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The map label for this gene is udg [H]

Identifier: 21674003

GI number: 21674003

Start: 1106228

End: 1107565

Strand: Reverse

Name: udg [H]

Synonym: CT1177

Alternate gene names: 21674003

Gene position: 1107565-1106228 (Counterclockwise)

Preceding gene: 21674004

Following gene: 21673999

Centisome position: 51.4

GC content: 54.78

Gene sequence:

>1338_bases
ATGAAGATAACCATATTTGGTTCCGGTTATGTAGGCCTGGTTACCGGCGCCTGTTTTGCCGAGGTTGGCAATGAGGTTAT
GTGCGTCGATATCGACGAGAACAAGATCAATCGTCTCCTGAACGGGGAGATTCCGATTTACGAGCCAGGCCTTGACACTA
TCGTTAGTGAAAACCTGCGTGAAGGACGCCTGAAATTCACCACCAGCATTACTGACGGTGTCGATTTCGGTCTGTACCAG
TTTATCGCCGTCGGTACTCCACCTGATGAAGATGGGTCAGCTGATTTGAGTCATGTGTTGAGCGTTGCCGAGAGCATCGG
CCGCAATATGGAGGATTATCGTATTGTGATCAACAAATCGACGGTTCCGGTCGGTACGGCCGATCTGGTGCGCGAAACGA
TCAGGACTGTACTCGAAGAACGGGGGCGGGCGATTGATTTCGATGTCGTGTCGAATCCGGAGTTCCTTAAAGAAGGTGAT
GCCGTGGACGATTTCATGAAGCCCGATCGCATCATCGTTGGAGTGGACAACCCGCGCACCAAGGAGCTTCTGCGCAACCT
GTACGCGCCGTTCAACCGCAGTCACGAGCGTTTCATTGCCATGGACATCCGCTCGGCGGAGTTGACCAAGTATGCAGCTA
ACGCCATGCTTGCCACCAAGATCAGCTTCATGAACGAGATCGCCAACATTGCTGAACGGGCCGGGGCGGATGTCGAAGCG
GTGCGCCGCGGTATCGGTTCCGATTCGAGGATCGGCTTCTCCTTTATCTATCCCGGAGTGGGTTATGGCGGCTCCTGCTT
CCCTAAGGATGTGCGAGCCCTGGAGCGCACGTCAAGGAAGCTTGGCTATAATTCGCGAATTCTGCAAGCGGTTGAGGCGG
TCAACGATGATCAGAAGCTGAGCCTTGTTTCAAAGATTCGTGACCATTTCGACGGCGATCTTAAAGGGCGCGTCATTGCA
ATGTGGGGGCTGGCGTTCAAGCCAAATACCGATGACATGCGTGAAGCCCCGAGCCGGAAGGTCATGGAAGAGCTCTGGAA
GGCGGGGGCAATCGTCAGAGCCTACGATCCCGTTGCCATGGACGAGGCCCGGCGCATCTATGGCGACCGGCCCGATCTAG
TGCTGGTGGAGCATCCCGACGAGGCTCTCAAGGGCGCAGATGCGCTAACCATCATGACGGAGTGGATGGTGTTTCGTAGT
CCCGATTTCGAACTGATCAGAAACTCTCTGAAAGAACCCGTGATCTTCGACGGCAGGAATATCTACAATCCCGATATGGT
GGAACAGGTGGGCATCAGCTACTACTCTATCGGCCGTCGTCCTCGCCTGGTGCGCTAA

Upstream 100 bases:

>100_bases
GCTCTTCCATTGGTTTATCTCACAAGGTTGAATCCTCGCCTTTCGGTAGTAACCGGAAGGCATTATCGTTTTTTTTCTGA
TCAATTAAACCACAGAATGC

Downstream 100 bases:

>100_bases
GCTTGTTTTATTGCAGTTTTCCCGGCCGTCTTTCGACTGTCCGGTCGGGAAAATGCTCCAGCGGACCATTTCCGTGTCCC
AGCCGCCATGATGCGCCTGC

Product: UDP-glucose/GDP-mannose dehydrogenase family protein

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MKITIFGSGYVGLVTGACFAEVGNEVMCVDIDENKINRLLNGEIPIYEPGLDTIVSENLREGRLKFTTSITDGVDFGLYQ
FIAVGTPPDEDGSADLSHVLSVAESIGRNMEDYRIVINKSTVPVGTADLVRETIRTVLEERGRAIDFDVVSNPEFLKEGD
AVDDFMKPDRIIVGVDNPRTKELLRNLYAPFNRSHERFIAMDIRSAELTKYAANAMLATKISFMNEIANIAERAGADVEA
VRRGIGSDSRIGFSFIYPGVGYGGSCFPKDVRALERTSRKLGYNSRILQAVEAVNDDQKLSLVSKIRDHFDGDLKGRVIA
MWGLAFKPNTDDMREAPSRKVMEELWKAGAIVRAYDPVAMDEARRIYGDRPDLVLVEHPDEALKGADALTIMTEWMVFRS
PDFELIRNSLKEPVIFDGRNIYNPDMVEQVGISYYSIGRRPRLVR

Sequences:

>Translated_445_residues
MKITIFGSGYVGLVTGACFAEVGNEVMCVDIDENKINRLLNGEIPIYEPGLDTIVSENLREGRLKFTTSITDGVDFGLYQ
FIAVGTPPDEDGSADLSHVLSVAESIGRNMEDYRIVINKSTVPVGTADLVRETIRTVLEERGRAIDFDVVSNPEFLKEGD
AVDDFMKPDRIIVGVDNPRTKELLRNLYAPFNRSHERFIAMDIRSAELTKYAANAMLATKISFMNEIANIAERAGADVEA
VRRGIGSDSRIGFSFIYPGVGYGGSCFPKDVRALERTSRKLGYNSRILQAVEAVNDDQKLSLVSKIRDHFDGDLKGRVIA
MWGLAFKPNTDDMREAPSRKVMEELWKAGAIVRAYDPVAMDEARRIYGDRPDLVLVEHPDEALKGADALTIMTEWMVFRS
PDFELIRNSLKEPVIFDGRNIYNPDMVEQVGISYYSIGRRPRLVR
>Mature_445_residues
MKITIFGSGYVGLVTGACFAEVGNEVMCVDIDENKINRLLNGEIPIYEPGLDTIVSENLREGRLKFTTSITDGVDFGLYQ
FIAVGTPPDEDGSADLSHVLSVAESIGRNMEDYRIVINKSTVPVGTADLVRETIRTVLEERGRAIDFDVVSNPEFLKEGD
AVDDFMKPDRIIVGVDNPRTKELLRNLYAPFNRSHERFIAMDIRSAELTKYAANAMLATKISFMNEIANIAERAGADVEA
VRRGIGSDSRIGFSFIYPGVGYGGSCFPKDVRALERTSRKLGYNSRILQAVEAVNDDQKLSLVSKIRDHFDGDLKGRVIA
MWGLAFKPNTDDMREAPSRKVMEELWKAGAIVRAYDPVAMDEARRIYGDRPDLVLVEHPDEALKGADALTIMTEWMVFRS
PDFELIRNSLKEPVIFDGRNIYNPDMVEQVGISYYSIGRRPRLVR

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=465, Percent_Identity=35.9139784946237, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI296040438, Length=367, Percent_Identity=35.4223433242507, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI296040443, Length=310, Percent_Identity=35.8064516129032, Blast_Score=174, Evalue=2e-43,
Organism=Escherichia coli, GI48994968, Length=448, Percent_Identity=26.7857142857143, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI1788340, Length=365, Percent_Identity=27.6712328767123, Blast_Score=139, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17560350, Length=465, Percent_Identity=33.7634408602151, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI17136908, Length=466, Percent_Identity=33.6909871244635, Blast_Score=237, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 49738; Mature: 49738

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITIFGSGYVGLVTGACFAEVGNEVMCVDIDENKINRLLNGEIPIYEPGLDTIVSENLR
CEEEEEECCHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCCEECCCHHHHHHHHHH
EGRLKFTTSITDGVDFGLYQFIAVGTPPDEDGSADLSHVLSVAESIGRNMEDYRIVINKS
CCCEEEEEECCCCCHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECC
TVPVGTADLVRETIRTVLEERGRAIDFDVVSNPEFLKEGDAVDDFMKPDRIIVGVDNPRT
CCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHCCCCHHHHCCCCEEEEECCCCHH
KELLRNLYAPFNRSHERFIAMDIRSAELTKYAANAMLATKISFMNEIANIAERAGADVEA
HHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
VRRGIGSDSRIGFSFIYPGVGYGGSCFPKDVRALERTSRKLGYNSRILQAVEAVNDDQKL
HHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHH
SLVSKIRDHFDGDLKGRVIAMWGLAFKPNTDDMREAPSRKVMEELWKAGAIVRAYDPVAM
HHHHHHHHHCCCCCCCCEEEEEEEEECCCCCHHHHCCHHHHHHHHHHCCCEEEECCCHHH
DEARRIYGDRPDLVLVEHPDEALKGADALTIMTEWMVFRSPDFELIRNSLKEPVIFDGRN
HHHHHHHCCCCCEEEEECCHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHCCCCEEECCCC
IYNPDMVEQVGISYYSIGRRPRLVR
CCCCHHHHHHCCHHHHCCCCCCCCC
>Mature Secondary Structure
MKITIFGSGYVGLVTGACFAEVGNEVMCVDIDENKINRLLNGEIPIYEPGLDTIVSENLR
CEEEEEECCHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCCEECCCHHHHHHHHHH
EGRLKFTTSITDGVDFGLYQFIAVGTPPDEDGSADLSHVLSVAESIGRNMEDYRIVINKS
CCCEEEEEECCCCCHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECC
TVPVGTADLVRETIRTVLEERGRAIDFDVVSNPEFLKEGDAVDDFMKPDRIIVGVDNPRT
CCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHCCCCHHHHCCCCEEEEECCCCHH
KELLRNLYAPFNRSHERFIAMDIRSAELTKYAANAMLATKISFMNEIANIAERAGADVEA
HHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
VRRGIGSDSRIGFSFIYPGVGYGGSCFPKDVRALERTSRKLGYNSRILQAVEAVNDDQKL
HHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHH
SLVSKIRDHFDGDLKGRVIAMWGLAFKPNTDDMREAPSRKVMEELWKAGAIVRAYDPVAM
HHHHHHHHHCCCCCCCCEEEEEEEEECCCCCHHHHCCHHHHHHHHHHCCCEEEECCCHHH
DEARRIYGDRPDLVLVEHPDEALKGADALTIMTEWMVFRSPDFELIRNSLKEPVIFDGRN
HHHHHHHCCCCCEEEEECCHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHCCCCEEECCCC
IYNPDMVEQVGISYYSIGRRPRLVR
CCCCHHHHHHCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]