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The map label for this gene is rnhA [H]

Identifier: 21674430

GI number: 21674430

Start: 1518500

End: 1518940

Strand: Direct

Name: rnhA [H]

Synonym: CT1612

Alternate gene names: 21674430

Gene position: 1518500-1518940 (Clockwise)

Preceding gene: 21674429

Following gene: 21674431

Centisome position: 70.47

GC content: 56.69

Gene sequence:

>441_bases
ATGGAAAAAACGATCACGATCTACACCGACGGCGCGTGCAGCGGCAATCCGGGCAAGGGCGGCTGGGGTGCGCTGCTCAT
GTATGGCAGCAGCCGGAAGGAGATTTCAGGGTACGATCCGGCCACGACCAACAACCGCATGGAGCTGATGGCGGCCATCA
AGGGGCTTGAGGCGCTCAAGGAGCCTTGTCGGGTGCAGCTCTATAGCGATTCAGCATATTTGGTCAACGCGATGAACGAA
GGGTGGTTGAAACGCTGGGTAAAAAACGGCTGGAAAACCGCTGCGAAGAAGCCGGTGGAGAACATCGACCTCTGGCAGGA
AATCCTGAAGTTGACTACATTACACCGCGTCACCTTTCACAAAGTCAAGGGCCACAGCGATAACCCGTACAACAGCCGGT
GCGACGAGCTGGCCCGGCTTGCCATCAAGGAAAACTCCTAA

Upstream 100 bases:

>100_bases
ACCGCCGAACTCGCGAAGCTTCTGAAGTAAGCGTCACCAGCAGTGAAAATCCCAAATTAATTGAGAAGGCTCATCAGCAG
GTGAGCCTTTTTTATTATCG

Downstream 100 bases:

>100_bases
CCTGTCCCGACCTATGAGCGGCAACGAGTCCATGCCTGCAACGCCTCAAATGCAGGCACCCAAAAAGAAAGGCCCAAAGG
TCATCGCCACGCTGTTTGTC

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H [H]

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MEKTITIYTDGACSGNPGKGGWGALLMYGSSRKEISGYDPATTNNRMELMAAIKGLEALKEPCRVQLYSDSAYLVNAMNE
GWLKRWVKNGWKTAAKKPVENIDLWQEILKLTTLHRVTFHKVKGHSDNPYNSRCDELARLAIKENS

Sequences:

>Translated_146_residues
MEKTITIYTDGACSGNPGKGGWGALLMYGSSRKEISGYDPATTNNRMELMAAIKGLEALKEPCRVQLYSDSAYLVNAMNE
GWLKRWVKNGWKTAAKKPVENIDLWQEILKLTTLHRVTFHKVKGHSDNPYNSRCDELARLAIKENS
>Mature_146_residues
MEKTITIYTDGACSGNPGKGGWGALLMYGSSRKEISGYDPATTNNRMELMAAIKGLEALKEPCRVQLYSDSAYLVNAMNE
GWLKRWVKNGWKTAAKKPVENIDLWQEILKLTTLHRVTFHKVKGHSDNPYNSRCDELARLAIKENS

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids [H]

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Homo sapiens, GI21359816, Length=150, Percent_Identity=32.6666666666667, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI1786408, Length=141, Percent_Identity=53.1914893617021, Blast_Score=150, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI115532542, Length=139, Percent_Identity=38.8489208633094, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00075 RnaseH [H]

EC number: =3.1.26.4 [H]

Molecular weight: Translated: 16407; Mature: 16407

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTITIYTDGACSGNPGKGGWGALLMYGSSRKEISGYDPATTNNRMELMAAIKGLEALK
CCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
EPCRVQLYSDSAYLVNAMNEGWLKRWVKNGWKTAAKKPVENIDLWQEILKLTTLHRVTFH
CCCEEEEECCCEEEEHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
KVKGHSDNPYNSRCDELARLAIKENS
HHCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEKTITIYTDGACSGNPGKGGWGALLMYGSSRKEISGYDPATTNNRMELMAAIKGLEALK
CCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
EPCRVQLYSDSAYLVNAMNEGWLKRWVKNGWKTAAKKPVENIDLWQEILKLTTLHRVTFH
CCCEEEEECCCEEEEHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
KVKGHSDNPYNSRCDELARLAIKENS
HHCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA