Click here to switch to the map view.

The map label for this gene is fumC [H]

Identifier: 218231217

GI number: 218231217

Start: 1689720

End: 1691108

Strand: Direct

Name: fumC [H]

Synonym: BCB4264_A1783

Alternate gene names: 218231217

Gene position: 1689720-1691108 (Clockwise)

Preceding gene: 218233318

Following gene: 218232709

Centisome position: 31.18

GC content: 37.44

Gene sequence:

>1389_bases
ATGGAGTACAGAATTGAAAGAGATACATTAGGAGAAATAAAAGTTCCAGCTGATAAATTATGGGCAGCACAAACACAACG
TAGTAAAGAAAACTTTCCAATTGGAACAGAGCAAATGCCACTTGAAATTGTAAAAGCATTTGCAATTTTAAAGAAGAGTG
CAGCGCTTAGCAATCAAAAATTAGGAAAGCTATCAGAAGAAAAAGCAGAAGCAATTGTAGAAGCTGCGGATGAAGTGATT
GCAGGGAAATGGAATGAACATTTTCCGCTTGTCGTATGGCAAACAGGTAGTGGTACACAGTCAAACATGAATGTGAATGA
AGTAATTGCAAATCGTGGGAATCAAATTTTGAAAGAGAAGGGATCTGACGTACATATTCATCCGAATGATGATGTGAACA
TGTCACAAAGTTCAAATGATACATTTCCAACGGCGCTTCATGTAGCTTGTGTAATCGCAGTAGAAAATCACGTATTACCA
GCAATTACGAAATTAAAAGAAACTTTAGCAGAAAAAGTAACTGCATTTGAACATATTATAAAAATTGGTCGTACACATTT
ACAAGATGCAACGCCGTTAACTTTAGGGCAAGAAATTAGCGGATGGCACCGTATGCTTGAAAAAACAGAGCGTATGATTG
CAGAGAGCAATACATATATGAAAGAGTTAGCAATTGGTGGAACTGCGGTTGGAACAGGTATCAATGCTCATCCTAAATTT
GGTGAGATGGTATCAGAGGAAATTAGTCAATTTACAGGTAAACAATTTGTTTCTGCACCAAATAAGTTCCATGCATTAAC
GAGCCATGATGAAGTTGTATATACTCACGGTGCATTAAAAGCATTAGCTGCGGATTTAATGAAAATCGCTAACGATGTAC
GTTGGCTTGCAAGTGGTCCACGTAGTGGTCTTGGAGAAATTATTATTCCAGCAAATGAACCGGGAAGCTCTATTATGCCA
GGGAAAGTAAATCCAACGCAAAGTGAAGCATTAACGATGGTTGTAGCGCAAGTGATGGGGAATGATGCAACAATCGGATT
TGCTGCGAGCCAAGGTAACTTTGAGTTAAATGTATTTAAACCTGTTATTGCTTATAACTTCTTACAATCAGCTCACTTAT
TAGCGGATGCAATTGTTTCTTTTAATGACAATTGTGCAGTTGGTATTGAAGCAGATGAAGAAGTAATTAATGAAAATGTG
AATCGTTCACTAATGCTTGTAACAGCGCTAAACCCACATATCGGATATGAAAATGCAGCGAAAATTGCGAAGCATGCTCA
TAAAGAAGGGTTAACTTTAAAAGAAGCAGCATTGCAATCTGGGCTACTAACAGAAGAGCAATTTGATGAAATTGTAGATC
CGAAGAAAATGATTGCTCCAAAAGAGTAA

Upstream 100 bases:

>100_bases
ATATAGAATATCTATATATAAGAGTGAGAATTCTTATCATTTAAGAGAAAGTCTGTTATTATAAGAGATGTAGGTATTAT
ATTTTCAAGGGGATGAAAAC

Downstream 100 bases:

