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The map label for this gene is xseA

Identifier: 21674642

GI number: 21674642

Start: 1733205

End: 1734401

Strand: Direct

Name: xseA

Synonym: CT1828

Alternate gene names: 21674642

Gene position: 1733205-1734401 (Clockwise)

Preceding gene: 21674636

Following gene: 21674650

Centisome position: 80.43

GC content: 63.83

Gene sequence:

>1197_bases
ATGATCAAAACCGCGCAAAGCGTTGGCGAGCTGACCCGCGCCATCAAGAACGAGCTGGAGAGCCTCTTCCCCTTCGTGCG
GGTGAAGGGCGAGCTGTCGAACGTCAAGCAACACAGCTCCGGCCACGTCTATCTGACGCTCAAGGACAGCGAAGCGCAAA
TTCCGGCGGTGATCTGGAAGAGCGTTCGCGCCCGCTCTCCGCTGGAGCTGCGTGACGGGCTCGAAGTGATCGCCGAGGGG
CGGCTGGAGGTCTGGCCGCCCGCTGGTCGCTACCAGCTCATCTGCACGGCGCTCTTCGAAACCGGCGAAGGCGAACAGCG
CCTCGCGCTCGAACGGCTGATCGCCAAACTCGCCAAGGCGGGCTGGTTCGACGCCGAGCGCAAAAAGCCGATCCCGCGCA
TCCCGCGCCGCATCGGCATGATCACCTCACCCACCGGGGCGGTGATCCGTGACATGAGCGACGTTTTCGCGCGGCGCTTC
CCCGCGGCGGAGCTGCTGCTCTACCCGGTGCAGGTGCAGGGCGAGCGAGCCGTCGAATCGATCGTGCGGGCGCTCCGCTA
CTTCAACGACCCGCCAAAGCCGGAGCACAAGCCCGACGTGCTCATCGTGGCGCGAGGCGGCGGCTCGTCGGAAGACCTGC
AAGCCTTCAACGACGAAGCGGTGGCCGAAGCGATCTACCGCTCGGCAATTCCGGTGATCAGCGCCGTCGGCCACGAAACC
GACCTCTCGGTGGCCGACATGGTAGCCGACCTCCGCGCAGGCACGCCCTCCATCGCCGCCGAACGCGCCGTGCCCGACCG
CGAGGAACTGCTTCGCCTGATCGACAACCTCGTCAACCGGCAATCAATTCTGATGGAAGGCTTGATTTCCGGAGCACAAC
TCCAGGTGGACTCCATCACCAGCAGCTACGCCTTCAACCGCCCGGTGCAGATGCTCGGCCAGTTCGAGGAGCGGCTGGCG
CTGATGGAAAAAGAGATGAAACGAGCCATCGCCGAAAAAGTGCGCGACCGCGAACAGCAACTCACCGCCGCTGCCGACAG
GCTGGCAATGCTCGACATCAACCGAACCCTCAAACGCGGCTTCGCACTGGTAACGCAGGACGACCGCTACGTCACTTCAG
CAAAATCACTCGAAGCTGACGCGAAGATAGGTCTCACCTTCCACGACGGGCAAAGAGAAGCTAGGGTGACGGAGTAA

Upstream 100 bases:

>100_bases
CGTCAAGTTCGAATATAACACATCCCCACCAAAGGTCGGCCCTCCGCCCGACGCGGGAAACAGGTTGAAAAAGCGTAAGT
TCCTGAAAAACCGTGACCGT

Downstream 100 bases:

>100_bases
AAATTGCCGGCTACGCTTTGCAGGGAGTTATTTGTGCTTCCACACTTTAAGCGCTGAAATCAACAAAATTGCGGCAAGCA
TCGGCAGCAGATAACTGTCG

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MIKTAQSVGELTRAIKNELESLFPFVRVKGELSNVKQHSSGHVYLTLKDSEAQIPAVIWKSVRARSPLELRDGLEVIAEG
RLEVWPPAGRYQLICTALFETGEGEQRLALERLIAKLAKAGWFDAERKKPIPRIPRRIGMITSPTGAVIRDMSDVFARRF
PAAELLLYPVQVQGERAVESIVRALRYFNDPPKPEHKPDVLIVARGGGSSEDLQAFNDEAVAEAIYRSAIPVISAVGHET
DLSVADMVADLRAGTPSIAAERAVPDREELLRLIDNLVNRQSILMEGLISGAQLQVDSITSSYAFNRPVQMLGQFEERLA
LMEKEMKRAIAEKVRDREQQLTAAADRLAMLDINRTLKRGFALVTQDDRYVTSAKSLEADAKIGLTFHDGQREARVTE

Sequences:

