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The map label for this gene is tmk [H]

Identifier: 218231073

GI number: 218231073

Start: 35928

End: 36554

Strand: Direct

Name: tmk [H]

Synonym: BCB4264_A0035

Alternate gene names: 218231073

Gene position: 35928-36554 (Clockwise)

Preceding gene: 218232811

Following gene: 218231662

Centisome position: 0.66

GC content: 37.64

Gene sequence:

>627_bases
ATGAAGGGATTATTTGTAACAATTGAGGGCCCAGAAGGTTCAGGTAAAACAACGTTAATTAAAAGCTTATTGCCATATTT
TGAACAAAAAGCACAAAAGGTAATGGCGACAAGGGAACCAGGCGGTATTGCAATTTCTGAGGACATTAGGACGATTTTAC
ATAAACAAGAATATACGATGATGGAAGCACGTACAGAAGCGCTTCTTTATGCTGCTGCGCGCAGACAACATTTAGTAGAA
AAAGTTATGCCAGCACTTAATGAGAAATACCTCGTGTTATGTGATCGTTTTATAGATAGCTCTTTAGCATACCAAGGCTA
TGCAAGAGGATTGGGTATGGATAAGGTATTTGAAATAAATCGTTTCGCAACAGAGGACTGTATGCCTAGTTTAACAATTT
ATCTAGACATTGAGCCTGAGGTTGGTTTGGCTCGGATTGAAAAAGATGCAGGACGTGAAGTAAATCGACTAGATATGGAA
GATATCTCTTTCCATAAACGTGTGCGCGAAGGGTATTTACAAGTTGTAGAACGTTTCTCGGATCGTATTGTATTGGTAAA
TGCTGATCAACCGATGGAAAAACTTATAGAAGAAGTTGTTCAGATTATAGAAGATAAATTGTTATAA

Upstream 100 bases:

>100_bases
GAGCATAAAGAGCAAATTATGTATTTAGAAAGAGCAGGAGCTCGTTTTCAAGGTAATACGAAATATATGAAAGTGTATGA
TATAGAAAGTAGGTTTTAGG

Downstream 100 bases:

>100_bases
TAGAAGGAAAGAATGAAATAAGTGAGGTATGCATTATGACGAAGACGTGGGAGCAGCTTTCTGCTATACAACCCATCGGT
GTAAAAATGTTGATGAATAG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MKGLFVTIEGPEGSGKTTLIKSLLPYFEQKAQKVMATREPGGIAISEDIRTILHKQEYTMMEARTEALLYAAARRQHLVE
KVMPALNEKYLVLCDRFIDSSLAYQGYARGLGMDKVFEINRFATEDCMPSLTIYLDIEPEVGLARIEKDAGREVNRLDME
DISFHKRVREGYLQVVERFSDRIVLVNADQPMEKLIEEVVQIIEDKLL

Sequences:

>Translated_208_residues
MKGLFVTIEGPEGSGKTTLIKSLLPYFEQKAQKVMATREPGGIAISEDIRTILHKQEYTMMEARTEALLYAAARRQHLVE
KVMPALNEKYLVLCDRFIDSSLAYQGYARGLGMDKVFEINRFATEDCMPSLTIYLDIEPEVGLARIEKDAGREVNRLDME
DISFHKRVREGYLQVVERFSDRIVLVNADQPMEKLIEEVVQIIEDKLL
>Mature_208_residues
MKGLFVTIEGPEGSGKTTLIKSLLPYFEQKAQKVMATREPGGIAISEDIRTILHKQEYTMMEARTEALLYAAARRQHLVE
KVMPALNEKYLVLCDRFIDSSLAYQGYARGLGMDKVFEINRFATEDCMPSLTIYLDIEPEVGLARIEKDAGREVNRLDME
DISFHKRVREGYLQVVERFSDRIVLVNADQPMEKLIEEVVQIIEDKLL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=204, Percent_Identity=34.8039215686275, Blast_Score=104, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23818; Mature: 23818

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLFVTIEGPEGSGKTTLIKSLLPYFEQKAQKVMATREPGGIAISEDIRTILHKQEYTM
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHH
MEARTEALLYAAARRQHLVEKVMPALNEKYLVLCDRFIDSSLAYQGYARGLGMDKVFEIN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
RFATEDCMPSLTIYLDIEPEVGLARIEKDAGREVNRLDMEDISFHKRVREGYLQVVERFS
HHHHHCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
DRIVLVNADQPMEKLIEEVVQIIEDKLL
CCEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKGLFVTIEGPEGSGKTTLIKSLLPYFEQKAQKVMATREPGGIAISEDIRTILHKQEYTM
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHH
MEARTEALLYAAARRQHLVEKVMPALNEKYLVLCDRFIDSSLAYQGYARGLGMDKVFEIN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
RFATEDCMPSLTIYLDIEPEVGLARIEKDAGREVNRLDMEDISFHKRVREGYLQVVERFS
HHHHHCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
DRIVLVNADQPMEKLIEEVVQIIEDKLL
CCEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA