BacMap

Definition	Bacillus cereus B4264, complete genome.
Accession	NC_011725
Length	5,419,036

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The map label for this gene is fabG [C]

Identifier: 218231563

GI number: 218231563

Start: 1071323

End: 1072069

Strand: Direct

Name: fabG [C]

Synonym: BCB4264_A1097

Alternate gene names: 218231563

Gene position: 1071323-1072069 (Clockwise)

Preceding gene: 218231148

Following gene: 218236102

Centisome position: 19.77

GC content: 32.13

Gene sequence:

>747_bases
ATGAGAGAGAATAAAATAATTATGATTTCTGGAGCCAATAGCGGTATAGGTCATGCTTGTATAAAATACTTTTTAGAAAA
ATCATTTCATGTAATAGCGCTTGATATTCATAATAATAATTTAATAGATTATATGAAAACAGATATGCCTTTGAAAGTAG
TGCAAATTGATTTAAGTAATAGCGAAGCGATTCATAATCTTTTTACTCAATTAGATTTAGAAAAGCTTTCTCCTGATATA
TTAATAAATGCAGCTGGTATTCGAGAGATAACACCTGTTTTACATTTATCCGATGATATGTTTAAAAAAGTAATTGATGT
AAATTTAGTAGCCCCATTTATCCTTTCTAGGGAAGTAGCTAAGCGATGGTGTGAATCGAAAATAAAAGGTTGTATTGTGA
ATATAGCATCGGTTTCTGGATTAATGGCTGAACCAGAGCGAGCTGCTTATGTTGCATCAAAACATGCTTTAATCGGATTG
ACTAAACAGATGGCTATGGAATTTGGGAAGCAAAATATAAGGGTAAATAGTATTTCTCCCGGTGTTATTAGAACTGAACT
TACAGAAGAATACTTTAGTAATAAAGCCTTGATGTCTATGATAAAAAGTAATCAATCTTTAGATACTTGGGGGTTGCCGC
AGGATATTGTTTCATGTATTGAGTACTTGATTTCTGATCAGGCCCGCTTTATTACTGGTTCTAATTTTGTAATTGATGGT
GGTTGGACTGCTGGAAAAAATTTATAA

Upstream 100 bases:

>100_bases
GACAAAAGGTCTTCCATGCCGTAACGCCACTTGGAACAGAATGTAGTACGGAGGCTTTTCGTGATATTTTATTAGTAACA
TTTTCTTATAAGGAGACAAA

Downstream 100 bases:

>100_bases
TTGAGTGTTTTTGAGGAAAAGCACCTGTCCTTTTTTTAGGCTGGTGTTTTTCTCACTATAAACCGAGTTTTTATTGGAGG
GGGATTAATTTGCTTCAAAA

Product: 3-oxoacyl-[acyl-carrier protein] reductase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MRENKIIMISGANSGIGHACIKYFLEKSFHVIALDIHNNNLIDYMKTDMPLKVVQIDLSNSEAIHNLFTQLDLEKLSPDI
LINAAGIREITPVLHLSDDMFKKVIDVNLVAPFILSREVAKRWCESKIKGCIVNIASVSGLMAEPERAAYVASKHALIGL
TKQMAMEFGKQNIRVNSISPGVIRTELTEEYFSNKALMSMIKSNQSLDTWGLPQDIVSCIEYLISDQARFITGSNFVIDG
GWTAGKNL

Sequences:

