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The map label for this gene is ipdC [H]

Identifier: 218230913

GI number: 218230913

Start: 2340276

End: 2341952

Strand: Reverse

Name: ipdC [H]

Synonym: BCB4264_A2440

Alternate gene names: 218230913

Gene position: 2341952-2340276 (Counterclockwise)

Preceding gene: 218235163

Following gene: 218232258

Centisome position: 43.22

GC content: 34.7

Gene sequence:

>1677_bases
TTGAAAAAACAATATACTATAAGTGCATATTTATTGGATAGACTACACGAATTAGGAATTGAACATATATTTGGCGTTCC
TGGTGATTATAATCTTGCCTTTTTAGATGATGTAGTAGCACATGAAAATTTAAAGTGGATTGGAAATTGTAATGAATTAA
ATGCTGCATATGCAGCAGATGGGTACGCTCGCATAAAAGGAATCGCCGCTCTTATTACTACTTTCGGTGTTGGAGAATTA
AGTGCTATTAACGGTATTGCTGGCTCATATGCGGAAAACGTGCCAGTTATAAAAATTACGGGTACGCCACCAACAAAAGT
AATGGAAAATGGAGCAATCGTCCATCATACGTTAGGAGATGGAAAGTTCGATCACTTTTCCAATATGTATCGAGAAATCA
CTATAGCACAAACAAATGTAACACCTGAGCATGCTGCTGAGGAAATTGACCGTGTTTTACGTGCATGTTGGAATGAAAAA
CGCCCGGTTCATATTAATTTGCCAATTGATGTGTATAATAAACCAATTAATAAACCGACAGAACCTATTATAAATAAACC
TATTTTAAGTAATAAAGAAGCATTAAATAAAATGCTTCTACATGCCATTTCAAAAATAAATAGTGCCAAAAAACCTGTTA
TTTTAGCTGATTTTGAAGTAGATCGATTTCACGCTAAAGAAAATTTACATCAATTCGTAGAAAAAACTGGGTTTCCCATC
GCGACGTTAAGTATGGGAAAAGGAATATTCCCAGAAAAACAGCCTCAATTTATAGGGGTTTATACTGGTGATGTAAGTTC
TCCGTACTTGCGAAAAAGAATTGATGAATCTGATTGTATTATTAGTATTGGTGTGAAGTTAACTGATACTATTACAGGTG
GCTTCACACAAGGTTTTACAAAAGAACAAGTTATAGAAATCCATCCCTACACTGTGAAAATTATAGATAAAAAATACGGT
CCAGTTGTAATGCAGGATGTTTTACAACATTTAAGTGATTCAATTGAGCATCGTAATAAAGATACCCTTGACGTTAAGCC
ATTTATTTTAGAATCATCACCTTTTACTGAAGAGTTCATTCCAAAAGCACAAATGGTCACACAAAAACGTTTTTGGCAGC
AAATGTACCATTTCTTACAAGAAAACGACGTCTTAATTGTAGAGCAAGGAACACCTTTCTTTGGTAGTGCTGCTATCCCT
CTACCTAATAACACTGCATATGTAGGACAACCGTTATGGGGATCTATCGGCTACACACTGCCTGCTCTACTTGGTACACA
GCTCGCCAATTTATCACGGCGCAACATTTTAATTATTGGTGACGGTTCTTTCCAAGTAACTGCCCAAGAGTTATCAACTG
TACTACGTCATAATTTAAAACCGATTATATTTTTAATCAATAACAACGGATACACTGTTGAACGTGCCATTCACGGCCAA
AACCAACCTTATAATGATATACAAATTTGGGATTACAATAAACTATCAATGGTATTTGGGGCAGAAGAAAAAAGTCTAAC
ATTTAAAGTAGAAAATGAATCAGAATTAGCAGAAGTCTTAACAAATATAACTTTTAATAAGAATCAACTTATCTTTATTG
AAGTTATAATGAGCCAAAGCGATCAACCTGAATTGTTAGCTAAACTCGGGAAAAGATTTGGTCAGCAAAATTCTTAA

Upstream 100 bases:

>100_bases
TGTAAATTATACCACAATCTAGTAATGAATATTTTAATCAACGCATTAGAACTTATTTAGTCTATTGAAACATTCATTGC
ATAATTAGGAGATGATTCAT

Downstream 100 bases:

>100_bases
TATAAAAGCATAACCTAATTATACAATTGGTAGTGTAAAACTTGTTTTGAGAATAGTTTCGACACTCAAAATACATAAGG
AAAAGGATGGAAAGCACCAT

Product: putative indolepyruvate decarboxylase

Products: NA

Alternate protein names: Indolepyruvate decarboxylase [H]

