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The map label for this gene is gltA [H]

Identifier: 21674648

GI number: 21674648

Start: 1737111

End: 1738454

Strand: Reverse

Name: gltA [H]

Synonym: CT1834

Alternate gene names: 21674648

Gene position: 1738454-1737111 (Counterclockwise)

Preceding gene: 21674649

Following gene: 21674647

Centisome position: 80.67

GC content: 58.63

Gene sequence:

>1344_bases
ATGAGTGATTCAGACCACCGCAATTCGCTGACGATCATCGATAACCGTACCGGCAAATCGTACGAGCTTCCGATTGAAAA
CGGCACCATCCGCACCATGGATCTTCGCAAGATCAAGGAGTCGGAGGATGATTTCGGTCTTCTCGGCTACGATCCCGCGT
TTCTGAACACCTGCTCCTGCAAGAGCACGATCACCTTCATCGATGGTGACAAGGGCATCCTGCGCTATCGCGGCTATCCG
ATCGAGCAGCTCGCCGAAAAAAGCTCGTTCCTCGAAACGGCCTACCTGCTCATCAAGGGCGAGCTTCCAGACAAGGAGCG
TCTCGCGGTCTGGACCTACAACATCCGTCACCACACCATGACCCACGCCAACCTGACCAAGTTCATGGATGGCTTCCGCT
ACGATGCCCATCCGATGGGCATCCTCGTGGGCACGCTGGGCGCGCTTTCAACCTTCTACCCCGACGCCAAGAATGTCGGC
GAGGAGGAGTCGCGCAAGCTCCAGGTGCGGCGGCTGATCGGCAAGATGCCGACGCTCGCGGCGATGAGCTTCCGGCACAG
CCTCGGTTTCCCCTACGTGCTGCCCGACAACGATCTGAGCTACGCAGGCAACTTTCTCTCCATGATGTTCCGCATGACGG
AAAAAAACTACAAGCCCAATCCTGTGCTCGAACATGCGCTCGACGTGCTTTTCATTCTGCACGCCGACCACGAGCAGAAC
TGTTCGACCAACGCCGTGCGCTCGGTGAGCAGCTCGATGGTCGATCCCTACTCGGCCATCGCCGCCGGTTGTGCCGCGCT
TTACGGCCCGCTACACGGCGGAGCGAACGAGGCGGTGATCCACATGCTCAAACAGATCGGTTCCGTCGATAAAATCCCGG
AGTTCATCAAGTTGGTCAAGAGCGGCGAGGGACGCCTGATGGGCTTCGGCCACCGCGTTTACAAGAATTACGATCCACGT
GCGCGGATCATCAAGAAGATCGCCTTCGATGTGTTCGAGGAAACCGGGCGCAATCCGCTGCTCGATATCGCCATCGAGCT
GGAGCGGATCGCACTCGAAGACGATTACTTCATCCAGCGCAAGCTCTACCCGAACGTCGATTTCTACTCCGGTCTCATCT
ACCAGGCGATGGGCTTTCCGACCGAGATGTTCCCGGTGCTGTTCGCCATCGGACGCACGCCGGGGTGGCTCGCGCAGTGG
ATCGAGCACGTCAAGGATCCGGAGCAGAAGATCGCCCGACCGCGCCAGATTTACCTCGGCGAGAAGTGCCGCGATTACGT
GCCGATCGACGAGCGGCCGAGAAAAGGGGATGACGAGCAGAAATTTGGTATCTGCCGGCTCTGA

Upstream 100 bases:

>100_bases
AGGATAATACCGGGAGTTTCGTAAATTCAAAGCCGTAGTGACGGCAAGCTTTGCTTCCGGAGGCGTTCTTATTTCTGTAA
ACGCAAAAGGTCACACGCTC

Downstream 100 bases:

>100_bases
TTCCGGTCTGCTAAATGCAAAGTATTTGTTTGAATTAAATCGATTTACACCATGTCTGTCACCACAAAGGATGTTGCCTA
CATCGCCGAACTTGCCCGCC

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MSDSDHRNSLTIIDNRTGKSYELPIENGTIRTMDLRKIKESEDDFGLLGYDPAFLNTCSCKSTITFIDGDKGILRYRGYP
IEQLAEKSSFLETAYLLIKGELPDKERLAVWTYNIRHHTMTHANLTKFMDGFRYDAHPMGILVGTLGALSTFYPDAKNVG
EEESRKLQVRRLIGKMPTLAAMSFRHSLGFPYVLPDNDLSYAGNFLSMMFRMTEKNYKPNPVLEHALDVLFILHADHEQN
CSTNAVRSVSSSMVDPYSAIAAGCAALYGPLHGGANEAVIHMLKQIGSVDKIPEFIKLVKSGEGRLMGFGHRVYKNYDPR
ARIIKKIAFDVFEETGRNPLLDIAIELERIALEDDYFIQRKLYPNVDFYSGLIYQAMGFPTEMFPVLFAIGRTPGWLAQW
IEHVKDPEQKIARPRQIYLGEKCRDYVPIDERPRKGDDEQKFGICRL

Sequences:

>Translated_447_residues
MSDSDHRNSLTIIDNRTGKSYELPIENGTIRTMDLRKIKESEDDFGLLGYDPAFLNTCSCKSTITFIDGDKGILRYRGYP
IEQLAEKSSFLETAYLLIKGELPDKERLAVWTYNIRHHTMTHANLTKFMDGFRYDAHPMGILVGTLGALSTFYPDAKNVG
EEESRKLQVRRLIGKMPTLAAMSFRHSLGFPYVLPDNDLSYAGNFLSMMFRMTEKNYKPNPVLEHALDVLFILHADHEQN
CSTNAVRSVSSSMVDPYSAIAAGCAALYGPLHGGANEAVIHMLKQIGSVDKIPEFIKLVKSGEGRLMGFGHRVYKNYDPR
ARIIKKIAFDVFEETGRNPLLDIAIELERIALEDDYFIQRKLYPNVDFYSGLIYQAMGFPTEMFPVLFAIGRTPGWLAQW
IEHVKDPEQKIARPRQIYLGEKCRDYVPIDERPRKGDDEQKFGICRL
>Mature_446_residues
SDSDHRNSLTIIDNRTGKSYELPIENGTIRTMDLRKIKESEDDFGLLGYDPAFLNTCSCKSTITFIDGDKGILRYRGYPI
EQLAEKSSFLETAYLLIKGELPDKERLAVWTYNIRHHTMTHANLTKFMDGFRYDAHPMGILVGTLGALSTFYPDAKNVGE
EESRKLQVRRLIGKMPTLAAMSFRHSLGFPYVLPDNDLSYAGNFLSMMFRMTEKNYKPNPVLEHALDVLFILHADHEQNC
STNAVRSVSSSMVDPYSAIAAGCAALYGPLHGGANEAVIHMLKQIGSVDKIPEFIKLVKSGEGRLMGFGHRVYKNYDPRA
RIIKKIAFDVFEETGRNPLLDIAIELERIALEDDYFIQRKLYPNVDFYSGLIYQAMGFPTEMFPVLFAIGRTPGWLAQWI
EHVKDPEQKIARPRQIYLGEKCRDYVPIDERPRKGDDEQKFGICRL

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=370, Percent_Identity=28.1081081081081, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI1786939, Length=412, Percent_Identity=50.4854368932039, Blast_Score=432, Evalue=1e-122,
Organism=Escherichia coli, GI1786527, Length=360, Percent_Identity=32.5, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17555174, Length=374, Percent_Identity=28.6096256684492, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319850, Length=391, Percent_Identity=26.0869565217391, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6324328, Length=393, Percent_Identity=24.4274809160305, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6325257, Length=400, Percent_Identity=25, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24640126, Length=387, Percent_Identity=27.390180878553, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24640124, Length=390, Percent_Identity=27.1794871794872, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI21356863, Length=396, Percent_Identity=26.7676767676768, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 50890; Mature: 50759

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSDHRNSLTIIDNRTGKSYELPIENGTIRTMDLRKIKESEDDFGLLGYDPAFLNTCSC
CCCCCCCCCEEEEECCCCCEEEEECCCCCEEEEHHHHHHCCCCCCCEECCCHHHHCCCCC
KSTITFIDGDKGILRYRGYPIEQLAEKSSFLETAYLLIKGELPDKERLAVWTYNIRHHTM
CCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHEEEEEECCCCCCCCEEEEEEECCHHEE
THANLTKFMDGFRYDAHPMGILVGTLGALSTFYPDAKNVGEEESRKLQVRRLIGKMPTLA
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHCCCCHHH
AMSFRHSLGFPYVLPDNDLSYAGNFLSMMFRMTEKNYKPNPVLEHALDVLFILHADHEQN
HHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHEEEEEECCCCCC
CSTNAVRSVSSSMVDPYSAIAAGCAALYGPLHGGANEAVIHMLKQIGSVDKIPEFIKLVK
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHH
SGEGRLMGFGHRVYKNYDPRARIIKKIAFDVFEETGRNPLLDIAIELERIALEDDYFIQR
CCCCCEEECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEHEEEEEHHEECCCCEEHH
KLYPNVDFYSGLIYQAMGFPTEMFPVLFAIGRTPGWLAQWIEHVKDPEQKIARPRQIYLG
HCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHCCCCEEHCC
EKCRDYVPIDERPRKGDDEQKFGICRL
CHHCCCCCCCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure 
SDSDHRNSLTIIDNRTGKSYELPIENGTIRTMDLRKIKESEDDFGLLGYDPAFLNTCSC
CCCCCCCCEEEEECCCCCEEEEECCCCCEEEEHHHHHHCCCCCCCEECCCHHHHCCCCC
KSTITFIDGDKGILRYRGYPIEQLAEKSSFLETAYLLIKGELPDKERLAVWTYNIRHHTM
CCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHEEEEEECCCCCCCCEEEEEEECCHHEE
THANLTKFMDGFRYDAHPMGILVGTLGALSTFYPDAKNVGEEESRKLQVRRLIGKMPTLA
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHCCCCHHH
AMSFRHSLGFPYVLPDNDLSYAGNFLSMMFRMTEKNYKPNPVLEHALDVLFILHADHEQN
HHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHEEEEEECCCCCC
CSTNAVRSVSSSMVDPYSAIAAGCAALYGPLHGGANEAVIHMLKQIGSVDKIPEFIKLVK
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHH
SGEGRLMGFGHRVYKNYDPRARIIKKIAFDVFEETGRNPLLDIAIELERIALEDDYFIQR
CCCCCEEECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEHEEEEEHHEECCCCEEHH
KLYPNVDFYSGLIYQAMGFPTEMFPVLFAIGRTPGWLAQWIEHVKDPEQKIARPRQIYLG
HCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHCCCCEEHCC
EKCRDYVPIDERPRKGDDEQKFGICRL
CHHCCCCCCCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]