>Translated_248_residues
MRENKIIMISGANSGIGHACIKYFLEKSFHVIALDIHNNNLIDYMKTDMPLKVVQIDLSNSEAIHNLFTQLDLEKLSPDI
LINAAGIREITPVLHLSDDMFKKVIDVNLVAPFILSREVAKRWCESKIKGCIVNIASVSGLMAEPERAAYVASKHALIGL
TKQMAMEFGKQNIRVNSISPGVIRTELTEEYFSNKALMSMIKSNQSLDTWGLPQDIVSCIEYLISDQARFITGSNFVIDG
GWTAGKNL
>Mature_248_residues
MRENKIIMISGANSGIGHACIKYFLEKSFHVIALDIHNNNLIDYMKTDMPLKVVQIDLSNSEAIHNLFTQLDLEKLSPDI
LINAAGIREITPVLHLSDDMFKKVIDVNLVAPFILSREVAKRWCESKIKGCIVNIASVSGLMAEPERAAYVASKHALIGL
TKQMAMEFGKQNIRVNSISPGVIRTELTEEYFSNKALMSMIKSNQSLDTWGLPQDIVSCIEYLISDQARFITGSNFVIDG
GWTAGKNL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=251, Percent_Identity=27.8884462151394, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI32483357, Length=249, Percent_Identity=26.1044176706827, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI7705925, Length=242, Percent_Identity=27.6859504132231, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI19923817, Length=252, Percent_Identity=26.984126984127, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI5031737, Length=247, Percent_Identity=24.6963562753036, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI10190704, Length=250, Percent_Identity=28.8, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI40254992, Length=244, Percent_Identity=26.6393442622951, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI126723750, Length=253, Percent_Identity=24.1106719367589, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI20149619, Length=197, Percent_Identity=29.4416243654822, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI66933014, Length=225, Percent_Identity=26.2222222222222, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI109715829, Length=252, Percent_Identity=26.1904761904762, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI157739938, Length=193, Percent_Identity=27.979274611399, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI33667109, Length=196, Percent_Identity=25, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI59889578, Length=156, Percent_Identity=30.7692307692308, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI4758504, Length=194, Percent_Identity=25.7731958762887, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI31542939, Length=197, Percent_Identity=24.8730964467005, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI210032110, Length=192, Percent_Identity=26.0416666666667, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787335, Length=244, Percent_Identity=29.0983606557377, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1789208, Length=244, Percent_Identity=27.0491803278689, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI87082160, Length=243, Percent_Identity=30.4526748971193, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1788459, Length=249, Percent_Identity=28.9156626506024, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI87082100, Length=250, Percent_Identity=28.4, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI2367175, Length=249, Percent_Identity=29.718875502008, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790717, Length=163, Percent_Identity=31.9018404907975, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI2367365, Length=244, Percent_Identity=28.2786885245902, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786812, Length=250, Percent_Identity=27.2, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1787905, Length=245, Percent_Identity=27.3469387755102, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787526, Length=251, Percent_Identity=26.6932270916335, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789057, Length=194, Percent_Identity=24.7422680412371, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786701, Length=242, Percent_Identity=26.0330578512397, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1789378, Length=246, Percent_Identity=23.1707317073171, Blast_Score=62, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=246, Percent_Identity=29.2682926829268, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI115534694, Length=244, Percent_Identity=29.0983606557377, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25147288, Length=244, Percent_Identity=27.4590163934426, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17561402, Length=255, Percent_Identity=30.9803921568627, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17560676, Length=255, Percent_Identity=25.8823529411765, Blast_Score=97, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=25.9109311740891, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994600, Length=252, Percent_Identity=26.5873015873016, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17538182, Length=254, Percent_Identity=24.0157480314961, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17536651, Length=248, Percent_Identity=24.1935483870968, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17508651, Length=246, Percent_Identity=27.2357723577236, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI72000259, Length=266, Percent_Identity=27.4436090225564, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=259, Percent_Identity=28.957528957529, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17559104, Length=262, Percent_Identity=26.7175572519084, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=268, Percent_Identity=27.2388059701493, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17536025, Length=248, Percent_Identity=23.7903225806452, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=265, Percent_Identity=27.1698113207547, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=261, Percent_Identity=27.2030651340996, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=263, Percent_Identity=25.8555133079848, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=264, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17561272, Length=192, Percent_Identity=26.0416666666667, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=261, Percent_Identity=25.6704980842912, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=274, Percent_Identity=27.007299270073, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=25.6704980842912, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=233, Percent_Identity=25.7510729613734, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI193203117, Length=232, Percent_Identity=25.8620689655172, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=259, Percent_Identity=25.4826254826255, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322861, Length=252, Percent_Identity=27.3809523809524, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324126, Length=205, Percent_Identity=29.2682926829268, Blast_Score=76, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6323882, Length=194, Percent_Identity=29.8969072164948, Blast_Score=69, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320089, Length=203, Percent_Identity=27.0935960591133, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24643142, Length=241, Percent_Identity=29.8755186721992, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24639444, Length=246, Percent_Identity=28.8617886178862, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21355319, Length=245, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI21357041, Length=254, Percent_Identity=29.9212598425197, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI23397609, Length=246, Percent_Identity=30.4878048780488, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28571526, Length=254, Percent_Identity=27.9527559055118, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24644339, Length=254, Percent_Identity=29.9212598425197, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24644337, Length=167, Percent_Identity=33.5329341317365, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21358495, Length=193, Percent_Identity=31.6062176165803, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI116007236, Length=241, Percent_Identity=26.1410788381743, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24648693, Length=236, Percent_Identity=27.1186440677966, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21355889, Length=236, Percent_Identity=27.1186440677966, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24641388, Length=237, Percent_Identity=26.1603375527426, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI281364494, Length=219, Percent_Identity=25.5707762557078, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI17737361, Length=200, Percent_Identity=25.5, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 27587; Mature: 27587

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRENKIIMISGANSGIGHACIKYFLEKSFHVIALDIHNNNLIDYMKTDMPLKVVQIDLSN
CCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHCCCCEEEEEEECCC
SEAIHNLFTQLDLEKLSPDILINAAGIREITPVLHLSDDMFKKVIDVNLVAPFILSREVA
CHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
KRWCESKIKGCIVNIASVSGLMAEPERAAYVASKHALIGLTKQMAMEFGKQNIRVNSISP
HHHHHHHHHHHEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
GVIRTELTEEYFSNKALMSMIKSNQSLDTWGLPQDIVSCIEYLISDQARFITGSNFVIDG
CHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCEEEEC
GWTAGKNL
CCCCCCCC
>Mature Secondary Structure
MRENKIIMISGANSGIGHACIKYFLEKSFHVIALDIHNNNLIDYMKTDMPLKVVQIDLSN
CCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHCCCCEEEEEEECCC
SEAIHNLFTQLDLEKLSPDILINAAGIREITPVLHLSDDMFKKVIDVNLVAPFILSREVA
CHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
KRWCESKIKGCIVNIASVSGLMAEPERAAYVASKHALIGLTKQMAMEFGKQNIRVNSISP
HHHHHHHHHHHEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
GVIRTELTEEYFSNKALMSMIKSNQSLDTWGLPQDIVSCIEYLISDQARFITGSNFVIDG
CHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCEEEEC
GWTAGKNL
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8796346; 9163424 [H]