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MKKQYTISAYLLDRLHELGIEHIFGVPGDYNLAFLDDVVAHENLKWIGNCNELNAAYAADGYARIKGIAALITTFGVGEL
SAINGIAGSYAENVPVIKITGTPPTKVMENGAIVHHTLGDGKFDHFSNMYREITIAQTNVTPEHAAEEIDRVLRACWNEK
RPVHINLPIDVYNKPINKPTEPIINKPILSNKEALNKMLLHAISKINSAKKPVILADFEVDRFHAKENLHQFVEKTGFPI
ATLSMGKGIFPEKQPQFIGVYTGDVSSPYLRKRIDESDCIISIGVKLTDTITGGFTQGFTKEQVIEIHPYTVKIIDKKYG
PVVMQDVLQHLSDSIEHRNKDTLDVKPFILESSPFTEEFIPKAQMVTQKRFWQQMYHFLQENDVLIVEQGTPFFGSAAIP
LPNNTAYVGQPLWGSIGYTLPALLGTQLANLSRRNILIIGDGSFQVTAQELSTVLRHNLKPIIFLINNNGYTVERAIHGQ
NQPYNDIQIWDYNKLSMVFGAEEKSLTFKVENESELAEVLTNITFNKNQLIFIEVIMSQSDQPELLAKLGKRFGQQNS

Sequences:

>Translated_558_residues
MKKQYTISAYLLDRLHELGIEHIFGVPGDYNLAFLDDVVAHENLKWIGNCNELNAAYAADGYARIKGIAALITTFGVGEL
SAINGIAGSYAENVPVIKITGTPPTKVMENGAIVHHTLGDGKFDHFSNMYREITIAQTNVTPEHAAEEIDRVLRACWNEK
RPVHINLPIDVYNKPINKPTEPIINKPILSNKEALNKMLLHAISKINSAKKPVILADFEVDRFHAKENLHQFVEKTGFPI
ATLSMGKGIFPEKQPQFIGVYTGDVSSPYLRKRIDESDCIISIGVKLTDTITGGFTQGFTKEQVIEIHPYTVKIIDKKYG
PVVMQDVLQHLSDSIEHRNKDTLDVKPFILESSPFTEEFIPKAQMVTQKRFWQQMYHFLQENDVLIVEQGTPFFGSAAIP
LPNNTAYVGQPLWGSIGYTLPALLGTQLANLSRRNILIIGDGSFQVTAQELSTVLRHNLKPIIFLINNNGYTVERAIHGQ
NQPYNDIQIWDYNKLSMVFGAEEKSLTFKVENESELAEVLTNITFNKNQLIFIEVIMSQSDQPELLAKLGKRFGQQNS
>Mature_558_residues
MKKQYTISAYLLDRLHELGIEHIFGVPGDYNLAFLDDVVAHENLKWIGNCNELNAAYAADGYARIKGIAALITTFGVGEL
SAINGIAGSYAENVPVIKITGTPPTKVMENGAIVHHTLGDGKFDHFSNMYREITIAQTNVTPEHAAEEIDRVLRACWNEK
RPVHINLPIDVYNKPINKPTEPIINKPILSNKEALNKMLLHAISKINSAKKPVILADFEVDRFHAKENLHQFVEKTGFPI
ATLSMGKGIFPEKQPQFIGVYTGDVSSPYLRKRIDESDCIISIGVKLTDTITGGFTQGFTKEQVIEIHPYTVKIIDKKYG
PVVMQDVLQHLSDSIEHRNKDTLDVKPFILESSPFTEEFIPKAQMVTQKRFWQQMYHFLQENDVLIVEQGTPFFGSAAIP
LPNNTAYVGQPLWGSIGYTLPALLGTQLANLSRRNILIIGDGSFQVTAQELSTVLRHNLKPIIFLINNNGYTVERAIHGQ
NQPYNDIQIWDYNKLSMVFGAEEKSLTFKVENESELAEVLTNITFNKNQLIFIEVIMSQSDQPELLAKLGKRFGQQNS

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI87081685, Length=564, Percent_Identity=23.5815602836879, Blast_Score=115, Evalue=9e-27,
Organism=Escherichia coli, GI1790104, Length=544, Percent_Identity=22.6102941176471, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI1786717, Length=497, Percent_Identity=24.1448692152917, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17531299, Length=489, Percent_Identity=25.7668711656442, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17531301, Length=489, Percent_Identity=25.7668711656442, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6323073, Length=563, Percent_Identity=38.7211367673179, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6323163, Length=566, Percent_Identity=39.2226148409894, Blast_Score=382, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6321524, Length=570, Percent_Identity=37.8947368421053, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6320123, Length=564, Percent_Identity=35.2836879432624, Blast_Score=352, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6320588, Length=595, Percent_Identity=29.9159663865546, Blast_Score=256, Evalue=7e-69,
Organism=Saccharomyces cerevisiae, GI6323755, Length=498, Percent_Identity=22.289156626506, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017764
- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.74 [H]

Molecular weight: Translated: 62619; Mature: 62619

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKQYTISAYLLDRLHELGIEHIFGVPGDYNLAFLDDVVAHENLKWIGNCNELNAAYAAD
CCCEEEHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHCCCEEECCCCCCCCHHHCC
GYARIKGIAALITTFGVGELSAINGIAGSYAENVPVIKITGTPPTKVMENGAIVHHTLGD
CHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHCCCCEEEEECCCCHHHHCCCCEEEEECCC
GKFDHFSNMYREITIAQTNVTPEHAAEEIDRVLRACWNEKRPVHINLPIDVYNKPINKPT
CCHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEECCHHHCCCCCCCCC
EPIINKPILSNKEALNKMLLHAISKINSAKKPVILADFEVDRFHAKENLHQFVEKTGFPI
CHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCE
ATLSMGKGIFPEKQPQFIGVYTGDVSSPYLRKRIDESDCIISIGVKLTDTITGGFTQGFT
EEEECCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCEEEECCEEEEEECCCCCCCCC
KEQVIEIHPYTVKIIDKKYGPVVMQDVLQHLSDSIEHRNKDTLDVKPFILESSPFTEEFI
CCCEEEECCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHC
PKAQMVTQKRFWQQMYHFLQENDVLIVEQGTPFFGSAAIPLPNNTAYVGQPLWGSIGYTL
CHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEECCCCCCCEEECCCCCCCHHHHH
PALLGTQLANLSRRNILIIGDGSFQVTAQELSTVLRHNLKPIIFLINNNGYTVERAIHGQ
HHHHHHHHHCCCCCEEEEEECCCCEEEHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCC
NQPYNDIQIWDYNKLSMVFGAEEKSLTFKVENESELAEVLTNITFNKNQLIFIEVIMSQS
CCCCCCEEEEECCCEEEEECCCCCEEEEEECCHHHHHHHHHHCCCCCCCEEEEEEEECCC
DQPELLAKLGKRFGQQNS
CCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKKQYTISAYLLDRLHELGIEHIFGVPGDYNLAFLDDVVAHENLKWIGNCNELNAAYAAD
CCCEEEHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHCCCEEECCCCCCCCHHHCC
GYARIKGIAALITTFGVGELSAINGIAGSYAENVPVIKITGTPPTKVMENGAIVHHTLGD
CHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHCCCCEEEEECCCCHHHHCCCCEEEEECCC
GKFDHFSNMYREITIAQTNVTPEHAAEEIDRVLRACWNEKRPVHINLPIDVYNKPINKPT
CCHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEECCHHHCCCCCCCCC
EPIINKPILSNKEALNKMLLHAISKINSAKKPVILADFEVDRFHAKENLHQFVEKTGFPI
CHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCE
ATLSMGKGIFPEKQPQFIGVYTGDVSSPYLRKRIDESDCIISIGVKLTDTITGGFTQGFT
EEEECCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCEEEECCEEEEEECCCCCCCCC
KEQVIEIHPYTVKIIDKKYGPVVMQDVLQHLSDSIEHRNKDTLDVKPFILESSPFTEEFI
CCCEEEECCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHC
PKAQMVTQKRFWQQMYHFLQENDVLIVEQGTPFFGSAAIPLPNNTAYVGQPLWGSIGYTL
CHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEECCCCCCCEEECCCCCCCHHHHH
PALLGTQLANLSRRNILIIGDGSFQVTAQELSTVLRHNLKPIIFLINNNGYTVERAIHGQ
HHHHHHHHHCCCCCEEEEEECCCCEEEHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCC
NQPYNDIQIWDYNKLSMVFGAEEKSLTFKVENESELAEVLTNITFNKNQLIFIEVIMSQS
CCCCCCEEEEECCCEEEEECCCCCEEEEEECCHHHHHHHHHHCCCCCCCEEEEEEEECCC
DQPELLAKLGKRFGQQNS
CCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034209 [H]