Click here to switch to the map view.

The map label for this gene is disA [H]

Identifier: 218231574

GI number: 218231574

Start: 99223

End: 100296

Strand: Direct

Name: disA [H]

Synonym: BCB4264_A0104

Alternate gene names: 218231574

Gene position: 99223-100296 (Clockwise)

Preceding gene: 218235539

Following gene: 218231556

Centisome position: 1.83

GC content: 36.87

Gene sequence:

>1074_bases
ATGGAAGAAAATAAGCAACGTGTCAAAAGTATAATTAATATTTTACAGCTCGTGGCCCCGGGAACACCACTGCGCGAAGG
GATAGATAATGTACTTCGCGCACAAACAGGGGGACTAATTGTTCTTGGGTATAATGAGCAGATTAAAAGCATTGTTGATG
GTGGTTTTCATATTAATTGCGCATTCTCTCCTGCTAGTTTATATGAATTAGCAAAAATGGATGGAGCACTTATTTTAAAT
GAAACTGGAAGTAAAATTTTAATTGCAAACGCACAGTTAGTTCCGGATTCATCTATTGATTCTATTGAAACAGGTATGCG
TCACCGAACAGCAGAGCGTGTAGCAAAGCAGACGGGCAGCCTTGTTGTGGCCATTTCACAAAGACGTAATGTAATTACGC
TATATCAAGGGAACTTACGTTATACATTAAAAGATATAGGTGTCATTTTAACGAAGGCAAATCAAGCAATTCAAACGCTA
GAAAAATATAAGGCTGTATGGAATGACGGCATTACGAATTTGGGTATTCTAGAATTTGAAGAGGTCGTTACAATGTCCGA
GGTGGTTCACGTTTTACATAGTGTTGAAATGGTGCTGCGTATTAAAAATGAAATATTGAGCTATATTCATGAGTTAGGAA
CAGAAGGTAGGTTAATTCGTTTACAGCTTACAGAATTACTAGCTGATTTAGAGGCAGAGGCAGCATTGTTAATTAAAGAT
TATCACCAGGAGAAAACACAAGACCATCATCAAATATTGAAAAAGTTACAAGATCTTGCAAATACACAACTTTTAGAGGA
TAGTGATTTAGTTAAATTGCTTGGCTATCCAGGACAAACAAGTTTAGAAGAAAGTGTGACACCTAGAGGGTACCGAATCA
CAAGCAAGATTTCTCGTGTTCCGCCACTTATTATCGAGAATTTAATTAATCGATTTAAAACATTGCAAGGTGTTTGCCGA
GCAACTATTAATGAATTGGATGATGTGGAAGGAATTGGAGAAGTGAGAGCGAAGAAAATACGAGAAGGTCTAAAAAGAAT
TCAAGAGCATCTCTATATGAGTAGACACAATTAA

Upstream 100 bases:

>100_bases
TAGAAAAAATTTAGGGGGGTGGACAATTCCAGAGGGGATTGAGGTTGTAGGTGTTTCTAATTTAGGAGAAGCGCTTCGTT
TGACATTAGGAGGCTAGGCT

Downstream 100 bases:

>100_bases
GAATATTACATTGATTCTATAATATAACGACACTAGAACATTTTTGGTATATGATATGATATATTGGTAAATAAAACTAT
TTACAAAAAAACACGTCCGC

Product: DNA integrity scanning protein DisA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MEENKQRVKSIINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILN
ETGSKILIANAQLVPDSSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTL
EKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKD
YHQEKTQDHHQILKKLQDLANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCR
ATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN

Sequences:

>Translated_357_residues
MEENKQRVKSIINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILN
ETGSKILIANAQLVPDSSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTL
EKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKD
YHQEKTQDHHQILKKLQDLANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCR
ATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
>Mature_357_residues
MEENKQRVKSIINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILN
ETGSKILIANAQLVPDSSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTL
EKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKD
YHQEKTQDHHQILKKLQDLANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCR
ATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN

Specific function: Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, disA pauses at

COG id: COG1623

COG function: function code R; Predicted nucleic-acid-binding protein (contains the HHH domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the disA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018906
- InterPro:   IPR003390
- InterPro:   IPR003583
- InterPro:   IPR010994 [H]

Pfam domain/function: PF10635 DisA-linker; PF02457 DisA_N [H]

EC number: NA

Molecular weight: Translated: 40024; Mature: 40024

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEENKQRVKSIINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINC
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCEEEEE
AFSPASLYELAKMDGALILNETGSKILIANAQLVPDSSIDSIETGMRHRTAERVAKQTGS
ECCHHHHHHHHHCCCEEEEECCCCEEEEEECEECCCCCHHHHHHHHHHHHHHHHHHHCCC
LVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFE
EEEEEECCCCEEEEEECCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
EVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHH
YHQEKTQDHHQILKKLQDLANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCHHHCCCCCCEEHHHHHHHC
PPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEENKQRVKSIINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINC
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCEEEEE
AFSPASLYELAKMDGALILNETGSKILIANAQLVPDSSIDSIETGMRHRTAERVAKQTGS
ECCHHHHHHHHHCCCEEEEECCCCEEEEEECEECCCCCHHHHHHHHHHHHHHHHHHHCCC
LVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFE
EEEEEECCCCEEEEEECCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
EVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHH
YHQEKTQDHHQILKKLQDLANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCHHHCCCCCCEEHHHHHHHC
PPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA