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The map label for this gene is msrA [H]

Identifier: 21674101

GI number: 21674101

Start: 1195645

End: 1196499

Strand: Reverse

Name: msrA [H]

Synonym: CT1278

Alternate gene names: 21674101

Gene position: 1196499-1195645 (Counterclockwise)

Preceding gene: 21674103

Following gene: 21674100

Centisome position: 55.52

GC content: 55.44

Gene sequence:

>855_bases
ATGAAATACAAGACGCTCACCCCTGAAGAGAAGCGGGTTATCATCGACAAGGGCACCGAAAGACCATTCAGTGGCAAGTA
CTACCTGACCAAGGAGAAGGGGGTGTACCAGTGCAAACAGTGCGGTGCGGATCTTTTCCGGTCGGATGCCAAGTTCGATT
CGGGCACCGGCTGGCCGAGTTTCGACGATGCCATTCCGGGTGCGGTCAGGCAGGAGACCGACCGGGACGGAATGAGGATC
GAGATTCTCTGTGCCAATTGCGGAGGGCACCTGGGGCATGTTTTCTACAATGAAGGTTTTACCTCAAAAAACGCCCGCTA
TTGCGTCAACTCGGTGTCGCTCTCCTTCGAGCCTTCGGACAAGCCTGCTACGGCAACCGAAAAGGCGGTGTTCGCGGGCG
GATGCTTCTGGGGCGTCGAGTACCATTTCAAGAAGATGAAAGGAGTGCTTTCGACTACGGTTGGCTACACGGGCGGCAAA
ACCGCTCATCCCACCTATGAGCAGGTGTGCAGCGGTCGCACCGGTCATGCCGAGGCGATCGAGGTGGAGTTCGATCCGTC
CGTTGTCAGCTACGAGGAGCTGGCAAAGCTCTTTTTCGAGATTCACGACCCGACGCAGGTTGACCGGCAAGGCCCCGATG
TTGGCGAACAGTACCGCTCAGCGGTCTTTTACCAGAACGACCAGCAGAAAAAAATAGCCGAGGCGCTGATCGAGCAGCTT
AAAAAACGGGGGTACGACGTGGTAACCAGTGTGGAAAAAGGGGGGGAGTTCTGGCCGGCGGAGCTCTACCATCAGGATTA
TTACGAAAAGACAGGGCATAAGCCCTACTGCCATATTTATCAGAAGCGGTTTTAA

Upstream 100 bases:

>100_bases
TTTATCCATCATTTTGGTTTTACTCCTGGCGAGCTGTAGTGCCGGGTCTGTGGACAAGACTGTTACGGCGCCAGCAACAA
CAACCCAGAAGGAGGCTTCA

Downstream 100 bases:

>100_bases
GGTGATTAGGGGCGGCTCTTGTGGCTGCCCTGTTTTTTTGTGGGCTTGACATCCCGCTTTTTTTTGTTAAATTATTGGCA
TATGCTAATAATTGCTGACT

Product: bifunctional methionine sulfoxide reductase B/A protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase; Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MKYKTLTPEEKRVIIDKGTERPFSGKYYLTKEKGVYQCKQCGADLFRSDAKFDSGTGWPSFDDAIPGAVRQETDRDGMRI
EILCANCGGHLGHVFYNEGFTSKNARYCVNSVSLSFEPSDKPATATEKAVFAGGCFWGVEYHFKKMKGVLSTTVGYTGGK
TAHPTYEQVCSGRTGHAEAIEVEFDPSVVSYEELAKLFFEIHDPTQVDRQGPDVGEQYRSAVFYQNDQQKKIAEALIEQL
KKRGYDVVTSVEKGGEFWPAELYHQDYYEKTGHKPYCHIYQKRF

Sequences:

>Translated_284_residues
MKYKTLTPEEKRVIIDKGTERPFSGKYYLTKEKGVYQCKQCGADLFRSDAKFDSGTGWPSFDDAIPGAVRQETDRDGMRI
EILCANCGGHLGHVFYNEGFTSKNARYCVNSVSLSFEPSDKPATATEKAVFAGGCFWGVEYHFKKMKGVLSTTVGYTGGK
TAHPTYEQVCSGRTGHAEAIEVEFDPSVVSYEELAKLFFEIHDPTQVDRQGPDVGEQYRSAVFYQNDQQKKIAEALIEQL
KKRGYDVVTSVEKGGEFWPAELYHQDYYEKTGHKPYCHIYQKRF
>Mature_284_residues
MKYKTLTPEEKRVIIDKGTERPFSGKYYLTKEKGVYQCKQCGADLFRSDAKFDSGTGWPSFDDAIPGAVRQETDRDGMRI
EILCANCGGHLGHVFYNEGFTSKNARYCVNSVSLSFEPSDKPATATEKAVFAGGCFWGVEYHFKKMKGVLSTTVGYTGGK
TAHPTYEQVCSGRTGHAEAIEVEFDPSVVSYEELAKLFFEIHDPTQVDRQGPDVGEQYRSAVFYQNDQQKKIAEALIEQL
KKRGYDVVTSVEKGGEFWPAELYHQDYYEKTGHKPYCHIYQKRF

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=160, Percent_Identity=45.625, Blast_Score=134, Evalue=9e-32,
Organism=Homo sapiens, GI208609995, Length=152, Percent_Identity=46.7105263157895, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI301336164, Length=125, Percent_Identity=48, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI301336162, Length=125, Percent_Identity=48, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI73089054, Length=125, Percent_Identity=48, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI37620216, Length=125, Percent_Identity=48, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI117606353, Length=125, Percent_Identity=44.8, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI208609993, Length=110, Percent_Identity=41.8181818181818, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI7706511, Length=99, Percent_Identity=36.3636363636364, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1790665, Length=171, Percent_Identity=43.859649122807, Blast_Score=140, Evalue=8e-35,
Organism=Escherichia coli, GI1788077, Length=116, Percent_Identity=47.4137931034483, Blast_Score=95, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17533973, Length=142, Percent_Identity=40.1408450704225, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17553450, Length=124, Percent_Identity=41.9354838709677, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI115532676, Length=124, Percent_Identity=41.9354838709677, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319816, Length=120, Percent_Identity=48.3333333333333, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6320881, Length=151, Percent_Identity=37.7483443708609, Blast_Score=106, Evalue=5e-24,
Organism=Drosophila melanogaster, GI45553335, Length=127, Percent_Identity=46.4566929133858, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21356369, Length=127, Percent_Identity=46.4566929133858, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24645799, Length=127, Percent_Identity=46.4566929133858, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI221378664, Length=126, Percent_Identity=46.8253968253968, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI221378662, Length=133, Percent_Identity=44.3609022556391, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24645804, Length=138, Percent_Identity=42.7536231884058, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24645801, Length=138, Percent_Identity=42.7536231884058, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24664627, Length=166, Percent_Identity=35.5421686746988, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24664631, Length=166, Percent_Identity=34.9397590361446, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45553131, Length=146, Percent_Identity=37.6712328767123, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.12; =1.8.4.11 [H]

Molecular weight: Translated: 32160; Mature: 32160

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYKTLTPEEKRVIIDKGTERPFSGKYYLTKEKGVYQCKQCGADLFRSDAKFDSGTGWPS
CCCCCCCCCCCEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
FDDAIPGAVRQETDRDGMRIEILCANCGGHLGHVFYNEGFTSKNARYCVNSVSLSFEPSD
CHHCCCCHHHHCCCCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCEEEEEEEEEECCCC
KPATATEKAVFAGGCFWGVEYHFKKMKGVLSTTVGYTGGKTAHPTYEQVCSGRTGHAEAI
CCCCCHHHHEEECCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCEEE
EVEFDPSVVSYEELAKLFFEIHDPTQVDRQGPDVGEQYRSAVFYQNDQQKKIAEALIEQL
EEEECCCEECHHHHHHHHHHCCCCCHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
KKRGYDVVTSVEKGGEFWPAELYHQDYYEKTGHKPYCHIYQKRF
HHCCCEEEEHHHCCCCCCCHHHHHHHHHHHCCCCCEEHHHCCCC
>Mature Secondary Structure
MKYKTLTPEEKRVIIDKGTERPFSGKYYLTKEKGVYQCKQCGADLFRSDAKFDSGTGWPS
CCCCCCCCCCCEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
FDDAIPGAVRQETDRDGMRIEILCANCGGHLGHVFYNEGFTSKNARYCVNSVSLSFEPSD
CHHCCCCHHHHCCCCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCEEEEEEEEEECCCC
KPATATEKAVFAGGCFWGVEYHFKKMKGVLSTTVGYTGGKTAHPTYEQVCSGRTGHAEAI
CCCCCHHHHEEECCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCEEE
EVEFDPSVVSYEELAKLFFEIHDPTQVDRQGPDVGEQYRSAVFYQNDQQKKIAEALIEQL
EEEECCCEECHHHHHHHHHHCCCCCHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
KKRGYDVVTSVEKGGEFWPAELYHQDYYEKTGHKPYCHIYQKRF
HHCCCEEEEHHHCCCCCCCHHHHHHHHHHHCCCCCEEHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]