>Translated_398_residues
MIKTAQSVGELTRAIKNELESLFPFVRVKGELSNVKQHSSGHVYLTLKDSEAQIPAVIWKSVRARSPLELRDGLEVIAEG
RLEVWPPAGRYQLICTALFETGEGEQRLALERLIAKLAKAGWFDAERKKPIPRIPRRIGMITSPTGAVIRDMSDVFARRF
PAAELLLYPVQVQGERAVESIVRALRYFNDPPKPEHKPDVLIVARGGGSSEDLQAFNDEAVAEAIYRSAIPVISAVGHET
DLSVADMVADLRAGTPSIAAERAVPDREELLRLIDNLVNRQSILMEGLISGAQLQVDSITSSYAFNRPVQMLGQFEERLA
LMEKEMKRAIAEKVRDREQQLTAAADRLAMLDINRTLKRGFALVTQDDRYVTSAKSLEADAKIGLTFHDGQREARVTE
>Mature_398_residues
MIKTAQSVGELTRAIKNELESLFPFVRVKGELSNVKQHSSGHVYLTLKDSEAQIPAVIWKSVRARSPLELRDGLEVIAEG
RLEVWPPAGRYQLICTALFETGEGEQRLALERLIAKLAKAGWFDAERKKPIPRIPRRIGMITSPTGAVIRDMSDVFARRF
PAAELLLYPVQVQGERAVESIVRALRYFNDPPKPEHKPDVLIVARGGGSSEDLQAFNDEAVAEAIYRSAIPVISAVGHET
DLSVADMVADLRAGTPSIAAERAVPDREELLRLIDNLVNRQSILMEGLISGAQLQVDSITSSYAFNRPVQMLGQFEERLA
LMEKEMKRAIAEKVRDREQQLTAAADRLAMLDINRTLKRGFALVTQDDRYVTSAKSLEADAKIGLTFHDGQREARVTE

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=329, Percent_Identity=38.2978723404255, Blast_Score=219, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_CHLTE (Q8KBF9)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662707.1
- GeneID:   1008084
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1828
- NMPDR:   fig|194439.1.peg.1801
- TIGR:   CT1828
- HOGENOM:   HBG634411
- OMA:   PWPVRTV
- ProtClustDB:   PRK00286
- BioCyc:   CTEP194439:CT_1828-MONOMER
- BRENDA:   3.1.11.6
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 44260; Mature: 44260

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKTAQSVGELTRAIKNELESLFPFVRVKGELSNVKQHSSGHVYLTLKDSEAQIPAVIWK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCEEEEEEECCCCCHHHHHHH
SVRARSPLELRDGLEVIAEGRLEVWPPAGRYQLICTALFETGEGEQRLALERLIAKLAKA
HHHCCCCHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
GWFDAERKKPIPRIPRRIGMITSPTGAVIRDMSDVFARRFPAAELLLYPVQVQGERAVES
CCCCCHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHEEEEEEECCHHHHHH
IVRALRYFNDPPKPEHKPDVLIVARGGGSSEDLQAFNDEAVAEAIYRSAIPVISAVGHET
HHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCC
DLSVADMVADLRAGTPSIAAERAVPDREELLRLIDNLVNRQSILMEGLISGAQLQVDSIT
CCHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHH
SSYAFNRPVQMLGQFEERLALMEKEMKRAIAEKVRDREQQLTAAADRLAMLDINRTLKRG
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FALVTQDDRYVTSAKSLEADAKIGLTFHDGQREARVTE
EEEEECCCCHHHHHHHCCCCCEEEEEEECCCCCCCCCC
>Mature Secondary Structure
MIKTAQSVGELTRAIKNELESLFPFVRVKGELSNVKQHSSGHVYLTLKDSEAQIPAVIWK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCEEEEEEECCCCCHHHHHHH
SVRARSPLELRDGLEVIAEGRLEVWPPAGRYQLICTALFETGEGEQRLALERLIAKLAKA
HHHCCCCHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
GWFDAERKKPIPRIPRRIGMITSPTGAVIRDMSDVFARRFPAAELLLYPVQVQGERAVES
CCCCCHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHEEEEEEECCHHHHHH
IVRALRYFNDPPKPEHKPDVLIVARGGGSSEDLQAFNDEAVAEAIYRSAIPVISAVGHET
HHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCC
DLSVADMVADLRAGTPSIAAERAVPDREELLRLIDNLVNRQSILMEGLISGAQLQVDSIT
CCHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHH
SSYAFNRPVQMLGQFEERLALMEKEMKRAIAEKVRDREQQLTAAADRLAMLDINRTLKRG
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FALVTQDDRYVTSAKSLEADAKIGLTFHDGQREARVTE
EEEEECCCCHHHHHHHCCCCCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901