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The map label for this gene is map [H]

Identifier: 21674977

GI number: 21674977

Start: 2052761

End: 2053534

Strand: Reverse

Name: map [H]

Synonym: CT2168

Alternate gene names: 21674977

Gene position: 2053534-2052761 (Counterclockwise)

Preceding gene: 21674978

Following gene: 21674976

Centisome position: 95.29

GC content: 54.91

Gene sequence:

>774_bases
ATGATCACCATCAAGAGCGAACGGGAAATAGAACTGATGCGGGAGGCTGGAAGACTGGTCGCCCGCGTGCTTGACATGCT
GGAGAACGAGATTAGGCCCGGCATTTCAACCAAGCGCCTTGACGAGCTTGCCGAACAGTTCATCAGAGATCATAACGCTG
TGCCGAGTTTTCTGAATTACGTTCCGAAAGGCGAGTCTGGCGTGACGCCTTATCCGGCGACGCTTTGCGTGTCGATCAAT
GAGGAGGTTGTTCACGGTGTGCCGAGCACGAAGCGCATTATTCACGAGGGCGAAATCGTCTCGGTCGATTGCGGAGTATA
CAAGAGCGGTTATCATGGAGATTCAGCGCGGACGTACATTATCGGCGAGGTCGATCCTGCGGTGCGGCAACTGGTTGATG
TTACTCGTGAGTGTCTTGATCTTGGCATCGAGCAGGCTGTCGAGGGAAACCGTCTGCATGATATTTCGGCAGCGATTGAA
AAGCATGCTCGCTCATTTGGCTACAGTGTGATCGAGAATATGGTTGGCCATGGCATCGGCAGCGAGTTGCATGAAGAACC
GGCAGTACCGAATTATGGAAGACCGCATACCGGGGTGAAGCTTCGTTCCGGTATGACGCTGGCCATTGAGCCGATGATCG
CGCTCGGTCGTTCCCGTCGTGCGGTCAGCAAGCGGGGTGCCTGGGCCGCGGTGACCGAGGATGGAAGCTATTCAGCCCAT
TTTGAGCATACCATCGCCATCGGGAAAGCTCAGGCGGAAATCCTGACGAAGTAA

Upstream 100 bases:

>100_bases
ATACGCTTCAGCAGGTCGAGAGCCACTTGATGATGCGTCATTACGACGGATTCATGAAGACGGCCAAGGCGCGCGGACGC
CGGTAAGCAAGAGACGGGAC

Downstream 100 bases:

>100_bases
CGCAGGCAGGGCAAGCATCACAATCATAGTATAACGATCAGAAAGCGGAGAGATACACATTGGCCAAGGAAGAATCAATT
GAGGTAGAAGGCGAAATTCT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MITIKSEREIELMREAGRLVARVLDMLENEIRPGISTKRLDELAEQFIRDHNAVPSFLNYVPKGESGVTPYPATLCVSIN
EEVVHGVPSTKRIIHEGEIVSVDCGVYKSGYHGDSARTYIIGEVDPAVRQLVDVTRECLDLGIEQAVEGNRLHDISAAIE
KHARSFGYSVIENMVGHGIGSELHEEPAVPNYGRPHTGVKLRSGMTLAIEPMIALGRSRRAVSKRGAWAAVTEDGSYSAH
FEHTIAIGKAQAEILTK

Sequences:

>Translated_257_residues
MITIKSEREIELMREAGRLVARVLDMLENEIRPGISTKRLDELAEQFIRDHNAVPSFLNYVPKGESGVTPYPATLCVSIN
EEVVHGVPSTKRIIHEGEIVSVDCGVYKSGYHGDSARTYIIGEVDPAVRQLVDVTRECLDLGIEQAVEGNRLHDISAAIE
KHARSFGYSVIENMVGHGIGSELHEEPAVPNYGRPHTGVKLRSGMTLAIEPMIALGRSRRAVSKRGAWAAVTEDGSYSAH
FEHTIAIGKAQAEILTK
>Mature_257_residues
MITIKSEREIELMREAGRLVARVLDMLENEIRPGISTKRLDELAEQFIRDHNAVPSFLNYVPKGESGVTPYPATLCVSIN
EEVVHGVPSTKRIIHEGEIVSVDCGVYKSGYHGDSARTYIIGEVDPAVRQLVDVTRECLDLGIEQAVEGNRLHDISAAIE
KHARSFGYSVIENMVGHGIGSELHEEPAVPNYGRPHTGVKLRSGMTLAIEPMIALGRSRRAVSKRGAWAAVTEDGSYSAH
FEHTIAIGKAQAEILTK

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=256, Percent_Identity=38.671875, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI40385867, Length=256, Percent_Identity=33.984375, Blast_Score=152, Evalue=4e-37,
Organism=Escherichia coli, GI1786364, Length=256, Percent_Identity=40.234375, Blast_Score=192, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71996291, Length=258, Percent_Identity=32.9457364341085, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323273, Length=256, Percent_Identity=36.328125, Blast_Score=170, Evalue=3e-43,
Organism=Drosophila melanogaster, GI21355531, Length=256, Percent_Identity=36.328125, Blast_Score=164, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24583427, Length=254, Percent_Identity=36.2204724409449, Blast_Score=162, Evalue=3e-40,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28190; Mature: 28190

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITIKSEREIELMREAGRLVARVLDMLENEIRPGISTKRLDELAEQFIRDHNAVPSFLNY
CEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
VPKGESGVTPYPATLCVSINEEVVHGVPSTKRIIHEGEIVSVDCGVYKSGYHGDSARTYI
CCCCCCCCCCCCCEEEEECCHHHHHCCCHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEE
IGEVDPAVRQLVDVTRECLDLGIEQAVEGNRLHDISAAIEKHARSFGYSVIENMVGHGIG
EECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SELHEEPAVPNYGRPHTGVKLRSGMTLAIEPMIALGRSRRAVSKRGAWAAVTEDGSYSAH
CHHHHCCCCCCCCCCCCCEEECCCCEEEEHHHHHHCCHHHHHHHCCCEEEEECCCCCCCC
FEHTIAIGKAQAEILTK
CHHHEEECHHHHHHHCC
>Mature Secondary Structure
MITIKSEREIELMREAGRLVARVLDMLENEIRPGISTKRLDELAEQFIRDHNAVPSFLNY
CEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
VPKGESGVTPYPATLCVSINEEVVHGVPSTKRIIHEGEIVSVDCGVYKSGYHGDSARTYI
CCCCCCCCCCCCCEEEEECCHHHHHCCCHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEE
IGEVDPAVRQLVDVTRECLDLGIEQAVEGNRLHDISAAIEKHARSFGYSVIENMVGHGIG
EECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SELHEEPAVPNYGRPHTGVKLRSGMTLAIEPMIALGRSRRAVSKRGAWAAVTEDGSYSAH
CHHHHCCCCCCCCCCCCCEEECCCCEEEEHHHHHHCCHHHHHHHCCCEEEEECCCCCCCC
FEHTIAIGKAQAEILTK
CHHHEEECHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]