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The map label for this gene is rnc

Identifier: 21674928

GI number: 21674928

Start: 2005028

End: 2005846

Strand: Direct

Name: rnc

Synonym: CT2119

Alternate gene names: 21674928

Gene position: 2005028-2005846 (Clockwise)

Preceding gene: 21674927

Following gene: 21674929

Centisome position: 93.04

GC content: 58.97

Gene sequence:

>819_bases
ATGTCACTTCAGTTCCTTCGTTCAGAAGCGTCCGACGGTGCCGGTGAAACTTCGGACGCCAGCTCCGCTGACTTTCTTCT
CGACCCACAAACAGCAACGCACCTCGCACGCCTGACCGGGCGTCCGTGCAACCGGCTGATCTACCGCACCGCCCTGACGC
ATCGCTCCGTCCTGCACGACCACCACAGCGAAGAGCATAAGCCCGAGTCAAACCAGCGCCTCGAATTTCTCGGCGACGCG
GTGCTCGACCTGCTGATCTCCGAGCACCTCTTCAAGCAATTTCCCGGAAGTGACGAGGGGCACCTGTCGAGCAACCGGGC
CAAAATCGTCAACCGCAAATCCCTTGCGGCATTTGCCCTTGAACTGCAACTCGGCGAGCACCTTATCATAGGCGAATCCG
CCGACAAGCAGAAGATACGCACCAGCGAATCGGCGCTTGCCGATGCCTTGGAGGCGTTGGTCGGCGCCATCTACCTCGAC
CAGGGCCTCGCCGGAGCTGAGCGTTTCATCACGAACCACGTCATCGCAAAGGTCGATCTGCACAAGCTTGTCGAAGCGGA
ATACAACTACAAAAGCCGCCTGATCGAGTACACCCAGTCGCGCCAGCTTCCCCCGCCGCTTTATACGGTCATCACCGAAG
AGGGGGCAGAGCACGAAAAGACGTTCGTCGTCGAAGTCTCCTGCAACGGTCAGCCGCTCGGCAGAGGAACCGCGCCGAGA
AAAAAAGATGCCGAACAGCTCGCCGCCAAAGAGGCCATGAAGAGACTGGAAAGCGGGGATTTGGGCAACCTGAACGAACC
ATCTCCACAGAACAGCTAA

Upstream 100 bases:

>100_bases
GTTTCGGATTCGGCGGGCACAACGGCTGCCTGATCTTCAGGAAGGCTCCGGCCGCCTGACCGGGAATGGCTCGACGATGG
CGCACCTGTGGCAAAAACTG

Downstream 100 bases:

>100_bases
CACGAACCTCATGCAGATCGACCAGTACAAAGAGATTCACCGCAATCATGCCGGTTATGGACAGGGCGGCAATGCGCACC
ATGGCTACCTTGCAACCATC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MSLQFLRSEASDGAGETSDASSADFLLDPQTATHLARLTGRPCNRLIYRTALTHRSVLHDHHSEEHKPESNQRLEFLGDA
VLDLLISEHLFKQFPGSDEGHLSSNRAKIVNRKSLAAFALELQLGEHLIIGESADKQKIRTSESALADALEALVGAIYLD
QGLAGAERFITNHVIAKVDLHKLVEAEYNYKSRLIEYTQSRQLPPPLYTVITEEGAEHEKTFVVEVSCNGQPLGRGTAPR
KKDAEQLAAKEAMKRLESGDLGNLNEPSPQNS

Sequences:

>Translated_272_residues
MSLQFLRSEASDGAGETSDASSADFLLDPQTATHLARLTGRPCNRLIYRTALTHRSVLHDHHSEEHKPESNQRLEFLGDA
VLDLLISEHLFKQFPGSDEGHLSSNRAKIVNRKSLAAFALELQLGEHLIIGESADKQKIRTSESALADALEALVGAIYLD
QGLAGAERFITNHVIAKVDLHKLVEAEYNYKSRLIEYTQSRQLPPPLYTVITEEGAEHEKTFVVEVSCNGQPLGRGTAPR
KKDAEQLAAKEAMKRLESGDLGNLNEPSPQNS
>Mature_271_residues
SLQFLRSEASDGAGETSDASSADFLLDPQTATHLARLTGRPCNRLIYRTALTHRSVLHDHHSEEHKPESNQRLEFLGDAV
LDLLISEHLFKQFPGSDEGHLSSNRAKIVNRKSLAAFALELQLGEHLIIGESADKQKIRTSESALADALEALVGAIYLDQ
GLAGAERFITNHVIAKVDLHKLVEAEYNYKSRLIEYTQSRQLPPPLYTVITEEGAEHEKTFVVEVSCNGQPLGRGTAPRK
KDAEQLAAKEAMKRLESGDLGNLNEPSPQNS

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=216, Percent_Identity=31.9444444444444, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI155030236, Length=216, Percent_Identity=31.9444444444444, Blast_Score=104, Evalue=8e-23,
Organism=Escherichia coli, GI1788920, Length=219, Percent_Identity=35.6164383561644, Blast_Score=123, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI193202651, Length=232, Percent_Identity=29.7413793103448, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17506883, Length=225, Percent_Identity=30.2222222222222, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17137682, Length=191, Percent_Identity=31.413612565445, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_CHLTE (Q8KAN7)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662993.1
- ProteinModelPortal:   Q8KAN7
- SMR:   Q8KAN7
- GeneID:   1007442
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT2119
- NMPDR:   fig|194439.1.peg.2087
- TIGR:   CT2119
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- ProtClustDB:   CLSK2755591
- BioCyc:   CTEP194439:CT_2119-MONOMER
- BRENDA:   3.1.26.3
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 29984; Mature: 29853

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLQFLRSEASDGAGETSDASSADFLLDPQTATHLARLTGRPCNRLIYRTALTHRSVLHD
CCHHHHHHHCCCCCCCCCCCCCCCEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
HHSEEHKPESNQRLEFLGDAVLDLLISEHLFKQFPGSDEGHLSSNRAKIVNRKSLAAFAL
CCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
ELQLGEHLIIGESADKQKIRTSESALADALEALVGAIYLDQGLAGAERFITNHVIAKVDL
HHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
HKLVEAEYNYKSRLIEYTQSRQLPPPLYTVITEEGAEHEKTFVVEVSCNGQPLGRGTAPR
HHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCC
KKDAEQLAAKEAMKRLESGDLGNLNEPSPQNS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SLQFLRSEASDGAGETSDASSADFLLDPQTATHLARLTGRPCNRLIYRTALTHRSVLHD
CHHHHHHHCCCCCCCCCCCCCCCEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
HHSEEHKPESNQRLEFLGDAVLDLLISEHLFKQFPGSDEGHLSSNRAKIVNRKSLAAFAL
CCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
ELQLGEHLIIGESADKQKIRTSESALADALEALVGAIYLDQGLAGAERFITNHVIAKVDL
HHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
HKLVEAEYNYKSRLIEYTQSRQLPPPLYTVITEEGAEHEKTFVVEVSCNGQPLGRGTAPR
HHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCC
KKDAEQLAAKEAMKRLESGDLGNLNEPSPQNS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901