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The map label for this gene is acr3 [H]

Identifier: 218231356

GI number: 218231356

Start: 3070543

End: 3071529

Strand: Reverse

Name: acr3 [H]

Synonym: BCB4264_A3187

Alternate gene names: 218231356

Gene position: 3071529-3070543 (Counterclockwise)

Preceding gene: 218233242

Following gene: 218231956

Centisome position: 56.68

GC content: 35.97

Gene sequence:

>987_bases
ATGGCTGTTGGGATTGGTTTAGGGTTTGTGTTTCCTAGTGTAGTAGACGGACTAAATACATTACAGGTTGGAACGACGTC
TATTCCACTTGCTGTTGGTTTAATTGTAATGATGTATCCACCATTAGCGAAAGTTCGCTATGAGGAAATGGGCCGAGTAT
TTAAAGATGTAAAAGTGTTAGTTCTATCTTTAGTACAAAATTGGATTATTGGTCCGGTACTTATGTTTGTTTTAGCAATT
ATTTTTCTTCCTGATAAACCAGAATACATGGTTGGTCTCATTATGATTGGGTTAGCACGTTGTATTGCAATGGTCATTGT
TTGGAACGATCTTGCCGATGGAGATAAAGAGTATGCGGCAGGTTTAGTTGCTTTTAATTCGGTATTCCAAATGCTCTTTT
TCTCAGTTTATGCATACGTATTTGTAACTGTAATTCCAGAATGGTTAGGGATTGAAGTTGCTATTGTTGATATTACAATG
ATAGAAGTAGCAAAATCAGTATTTATCTATTTAGGAATTCCTTTTATAGCAGGTATGTTAACACGCTTTGTACTCGTTAA
GTTAAAAGGAAGACAGTGGTACGAAAAGGTGTTTATACCTAAAATTAGTCCACTTACATTACTTGCATTACTATTTACAA
TCATCATTATGTTCTCCTTAAAAGGGGAGATGATTGTTAGCATGCCACTAGATGTGGTAAGAATAGCGATGCCGTTATTA
ATCTATTTTATTGTAATGTTTTTTGTATCTTTCTTTATGGGAAGAAAAATTGGTGCAAACTATCCGGTAACAACAACGTT
AGCATTTACAGCTGGTAGTAATAACTTTGAGTTAGCAATTGCTGTAGCAGTTGGTGTGTTTGGTATTCATTCGGGCGCAG
CATTCGCAGCTGTTATCGGACCGTTAGTGGAAGTGCCTGTAATGATTGCACTTGTAAACGTCGCTTTTTGGTTTAAACGT
AAATATTTTAATGACCAACCAGTCTAA

Upstream 100 bases:

>100_bases
CGTAGTAGAAAAAAATTCTTGTTGTTAATAGGAGCTGGAAAATAAAATGAAACGTTTATCCTTTCTAGACCGATATTTAA
CACTATGGATCTTTCTAGCG

Downstream 100 bases:

>100_bases
ATTTAAAAATAAAGGCGGAAAATACCATGGAAAACAAAAAGACAATCTACTTTTTATGTACGGGAAATTCATGCAGAAGC
CAAATGGCAGAAGCGTGGGG

Product: arsenical-resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MAVGIGLGFVFPSVVDGLNTLQVGTTSIPLAVGLIVMMYPPLAKVRYEEMGRVFKDVKVLVLSLVQNWIIGPVLMFVLAI
IFLPDKPEYMVGLIMIGLARCIAMVIVWNDLADGDKEYAAGLVAFNSVFQMLFFSVYAYVFVTVIPEWLGIEVAIVDITM
IEVAKSVFIYLGIPFIAGMLTRFVLVKLKGRQWYEKVFIPKISPLTLLALLFTIIIMFSLKGEMIVSMPLDVVRIAMPLL
IYFIVMFFVSFFMGRKIGANYPVTTTLAFTAGSNNFELAIAVAVGVFGIHSGAAFAAVIGPLVEVPVMIALVNVAFWFKR
KYFNDQPV

Sequences:

>Translated_328_residues
MAVGIGLGFVFPSVVDGLNTLQVGTTSIPLAVGLIVMMYPPLAKVRYEEMGRVFKDVKVLVLSLVQNWIIGPVLMFVLAI
IFLPDKPEYMVGLIMIGLARCIAMVIVWNDLADGDKEYAAGLVAFNSVFQMLFFSVYAYVFVTVIPEWLGIEVAIVDITM
IEVAKSVFIYLGIPFIAGMLTRFVLVKLKGRQWYEKVFIPKISPLTLLALLFTIIIMFSLKGEMIVSMPLDVVRIAMPLL
IYFIVMFFVSFFMGRKIGANYPVTTTLAFTAGSNNFELAIAVAVGVFGIHSGAAFAAVIGPLVEVPVMIALVNVAFWFKR
KYFNDQPV
>Mature_327_residues
AVGIGLGFVFPSVVDGLNTLQVGTTSIPLAVGLIVMMYPPLAKVRYEEMGRVFKDVKVLVLSLVQNWIIGPVLMFVLAII
FLPDKPEYMVGLIMIGLARCIAMVIVWNDLADGDKEYAAGLVAFNSVFQMLFFSVYAYVFVTVIPEWLGIEVAIVDITMI
EVAKSVFIYLGIPFIAGMLTRFVLVKLKGRQWYEKVFIPKISPLTLLALLFTIIIMFSLKGEMIVSMPLDVVRIAMPLLI
YFIVMFFVSFFMGRKIGANYPVTTTLAFTAGSNNFELAIAVAVGVFGIHSGAAFAAVIGPLVEVPVMIALVNVAFWFKRK
YFNDQPV

Specific function: Seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump [H]

COG id: COG0798

COG function: function code P; Arsenite efflux pump ACR3 and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ACR3 family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6325459, Length=333, Percent_Identity=36.3363363363363, Blast_Score=177, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004706
- InterPro:   IPR002657 [H]

Pfam domain/function: PF01758 SBF [H]

EC number: NA

Molecular weight: Translated: 36258; Mature: 36126

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVGIGLGFVFPSVVDGLNTLQVGTTSIPLAVGLIVMMYPPLAKVRYEEMGRVFKDVKVL
CEEEEHHHHHHHHHHCCCHHEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
VLSLVQNWIIGPVLMFVLAIIFLPDKPEYMVGLIMIGLARCIAMVIVWNDLADGDKEYAA
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
GLVAFNSVFQMLFFSVYAYVFVTVIPEWLGIEVAIVDITMIEVAKSVFIYLGIPFIAGML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
TRFVLVKLKGRQWYEKVFIPKISPLTLLALLFTIIIMFSLKGEMIVSMPLDVVRIAMPLL
HHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHH
IYFIVMFFVSFFMGRKIGANYPVTTTLAFTAGSNNFELAIAVAVGVFGIHSGAAFAAVIG
HHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEEHHHHHHHHHHCCCHHHHHHHH
PLVEVPVMIALVNVAFWFKRKYFNDQPV
HHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AVGIGLGFVFPSVVDGLNTLQVGTTSIPLAVGLIVMMYPPLAKVRYEEMGRVFKDVKVL
EEEEHHHHHHHHHHCCCHHEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH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HHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7704261; 8969508; 9384377; 7489895; 9537360 [H]