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The map label for this gene is hdrA-2 [H]

Identifier: 21674069

GI number: 21674069

Start: 1172713

End: 1174719

Strand: Direct

Name: hdrA-2 [H]

Synonym: CT1246

Alternate gene names: 21674069

Gene position: 1172713-1174719 (Clockwise)

Preceding gene: 21674068

Following gene: 21674070

Centisome position: 54.42

GC content: 59.19

Gene sequence:

>2007_bases
ATGCCGGAAACAATATCAACTCAGGGCTTCAGGATGGCAAAAATAGGAGTCTTTGTTTGTCACTGCGGTGAAAATATCGC
CTCGAAGGTCGATACGGGCAACCTTGTCAAGGCATTGTCCGACCATCCCGGCGTGGAAATCTGCAACGAGTATAAATATT
TCTGCTCCGATCCCGGGCAGGAAACGGTCAAACGCGCGATCCGGGAGAACAACCTGACGGGCGTCGTGGTGGCAGCCTGT
TCGCCGAGGATGCACGAAACGACCTTCCGCAAGGCGTGTGCCGAGGCCGGACTCAACCCGTATATGCTCGAACTGGCCAA
CATCCGCGAGCAGTGCTCATGGGTGCATTCGGACAAGGATCAGGCTACTAAAAAGGCGATCGAGATCACCCGCTCGCTGG
TCGAAAAGGTCAAGCGAAACAACGAGTTGAAGCCGATCTCCGTGCCGATCACCCGACGCGCTCTGGTCATCGGCGGCGGC
ATCGCGGGCATCCAGGCCGCGCTCGACATCGCCGGAGCCGGACGCGAAGTGATTCTGGTCGAACGTGAGCCATCGATTGG
CGGCCACATGTCACAACTCTCCGAAACCTTCCCGACGCTCGACTGCTCACAGTGCATCCTGACGCCGCGCATGGTCGAGG
CGATCCAGCATCCGAACATCACGGTACTGACCTACTCCGAAGTCGAAGAGGTTGACGGCTATATCGGCAACTTCAGGGTA
AAGGTGCGCAAGAAGGCGCGCTACGTCGATATAGACAAGTGCACCGGCTGCGGCGACTGCATCCAGAAGTGCCCGGTCAA
AAAGATTCCGAGCGAGTTCGAGTGCGGCCTCGGCAACCGCACGGCGATTTATACGCCATTCGCGCAGGCCGTGCCGAACG
TGCCGGTGATCGACAAGAACCGCTGCACCTACTTCAAAAACGGCAAGTGCAAAATCTGCCAGAAGACCTGCCAGATCGAG
AACTGCATCGATTTCGAGATGCAGGACACCTTCGAGGAGTACGAGGTTGGCGCGATTGTCGTAGCCACCGGCTTCCAGAT
TCAGGACACGAGTGTGTACGGCGAATACGGTTACGGCAAGTACAAGGACGTGATTACCGGCCTCAGCTTCGAACGGCTCG
CCTCGGCCAGCGGCCCGACTGCCGGAAAGATTCTGCGCCCGTCGGACGGCAAGGAACCGGAGACCGTGGTCTTCATCCAG
TGCGCCGGTTCGCGCGATCCGTCGAAAGGCGTCAAATACTGCTCCAAGATTTGCTGCATGTACACGGCAAAACACGCCAT
GCTCTATGCGCACAAGCACCATGGCAGCAACAGCAAGATTTTCTACATGGACATCCGCGCCGCGGGCAAAGGGTACGACG
AGTTCACCCGCCGTGCCATCGAAGAGGATGAGGCCGAGTACCTGAGGGGCCGTGTCAGCAAGGTGTTCGAAGAGAACGGC
AAGCTGATCGTGCGCGGCGTCGATACGCTGCTCGGCAAGCCGGTCGAGGTGGCTGCCGATATGGTGGTGCTCGCCACGGC
CATCGTCCCGCAGCCGGACGCAAAGGAGTTTGCCAAACGCATCGGCATCGGCTACGACGAGTACGGTTTCTACAACGAAG
CGCACCTGAAGCTGCGCCCGGTCGAAACCGCCACCGCCGGCATCTACCTCTGCGGTGCATGCCAGTCACCGAAAGATATT
CCCGATTCGGTCGCTCAGGCTTCAGCGGCAGCAGCCAAGGTGCTCGGCCTGTTCAACCGCGAACAGCTCGAACGCGAGCC
GGTAGTGGCTGCTGTCGGCGAATCGACCTGCGCCGGATGCTGGGGCTGCGTCTATGCCTGTCCGTACAACGCTATCGAGC
AGAAGGAGATCAGGGACCGCAACGGCAACCTTATCAAGGAGGTCGCCAGCGTCAATCCGGGCCTCTGCCAGGGATGCGGC
ACCTGCGTGACCTTCTGCCGATCGAACAGTATCGATCTGGCGGGATTCACCGAAAAGCAGATATTCGCCGAAGTGATGGC
GCTCTGA

Upstream 100 bases:

>100_bases
GGAATTTCAATACGCAAAGCTTGAACTGCACTGCTGAAAACAGCGGTATTCGGGGCTGATTGTCCCCATAGTCTGGCGGC
ATGCGGTGCTTTTCGCTCCG

Downstream 100 bases:

>100_bases
CAATATGCCAAACGCCGTAACAGCAACCTGAACTCAACCAAGCGACCGAATCAGCCGATGAGCGAACCATTCGAACCGAA
AATCGTGGCTTTTGTCTGCA

Product: heterodisulfide reductase, subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 668; Mature: 667

Protein sequence:

>668_residues
MPETISTQGFRMAKIGVFVCHCGENIASKVDTGNLVKALSDHPGVEICNEYKYFCSDPGQETVKRAIRENNLTGVVVAAC
SPRMHETTFRKACAEAGLNPYMLELANIREQCSWVHSDKDQATKKAIEITRSLVEKVKRNNELKPISVPITRRALVIGGG
IAGIQAALDIAGAGREVILVEREPSIGGHMSQLSETFPTLDCSQCILTPRMVEAIQHPNITVLTYSEVEEVDGYIGNFRV
KVRKKARYVDIDKCTGCGDCIQKCPVKKIPSEFECGLGNRTAIYTPFAQAVPNVPVIDKNRCTYFKNGKCKICQKTCQIE
NCIDFEMQDTFEEYEVGAIVVATGFQIQDTSVYGEYGYGKYKDVITGLSFERLASASGPTAGKILRPSDGKEPETVVFIQ
CAGSRDPSKGVKYCSKICCMYTAKHAMLYAHKHHGSNSKIFYMDIRAAGKGYDEFTRRAIEEDEAEYLRGRVSKVFEENG
KLIVRGVDTLLGKPVEVAADMVVLATAIVPQPDAKEFAKRIGIGYDEYGFYNEAHLKLRPVETATAGIYLCGACQSPKDI
PDSVAQASAAAAKVLGLFNREQLEREPVVAAVGESTCAGCWGCVYACPYNAIEQKEIRDRNGNLIKEVASVNPGLCQGCG
TCVTFCRSNSIDLAGFTEKQIFAEVMAL

Sequences:

>Translated_668_residues
MPETISTQGFRMAKIGVFVCHCGENIASKVDTGNLVKALSDHPGVEICNEYKYFCSDPGQETVKRAIRENNLTGVVVAAC
SPRMHETTFRKACAEAGLNPYMLELANIREQCSWVHSDKDQATKKAIEITRSLVEKVKRNNELKPISVPITRRALVIGGG
IAGIQAALDIAGAGREVILVEREPSIGGHMSQLSETFPTLDCSQCILTPRMVEAIQHPNITVLTYSEVEEVDGYIGNFRV
KVRKKARYVDIDKCTGCGDCIQKCPVKKIPSEFECGLGNRTAIYTPFAQAVPNVPVIDKNRCTYFKNGKCKICQKTCQIE
NCIDFEMQDTFEEYEVGAIVVATGFQIQDTSVYGEYGYGKYKDVITGLSFERLASASGPTAGKILRPSDGKEPETVVFIQ
CAGSRDPSKGVKYCSKICCMYTAKHAMLYAHKHHGSNSKIFYMDIRAAGKGYDEFTRRAIEEDEAEYLRGRVSKVFEENG
KLIVRGVDTLLGKPVEVAADMVVLATAIVPQPDAKEFAKRIGIGYDEYGFYNEAHLKLRPVETATAGIYLCGACQSPKDI
PDSVAQASAAAAKVLGLFNREQLEREPVVAAVGESTCAGCWGCVYACPYNAIEQKEIRDRNGNLIKEVASVNPGLCQGCG
TCVTFCRSNSIDLAGFTEKQIFAEVMAL
>Mature_667_residues
PETISTQGFRMAKIGVFVCHCGENIASKVDTGNLVKALSDHPGVEICNEYKYFCSDPGQETVKRAIRENNLTGVVVAACS
PRMHETTFRKACAEAGLNPYMLELANIREQCSWVHSDKDQATKKAIEITRSLVEKVKRNNELKPISVPITRRALVIGGGI
AGIQAALDIAGAGREVILVEREPSIGGHMSQLSETFPTLDCSQCILTPRMVEAIQHPNITVLTYSEVEEVDGYIGNFRVK
VRKKARYVDIDKCTGCGDCIQKCPVKKIPSEFECGLGNRTAIYTPFAQAVPNVPVIDKNRCTYFKNGKCKICQKTCQIEN
CIDFEMQDTFEEYEVGAIVVATGFQIQDTSVYGEYGYGKYKDVITGLSFERLASASGPTAGKILRPSDGKEPETVVFIQC
AGSRDPSKGVKYCSKICCMYTAKHAMLYAHKHHGSNSKIFYMDIRAAGKGYDEFTRRAIEEDEAEYLRGRVSKVFEENGK
LIVRGVDTLLGKPVEVAADMVVLATAIVPQPDAKEFAKRIGIGYDEYGFYNEAHLKLRPVETATAGIYLCGACQSPKDIP
DSVAQASAAAAKVLGLFNREQLEREPVVAAVGESTCAGCWGCVYACPYNAIEQKEIRDRNGNLIKEVASVNPGLCQGCGT
CVTFCRSNSIDLAGFTEKQIFAEVMAL

Specific function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). May act as the catalytic subunit [H]

COG id: COG1148

COG function: function code C; Heterodisulfide reductase, subunit A and related polyferredoxins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR003953
- InterPro:   IPR012285 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF00037 Fer4 [H]

EC number: =1.8.98.1 [H]

Molecular weight: Translated: 73177; Mature: 73045

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
4.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPETISTQGFRMAKIGVFVCHCGENIASKVDTGNLVKALSDHPGVEICNEYKYFCSDPGQ
CCCCCCCCCEEEEEEEEEEEECCCHHHHHCCCCHHHHHHHCCCCHHHHHCCHHHHCCCCH
ETVKRAIRENNLTGVVVAACSPRMHETTFRKACAEAGLNPYMLELANIREQCSWVHSDKD
HHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHH
QATKKAIEITRSLVEKVKRNNELKPISVPITRRALVIGGGIAGIQAALDIAGAGREVILV
HHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEEEECCHHHHHHHHHHCCCCCEEEEE
EREPSIGGHMSQLSETFPTLDCSQCILTPRMVEAIQHPNITVLTYSEVEEVDGYIGNFRV
ECCCCCCCHHHHHHHHCCCCCHHHHHCCHHHHHHHCCCCEEEEEHHHHHHHCCCCCCEEE
KVRKKARYVDIDKCTGCGDCIQKCPVKKIPSEFECGLGNRTAIYTPFAQAVPNVPVIDKN
EEEECCCEEECCCCCCHHHHHHHCCHHHCCCHHCCCCCCCEEEECCHHHHCCCCCEEECC
RCTYFKNGKCKICQKTCQIENCIDFEMQDTFEEYEVGAIVVATGFQIQDTSVYGEYGYGK
CCCEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCEEECCEEECCCCCCH
YKDVITGLSFERLASASGPTAGKILRPSDGKEPETVVFIQCAGSRDPSKGVKYCSKICCM
HHHHHHCCCHHHHHCCCCCCCCCEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHH
YTAKHAMLYAHKHHGSNSKIFYMDIRAAGKGYDEFTRRAIEEDEAEYLRGRVSKVFEENG
HHHHHHHEEEEECCCCCCEEEEEEEECCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCC
KLIVRGVDTLLGKPVEVAADMVVLATAIVPQPDAKEFAKRIGIGYDEYGFYNEAHLKLRP
CEEEEEHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHCCCCCCCEEEEEC
VETATAGIYLCGACQSPKDIPDSVAQASAAAAKVLGLFNREQLEREPVVAAVGESTCAGC
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCCCEEECCCCHHHHH
WGCVYACPYNAIEQKEIRDRNGNLIKEVASVNPGLCQGCGTCVTFCRSNSIDLAGFTEKQ
HHHHHHCCCCHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHH
IFAEVMAL
HHHHHHCC
>Mature Secondary Structure 
PETISTQGFRMAKIGVFVCHCGENIASKVDTGNLVKALSDHPGVEICNEYKYFCSDPGQ
CCCCCCCCEEEEEEEEEEEECCCHHHHHCCCCHHHHHHHCCCCHHHHHCCHHHHCCCCH
ETVKRAIRENNLTGVVVAACSPRMHETTFRKACAEAGLNPYMLELANIREQCSWVHSDKD
HHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHH
QATKKAIEITRSLVEKVKRNNELKPISVPITRRALVIGGGIAGIQAALDIAGAGREVILV
HHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEEEECCHHHHHHHHHHCCCCCEEEEE
EREPSIGGHMSQLSETFPTLDCSQCILTPRMVEAIQHPNITVLTYSEVEEVDGYIGNFRV
ECCCCCCCHHHHHHHHCCCCCHHHHHCCHHHHHHHCCCCEEEEEHHHHHHHCCCCCCEEE
KVRKKARYVDIDKCTGCGDCIQKCPVKKIPSEFECGLGNRTAIYTPFAQAVPNVPVIDKN
EEEECCCEEECCCCCCHHHHHHHCCHHHCCCHHCCCCCCCEEEECCHHHHCCCCCEEECC
RCTYFKNGKCKICQKTCQIENCIDFEMQDTFEEYEVGAIVVATGFQIQDTSVYGEYGYGK
CCCEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCEEECCEEECCCCCCH
YKDVITGLSFERLASASGPTAGKILRPSDGKEPETVVFIQCAGSRDPSKGVKYCSKICCM
HHHHHHCCCHHHHHCCCCCCCCCEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHH
YTAKHAMLYAHKHHGSNSKIFYMDIRAAGKGYDEFTRRAIEEDEAEYLRGRVSKVFEENG
HHHHHHHEEEEECCCCCCEEEEEEEECCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCC
KLIVRGVDTLLGKPVEVAADMVVLATAIVPQPDAKEFAKRIGIGYDEYGFYNEAHLKLRP
CEEEEEHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHCCCCCCCEEEEEC
VETATAGIYLCGACQSPKDIPDSVAQASAAAAKVLGLFNREQLEREPVVAAVGESTCAGC
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCCCEEECCCCHHHHH
WGCVYACPYNAIEQKEIRDRNGNLIKEVASVNPGLCQGCGTCVTFCRSNSIDLAGFTEKQ
HHHHHHCCCCHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHH
IFAEVMAL
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9063468; 11930014 [H]