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The map label for this gene is lysA [H]

Identifier: 21674193

GI number: 21674193

Start: 1289462

End: 1290712

Strand: Reverse

Name: lysA [H]

Synonym: CT1371

Alternate gene names: 21674193

Gene position: 1290712-1289462 (Counterclockwise)

Preceding gene: 21674196

Following gene: 21674191

Centisome position: 59.9

GC content: 58.19

Gene sequence:

>1251_bases
GTGCTGGATAGTCATTTTTTCTCATTTTCCGACGGAATCCTCTGCTGTGAATCGGTCGCGCTCGACGAGCTTGCCCGACA
GTTCGGAACTCCGCTTTTCGTGACCAGCCGGCAGAGCCTGGTCAGTCAGTACCGCTCGTTCGAGGAGGCTTTTGCCTCTC
TGCCGCACTTCACCTGCTACTCGGTCAAAGCGAACTTCAACCTTGCTGTTATCCGCACGCTTGCCGAAGAGGGGTGTGGC
TGCGATGTCAACTCCGGCGGCGAACTTTACCGCGCCCTCACAGCCGGAGTTCCTGCCAACAAAATCATCATGGCCGGCGT
CGGCAAGAGCGAGGCGGAAATCAAGTATGGCCTAACCTCGGGCGTGATGATGATCAAGGCCGAGTCGATCTCCGAGCTCA
AGGCGATCAACAGCGTCGCCGAGCACCTCGGCAAGGTTGCGCAGGTCGGTGTCAGGATCAACCCCAACGTCACCGCCGAG
ACTCATCCGTATATCACCACCGGCGACAGCAAGGAGAAGTTCGGTATCGATGAAGCCGGACTTGGCGAGGTGTTCGAGCT
GTTCAAAACGCTGCCGAACCTTGAACTGCACGGCCTCGACATGCACATCGGCTCGCAGATTTTCGATCCGGAGTACTATG
TCGCCGCCACGCAGAAGCTGCTCGAAGTGCTCGAATCGGCGCGGCACCTCGGTTTCGACATCAAATGGCTCGATCTCGGT
GGTGGTTTCCCGGTGACCTATGATCCGCAGAAACCCGCCCCGCCGATCACGAAATTTGCCGAAAAGCTCATTCCGATGCT
CCAGGACAAGGGCGTGACGGTCATTTTCGAGCCAGGCCGGTTCATTGCGGCCAACGCTTCGGTGATTGTGACCAAGATTC
TGTACCGCAAGAAAAACCAGATCGGCAAGGAGTTTTTCATTGTCGATGCAGGTATGACCGAGCTGATCCGTCCGGCGCTT
TACCAGTCGCACCATGAAGTGCTCTCGGTCAAACAGCATGACAGGAGTGTCGTAGCCGACGTGGTTGGTCCGATCTGCGA
ATCGAGCGACTTCTTTGCTCGCCACCGCACCATCGACGACGCCCCGGAAGGCGAACTCCTCGCCGTGCTCTCATCCGGCG
CATACGGCGCGGTGATGAGCAGCAACTACAACGGCCGTCTCCGTCCAGCCGAGGTGATGGTCGATGGCGACGAAGTCACG
CTGACCCGCCGCCGCGAAACCTACGAACAGCTCGTGCAGAACGAACTGTAA

Upstream 100 bases:

>100_bases
GGCGACCCTATTATGCAAGCACTGCCGTTTTTTTGTTTCGAGTTCAGGAAACGCTATTATTGATACTCTTTTCATTAATT
ACCCAAAATCAAGGCGTATC

Downstream 100 bases:

>100_bases
GAGCGATCAAATGGACGAGGTGGATAACAATGCTTCACGTTCACTTCCGTCCATTGACATTTTGCGAAAGCGCCACCGTT
CACCATGCAGAAGCATGATA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MLDSHFFSFSDGILCCESVALDELARQFGTPLFVTSRQSLVSQYRSFEEAFASLPHFTCYSVKANFNLAVIRTLAEEGCG
CDVNSGGELYRALTAGVPANKIIMAGVGKSEAEIKYGLTSGVMMIKAESISELKAINSVAEHLGKVAQVGVRINPNVTAE
THPYITTGDSKEKFGIDEAGLGEVFELFKTLPNLELHGLDMHIGSQIFDPEYYVAATQKLLEVLESARHLGFDIKWLDLG
GGFPVTYDPQKPAPPITKFAEKLIPMLQDKGVTVIFEPGRFIAANASVIVTKILYRKKNQIGKEFFIVDAGMTELIRPAL
YQSHHEVLSVKQHDRSVVADVVGPICESSDFFARHRTIDDAPEGELLAVLSSGAYGAVMSSNYNGRLRPAEVMVDGDEVT
LTRRRETYEQLVQNEL

Sequences:

>Translated_416_residues
MLDSHFFSFSDGILCCESVALDELARQFGTPLFVTSRQSLVSQYRSFEEAFASLPHFTCYSVKANFNLAVIRTLAEEGCG
CDVNSGGELYRALTAGVPANKIIMAGVGKSEAEIKYGLTSGVMMIKAESISELKAINSVAEHLGKVAQVGVRINPNVTAE
THPYITTGDSKEKFGIDEAGLGEVFELFKTLPNLELHGLDMHIGSQIFDPEYYVAATQKLLEVLESARHLGFDIKWLDLG
GGFPVTYDPQKPAPPITKFAEKLIPMLQDKGVTVIFEPGRFIAANASVIVTKILYRKKNQIGKEFFIVDAGMTELIRPAL
YQSHHEVLSVKQHDRSVVADVVGPICESSDFFARHRTIDDAPEGELLAVLSSGAYGAVMSSNYNGRLRPAEVMVDGDEVT
LTRRRETYEQLVQNEL
>Mature_416_residues
MLDSHFFSFSDGILCCESVALDELARQFGTPLFVTSRQSLVSQYRSFEEAFASLPHFTCYSVKANFNLAVIRTLAEEGCG
CDVNSGGELYRALTAGVPANKIIMAGVGKSEAEIKYGLTSGVMMIKAESISELKAINSVAEHLGKVAQVGVRINPNVTAE
THPYITTGDSKEKFGIDEAGLGEVFELFKTLPNLELHGLDMHIGSQIFDPEYYVAATQKLLEVLESARHLGFDIKWLDLG
GGFPVTYDPQKPAPPITKFAEKLIPMLQDKGVTVIFEPGRFIAANASVIVTKILYRKKNQIGKEFFIVDAGMTELIRPAL
YQSHHEVLSVKQHDRSVVADVVGPICESSDFFARHRTIDDAPEGELLAVLSSGAYGAVMSSNYNGRLRPAEVMVDGDEVT
LTRRRETYEQLVQNEL

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=365, Percent_Identity=29.8630136986301, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI16506287, Length=379, Percent_Identity=24.5382585751979, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI22538418, Length=273, Percent_Identity=26.7399267399267, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI21361583, Length=273, Percent_Identity=26.7399267399267, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1789203, Length=438, Percent_Identity=29.2237442922374, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1789307, Length=295, Percent_Identity=24.0677966101695, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562780, Length=418, Percent_Identity=25.1196172248804, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24586472, Length=372, Percent_Identity=24.7311827956989, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24586474, Length=372, Percent_Identity=25.8064516129032, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45695; Mature: 45695

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00014 ER_TARGET ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDSHFFSFSDGILCCESVALDELARQFGTPLFVTSRQSLVSQYRSFEEAFASLPHFTCY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHCCCCEEEE
SVKANFNLAVIRTLAEEGCGCDVNSGGELYRALTAGVPANKIIMAGVGKSEAEIKYGLTS
EEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCEEEECCCC
GVMMIKAESISELKAINSVAEHLGKVAQVGVRINPNVTAETHPYITTGDSKEKFGIDEAG
CEEEEEHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCEEECCCCCHHCCCCCCC
LGEVFELFKTLPNLELHGLDMHIGSQIFDPEYYVAATQKLLEVLESARHLGFDIKWLDLG
HHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECC
GGFPVTYDPQKPAPPITKFAEKLIPMLQDKGVTVIFEPGRFIAANASVIVTKILYRKKNQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCEEEECHHHHHHHHHHHHHHH
IGKEFFIVDAGMTELIRPALYQSHHEVLSVKQHDRSVVADVVGPICESSDFFARHRTIDD
CCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCC
APEGELLAVLSSGAYGAVMSSNYNGRLRPAEVMVDGDEVTLTRRRETYEQLVQNEL
CCCCCEEEEEECCCCEEEEECCCCCCCCCEEEEECCCCEEEEHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDSHFFSFSDGILCCESVALDELARQFGTPLFVTSRQSLVSQYRSFEEAFASLPHFTCY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHCCCCEEEE
SVKANFNLAVIRTLAEEGCGCDVNSGGELYRALTAGVPANKIIMAGVGKSEAEIKYGLTS
EEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCEEEECCCC
GVMMIKAESISELKAINSVAEHLGKVAQVGVRINPNVTAETHPYITTGDSKEKFGIDEAG
CEEEEEHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCEEECCCCCHHCCCCCCC
LGEVFELFKTLPNLELHGLDMHIGSQIFDPEYYVAATQKLLEVLESARHLGFDIKWLDLG
HHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECC
GGFPVTYDPQKPAPPITKFAEKLIPMLQDKGVTVIFEPGRFIAANASVIVTKILYRKKNQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCEEEECHHHHHHHHHHHHHHH
IGKEFFIVDAGMTELIRPALYQSHHEVLSVKQHDRSVVADVVGPICESSDFFARHRTIDD
CCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCC
APEGELLAVLSSGAYGAVMSSNYNGRLRPAEVMVDGDEVTLTRRRETYEQLVQNEL
CCCCCEEEEEECCCCEEEEECCCCCCCCCEEEEECCCCEEEEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]