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The map label for this gene is aroC

Identifier: 21674253

GI number: 21674253

Start: 1344156

End: 1345349

Strand: Direct

Name: aroC

Synonym: CT1432

Alternate gene names: 21674253

Gene position: 1344156-1345349 (Clockwise)

Preceding gene: 21674252

Following gene: 21674255

Centisome position: 62.38

GC content: 63.23

Gene sequence:

>1194_bases
ATGATCCGTTACTTCACCGCAGGCGAATCGCACGGCCCGGCGCTTTCAGCAATCGTCGAGGGAATGCCCGCAGGCGTGGC
GCTGACCGAATCCGACATCAACGACCAGCTCGCCCGCCGCCAGCAGGGTTACGGTCGTGGCGGCCGCATGAAGATCGAGA
CCGACCGTGCCGAGGTGCTCTCCGGCGTCCGGTTCGGCAAAACCATCGGCTCGCCCGTCGCGATGCTCATCCGCAACCGT
GACTGGGAGAACTGGACAACATCGATGGCGCAGTTCGAAGACCACGCCACCGAGGTGCAGAAGATCACCATCCCCCGCCC
CGGCCACGCCGACCTGACCGGCTTCGTGAAATACGGCTTCGACGACATTCGCCCGGTCATCGACCGCTCCTCGGCCCGCG
AAACCGCCGCCAGAGTCGCTGCCGGATCGCTCGCACGAGCATTTTTGAGACAGCTCGGCATCCAGATTGGAAGCTACATC
TCCACCATAGGTCCCGTCTCCGAAGCCGCCGCCCCCGCCTCGTTGCAGGAGCTGCTCGACGCCGGAGCTGAAAGCCTCGC
CGCCGAAGCCGACAAATCGCCGGTGCGGATGCTCGACCCGGAAGCAGAAACCGCAGCCATCGCGGCTATCGACCAGGCCA
AAGCCGATGGCGACACTCTCGGTGGCATCGTCGAACTCTACATCACCGGCGTACCAATGGGCCTCGGCAGCTACGTCCAG
CACGACCGCCGGCTCGACTCGGAACTCGCCGCCGCAATCATGTCTATCCAGGCGATCAAAGGCGTCGAAATCGGTCCGGC
CTTCGACAACGCCCGCAAACCAGGTTCCCAGGTACACGACGAACTGTTCGCCGGTGGTGAAAAGGGATTGAGACGCGAAA
CCAACCGAGCTGGAGGCATCGAAGGCAGCATGTCAAGCGGCCAGCCGATCCACATCCGCGCCGCCATGAAACCGATCTCC
TCGCTCGTCTCCCCGCTCAGCTCTTTCGACCTCGCCACACTCGAAGCCGTGCAGTCACGCTTCGAACGCAGCGACACCTG
CGCCGTCCCCGCCGCCGGAGTCGTCGCCGAAGCCGTCGTAGCCCCCGTCATCGCCAACGCGCTGTTGGAAAAACTTGGCG
GAGATCATATGGCGGAGATTAAGGAAAGGCTGGAGGTTTATCGGGCGGCGCTGAGGATGAGGTTTGAAAAATAA

Upstream 100 bases:

>100_bases
CTTGAAACTCGAACATCTTTGTAGGGGTATCCCGACAAGTCGCGATACCCTTTTATGATGCGCCCAAAAACAACCGATAC
ATTTTTCTCACCACACTGAC

Downstream 100 bases:

>100_bases
CTACAAACCGCCTTAAAAAGCCTCTTTTTTAAAGAGGCTTTTTTGTGGGTCTGACAACGATACTCTATCCATTCCTGCAT
AACCTGGATGTATCAAACCC

Product: chorismate synthase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate phospholyase

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MIRYFTAGESHGPALSAIVEGMPAGVALTESDINDQLARRQQGYGRGGRMKIETDRAEVLSGVRFGKTIGSPVAMLIRNR
DWENWTTSMAQFEDHATEVQKITIPRPGHADLTGFVKYGFDDIRPVIDRSSARETAARVAAGSLARAFLRQLGIQIGSYI
STIGPVSEAAAPASLQELLDAGAESLAAEADKSPVRMLDPEAETAAIAAIDQAKADGDTLGGIVELYITGVPMGLGSYVQ
HDRRLDSELAAAIMSIQAIKGVEIGPAFDNARKPGSQVHDELFAGGEKGLRRETNRAGGIEGSMSSGQPIHIRAAMKPIS
SLVSPLSSFDLATLEAVQSRFERSDTCAVPAAGVVAEAVVAPVIANALLEKLGGDHMAEIKERLEVYRAALRMRFEK

Sequences:

>Translated_397_residues
MIRYFTAGESHGPALSAIVEGMPAGVALTESDINDQLARRQQGYGRGGRMKIETDRAEVLSGVRFGKTIGSPVAMLIRNR
DWENWTTSMAQFEDHATEVQKITIPRPGHADLTGFVKYGFDDIRPVIDRSSARETAARVAAGSLARAFLRQLGIQIGSYI
STIGPVSEAAAPASLQELLDAGAESLAAEADKSPVRMLDPEAETAAIAAIDQAKADGDTLGGIVELYITGVPMGLGSYVQ
HDRRLDSELAAAIMSIQAIKGVEIGPAFDNARKPGSQVHDELFAGGEKGLRRETNRAGGIEGSMSSGQPIHIRAAMKPIS
SLVSPLSSFDLATLEAVQSRFERSDTCAVPAAGVVAEAVVAPVIANALLEKLGGDHMAEIKERLEVYRAALRMRFEK
>Mature_397_residues
MIRYFTAGESHGPALSAIVEGMPAGVALTESDINDQLARRQQGYGRGGRMKIETDRAEVLSGVRFGKTIGSPVAMLIRNR
DWENWTTSMAQFEDHATEVQKITIPRPGHADLTGFVKYGFDDIRPVIDRSSARETAARVAAGSLARAFLRQLGIQIGSYI
STIGPVSEAAAPASLQELLDAGAESLAAEADKSPVRMLDPEAETAAIAAIDQAKADGDTLGGIVELYITGVPMGLGSYVQ
HDRRLDSELAAAIMSIQAIKGVEIGPAFDNARKPGSQVHDELFAGGEKGLRRETNRAGGIEGSMSSGQPIHIRAAMKPIS
SLVSPLSSFDLATLEAVQSRFERSDTCAVPAAGVVAEAVVAPVIANALLEKLGGDHMAEIKERLEVYRAALRMRFEK

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; seventh step. [C]

COG id: COG0082

COG function: function code E; Chorismate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chorismate synthase family

Homologues:

Organism=Escherichia coli, GI1788669, Length=372, Percent_Identity=36.8279569892473, Blast_Score=176, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321290, Length=376, Percent_Identity=33.7765957446808, Blast_Score=190, Evalue=4e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROC_CHLTE (Q8KCI9)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662318.1
- ProteinModelPortal:   Q8KCI9
- SMR:   Q8KCI9
- GeneID:   1005980
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1432
- NMPDR:   fig|194439.1.peg.1412
- TIGR:   CT1432
- HOGENOM:   HBG292336
- OMA:   GSEAHDE
- ProtClustDB:   PRK05382
- BioCyc:   CTEP194439:CT_1432-MONOMER
- BRENDA:   4.2.3.5
- HAMAP:   MF_00300_B
- InterPro:   IPR000453
- InterPro:   IPR020541
- PANTHER:   PTHR21085
- PIRSF:   PIRSF001456
- TIGRFAMs:   TIGR00033

Pfam domain/function: PF01264 Chorismate_synt; SSF103263 Chorismate_synth

EC number: =4.2.3.5

Molecular weight: Translated: 42278; Mature: 42278

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00787 CHORISMATE_SYNTHASE_1; PS00788 CHORISMATE_SYNTHASE_2; PS00789 CHORISMATE_SYNTHASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRYFTAGESHGPALSAIVEGMPAGVALTESDINDQLARRQQGYGRGGRMKIETDRAEVL
CEEEEECCCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCEEEECCHHHHH
SGVRFGKTIGSPVAMLIRNRDWENWTTSMAQFEDHATEVQKITIPRPGHADLTGFVKYGF
HHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHCH
DDIRPVIDRSSARETAARVAAGSLARAFLRQLGIQIGSYISTIGPVSEAAAPASLQELLD
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHH
AGAESLAAEADKSPVRMLDPEAETAAIAAIDQAKADGDTLGGIVELYITGVPMGLGSYVQ
HCHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHH
HDRRLDSELAAAIMSIQAIKGVEIGPAFDNARKPGSQVHDELFAGGEKGLRRETNRAGGI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCC
EGSMSSGQPIHIRAAMKPISSLVSPLSSFDLATLEAVQSRFERSDTCAVPAAGVVAEAVV
CCCCCCCCCEEEHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
APVIANALLEKLGGDHMAEIKERLEVYRAALRMRFEK
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIRYFTAGESHGPALSAIVEGMPAGVALTESDINDQLARRQQGYGRGGRMKIETDRAEVL
CEEEEECCCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCEEEECCHHHHH
SGVRFGKTIGSPVAMLIRNRDWENWTTSMAQFEDHATEVQKITIPRPGHADLTGFVKYGF
HHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHCH
DDIRPVIDRSSARETAARVAAGSLARAFLRQLGIQIGSYISTIGPVSEAAAPASLQELLD
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHH
AGAESLAAEADKSPVRMLDPEAETAAIAAIDQAKADGDTLGGIVELYITGVPMGLGSYVQ
HCHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHH
HDRRLDSELAAAIMSIQAIKGVEIGPAFDNARKPGSQVHDELFAGGEKGLRRETNRAGGI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCC
EGSMSSGQPIHIRAAMKPISSLVSPLSSFDLATLEAVQSRFERSDTCAVPAAGVVAEAVV
CCCCCCCCCEEEHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
APVIANALLEKLGGDHMAEIKERLEVYRAALRMRFEK
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901