Click here to switch to the map view.

The map label for this gene is cbs [H]

Identifier: 21674733

GI number: 21674733

Start: 1815961

End: 1817331

Strand: Reverse

Name: cbs [H]

Synonym: CT1921

Alternate gene names: 21674733

Gene position: 1817331-1815961 (Counterclockwise)

Preceding gene: 21674738

Following gene: 21674732

Centisome position: 84.33

GC content: 60.61

Gene sequence:

>1371_bases
ATGACCAACGACATTTTTGACATCTCGGACAACACTCCGCTGGTTCTCATGAAGCAGCTTACCCGGCAGAAGCGCGCACG
GTTCATGGCGAAGCTCGAATACATGAGCCCCTGCTTTTCGCACTATTGCCGGGTTTCGGGGGCCATCGTGCGTGACGCCG
AGGAGCGCGGGGCGATTCATCCCGGCATGACGCTCGTGGACTGGACCTTCGGCACCAGCGGCATCGCGCTCGCGATGGCC
GCCGTCAGCCGGGGCTACAAAGTGTTGCTCGCCGCGCCGGAGAGCATCTGCCGCGAGAAGCAGGAGGTCCTTCGGGCGCT
GGGCGCGGAGCTGGTGCTCACCCCGTCCGAGGCGCTGCCGGGCGATCTGCAAAGCTGCGTCGATGTAGCCGAGAACCTTG
TCCGCACGCTGCCGAATGCCTGGTTTGCCAACATGTACCAAAATCCGGTCAGCCGCCAGGTGCATCAGGATGGCACGGGG
CCAGAGATTTTCCGGCAGACTGAGGGCAAGGTGACGCACCTCTTCGTGCCGATGGCTTCGGGCGCGATGATCTCCGGGAT
CGGCCGCTACTTCAAATCGGTCAATCCGGAGGTTCAGATCATTGGCGTTGAGCCGGAGGGTTCGGTTTACGGCGATCTGC
ATGGCGGCAAGAGCCAAGGCACTCCCTCCGCGTTCCAGCTCGAAGATATCGGCGCGGTCAGGCCGACCTCTTTCTGGGAC
CCCAACGTGATCGACCGGATCGTGCAGGTCAGCGATGCCGACGCATTCAACTGCGGCCGCGAGTTGCTGCGTGCCGAAGC
GGTCTTCGCGGGCGGAGCCTCCGGCGCGGCGATGGCTGCGGCTCTCCGGGAGGGCGAGGCGTACGGCGATGACGCGCTGG
TGGTGGTGATGATGACCGACTTTGGCGGCTACGACCTGTCGCGCATGTACAACGATGACTGGATGCGGCGTCAGGGATTT
TACCGGAAATCCAAGACCGCGCTCGACCAGATCACGGCGGACGACATTCTGCAACGCAAGGCCCACAAAGACCTCATCTT
CGCCCAGCCTGAGCAGACGCTTGCCGAGGTTTTCGAAACAATGAAGCAGAACGACGTTTCCCAGATGCCCATTGTTTCGT
TCGGCGCGCCCATCGGCAGCATCAGTGAAAACAGGATTCTCTCGATTCTCATTGAGAACGATTCGGCCATGAACGCCAAG
GTGGTTGCCTTCATGGAAAAGCCGTTCCCGGTCTGCCAGCCCGATGCAACCATTTCCGAACTGTCGGAAAAATTGCAGAC
AAATGCATCCGGCGTGCTCATCAGCCTCAGCGATGGCCGCTTGCAACTGATTAACAAATCAGACCTTATCGATGTGCTGA
CTCGCAAGTGA

Upstream 100 bases:

>100_bases
CATGATTTTCAAAACAATGGCGATTAACTGACGGGAATGGACAATTATTGTTCTATGTATTATTATTCACGGAAAAACCA
TTATCAGAGTATCGAGCACC

Downstream 100 bases:

>100_bases
TGTCTGTCTGAATTATATGGTTGTTTTTTTGGGGTGATTTACTTATCTAAGCACTCCTGAGCAGAGAGCTTTACGGAACC
ATCATCAGCTATGGTTCCTG

Product: cysteine synthase/cystathionine beta-synthase family protein

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MTNDIFDISDNTPLVLMKQLTRQKRARFMAKLEYMSPCFSHYCRVSGAIVRDAEERGAIHPGMTLVDWTFGTSGIALAMA
AVSRGYKVLLAAPESICREKQEVLRALGAELVLTPSEALPGDLQSCVDVAENLVRTLPNAWFANMYQNPVSRQVHQDGTG
PEIFRQTEGKVTHLFVPMASGAMISGIGRYFKSVNPEVQIIGVEPEGSVYGDLHGGKSQGTPSAFQLEDIGAVRPTSFWD
PNVIDRIVQVSDADAFNCGRELLRAEAVFAGGASGAAMAAALREGEAYGDDALVVVMMTDFGGYDLSRMYNDDWMRRQGF
YRKSKTALDQITADDILQRKAHKDLIFAQPEQTLAEVFETMKQNDVSQMPIVSFGAPIGSISENRILSILIENDSAMNAK
VVAFMEKPFPVCQPDATISELSEKLQTNASGVLISLSDGRLQLINKSDLIDVLTRK

Sequences:

>Translated_456_residues
MTNDIFDISDNTPLVLMKQLTRQKRARFMAKLEYMSPCFSHYCRVSGAIVRDAEERGAIHPGMTLVDWTFGTSGIALAMA
AVSRGYKVLLAAPESICREKQEVLRALGAELVLTPSEALPGDLQSCVDVAENLVRTLPNAWFANMYQNPVSRQVHQDGTG
PEIFRQTEGKVTHLFVPMASGAMISGIGRYFKSVNPEVQIIGVEPEGSVYGDLHGGKSQGTPSAFQLEDIGAVRPTSFWD
PNVIDRIVQVSDADAFNCGRELLRAEAVFAGGASGAAMAAALREGEAYGDDALVVVMMTDFGGYDLSRMYNDDWMRRQGF
YRKSKTALDQITADDILQRKAHKDLIFAQPEQTLAEVFETMKQNDVSQMPIVSFGAPIGSISENRILSILIENDSAMNAK
VVAFMEKPFPVCQPDATISELSEKLQTNASGVLISLSDGRLQLINKSDLIDVLTRK
>Mature_455_residues
TNDIFDISDNTPLVLMKQLTRQKRARFMAKLEYMSPCFSHYCRVSGAIVRDAEERGAIHPGMTLVDWTFGTSGIALAMAA
VSRGYKVLLAAPESICREKQEVLRALGAELVLTPSEALPGDLQSCVDVAENLVRTLPNAWFANMYQNPVSRQVHQDGTGP
EIFRQTEGKVTHLFVPMASGAMISGIGRYFKSVNPEVQIIGVEPEGSVYGDLHGGKSQGTPSAFQLEDIGAVRPTSFWDP
NVIDRIVQVSDADAFNCGRELLRAEAVFAGGASGAAMAAALREGEAYGDDALVVVMMTDFGGYDLSRMYNDDWMRRQGFY
RKSKTALDQITADDILQRKAHKDLIFAQPEQTLAEVFETMKQNDVSQMPIVSFGAPIGSISENRILSILIENDSAMNAKV
VAFMEKPFPVCQPDATISELSEKLQTNASGVLISLSDGRLQLINKSDLIDVLTRK

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=445, Percent_Identity=28.0898876404494, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI295821200, Length=445, Percent_Identity=28.0898876404494, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI4557415, Length=445, Percent_Identity=28.0898876404494, Blast_Score=189, Evalue=4e-48,
Organism=Escherichia coli, GI1788754, Length=314, Percent_Identity=33.1210191082803, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI2367138, Length=298, Percent_Identity=31.8791946308725, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17562970, Length=317, Percent_Identity=35.9621451104101, Blast_Score=174, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI32566674, Length=285, Percent_Identity=37.8947368421053, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17535051, Length=302, Percent_Identity=35.0993377483444, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17561720, Length=307, Percent_Identity=35.8306188925081, Blast_Score=148, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI115535073, Length=275, Percent_Identity=33.4545454545455, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17534315, Length=328, Percent_Identity=30.7926829268293, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI25147552, Length=324, Percent_Identity=29.320987654321, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI32566672, Length=224, Percent_Identity=33.0357142857143, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321594, Length=500, Percent_Identity=27, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6321449, Length=328, Percent_Identity=26.219512195122, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24643623, Length=462, Percent_Identity=27.9220779220779, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI20129101, Length=462, Percent_Identity=27.9220779220779, Blast_Score=183, Evalue=2e-46,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 49946; Mature: 49814

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNDIFDISDNTPLVLMKQLTRQKRARFMAKLEYMSPCFSHYCRVSGAIVRDAEERGAIH
CCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECHHHCCCCC
PGMTLVDWTFGTSGIALAMAAVSRGYKVLLAAPESICREKQEVLRALGAELVLTPSEALP
CCCEEEEEECCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHCCCCEEECCCCCCC
GDLQSCVDVAENLVRTLPNAWFANMYQNPVSRQVHQDGTGPEIFRQTEGKVTHLFVPMAS
HHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHCCCCCHHHHHHCCCCEEEEEEECCC
GAMISGIGRYFKSVNPEVQIIGVEPEGSVYGDLHGGKSQGTPSAFQLEDIGAVRPTSFWD
CHHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCCCCCCCCCCEEECCCCCCCCCCCCC
PNVIDRIVQVSDADAFNCGRELLRAEAVFAGGASGAAMAAALREGEAYGDDALVVVMMTD
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEEEEEEC
FGGYDLSRMYNDDWMRRQGFYRKSKTALDQITADDILQRKAHKDLIFAQPEQTLAEVFET
CCCCCHHHHHCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHH
MKQNDVSQMPIVSFGAPIGSISENRILSILIENDSAMNAKVVAFMEKPFPVCQPDATISE
HHHCCCCCCCCCEECCCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCCHHHH
LSEKLQTNASGVLISLSDGRLQLINKSDLIDVLTRK
HHHHHHCCCCEEEEEECCCEEEEECCHHHHHHHHCC
>Mature Secondary Structure 
TNDIFDISDNTPLVLMKQLTRQKRARFMAKLEYMSPCFSHYCRVSGAIVRDAEERGAIH
CCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECHHHCCCCC
PGMTLVDWTFGTSGIALAMAAVSRGYKVLLAAPESICREKQEVLRALGAELVLTPSEALP
CCCEEEEEECCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHCCCCEEECCCCCCC
GDLQSCVDVAENLVRTLPNAWFANMYQNPVSRQVHQDGTGPEIFRQTEGKVTHLFVPMAS
HHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHCCCCCHHHHHHCCCCEEEEEEECCC
GAMISGIGRYFKSVNPEVQIIGVEPEGSVYGDLHGGKSQGTPSAFQLEDIGAVRPTSFWD
CHHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCCCCCCCCCCEEECCCCCCCCCCCCC
PNVIDRIVQVSDADAFNCGRELLRAEAVFAGGASGAAMAAALREGEAYGDDALVVVMMTD
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEEEEEEC
FGGYDLSRMYNDDWMRRQGFYRKSKTALDQITADDILQRKAHKDLIFAQPEQTLAEVFET
CCCCCHHHHHCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHH
MKQNDVSQMPIVSFGAPIGSISENRILSILIENDSAMNAKVVAFMEKPFPVCQPDATISE
HHHCCCCCCCCCEECCCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCCHHHH
LSEKLQTNASGVLISLSDGRLQLINKSDLIDVLTRK
HHHHHHCCCCEEEEEECCCEEEEECCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]