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The map label for this gene is yisQ [H]

Identifier: 218230948

GI number: 218230948

Start: 1206074

End: 1207468

Strand: Reverse

Name: yisQ [H]

Synonym: BCB4264_A1239

Alternate gene names: 218230948

Gene position: 1207468-1206074 (Counterclockwise)

Preceding gene: 218235288

Following gene: 218234912

Centisome position: 22.28

GC content: 39.64

Gene sequence:

>1395_bases
ATGGCAGCAATTCAGGCAAAAAACGGGCCTACTGAGAAATTAAGTTTATTCTTATTAACATGGCCTATTTTTCTAGAAGT
TTTTCTTTTTATGTTAATGGGGATCGCTGATACTTTCATGTTAAGTGCATTATCAGACGATGCTGTATCTGGGGTTGGTG
CAGCGAATCAATACCTCCATATCGCTATTTTGGTACTAGAAGTCATCGGGAACGGCGCAGCTATCGTCGTATCTCAATAC
CTCGGTTCCAAACGCTTTATGGAAGCATCTAAAATATCAGCATTAGCCGTCACATTAAATTTAATAGTTGGGCTCGTTAT
AAGCGCTGGTTTTCTTTTATTTTCGAAACATATGATGCTCGCAATGAACTTACAAGGCGATGTACTAACGTATGCGCAAA
ACTACTTATCTATCGTCGGAGGAGCCATCTTCCTACAAGCTATTATTAACTCATTAGCCGCAATTATCCGTGTACACGGT
TTTACAAAGCAAGCGATGTTTATTTCACTCGGAATGAATATGATTCATATCGCTGGAAACTACGTACTCATTTTCGGGAA
ATTTGGTTTCCCTGAGCTCGGTGTACAAGGGGCTGCCATTTCTTCTGCTGTCAGCCGACTTATAGCGCTTATTGTTTTCT
TCTGGTTACTATACCGCGTTATGGAATATCGTGTAAAATTACAATATTATTTCACCTTATCAAAAGAATATATCGGGAAA
ATTTTAAAAATCGGGATTCCATCTGCTTTTGAGCAAGTTATGTATCAAGCTTGTCAAATTGTCTTCTTATACTATGCAAC
ATATTTAGGAACGGAATCGTTAGCGGCTAGACAATACGCTACGAACATTTCTATGTTCACTTATTTATTCGCTATTGCAA
TTGGTATGGGAACAGCCATTATTATTGGCCGCCTCGTTGGTGGTGGCGAAAAAGATGAAGCATACGAACGCTTGTGGAAA
AGTGTAAAATGGGCGATTGGTGTAACTTTATGTATGGTCGCTCTCGTTATTACATTCCGTACACAATTAATGGGACTGTT
TACAGATAATCCGTACATTATCGGGTTAGGCGCAAGTGTTCTTTTACTAAGTGTACTACTTGAAACGGGACGTACGATGA
ACATCGTCATCATTAATTCGCTTCGTGCAACTGGTGATGCAAAATACCCTGTTTTAATCGGTGCATTCTCTATGGTGTTA
ATGAGTTTACCACTAGGTTACTTTTTCGCCTTTCATTTAGATATGGGGCTCGTTGGTATTTGGCTAGCAATCGCCATCGA
CGAATGGACACGTGCCATTATTATGTTCTTCCGCTGGAAAAGTAGAGCATGGGAGCGTTATGCACTTGTTAAACCTGAAG
AACAAGAGGAGAATGTTTCTGTTCAAGTTCAGTAA

Upstream 100 bases:

>100_bases
TTCATAATAAAAATATGTAGGCTAAAATGAGTGCAAAGGTTAAGAAAGTATGTTACGATACATTTTGCTAAAAATAGATA
TCGGTAAAGAGGGGACGGAC

Downstream 100 bases:

>100_bases
TTTTGCATATGGATATCACTAACGATACATGAGATTTATATCGGCGATTCTTTAAATATATCGACTGACCGACAAATGTA
TACAATTCTTTTATATAGTA

Product: MATE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MAAIQAKNGPTEKLSLFLLTWPIFLEVFLFMLMGIADTFMLSALSDDAVSGVGAANQYLHIAILVLEVIGNGAAIVVSQY
LGSKRFMEASKISALAVTLNLIVGLVISAGFLLFSKHMMLAMNLQGDVLTYAQNYLSIVGGAIFLQAIINSLAAIIRVHG
FTKQAMFISLGMNMIHIAGNYVLIFGKFGFPELGVQGAAISSAVSRLIALIVFFWLLYRVMEYRVKLQYYFTLSKEYIGK
ILKIGIPSAFEQVMYQACQIVFLYYATYLGTESLAARQYATNISMFTYLFAIAIGMGTAIIIGRLVGGGEKDEAYERLWK
SVKWAIGVTLCMVALVITFRTQLMGLFTDNPYIIGLGASVLLLSVLLETGRTMNIVIINSLRATGDAKYPVLIGAFSMVL
MSLPLGYFFAFHLDMGLVGIWLAIAIDEWTRAIIMFFRWKSRAWERYALVKPEEQEENVSVQVQ

Sequences:

>Translated_464_residues
MAAIQAKNGPTEKLSLFLLTWPIFLEVFLFMLMGIADTFMLSALSDDAVSGVGAANQYLHIAILVLEVIGNGAAIVVSQY
LGSKRFMEASKISALAVTLNLIVGLVISAGFLLFSKHMMLAMNLQGDVLTYAQNYLSIVGGAIFLQAIINSLAAIIRVHG
FTKQAMFISLGMNMIHIAGNYVLIFGKFGFPELGVQGAAISSAVSRLIALIVFFWLLYRVMEYRVKLQYYFTLSKEYIGK
ILKIGIPSAFEQVMYQACQIVFLYYATYLGTESLAARQYATNISMFTYLFAIAIGMGTAIIIGRLVGGGEKDEAYERLWK
SVKWAIGVTLCMVALVITFRTQLMGLFTDNPYIIGLGASVLLLSVLLETGRTMNIVIINSLRATGDAKYPVLIGAFSMVL
MSLPLGYFFAFHLDMGLVGIWLAIAIDEWTRAIIMFFRWKSRAWERYALVKPEEQEENVSVQVQ
>Mature_463_residues
AAIQAKNGPTEKLSLFLLTWPIFLEVFLFMLMGIADTFMLSALSDDAVSGVGAANQYLHIAILVLEVIGNGAAIVVSQYL
GSKRFMEASKISALAVTLNLIVGLVISAGFLLFSKHMMLAMNLQGDVLTYAQNYLSIVGGAIFLQAIINSLAAIIRVHGF
TKQAMFISLGMNMIHIAGNYVLIFGKFGFPELGVQGAAISSAVSRLIALIVFFWLLYRVMEYRVKLQYYFTLSKEYIGKI
LKIGIPSAFEQVMYQACQIVFLYYATYLGTESLAARQYATNISMFTYLFAIAIGMGTAIIIGRLVGGGEKDEAYERLWKS
VKWAIGVTLCMVALVITFRTQLMGLFTDNPYIIGLGASVLLLSVLLETGRTMNIVIINSLRATGDAKYPVLIGAFSMVLM
SLPLGYFFAFHLDMGLVGIWLAIAIDEWTRAIIMFFRWKSRAWERYALVKPEEQEENVSVQVQ

Specific function: Unknown

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI153792564, Length=419, Percent_Identity=22.4343675417661, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI38261960, Length=451, Percent_Identity=21.5077605321508, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI226510954, Length=448, Percent_Identity=25.2232142857143, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI48994890, Length=453, Percent_Identity=22.9580573951435, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 51333; Mature: 51202

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAIQAKNGPTEKLSLFLLTWPIFLEVFLFMLMGIADTFMLSALSDDAVSGVGAANQYLH
CCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHH
IAILVLEVIGNGAAIVVSQYLGSKRFMEASKISALAVTLNLIVGLVISAGFLLFSKHMML
HHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
AMNLQGDVLTYAQNYLSIVGGAIFLQAIINSLAAIIRVHGFTKQAMFISLGMNMIHIAGN
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECC
YVLIFGKFGFPELGVQGAAISSAVSRLIALIVFFWLLYRVMEYRVKLQYYFTLSKEYIGK
EEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECHHHHHH
ILKIGIPSAFEQVMYQACQIVFLYYATYLGTESLAARQYATNISMFTYLFAIAIGMGTAI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIGRLVGGGEKDEAYERLWKSVKWAIGVTLCMVALVITFRTQLMGLFTDNPYIIGLGASV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHH
LLLSVLLETGRTMNIVIINSLRATGDAKYPVLIGAFSMVLMSLPLGYFFAFHLDMGLVGI
HHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLAIAIDEWTRAIIMFFRWKSRAWERYALVKPEEQEENVSVQVQ
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCEEEEC
>Mature Secondary Structure 
AAIQAKNGPTEKLSLFLLTWPIFLEVFLFMLMGIADTFMLSALSDDAVSGVGAANQYLH
CCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHH
IAILVLEVIGNGAAIVVSQYLGSKRFMEASKISALAVTLNLIVGLVISAGFLLFSKHMML
HHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
AMNLQGDVLTYAQNYLSIVGGAIFLQAIINSLAAIIRVHGFTKQAMFISLGMNMIHIAGN
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECC
YVLIFGKFGFPELGVQGAAISSAVSRLIALIVFFWLLYRVMEYRVKLQYYFTLSKEYIGK
EEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECHHHHHH
ILKIGIPSAFEQVMYQACQIVFLYYATYLGTESLAARQYATNISMFTYLFAIAIGMGTAI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIGRLVGGGEKDEAYERLWKSVKWAIGVTLCMVALVITFRTQLMGLFTDNPYIIGLGASV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHH
LLLSVLLETGRTMNIVIINSLRATGDAKYPVLIGAFSMVLMSLPLGYFFAFHLDMGLVGI
HHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLAIAIDEWTRAIIMFFRWKSRAWERYALVKPEEQEENVSVQVQ
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9353932; 9384377 [H]