>100_bases
TAGAGAAAGCCAAGGTTCTTAGTATAGAATCTTGGCTTTTTTGATGTTCATTTTTATGTTTCATCTACTTGCAATACTAC
AAGCTTCAAAATATATTATT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALSNQKLGKLSEEKAEAIVEAADEVI
AGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEKGSDVHIHPNDDVNMSQSSNDTFPTALHVACVIAVENHVLP
AITKLKETLAEKVTAFEHIIKIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
GEMVSEEISQFTGKQFVSAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGPRSGLGEIIIPANEPGSSIMP
GKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFKPVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEVINENV
NRSLMLVTALNPHIGYENAAKIAKHAHKEGLTLKEAALQSGLLTEEQFDEIVDPKKMIAPKE

Sequences:

>Translated_462_residues
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALSNQKLGKLSEEKAEAIVEAADEVI
AGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEKGSDVHIHPNDDVNMSQSSNDTFPTALHVACVIAVENHVLP
AITKLKETLAEKVTAFEHIIKIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
GEMVSEEISQFTGKQFVSAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGPRSGLGEIIIPANEPGSSIMP
GKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFKPVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEVINENV
NRSLMLVTALNPHIGYENAAKIAKHAHKEGLTLKEAALQSGLLTEEQFDEIVDPKKMIAPKE
>Mature_462_residues
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALSNQKLGKLSEEKAEAIVEAADEVI
AGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEKGSDVHIHPNDDVNMSQSSNDTFPTALHVACVIAVENHVLP
AITKLKETLAEKVTAFEHIIKIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
GEMVSEEISQFTGKQFVSAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGPRSGLGEIIIPANEPGSSIMP
GKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFKPVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEVINENV
NRSLMLVTALNPHIGYENAAKIAKHAHKEGLTLKEAALQSGLLTEEQFDEIVDPKKMIAPKE

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=462, Percent_Identity=60.1731601731602, Blast_Score=538, Evalue=1e-153,
Organism=Escherichia coli, GI1787896, Length=457, Percent_Identity=61.925601750547, Blast_Score=571, Evalue=1e-164,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=39.2624728850325, Blast_Score=328, Evalue=5e-91,
Organism=Caenorhabditis elegans, GI17553882, Length=463, Percent_Identity=58.3153347732181, Blast_Score=537, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI32565146, Length=328, Percent_Identity=57.3170731707317, Blast_Score=381, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=57.9175704989154, Blast_Score=541, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24640179, Length=464, Percent_Identity=56.8965517241379, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24640177, Length=464, Percent_Identity=56.8965517241379, Blast_Score=526, Evalue=1e-150,
Organism=Drosophila melanogaster, GI78710009, Length=464, Percent_Identity=55.3879310344828, Blast_Score=513, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24662684, Length=465, Percent_Identity=53.9784946236559, Blast_Score=490, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24583245, Length=465, Percent_Identity=46.6666666666667, Blast_Score=426, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50320; Mature: 50320

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALSNQK
CCEECCCCCCCCEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LGKLSEEKAEAIVEAADEVIAGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEK
HCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCHHHHHC
GSDVHIHPNDDVNMSQSSNDTFPTALHVACVIAVENHVLPAITKLKETLAEKVTAFEHII
CCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHCCCCCCCCCHH
GEMVSEEISQFTGKQFVSAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGP
HHHHHHHHHHHHHHHHHCCCCHHEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
RSGLGEIIIPANEPGSSIMPGKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFK
CCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHH
PVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEVINENVNRSLMLVTALNPHIGYENAA
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCCCCEEEEEEECCCCCCCHHHH
KIAKHAHKEGLTLKEAALQSGLLTEEQFDEIVDPKKMIAPKE
HHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCHHHCCCCC
>Mature Secondary Structure
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALSNQK
CCEECCCCCCCCEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LGKLSEEKAEAIVEAADEVIAGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEK
HCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCHHHHHC
GSDVHIHPNDDVNMSQSSNDTFPTALHVACVIAVENHVLPAITKLKETLAEKVTAFEHII
CCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHCCCCCCCCCHH
GEMVSEEISQFTGKQFVSAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGP
HHHHHHHHHHHHHHHHHCCCCHHEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
RSGLGEIIIPANEPGSSIMPGKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFK
CCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHH
PVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEVINENVNRSLMLVTALNPHIGYENAA
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCCCCEEEEEEECCCCCCCHHHH
KIAKHAHKEGLTLKEAALQSGLLTEEQFDEIVDPKKMIAPKE
HHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]