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The map label for this gene is argG [H]

Identifier: 21673940

GI number: 21673940

Start: 1047135

End: 1048340

Strand: Direct

Name: argG [H]

Synonym: CT1114

Alternate gene names: 21673940

Gene position: 1047135-1048340 (Clockwise)

Preceding gene: 21673939

Following gene: 21673944

Centisome position: 48.59

GC content: 59.7

Gene sequence:

>1206_bases
ATGAGCAAGGAAAAAATTGCGGTCGCCTACTCCGGCGGCCTTGACACGTCAGTCATGATCAAATGGCTGAAGGACAAGTA
TGAAGGGGCGGAAATCGTTGCCGTCACGGGCAACCTCGGCCAGAAGATGGAGGTCGACAACCTCGAACAGAAAGCCATAG
CCACCGGCGCAAAGTCGTTCCACTTCGTCGATCTGCGCAAAACCTTCGTCGAAGAGTACATCTGGAAAGCACTAAAAGCT
GGCGCGTTGTACGAGGATGTGTACCCACTGGCCACTGCGCTCGGACGCCCGCTGCTCGCCAAGGCGCTCGTCGATGTGGC
GCTCGCCGAAGGGTGCACCATGCTCACCCACGGCTGCACCGGTAAGGGCAACGACCAGGTGCGCTTCGAGGTCGCCTTCG
CCGCGCTCGCCCCGCATATGAAGGTGGTCGCCCCGCTGCGCGAGTGGGAGTTCACCTCACGCGAGCAGGAGATCGCCTAC
GCGATGGAGCACAACATCCCGGTTTCGGCGACCAAGAAAAATCCCTACTCGATCGACGAGAACATCTGGGGCATCAGCAT
CGAGTGCGGCGTGCTCGAAGATCCGATGGTCGCTCCCCCGGCTGACGCCTACCAGATCACTACGGCTCCCGAACTTGCAC
CCGACGAGCCGACCGTTGTCGATATCGAGTTTGCCCAGGGGGTGCCCGTGGCGCTCGACGGCCAGCAGATGGAGGGTCTC
GACCTCATCGTCAGACTCAACGAACTCGGCGCGATGAACGGCGTCGGCAGGCTCGACATGATCGAGAACCGTGTCGTCGG
CATCAAGTCTCGCGAAATCTACGAAGCCCCGGCAGCCACCATCCTGCACTTCGCCCACCGCGAGCTCGAACGCCTCACGC
TCGAAAAGTCGGTCTTCCAGTACAAGCGCAATATCGGCCAGGACTACGCCAACCTCATCTACAACGGCACCTGGTTCTCG
CCAATGCGCAAAGCGCTCGACGCCTTTGTGGACGAGACGCAGAAGCCGGTCACCGGCATGGTCAGAATCAAGCTCTACAA
AGGCTCGATGACCCTGCTCGGCCGCACCTCGCCCAACTCGCTCTACAACGAAGCGCTGGCCACCTATACCGAAGCCGATA
CCTTCGACCACAAATCTGCCGAAGGTTTCATCAAAATCTACGGATTGGGCCTGAAGACTTTCCACGAGGTAAACAAGAGC
GAGTGA

Upstream 100 bases:

>100_bases
GACGACACGGTGCTGGTGATTCCGTCCACGGTCAGGAAAATTTCGTCCGTCAAATCATATATTCAGAAAATTCTTTCACA
ACCATAACAGGTCCCTACGC

Downstream 100 bases:

>100_bases
TAATTCAAAATTATCGCAGTTAAAAACAAAAAAGCAGGCACAGATTTTCGTAGCCTGCTTTTTTTATAACATCGATTACT
TACCCGACAAACAAAAATCT

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MSKEKIAVAYSGGLDTSVMIKWLKDKYEGAEIVAVTGNLGQKMEVDNLEQKAIATGAKSFHFVDLRKTFVEEYIWKALKA
GALYEDVYPLATALGRPLLAKALVDVALAEGCTMLTHGCTGKGNDQVRFEVAFAALAPHMKVVAPLREWEFTSREQEIAY
AMEHNIPVSATKKNPYSIDENIWGISIECGVLEDPMVAPPADAYQITTAPELAPDEPTVVDIEFAQGVPVALDGQQMEGL
DLIVRLNELGAMNGVGRLDMIENRVVGIKSREIYEAPAATILHFAHRELERLTLEKSVFQYKRNIGQDYANLIYNGTWFS
PMRKALDAFVDETQKPVTGMVRIKLYKGSMTLLGRTSPNSLYNEALATYTEADTFDHKSAEGFIKIYGLGLKTFHEVNKS
E

Sequences:

>Translated_401_residues
MSKEKIAVAYSGGLDTSVMIKWLKDKYEGAEIVAVTGNLGQKMEVDNLEQKAIATGAKSFHFVDLRKTFVEEYIWKALKA
GALYEDVYPLATALGRPLLAKALVDVALAEGCTMLTHGCTGKGNDQVRFEVAFAALAPHMKVVAPLREWEFTSREQEIAY
AMEHNIPVSATKKNPYSIDENIWGISIECGVLEDPMVAPPADAYQITTAPELAPDEPTVVDIEFAQGVPVALDGQQMEGL
DLIVRLNELGAMNGVGRLDMIENRVVGIKSREIYEAPAATILHFAHRELERLTLEKSVFQYKRNIGQDYANLIYNGTWFS
PMRKALDAFVDETQKPVTGMVRIKLYKGSMTLLGRTSPNSLYNEALATYTEADTFDHKSAEGFIKIYGLGLKTFHEVNKS
E
>Mature_400_residues
SKEKIAVAYSGGLDTSVMIKWLKDKYEGAEIVAVTGNLGQKMEVDNLEQKAIATGAKSFHFVDLRKTFVEEYIWKALKAG
ALYEDVYPLATALGRPLLAKALVDVALAEGCTMLTHGCTGKGNDQVRFEVAFAALAPHMKVVAPLREWEFTSREQEIAYA
MEHNIPVSATKKNPYSIDENIWGISIECGVLEDPMVAPPADAYQITTAPELAPDEPTVVDIEFAQGVPVALDGQQMEGLD
LIVRLNELGAMNGVGRLDMIENRVVGIKSREIYEAPAATILHFAHRELERLTLEKSVFQYKRNIGQDYANLIYNGTWFSP
MRKALDAFVDETQKPVTGMVRIKLYKGSMTLLGRTSPNSLYNEALATYTEADTFDHKSAEGFIKIYGLGLKTFHEVNKSE

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=406, Percent_Identity=42.8571428571429, Blast_Score=332, Evalue=5e-91,
Organism=Homo sapiens, GI16950633, Length=406, Percent_Identity=42.8571428571429, Blast_Score=332, Evalue=5e-91,
Organism=Escherichia coli, GI1789563, Length=392, Percent_Identity=29.8469387755102, Blast_Score=144, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6324514, Length=416, Percent_Identity=41.5865384615385, Blast_Score=323, Evalue=3e-89,
Organism=Drosophila melanogaster, GI21358151, Length=405, Percent_Identity=40.2469135802469, Blast_Score=295, Evalue=3e-80,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 44423; Mature: 44292

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1 ; PS00565 ARGININOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKEKIAVAYSGGLDTSVMIKWLKDKYEGAEIVAVTGNLGQKMEVDNLEQKAIATGAKSF
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHCCCCCE
HFVDLRKTFVEEYIWKALKAGALYEDVYPLATALGRPLLAKALVDVALAEGCTMLTHGCT
EEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEECCCC
GKGNDQVRFEVAFAALAPHMKVVAPLREWEFTSREQEIAYAMEHNIPVSATKKNPYSIDE
CCCCCEEEEEEEEHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEECCCCCCCCCC
NIWGISIECGVLEDPMVAPPADAYQITTAPELAPDEPTVVDIEFAQGVPVALDGQQMEGL
CEEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCEEECCCCCCCC
DLIVRLNELGAMNGVGRLDMIENRVVGIKSREIYEAPAATILHFAHRELERLTLEKSVFQ
EEEEEEHHHCCCCCCCCHHHHHCCEEECCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
YKRNIGQDYANLIYNGTWFSPMRKALDAFVDETQKPVTGMVRIKLYKGSMTLLGRTSPNS
HHHHHCHHHHHHEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCEEEEECCCCHH
LYNEALATYTEADTFDHKSAEGFIKIYGLGLKTFHEVNKSE
HHHHHHHHHHCCCCCCCCCCCCEEEEEECCHHHHHHCCCCC
>Mature Secondary Structure 
SKEKIAVAYSGGLDTSVMIKWLKDKYEGAEIVAVTGNLGQKMEVDNLEQKAIATGAKSF
CCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHCCCCCE
HFVDLRKTFVEEYIWKALKAGALYEDVYPLATALGRPLLAKALVDVALAEGCTMLTHGCT
EEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEECCCC
GKGNDQVRFEVAFAALAPHMKVVAPLREWEFTSREQEIAYAMEHNIPVSATKKNPYSIDE
CCCCCEEEEEEEEHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEECCCCCCCCCC
NIWGISIECGVLEDPMVAPPADAYQITTAPELAPDEPTVVDIEFAQGVPVALDGQQMEGL
CEEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCEEECCCCCCCC
DLIVRLNELGAMNGVGRLDMIENRVVGIKSREIYEAPAATILHFAHRELERLTLEKSVFQ
EEEEEEHHHCCCCCCCCHHHHHCCEEECCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
YKRNIGQDYANLIYNGTWFSPMRKALDAFVDETQKPVTGMVRIKLYKGSMTLLGRTSPNS
HHHHHCHHHHHHEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCEEEEECCCCHH
LYNEALATYTEADTFDHKSAEGFIKIYGLGLKTFHEVNKSE
HHHHHHHHHHCCCCCCCCCCCCEEEEEECCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA