Click here to switch to the map view.

The map label for this gene is aroB

Identifier: 21674227

GI number: 21674227

Start: 1318923

End: 1320029

Strand: Direct

Name: aroB

Synonym: CT1406

Alternate gene names: 21674227

Gene position: 1318923-1320029 (Clockwise)

Preceding gene: 21674226

Following gene: 21674228

Centisome position: 61.2

GC content: 59.89

Gene sequence:

>1107_bases
ATGCAGACTCCGTCCAGCCATATCATCGTCAGAACGCCGGTCATCGACTCCGTCGGTGAACTCTACGCCACAAGGGGACT
CGGCAAGAAAACCGTGCTGCTTTTCGACGAGAACACCCGCAGGCTTTTCGGCGACGCGATCATCGAATCGATGCAGCGCC
AAGGCTTCCGCACCATCGAGCTGGTCGTGCCCGCACGCGAGACCTCGAAAAGCGTTTCGACGGCATGGAAACTCTATGGA
CAGATGATCGAGGCGGACGTTGACCGGAGCTGGAACCTGCTCTGCGCAGGCGGCGGAGTGGTAGGCGACCTCGGCGGCTA
CATCGCGGCAAGCTACTACCGCGGCATTCCGGTGGTGCAGCTCCCAACGACGCTGCTCGCCATGACCGACAGCTCCATTG
GCGGCAAGGTGGCCATCAACCACCCGCTCGGCAAAAATCTCATCGGCTTCTTCCATATGCCGGAGCTGGTGCTGATCGAC
CCCGCCTACCTCAGGACACTCCCCTCTCGTGAAATTTACGGAGGCATGTCGGAAGTGGTGAAGTACGGATTCATCGCTGA
CCGGGAGTTTTTCGACCTGCTTACCAAACATTGGGACGAGGTGGTACGCCTCGAAGAACCTTGGCTCTCCAAAGCGGTCA
GCCGCAGCGCTTTCATCAAGGCCAACGTGGTGGAAAAGGATTTCCGCGAAACCTCTGGACTGCGAGCGACGCTGAACTTC
GGCCACACCTTCGCGCACGGCCTCGAAAAGATGGCCGGGTACCGCAACCTGCGCCACGGCGAGGCAGTCACCATCGGCAT
GGTCTGCGCGCTCTTCCTTTCGCACCGGCCGGGATTCCTCGCCGAAGCTGATCTGCGCGAAGGACTCGCGCTGCTCGCCC
GCTTCCGCTTCCCGCGCGGCCTGGTCAACAAGCGCTTCCTTTCACTCGACCGCGACGAGCTGGTGGAGAGTATGCTCTCC
GACAAAAAGAAGATCGACAAGCAGCTCCGCTTCGTCCTGCTCGACCGCATCGGGCACGCTTTCCTGCACGACAAGGACAT
CACAAAAACCGATGTGCTGCAGGCAATTGACGATGCAATGGGGTGGTTCTCTTCAGCAGGGTTTTAA

Upstream 100 bases:

>100_bases
CGACTCGAAAAAGATCGGCGCAAGTGTCGAGGAGTTGACACGCAAAATCGAGCGGCACATCCGCCGCGCGTCGAAAAACA
ACACTAACGAGAAGTAAGAC

Downstream 100 bases:

>100_bases
CCCTGCTGCCACTCGATCGTTACATTCTTTTCTGTTGTCCCGGCTTTCAAGCCGGGGTGAGAAGAGAAAAGGTAAGCCTC
AAGGTCGAAACTTTGTAGCG

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MQTPSSHIIVRTPVIDSVGELYATRGLGKKTVLLFDENTRRLFGDAIIESMQRQGFRTIELVVPARETSKSVSTAWKLYG
QMIEADVDRSWNLLCAGGGVVGDLGGYIAASYYRGIPVVQLPTTLLAMTDSSIGGKVAINHPLGKNLIGFFHMPELVLID
PAYLRTLPSREIYGGMSEVVKYGFIADREFFDLLTKHWDEVVRLEEPWLSKAVSRSAFIKANVVEKDFRETSGLRATLNF
GHTFAHGLEKMAGYRNLRHGEAVTIGMVCALFLSHRPGFLAEADLREGLALLARFRFPRGLVNKRFLSLDRDELVESMLS
DKKKIDKQLRFVLLDRIGHAFLHDKDITKTDVLQAIDDAMGWFSSAGF

Sequences:

>Translated_368_residues
MQTPSSHIIVRTPVIDSVGELYATRGLGKKTVLLFDENTRRLFGDAIIESMQRQGFRTIELVVPARETSKSVSTAWKLYG
QMIEADVDRSWNLLCAGGGVVGDLGGYIAASYYRGIPVVQLPTTLLAMTDSSIGGKVAINHPLGKNLIGFFHMPELVLID
PAYLRTLPSREIYGGMSEVVKYGFIADREFFDLLTKHWDEVVRLEEPWLSKAVSRSAFIKANVVEKDFRETSGLRATLNF
GHTFAHGLEKMAGYRNLRHGEAVTIGMVCALFLSHRPGFLAEADLREGLALLARFRFPRGLVNKRFLSLDRDELVESMLS
DKKKIDKQLRFVLLDRIGHAFLHDKDITKTDVLQAIDDAMGWFSSAGF
>Mature_368_residues
MQTPSSHIIVRTPVIDSVGELYATRGLGKKTVLLFDENTRRLFGDAIIESMQRQGFRTIELVVPARETSKSVSTAWKLYG
QMIEADVDRSWNLLCAGGGVVGDLGGYIAASYYRGIPVVQLPTTLLAMTDSSIGGKVAINHPLGKNLIGFFHMPELVLID
PAYLRTLPSREIYGGMSEVVKYGFIADREFFDLLTKHWDEVVRLEEPWLSKAVSRSAFIKANVVEKDFRETSGLRATLNF
GHTFAHGLEKMAGYRNLRHGEAVTIGMVCALFLSHRPGFLAEADLREGLALLARFRFPRGLVNKRFLSLDRDELVESMLS
DKKKIDKQLRFVLLDRIGHAFLHDKDITKTDVLQAIDDAMGWFSSAGF

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=332, Percent_Identity=39.4578313253012, Blast_Score=217, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6320332, Length=333, Percent_Identity=36.6366366366366, Blast_Score=169, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_CHLTE (Q8KCK9)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662292.1
- ProteinModelPortal:   Q8KCK9
- SMR:   Q8KCK9
- GeneID:   1006815
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1406
- NMPDR:   fig|194439.1.peg.1386
- TIGR:   CT1406
- HOGENOM:   HBG632303
- OMA:   EKDFRET
- ProtClustDB:   PRK00002
- BioCyc:   CTEP194439:CT_1406-MONOMER
- BRENDA:   4.2.3.4
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 41156; Mature: 41156

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTPSSHIIVRTPVIDSVGELYATRGLGKKTVLLFDENTRRLFGDAIIESMQRQGFRTIE
CCCCCCCEEEECCCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEEE
LVVPARETSKSVSTAWKLYGQMIEADVDRSWNLLCAGGGVVGDLGGYIAASYYRGIPVVQ
EEECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEE
LPTTLLAMTDSSIGGKVAINHPLGKNLIGFFHMPELVLIDPAYLRTLPSREIYGGMSEVV
CCHHHHHCCCCCCCCEEEECCCCCCCHHHHHCCCCEEEECHHHHHHCCCHHHHCCHHHHH
KYGFIADREFFDLLTKHWDEVVRLEEPWLSKAVSRSAFIKANVVEKDFRETSGLRATLNF
HHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
GHTFAHGLEKMAGYRNLRHGEAVTIGMVCALFLSHRPGFLAEADLREGLALLARFRFPRG
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHH
LVNKRFLSLDRDELVESMLSDKKKIDKQLRFVLLDRIGHAFLHDKDITKTDVLQAIDDAM
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
GWFSSAGF
HHHHCCCC
>Mature Secondary Structure
MQTPSSHIIVRTPVIDSVGELYATRGLGKKTVLLFDENTRRLFGDAIIESMQRQGFRTIE
CCCCCCCEEEECCCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEEE
LVVPARETSKSVSTAWKLYGQMIEADVDRSWNLLCAGGGVVGDLGGYIAASYYRGIPVVQ
EEECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEE
LPTTLLAMTDSSIGGKVAINHPLGKNLIGFFHMPELVLIDPAYLRTLPSREIYGGMSEVV
CCHHHHHCCCCCCCCEEEECCCCCCCHHHHHCCCCEEEECHHHHHHCCCHHHHCCHHHHH
KYGFIADREFFDLLTKHWDEVVRLEEPWLSKAVSRSAFIKANVVEKDFRETSGLRATLNF
HHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
GHTFAHGLEKMAGYRNLRHGEAVTIGMVCALFLSHRPGFLAEADLREGLALLARFRFPRG
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHH
LVNKRFLSLDRDELVESMLSDKKKIDKQLRFVLLDRIGHAFLHDKDITKTDVLQAIDDAM
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
GWFSSAGF
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901