTAGTAGCTATGATCGCAGTTGTTTTAGCGTATCATCCAAGTGATACAATTTTAACACTTGTCGGTTATGCTTGGGCT
GGATTTGGTTCAGCATTCGGACCAGCCATTTTATTAAGTTTATATTGGAAAAGGACGAACAAGTGGGGTGTTCTTGCAGG
TATGATTGTTGGTGCAGTAGTTGTTATAGCATGGGTACAAATTCCAAGTTTAAAAGCAATTATGTATGAAATGGTACCGG
GATTCTTCTGTAGTTTATTAACTGTTATCGTTGTAAGTTTATTAACGAAAGAACCCGTTAAGGCAGTTCATCGTGAATTT
AATGAGATGGAAGCAGTACTGGAAGAAGAAACGAAATGA

Upstream 100 bases:

>100_bases
AAAATGTTTGTTAAGGTAGGGAACCATGAGCGAAAACAAGAAAATAGAAAAAGTCATTTTTCGAAATTTTGAATGGCTTA
TGGACTAAGGGAGAGATTTG

Downstream 100 bases:

>100_bases
TTAGCGAAGAGAGTAAACGAAACTGGCGTTTACTCTTTTTTTATTTAAAGTGAAAATAAGGAACTTATTGACAACTAAAA
GTAAGTAACTTATAATAAAT

Product: sodium/proline symporter family protein

Products: NA

Alternate protein names: Sodium/proline symporter [H]

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MKIEIMVSLAIYMAGMLYIGYWSYKKTSDLSGYMLGGRGLGPAVTALSAGASDMSGWMLMGLPGAMYATGLSSVWIAIGL
LIGAYANYLIIAPRLRTYTEVANDSITIPDFLENRFKDRTKILRFFSAIVILVFFTFYASAGLVSGGRLFENSFNLDYKI
GLFVTVGVVVAYTLFGGFLAVSWTDFVQGCIMFIALVLVPIVAVTDVGGVTETFNTIKQVDASHLDMFKGTTILGIISFL
AWGLGYFGQPHIIVRFMAITSIKDLKTSRRIGIGWMTISIIGAMLTGLIGIAYYAKNNATLQDPEMVFVTFSNILFHPYI
TGFLLSAILASIMSSISSQLLVISSAVTEDFYKTFFRRNASDKELVFIGRLSVLVVAMIAVVLAYHPSDTILTLVGYAWA
GFGSAFGPAILLSLYWKRTNKWGVLAGMIVGAVVVIAWVQIPSLKAIMYEMVPGFFCSLLTVIVVSLLTKEPVKAVHREF
NEMEAVLEEETK

Sequences:

>Translated_492_residues
MKIEIMVSLAIYMAGMLYIGYWSYKKTSDLSGYMLGGRGLGPAVTALSAGASDMSGWMLMGLPGAMYATGLSSVWIAIGL
LIGAYANYLIIAPRLRTYTEVANDSITIPDFLENRFKDRTKILRFFSAIVILVFFTFYASAGLVSGGRLFENSFNLDYKI
GLFVTVGVVVAYTLFGGFLAVSWTDFVQGCIMFIALVLVPIVAVTDVGGVTETFNTIKQVDASHLDMFKGTTILGIISFL
AWGLGYFGQPHIIVRFMAITSIKDLKTSRRIGIGWMTISIIGAMLTGLIGIAYYAKNNATLQDPEMVFVTFSNILFHPYI
TGFLLSAILASIMSSISSQLLVISSAVTEDFYKTFFRRNASDKELVFIGRLSVLVVAMIAVVLAYHPSDTILTLVGYAWA
GFGSAFGPAILLSLYWKRTNKWGVLAGMIVGAVVVIAWVQIPSLKAIMYEMVPGFFCSLLTVIVVSLLTKEPVKAVHREF
NEMEAVLEEETK
>Mature_492_residues
MKIEIMVSLAIYMAGMLYIGYWSYKKTSDLSGYMLGGRGLGPAVTALSAGASDMSGWMLMGLPGAMYATGLSSVWIAIGL
LIGAYANYLIIAPRLRTYTEVANDSITIPDFLENRFKDRTKILRFFSAIVILVFFTFYASAGLVSGGRLFENSFNLDYKI
GLFVTVGVVVAYTLFGGFLAVSWTDFVQGCIMFIALVLVPIVAVTDVGGVTETFNTIKQVDASHLDMFKGTTILGIISFL
AWGLGYFGQPHIIVRFMAITSIKDLKTSRRIGIGWMTISIIGAMLTGLIGIAYYAKNNATLQDPEMVFVTFSNILFHPYI
TGFLLSAILASIMSSISSQLLVISSAVTEDFYKTFFRRNASDKELVFIGRLSVLVVAMIAVVLAYHPSDTILTLVGYAWA
GFGSAFGPAILLSLYWKRTNKWGVLAGMIVGAVVVIAWVQIPSLKAIMYEMVPGFFCSLLTVIVVSLLTKEPVKAVHREF
NEMEAVLEEETK

Specific function: Catalyzes the sodium-dependent uptake of extracellular proline [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=494, Percent_Identity=55.4655870445344, Blast_Score=538, Evalue=1e-153,
Organism=Homo sapiens, GI110835708, Length=546, Percent_Identity=23.0769230769231, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI11141885, Length=465, Percent_Identity=24.7311827956989, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI14140236, Length=544, Percent_Identity=25.1838235294118, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI109659836, Length=386, Percent_Identity=22.279792746114, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI4507031, Length=542, Percent_Identity=24.3542435424354, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI109659839, Length=402, Percent_Identity=21.6417910447761, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1787251, Length=485, Percent_Identity=49.4845360824742, Blast_Score=483, Evalue=1e-137,
Organism=Escherichia coli, GI87082237, Length=460, Percent_Identity=30, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1790503, Length=471, Percent_Identity=26.963906581741, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1790113, Length=391, Percent_Identity=24.5524296675192, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17539284, Length=421, Percent_Identity=26.1282660332542, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI115533094, Length=382, Percent_Identity=21.9895287958115, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24640370, Length=358, Percent_Identity=24.0223463687151, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI221459584, Length=372, Percent_Identity=22.5806451612903, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24648033, Length=452, Percent_Identity=23.8938053097345, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21356865, Length=452, Percent_Identity=23.8938053097345, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24645928, Length=373, Percent_Identity=24.9329758713137, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24651741, Length=466, Percent_Identity=25.3218884120172, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24651739, Length=447, Percent_Identity=24.3847874720358, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281362918, Length=295, Percent_Identity=27.7966101694915, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 53832; Mature: 53832

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIEIMVSLAIYMAGMLYIGYWSYKKTSDLSGYMLGGRGLGPAVTALSAGASDMSGWMLM
CEEEEEHHHHHHHHHHHHHHEECCCCCCCCCCEEECCCCCCHHHHHHHCCCCCCCCEEEE
GLPGAMYATGLSSVWIAIGLLIGAYANYLIIAPRLRTYTEVANDSITIPDFLENRFKDRT
CCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHH
KILRFFSAIVILVFFTFYASAGLVSGGRLFENSFNLDYKIGLFVTVGVVVAYTLFGGFLA
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
VSWTDFVQGCIMFIALVLVPIVAVTDVGGVTETFNTIKQVDASHLDMFKGTTILGIISFL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHCCHHHHHHHHHH
AWGLGYFGQPHIIVRFMAITSIKDLKTSRRIGIGWMTISIIGAMLTGLIGIAYYAKNNAT
HHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LQDPEMVFVTFSNILFHPYITGFLLSAILASIMSSISSQLLVISSAVTEDFYKTFFRRNA
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SDKELVFIGRLSVLVVAMIAVVLAYHPSDTILTLVGYAWAGFGSAFGPAILLSLYWKRTN
CCCCEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
KWGVLAGMIVGAVVVIAWVQIPSLKAIMYEMVPGFFCSLLTVIVVSLLTKEPVKAVHREF
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
NEMEAVLEEETK
HHHHHHHHHCCC
>Mature Secondary Structure
MKIEIMVSLAIYMAGMLYIGYWSYKKTSDLSGYMLGGRGLGPAVTALSAGASDMSGWMLM
CEEEEEHHHHHHHHHHHHHHEECCCCCCCCCCEEECCCCCCHHHHHHHCCCCCCCCEEEE
GLPGAMYATGLSSVWIAIGLLIGAYANYLIIAPRLRTYTEVANDSITIPDFLENRFKDRT
CCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHH
KILRFFSAIVILVFFTFYASAGLVSGGRLFENSFNLDYKIGLFVTVGVVVAYTLFGGFLA
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
VSWTDFVQGCIMFIALVLVPIVAVTDVGGVTETFNTIKQVDASHLDMFKGTTILGIISFL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHCCHHHHHHHHHH
AWGLGYFGQPHIIVRFMAITSIKDLKTSRRIGIGWMTISIIGAMLTGLIGIAYYAKNNAT
HHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LQDPEMVFVTFSNILFHPYITGFLLSAILASIMSSISSQLLVISSAVTEDFYKTFFRRNA
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SDKELVFIGRLSVLVVAMIAVVLAYHPSDTILTLVGYAWAGFGSAFGPAILLSLYWKRTN
CCCCEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
KWGVLAGMIVGAVVVIAWVQIPSLKAIMYEMVPGFFCSLLTVIVVSLLTKEPVKAVHREF
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
NEMEAVLEEETK
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969499; 9384377 [H]