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The map label for this gene is thyX [H]

Identifier: 21674372

GI number: 21674372

Start: 1463997

End: 1464656

Strand: Direct

Name: thyX [H]

Synonym: CT1554

Alternate gene names: 21674372

Gene position: 1463997-1464656 (Clockwise)

Preceding gene: 21674369

Following gene: 21674374

Centisome position: 67.94

GC content: 56.67

Gene sequence:

>660_bases
ATGCAGGTACGCCTCATCTCCGTCACCAACCCGCTCATCGAAATCGACAACCGCCAGCTCACGCCGGAAGGACTCATGGC
CTACTGCGCTCGCGTATCGAGCCCGCACCAGGAAACACCGGATTATGAAAAGCTGCTCTCGTACTGCATCCAGAACAAGC
ACTGGAGCGTCTTCGAGATGGTTGACATGACGGTGGAAATCACCACCTCCCGCGCCATCTCCCCGCAGATTCTGCGCCAT
CGCAGCTTCTGTTTCCAGGAATTTTCACAGCGCTACGCCAAGGCGCAGACAACTGAAAAGTACAAGCCAAGGCGTCAGGA
TGTAAAAAACAGGCAGAACTCACTGGATGATCTCGACGAAGCGACCGTAAAGTGGTTTGACGAGGCGCAGGAGAAAATCG
CGCAGCTCGCCTTCGAGAGCTATGAAGAGGCGCTGGAGAAAGGTATCGCCAAGGAGTGCGCCCGCGTCCTGCTCCCGCTC
GCCACCCAGACCCGGCTCTACATGAAAGGCTCGATCAGAAGCTGGATCCACTACCTCGAAGTCCGCACCGACCCCGCTAC
CCAGAAAGAGCACCGCGACATTGCCAAAGCTGTGCAGGCAATTTTTGTGGAGCAGTTCCCGGTGACAAGCAAAGCGCTAG
GGTGGAAGTACGGATGTTGA

Upstream 100 bases:

>100_bases
GTTCCGCTTTCCATAAATTATCATGATAGCGCCTCCATCGCCGCTCCGCCTTTTGGTATATTGAACGCTTCATACCACCA
TTCAAGACCGTCAGATAACC

Downstream 100 bases:

>100_bases
ATGAAAAAAGGGAAAAGAAATTCTTTTCCCTTTTTCCCTCCAATTCGACCTGGAAAGTATCTCTGTTTTCCCCTTACTTC
ATATGCCCAAGCAGCTTGAT

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MQVRLISVTNPLIEIDNRQLTPEGLMAYCARVSSPHQETPDYEKLLSYCIQNKHWSVFEMVDMTVEITTSRAISPQILRH
RSFCFQEFSQRYAKAQTTEKYKPRRQDVKNRQNSLDDLDEATVKWFDEAQEKIAQLAFESYEEALEKGIAKECARVLLPL
ATQTRLYMKGSIRSWIHYLEVRTDPATQKEHRDIAKAVQAIFVEQFPVTSKALGWKYGC

Sequences:

>Translated_219_residues
MQVRLISVTNPLIEIDNRQLTPEGLMAYCARVSSPHQETPDYEKLLSYCIQNKHWSVFEMVDMTVEITTSRAISPQILRH
RSFCFQEFSQRYAKAQTTEKYKPRRQDVKNRQNSLDDLDEATVKWFDEAQEKIAQLAFESYEEALEKGIAKECARVLLPL
ATQTRLYMKGSIRSWIHYLEVRTDPATQKEHRDIAKAVQAIFVEQFPVTSKALGWKYGC
>Mature_219_residues
MQVRLISVTNPLIEIDNRQLTPEGLMAYCARVSSPHQETPDYEKLLSYCIQNKHWSVFEMVDMTVEITTSRAISPQILRH
RSFCFQEFSQRYAKAQTTEKYKPRRQDVKNRQNSLDDLDEATVKWFDEAQEKIAQLAFESYEEALEKGIAKECARVLLPL
ATQTRLYMKGSIRSWIHYLEVRTDPATQKEHRDIAKAVQAIFVEQFPVTSKALGWKYGC

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 25513; Mature: 25513

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVRLISVTNPLIEIDNRQLTPEGLMAYCARVSSPHQETPDYEKLLSYCIQNKHWSVFEM
CCEEEEECCCCCEECCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHH
VDMTVEITTSRAISPQILRHRSFCFQEFSQRYAKAQTTEKYKPRRQDVKNRQNSLDDLDE
HHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ATVKWFDEAQEKIAQLAFESYEEALEKGIAKECARVLLPLATQTRLYMKGSIRSWIHYLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRTDPATQKEHRDIAKAVQAIFVEQFPVTSKALGWKYGC
HCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCC
>Mature Secondary Structure
MQVRLISVTNPLIEIDNRQLTPEGLMAYCARVSSPHQETPDYEKLLSYCIQNKHWSVFEM
CCEEEEECCCCCEECCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHH
VDMTVEITTSRAISPQILRHRSFCFQEFSQRYAKAQTTEKYKPRRQDVKNRQNSLDDLDE
HHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ATVKWFDEAQEKIAQLAFESYEEALEKGIAKECARVLLPLATQTRLYMKGSIRSWIHYLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRTDPATQKEHRDIAKAVQAIFVEQFPVTSKALGWKYGC
HCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]