Click here to switch to the map view.

The map label for this gene is guaB [H]

Identifier: 21674116

GI number: 21674116

Start: 1209069

End: 1210553

Strand: Direct

Name: guaB [H]

Synonym: CT1293

Alternate gene names: 21674116

Gene position: 1209069-1210553 (Clockwise)

Preceding gene: 21674114

Following gene: 21674117

Centisome position: 56.11

GC content: 58.52

Gene sequence:

>1485_bases
ATGGACAAAATCCTCTATGATGCGCTGACCTTCGATGACGTGTTGCTCGTACCCGCATATTCCAACGTACTACCCAAAGA
GACGGTCGTCAAGTCGCGTCTGACCCGCCAGATCGAAGTCAACATTCCGCTGGTGAGTGCCGCCATGGACACGGTCACCG
AAGCCGAACTGGCCATTGCTCTCGCCCGGGCAGGCGGTATCGGCATCATCCACAAGAATCTCTCCATAGACGAACAGGCA
CGGCAGGTTGCAAAAGTCAAGCGTTTCGAGAGCGGCATCATCCGCAATCCCATCCATCTGTTCGAGGACGCGACTATCCA
GGATGCTATCGACCTGATGATCCGTCACTCGATTTCAGGCATTCCGGTCGTCGAGCATCCGACCCCCGAAGGCTGCCTGT
TGCTCAAAGGCATCGTCACCAACCGTGACCTGCGCATGACTGCATCATCCGACGAGAAAATCACTACCATCATGACGACT
AACCTCGTCACGGCCAAAGAGGGTATCGACCTGTTGACCGCCGAGGATATTCTCATGCGGAACAAGATCGAGAAACTCCT
CATCATCGACGATAACGGCTATCTCAAAGGCCTCATCACTTTCAAAGACATTCAGAAGCGCAAGCAGTGCCCCGACGCCT
GCAAGGACTCGCAGGGTCGGCTCCGGGCGGGCGCGGCAGTCGGCATCCGCGCAAACACGATGTCGCGCGTCGATGCGCTG
GTCGCAGCGGGGGTGGATGTCGTGGCGGTCGATACAGCGCACGGCCACAGCCAGGCAGTACTCGACATGGTGGCTACCAT
CAAGCAGAAATATCCGGAACTCCAGGTGATCGCGGGTAACGTGGCGACGCCGGAAGCGGTCAGGGATCTGGTCAAGGCCG
GCGCCGACGCCGTCAAGGTGGGCATCGGGCCGGGCAGTATCTGCACCACGCGCATCGTGGCTGGCGTCGGAATGCCGCAG
CTCACAGCTATCATGAAGTGCGCTGAAGAGGCGAAAAAAACCGACATTCCGCTCATCGCGGACGGCGGCATCAAGTACAG
CGGCGACATCGCCAAAGCACTCGCGGCTGGCGCGGATTCGGTGATGATGGGCAGCGTCTTCGCGGGCACTGACGAAAGCC
CCGGTGAAACCATCCTTTATGAAGGCCGCCGCTTCAAGGCGTACCGCGGCATGGGTTCACTGGGTGCGATGTCCGAACCG
GAAGGCAGCAGCGACCGCTACTTCCAGGATGTTTCGGCGGAGACAAAAAAGTATGTTCCCGAAGGCATCGAAGGCCGCAT
TCCGGCCAAAGGGAAGCTCGACGAGGTGGTTTATCAGCTCATCGGCGGCCTGAAATCCGCGATGGGCTACTGCGGCGTCA
GAACCATCACGGAGCTAAAAGAGAACACCCGTTTCGTACGCATCACCTCTGCTGGCCTCCGCGAAAGCCACCCGCACGAT
GTGATGATAACCAAAGAAGCACCGAACTACTCGACCTCTGCATAA

Upstream 100 bases:

>100_bases
CCTGCCACACACTTCTCATGCTCCTCAGCGTTGTCAATCCGTGCTCACTTTCGTAAATTGGCGGATTCATTTTTGCCGCA
ATCTCTTAACCAGGCACCCC

Downstream 100 bases:

>100_bases
GAATCCAGCACACCACACTCGAAAACCCCGGTTCAATGCCGGGGTTTTCTGGTTTTGGCGAAAAAAGATCGCCAATATCT
GCCGGATCAGTCTAATCGGA

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MDKILYDALTFDDVLLVPAYSNVLPKETVVKSRLTRQIEVNIPLVSAAMDTVTEAELAIALARAGGIGIIHKNLSIDEQA
RQVAKVKRFESGIIRNPIHLFEDATIQDAIDLMIRHSISGIPVVEHPTPEGCLLLKGIVTNRDLRMTASSDEKITTIMTT
NLVTAKEGIDLLTAEDILMRNKIEKLLIIDDNGYLKGLITFKDIQKRKQCPDACKDSQGRLRAGAAVGIRANTMSRVDAL
VAAGVDVVAVDTAHGHSQAVLDMVATIKQKYPELQVIAGNVATPEAVRDLVKAGADAVKVGIGPGSICTTRIVAGVGMPQ
LTAIMKCAEEAKKTDIPLIADGGIKYSGDIAKALAAGADSVMMGSVFAGTDESPGETILYEGRRFKAYRGMGSLGAMSEP
EGSSDRYFQDVSAETKKYVPEGIEGRIPAKGKLDEVVYQLIGGLKSAMGYCGVRTITELKENTRFVRITSAGLRESHPHD
VMITKEAPNYSTSA

Sequences:

>Translated_494_residues
MDKILYDALTFDDVLLVPAYSNVLPKETVVKSRLTRQIEVNIPLVSAAMDTVTEAELAIALARAGGIGIIHKNLSIDEQA
RQVAKVKRFESGIIRNPIHLFEDATIQDAIDLMIRHSISGIPVVEHPTPEGCLLLKGIVTNRDLRMTASSDEKITTIMTT
NLVTAKEGIDLLTAEDILMRNKIEKLLIIDDNGYLKGLITFKDIQKRKQCPDACKDSQGRLRAGAAVGIRANTMSRVDAL
VAAGVDVVAVDTAHGHSQAVLDMVATIKQKYPELQVIAGNVATPEAVRDLVKAGADAVKVGIGPGSICTTRIVAGVGMPQ
LTAIMKCAEEAKKTDIPLIADGGIKYSGDIAKALAAGADSVMMGSVFAGTDESPGETILYEGRRFKAYRGMGSLGAMSEP
EGSSDRYFQDVSAETKKYVPEGIEGRIPAKGKLDEVVYQLIGGLKSAMGYCGVRTITELKENTRFVRITSAGLRESHPHD
VMITKEAPNYSTSA
>Mature_494_residues
MDKILYDALTFDDVLLVPAYSNVLPKETVVKSRLTRQIEVNIPLVSAAMDTVTEAELAIALARAGGIGIIHKNLSIDEQA
RQVAKVKRFESGIIRNPIHLFEDATIQDAIDLMIRHSISGIPVVEHPTPEGCLLLKGIVTNRDLRMTASSDEKITTIMTT
NLVTAKEGIDLLTAEDILMRNKIEKLLIIDDNGYLKGLITFKDIQKRKQCPDACKDSQGRLRAGAAVGIRANTMSRVDAL
VAAGVDVVAVDTAHGHSQAVLDMVATIKQKYPELQVIAGNVATPEAVRDLVKAGADAVKVGIGPGSICTTRIVAGVGMPQ
LTAIMKCAEEAKKTDIPLIADGGIKYSGDIAKALAAGADSVMMGSVFAGTDESPGETILYEGRRFKAYRGMGSLGAMSEP
EGSSDRYFQDVSAETKKYVPEGIEGRIPAKGKLDEVVYQLIGGLKSAMGYCGVRTITELKENTRFVRITSAGLRESHPHD
VMITKEAPNYSTSA

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=458, Percent_Identity=43.8864628820961, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI34328930, Length=458, Percent_Identity=43.8864628820961, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI34328928, Length=458, Percent_Identity=43.8864628820961, Blast_Score=359, Evalue=4e-99,
Organism=Homo sapiens, GI156616279, Length=458, Percent_Identity=43.8864628820961, Blast_Score=358, Evalue=5e-99,
Organism=Homo sapiens, GI217035152, Length=452, Percent_Identity=43.8053097345133, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI217035148, Length=458, Percent_Identity=43.0131004366812, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI66933016, Length=484, Percent_Identity=40.2892561983471, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI217035150, Length=458, Percent_Identity=41.0480349344978, Blast_Score=322, Evalue=4e-88,
Organism=Homo sapiens, GI156104880, Length=225, Percent_Identity=39.1111111111111, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI50541954, Length=225, Percent_Identity=39.5555555555556, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI50541952, Length=225, Percent_Identity=39.5555555555556, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI50541948, Length=225, Percent_Identity=39.5555555555556, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI50541956, Length=225, Percent_Identity=39.5555555555556, Blast_Score=176, Evalue=4e-44,
Organism=Escherichia coli, GI1788855, Length=492, Percent_Identity=55.0813008130081, Blast_Score=486, Evalue=1e-138,
Organism=Escherichia coli, GI1786293, Length=224, Percent_Identity=37.9464285714286, Blast_Score=167, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71994385, Length=475, Percent_Identity=37.4736842105263, Blast_Score=287, Evalue=8e-78,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=39.0995260663507, Blast_Score=271, Evalue=7e-73,
Organism=Caenorhabditis elegans, GI17560440, Length=244, Percent_Identity=38.5245901639344, Blast_Score=185, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6323585, Length=491, Percent_Identity=39.1038696537678, Blast_Score=335, Evalue=8e-93,
Organism=Saccharomyces cerevisiae, GI6323464, Length=491, Percent_Identity=39.918533604888, Blast_Score=329, Evalue=5e-91,
Organism=Saccharomyces cerevisiae, GI6322012, Length=491, Percent_Identity=37.4745417515275, Blast_Score=327, Evalue=4e-90,
Organism=Saccharomyces cerevisiae, GI6319352, Length=346, Percent_Identity=36.7052023121387, Blast_Score=239, Evalue=8e-64,
Organism=Saccharomyces cerevisiae, GI6319353, Length=119, Percent_Identity=42.0168067226891, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24641071, Length=485, Percent_Identity=40, Blast_Score=338, Evalue=4e-93,
Organism=Drosophila melanogaster, GI24641073, Length=485, Percent_Identity=40, Blast_Score=338, Evalue=4e-93,
Organism=Drosophila melanogaster, GI28571163, Length=443, Percent_Identity=40.6320541760722, Blast_Score=308, Evalue=4e-84,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 53020; Mature: 53020

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKILYDALTFDDVLLVPAYSNVLPKETVVKSRLTRQIEVNIPLVSAAMDTVTEAELAIA
CCCHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHH
LARAGGIGIIHKNLSIDEQARQVAKVKRFESGIIRNPIHLFEDATIQDAIDLMIRHSISG
HHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHCCCC
IPVVEHPTPEGCLLLKGIVTNRDLRMTASSDEKITTIMTTNLVTAKEGIDLLTAEDILMR
CEEECCCCCCCEEEEEEHHCCCCEEEECCCCCEEEEEEEECEEEHHCCCCEEHHHHHHHH
NKIEKLLIIDDNGYLKGLITFKDIQKRKQCPDACKDSQGRLRAGAAVGIRANTMSRVDAL
CCCCEEEEECCCCCEEEEEEHHHHHHHHCCCHHHCCCCCCEEECEEEEEECHHHHHHHHH
VAAGVDVVAVDTAHGHSQAVLDMVATIKQKYPELQVIAGNVATPEAVRDLVKAGADAVKV
HHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEE
GIGPGSICTTRIVAGVGMPQLTAIMKCAEEAKKTDIPLIADGGIKYSGDIAKALAAGADS
ECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCCH
VMMGSVFAGTDESPGETILYEGRRFKAYRGMGSLGAMSEPEGSSDRYFQDVSAETKKYVP
HEECEEEECCCCCCCCEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
EGIEGRIPAKGKLDEVVYQLIGGLKSAMGYCGVRTITELKENTRFVRITSAGLRESHPHD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCCCCCCCC
VMITKEAPNYSTSA
EEEEECCCCCCCCC
>Mature Secondary Structure
MDKILYDALTFDDVLLVPAYSNVLPKETVVKSRLTRQIEVNIPLVSAAMDTVTEAELAIA
CCCHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHH
LARAGGIGIIHKNLSIDEQARQVAKVKRFESGIIRNPIHLFEDATIQDAIDLMIRHSISG
HHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHCCCC
IPVVEHPTPEGCLLLKGIVTNRDLRMTASSDEKITTIMTTNLVTAKEGIDLLTAEDILMR
CEEECCCCCCCEEEEEEHHCCCCEEEECCCCCEEEEEEEECEEEHHCCCCEEHHHHHHHH
NKIEKLLIIDDNGYLKGLITFKDIQKRKQCPDACKDSQGRLRAGAAVGIRANTMSRVDAL
CCCCEEEEECCCCCEEEEEEHHHHHHHHCCCHHHCCCCCCEEECEEEEEECHHHHHHHHH
VAAGVDVVAVDTAHGHSQAVLDMVATIKQKYPELQVIAGNVATPEAVRDLVKAGADAVKV
HHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEE
GIGPGSICTTRIVAGVGMPQLTAIMKCAEEAKKTDIPLIADGGIKYSGDIAKALAAGADS
ECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCCH
VMMGSVFAGTDESPGETILYEGRRFKAYRGMGSLGAMSEPEGSSDRYFQDVSAETKKYVP
HEECEEEECCCCCCCCEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
EGIEGRIPAKGKLDEVVYQLIGGLKSAMGYCGVRTITELKENTRFVRITSAGLRESHPHD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCCCCCCCC
VMITKEAPNYSTSA
EEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA