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The map label for this gene is xerC

Identifier: 21674453

GI number: 21674453

Start: 1545075

End: 1546085

Strand: Reverse

Name: xerC

Synonym: CT1635

Alternate gene names: 21674453

Gene position: 1546085-1545075 (Counterclockwise)

Preceding gene: 21674454

Following gene: 21674452

Centisome position: 71.75

GC content: 51.93

Gene sequence:

>1011_bases
ATGAAGAGAAGCGCTCCTGTTCAATTTGCAAAAAAAGATGTAGCCAATTGCCGGTGGCTCGGTGAGTTTCTTGTGCATCT
CGAATCGACTCGCAACGTTTCGGCCAAAACGGTAACCGCCTATACCACTGACCTTATCCAGTTTTTTGAGTTTTTGACCG
ATGAGAGCGGTCATCAAGAAATGTCCGCTGTCGATCCAGAGCTGGTCGAAGTGGCTGATGTCAGGCGTTTCATGGGCGAT
TTGCTCGACAGCGGCATCAAGCCCCGTTCAATCGCGCGCAAGCTTGCTTCGGTCAAAAGCTTTTACCGCTTTCTGCTTGA
CACAGGAAAGATCGAGCGCTCTCCGCTTTCTCTGGTTTTGACTCCAAGGCTCGAACGGAAGATTCCTGATTTTCTGAGCG
AAGAGGAGGCCTCACGGCTTTTCGACCAGCTTGTGCTTTCAGATCAAGAAAGTGTTGGCCCGGAGCAGGGGCAAAAGGCA
GCGGTGCAGAGGTTCGAGCTGGCAAGAGACCGGGCGGTGCTCGAATTGCTCTATGGTTGCGGCCTGCGCCTGTCTGAGGT
GACTGGTCTGGAAAATGCTGATGTCGATCTCGTGCACGGATTTCTGAAAGTTACCGGAAAGGGGCGCAAACAGCGCATTG
TGCCGTTCGGGGAGCCCGCTGCCGAAGCGCTCAGAAATTATTTTGAAGTCAGGCGAAACTTCTTTAGAATATTAAAAGAG
GGGGCCGGTGAAACTTCGAAAGTTTTCGTAACGGCAAAAGGCAGACAGATTTATCCCATGCTTGTGCAGAGAATGACAAA
GAGGTATCTCTCACCGGTTACCGAATCGGCAAGGAAAAATCCACACATGCTCCGGCACACTTTTGCAACACACATGCTCA
ATGGCGGCGCAGACCTGAAAAGCGTCAGCGAGATGCTGGGCCACAGCAACCTGACGACGACGGAGCTTTATACCCATGTG
ACATTCAACAGGTTGAGGGATGCCTACACCAAAGCTCATCCCAGGGCCTGA

Upstream 100 bases:

>100_bases
CTTCCGGGGAACCGATGCCAGTGTTCAACAGTTTTCTCATAAAAGACGACCGCTTGTATTACATCAGAGAGAGAGAATTT
CTCGTCAGCTTTGTTGTCTC

Downstream 100 bases:

>100_bases
TTTTCACAATTACCGGCATCTGTCCAGGTGACAGCCATTATGAATCGATGCCGGAGCCGTTCTTTCAAGGTATTTCAATT
TTTTCAAGGGAGGCAGGTAT

Product: phage/XerD family site-specific recombinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKRSAPVQFAKKDVANCRWLGEFLVHLESTRNVSAKTVTAYTTDLIQFFEFLTDESGHQEMSAVDPELVEVADVRRFMGD
LLDSGIKPRSIARKLASVKSFYRFLLDTGKIERSPLSLVLTPRLERKIPDFLSEEEASRLFDQLVLSDQESVGPEQGQKA
AVQRFELARDRAVLELLYGCGLRLSEVTGLENADVDLVHGFLKVTGKGRKQRIVPFGEPAAEALRNYFEVRRNFFRILKE
GAGETSKVFVTAKGRQIYPMLVQRMTKRYLSPVTESARKNPHMLRHTFATHMLNGGADLKSVSEMLGHSNLTTTELYTHV
TFNRLRDAYTKAHPRA

Sequences:

>Translated_336_residues
MKRSAPVQFAKKDVANCRWLGEFLVHLESTRNVSAKTVTAYTTDLIQFFEFLTDESGHQEMSAVDPELVEVADVRRFMGD
LLDSGIKPRSIARKLASVKSFYRFLLDTGKIERSPLSLVLTPRLERKIPDFLSEEEASRLFDQLVLSDQESVGPEQGQKA
AVQRFELARDRAVLELLYGCGLRLSEVTGLENADVDLVHGFLKVTGKGRKQRIVPFGEPAAEALRNYFEVRRNFFRILKE
GAGETSKVFVTAKGRQIYPMLVQRMTKRYLSPVTESARKNPHMLRHTFATHMLNGGADLKSVSEMLGHSNLTTTELYTHV
TFNRLRDAYTKAHPRA
>Mature_336_residues
MKRSAPVQFAKKDVANCRWLGEFLVHLESTRNVSAKTVTAYTTDLIQFFEFLTDESGHQEMSAVDPELVEVADVRRFMGD
LLDSGIKPRSIARKLASVKSFYRFLLDTGKIERSPLSLVLTPRLERKIPDFLSEEEASRLFDQLVLSDQESVGPEQGQKA
AVQRFELARDRAVLELLYGCGLRLSEVTGLENADVDLVHGFLKVTGKGRKQRIVPFGEPAAEALRNYFEVRRNFFRILKE
GAGETSKVFVTAKGRQIYPMLVQRMTKRYLSPVTESARKNPHMLRHTFATHMLNGGADLKSVSEMLGHSNLTTTELYTHV
TFNRLRDAYTKAHPRA

Specific function: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell div

COG id: COG4974

COG function: function code L; Site-specific recombinase XerD

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family. XerC subfamily

Homologues:

Organism=Escherichia coli, GI1789261, Length=327, Percent_Identity=34.8623853211009, Blast_Score=171, Evalue=6e-44,
Organism=Escherichia coli, GI1790244, Length=314, Percent_Identity=32.484076433121, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1790768, Length=152, Percent_Identity=27.6315789473684, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XERC_CHLTE (Q8KBZ5)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662518.1
- ProteinModelPortal:   Q8KBZ5
- SMR:   Q8KBZ5
- GeneID:   1006122
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1635
- NMPDR:   fig|194439.1.peg.1612
- TIGR:   CT1635
- HOGENOM:   HBG727654
- OMA:   PMLVQRM
- ProtClustDB:   CLSK637863
- BioCyc:   CTEP194439:CT_1635-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01808
- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR010998
- InterPro:   IPR023109
- InterPro:   IPR004107
- Gene3D:   G3DSA:1.10.150.130
- Gene3D:   G3DSA:1.10.443.10

Pfam domain/function: PF02899 Phage_integr_N; PF00589 Phage_integrase; SSF56349 DNA_brk_join_enz; SSF47823 L_intgrse_like_N

EC number: NA

Molecular weight: Translated: 38067; Mature: 38067

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: ACT_SITE 183-183 ACT_SITE 207-207 ACT_SITE 282-282 ACT_SITE 285-285 ACT_SITE 308-308 ACT_SITE 317-317

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRSAPVQFAKKDVANCRWLGEFLVHLESTRNVSAKTVTAYTTDLIQFFEFLTDESGHQE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCH
MSAVDPELVEVADVRRFMGDLLDSGIKPRSIARKLASVKSFYRFLLDTGKIERSPLSLVL
HHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
TPRLERKIPDFLSEEEASRLFDQLVLSDQESVGPEQGQKAAVQRFELARDRAVLELLYGC
CCHHHHHCHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GLRLSEVTGLENADVDLVHGFLKVTGKGRKQRIVPFGEPAAEALRNYFEVRRNFFRILKE
CCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GAGETSKVFVTAKGRQIYPMLVQRMTKRYLSPVTESARKNPHMLRHTFATHMLNGGADLK
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHH
SVSEMLGHSNLTTTELYTHVTFNRLRDAYTKAHPRA
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKRSAPVQFAKKDVANCRWLGEFLVHLESTRNVSAKTVTAYTTDLIQFFEFLTDESGHQE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCH
MSAVDPELVEVADVRRFMGDLLDSGIKPRSIARKLASVKSFYRFLLDTGKIERSPLSLVL
HHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
TPRLERKIPDFLSEEEASRLFDQLVLSDQESVGPEQGQKAAVQRFELARDRAVLELLYGC
CCHHHHHCHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GLRLSEVTGLENADVDLVHGFLKVTGKGRKQRIVPFGEPAAEALRNYFEVRRNFFRILKE
CCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GAGETSKVFVTAKGRQIYPMLVQRMTKRYLSPVTESARKNPHMLRHTFATHMLNGGADLK
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHH
SVSEMLGHSNLTTTELYTHVTFNRLRDAYTKAHPRA
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901