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The map label for this gene is bioF-1 [H]

Identifier: 21674763

GI number: 21674763

Start: 1841790

End: 1843028

Strand: Direct

Name: bioF-1 [H]

Synonym: CT1951

Alternate gene names: 21674763

Gene position: 1841790-1843028 (Clockwise)

Preceding gene: 21674762

Following gene: 21674764

Centisome position: 85.47

GC content: 57.06

Gene sequence:

>1239_bases
GTGCCTGGCAAAAACGTGGAAGTAAAACCGCAAACTGTGGAAAAAACGAAAGATATATTCAAAAAGTGTGTGGATTTCAC
CCTTGCCGACGAAGTCAAAGCACTGGGAGTATATCCTTTTTTTCGCCCTATAGATGACTCCGAAGGGCCGGTCGTCTCTT
TCGAGGGCCGGAAGCTCGTGATGGCCGGCTCGAACAACTACCTTGGCCTGACCAACGATCCGAACGTCAAGCAGGCCTCG
ATCGACGCCATCAAGAAATACGGCACGAGCTGTTCCGGCTCGCGCTACATGACCGGAACCGTCAGGCTTCATATCGAACT
TGAAGAGCAGCTTGCCGACTTTTTCGAAAAAGAGTGCTGCCTGCTGTTCAGCACCGGCTACCAGACCGGCCAGGGCATCA
TTCCAACCCTCGTACAACGAGGAGAGTATGTTGTTGCTGACCGCGACAATCACGCGAGCCTCGTCGCCGCGTCGATCATG
GCGATTGGCGGCGGCGCAAATCAGGTGCGCTACCGGCACAACGATATGGCCGACCTGGAGCGCGTGCTTCAGAACATTCC
CGAAAGCGCAGGCAAGCTGATCGTTTCGGACGGCGTGTTTTCGGTCTCGGGCGAAATCGTCGATCTTCCGGCGCTGGTGG
CGCTGGCCAAAAAGTACAATGCCCGCATCGTCATTGACGACGCGCACGCCGTCGGCGTCATCGGCAAGGGCGGACGCGGC
ACCCCCTCGGAGTTCGGGCTGGTGAACGAGGTCGATCTCATCATGGGCACCTTCTCCAAAACCTTTGGCTCGCTCGGAGG
CTACGTCGTCGGTGAGCGCTCGGTCATCAACTACATCAAGCACACCGCCTCGTCACTCATCTTCAGCGCCTCTCCGACTC
CCGCCAGCGTTGCGGCGGTGCTGGCGACTCTCAAGATCATCCGCGAGCAGCCGCAACTGACCGAACGCCTGATCGCCAAC
ACCGACTACGTTCGCCAGGGATTGCTGAAAGCCGGATTCACGCTTATGCCGTCTCGTACGGCGATCGTAACCGTGCTGAT
CGCCGATCAGATGAAAACGCTCTATTTCTGGAAAAAGCTTTTCGATGCCGGAGTCTATGTCAATGCCTTCATCCGGCCTG
GCGTCATGCCTGGCCACGAAGCGCTCCGCACCAGCTTCATGGCCACCCACGAAAAAGAGCACCTCGACAAGGTCATTACC
GAATTCTGCTCCATAGGACGCGAACTTGGCGTGATATAA

Upstream 100 bases:

>100_bases
AAATGAAAATTTTAATACATTTCTGTTTCATAGCAGAATCCGCAATACTGCTCAAGCCTTGCTAACACGATTTGCGGAAG
AGCTCCATCATCAATTTCAA

Downstream 100 bases:

>100_bases
AGCGTTGCGTCAAATCATGCCATTGATTACCATCAAAGCCCTGCGAAACCCGCAGGGCTTTTTTTTCTGCGAACAGACCA
TCAGCAAAACGACATACTTT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MPGKNVEVKPQTVEKTKDIFKKCVDFTLADEVKALGVYPFFRPIDDSEGPVVSFEGRKLVMAGSNNYLGLTNDPNVKQAS
IDAIKKYGTSCSGSRYMTGTVRLHIELEEQLADFFEKECCLLFSTGYQTGQGIIPTLVQRGEYVVADRDNHASLVAASIM
AIGGGANQVRYRHNDMADLERVLQNIPESAGKLIVSDGVFSVSGEIVDLPALVALAKKYNARIVIDDAHAVGVIGKGGRG
TPSEFGLVNEVDLIMGTFSKTFGSLGGYVVGERSVINYIKHTASSLIFSASPTPASVAAVLATLKIIREQPQLTERLIAN
TDYVRQGLLKAGFTLMPSRTAIVTVLIADQMKTLYFWKKLFDAGVYVNAFIRPGVMPGHEALRTSFMATHEKEHLDKVIT
EFCSIGRELGVI

Sequences:

>Translated_412_residues
MPGKNVEVKPQTVEKTKDIFKKCVDFTLADEVKALGVYPFFRPIDDSEGPVVSFEGRKLVMAGSNNYLGLTNDPNVKQAS
IDAIKKYGTSCSGSRYMTGTVRLHIELEEQLADFFEKECCLLFSTGYQTGQGIIPTLVQRGEYVVADRDNHASLVAASIM
AIGGGANQVRYRHNDMADLERVLQNIPESAGKLIVSDGVFSVSGEIVDLPALVALAKKYNARIVIDDAHAVGVIGKGGRG
TPSEFGLVNEVDLIMGTFSKTFGSLGGYVVGERSVINYIKHTASSLIFSASPTPASVAAVLATLKIIREQPQLTERLIAN
TDYVRQGLLKAGFTLMPSRTAIVTVLIADQMKTLYFWKKLFDAGVYVNAFIRPGVMPGHEALRTSFMATHEKEHLDKVIT
EFCSIGRELGVI
>Mature_411_residues
PGKNVEVKPQTVEKTKDIFKKCVDFTLADEVKALGVYPFFRPIDDSEGPVVSFEGRKLVMAGSNNYLGLTNDPNVKQASI
DAIKKYGTSCSGSRYMTGTVRLHIELEEQLADFFEKECCLLFSTGYQTGQGIIPTLVQRGEYVVADRDNHASLVAASIMA
IGGGANQVRYRHNDMADLERVLQNIPESAGKLIVSDGVFSVSGEIVDLPALVALAKKYNARIVIDDAHAVGVIGKGGRGT
PSEFGLVNEVDLIMGTFSKTFGSLGGYVVGERSVINYIKHTASSLIFSASPTPASVAAVLATLKIIREQPQLTERLIANT
DYVRQGLLKAGFTLMPSRTAIVTVLIADQMKTLYFWKKLFDAGVYVNAFIRPGVMPGHEALRTSFMATHEKEHLDKVITE
FCSIGRELGVI

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=384, Percent_Identity=29.9479166666667, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI284448556, Length=350, Percent_Identity=31.1428571428571, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI119220554, Length=391, Percent_Identity=31.4578005115089, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI4758668, Length=370, Percent_Identity=31.6216216216216, Blast_Score=181, Evalue=9e-46,
Organism=Homo sapiens, GI83977444, Length=381, Percent_Identity=28.3464566929134, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI83977442, Length=381, Percent_Identity=28.3464566929134, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI83977440, Length=381, Percent_Identity=28.3464566929134, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI4502025, Length=358, Percent_Identity=29.608938547486, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI40316939, Length=358, Percent_Identity=29.608938547486, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI5454084, Length=272, Percent_Identity=34.9264705882353, Blast_Score=158, Evalue=9e-39,
Organism=Escherichia coli, GI1790046, Length=384, Percent_Identity=33.0729166666667, Blast_Score=224, Evalue=6e-60,
Organism=Escherichia coli, GI1786993, Length=361, Percent_Identity=31.3019390581717, Blast_Score=172, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI71994529, Length=413, Percent_Identity=30.2663438256659, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI32566772, Length=420, Percent_Identity=30.2380952380952, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17560912, Length=362, Percent_Identity=30.1104972375691, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17560914, Length=362, Percent_Identity=30.1104972375691, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI71982617, Length=300, Percent_Identity=28.3333333333333, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71982625, Length=300, Percent_Identity=28.3333333333333, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320438, Length=384, Percent_Identity=30.46875, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320267, Length=367, Percent_Identity=29.4277929155313, Blast_Score=156, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6323954, Length=256, Percent_Identity=28.90625, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24662918, Length=384, Percent_Identity=33.0729166666667, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI17137420, Length=352, Percent_Identity=30.1136363636364, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24653280, Length=305, Percent_Identity=30.8196721311475, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI24653276, Length=305, Percent_Identity=30.8196721311475, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI24653278, Length=305, Percent_Identity=30.8196721311475, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI17136286, Length=401, Percent_Identity=29.6758104738155, Blast_Score=156, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 44837; Mature: 44706

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGKNVEVKPQTVEKTKDIFKKCVDFTLADEVKALGVYPFFRPIDDSEGPVVSFEGRKLV
CCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCEEE
MAGSNNYLGLTNDPNVKQASIDAIKKYGTSCSGSRYMTGTVRLHIELEEQLADFFEKECC
EECCCCEEECCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEEEEEEEEHHHHHHHHHHCEE
LLFSTGYQTGQGIIPTLVQRGEYVVADRDNHASLVAASIMAIGGGANQVRYRHNDMADLE
EEEECCCCCCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCCCEEECCCCHHHHH
RVLQNIPESAGKLIVSDGVFSVSGEIVDLPALVALAKKYNARIVIDDAHAVGVIGKGGRG
HHHHHCCHHHCCEEEECCEEEECCCEEHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCC
TPSEFGLVNEVDLIMGTFSKTFGSLGGYVVGERSVINYIKHTASSLIFSASPTPASVAAV
CHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHEEEECCCCHHHHHHH
LATLKIIREQPQLTERLIANTDYVRQGLLKAGFTLMPSRTAIVTVLIADQMKTLYFWKKL
HHHHHHHHCCHHHHHHHHCCHHHHHHHHHHCCCEECCCCHHEEEEEHHHHHHHHHHHHHH
FDAGVYVNAFIRPGVMPGHEALRTSFMATHEKEHLDKVITEFCSIGRELGVI
HHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PGKNVEVKPQTVEKTKDIFKKCVDFTLADEVKALGVYPFFRPIDDSEGPVVSFEGRKLV
CCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCEEE
MAGSNNYLGLTNDPNVKQASIDAIKKYGTSCSGSRYMTGTVRLHIELEEQLADFFEKECC
EECCCCEEECCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEEEEEEEEHHHHHHHHHHCEE
LLFSTGYQTGQGIIPTLVQRGEYVVADRDNHASLVAASIMAIGGGANQVRYRHNDMADLE
EEEECCCCCCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCCCEEECCCCHHHHH
RVLQNIPESAGKLIVSDGVFSVSGEIVDLPALVALAKKYNARIVIDDAHAVGVIGKGGRG
HHHHHCCHHHCCEEEECCEEEECCCEEHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCC
TPSEFGLVNEVDLIMGTFSKTFGSLGGYVVGERSVINYIKHTASSLIFSASPTPASVAAV
CHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHEEEECCCCHHHHHHH
LATLKIIREQPQLTERLIANTDYVRQGLLKAGFTLMPSRTAIVTVLIADQMKTLYFWKKL
HHHHHHHHCCHHHHHHHHCCHHHHHHHHHHCCCEECCCCHHEEEEEHHHHHHHHHHHHHH
FDAGVYVNAFIRPGVMPGHEALRTSFMATHEKEHLDKVITEFCSIGRELGVI
HHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA