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The map label for this gene is pyrC

Identifier: 21673868

GI number: 21673868

Start: 979560

End: 980879

Strand: Reverse

Name: pyrC

Synonym: CT1042

Alternate gene names: 21673868

Gene position: 980879-979560 (Counterclockwise)

Preceding gene: 21673869

Following gene: 21673867

Centisome position: 45.52

GC content: 59.24

Gene sequence:

>1320_bases
ATGAGCACTCTGTTTCTGAACGCAAGACTGCTGAATCCCGCTGAAAATCTCGATACCGTCGGTTCGATAAAGATAGGCGA
CGACGGCCTCATCGAGGCGGTCGCGACTGGAGGCGAATCAATCCCGGCGAAGGCGGAAGACAACGTCATCGATCTCGCAG
GCAAGGTGCTCGCTCCAGGCCTTTTCGATATGCACTGCCACTTCAGGGAACCTGGACAGGAATACAAGGAGACGCTTGAA
ACCGGCTCCGCCGCTGCTGTTGCCGGCGGGTTCACCGGTGTAGCGCTCATGCCGAACACCAGGCCGGTCATCGACAGCCC
GCTCGGCGTAGCCTACATCCGCCATCACAGCGCCGGACTGCCGATCGACCTCGAGGTGATTGGCGCCATGACTGTCGAAA
GCCGGGGCGAAGCGCTCGCGCCGTATGGCAAATACGCTTCGTACAGCGTCAAGGCCGTTTCGGATGACGGCACGGCCATC
CAGAGCTCACAGATCATGCGCCTCGCCATCGAATATGCCGCCAACTTCGACCTGCTCCTGATCCAGCACGCTGAAGACAA
GCACCTCACCGCTGGCGGCATCATGAACGATGGCGCAGTCTCGGCGATGCTCGGGCTGAAAGGGATTCCCGAAGTGGCCG
AACCGATCATGATCGCCCGCGACCTGCAACTCATCGCCTGGCTGAAAAAGCACAAACTGAACGGAGCCGTAGCGGAACCG
CGCTACCACGTGGCGCACATCAGCACCGCAGAATCGGTCGCTCTGGTGCGCAAGGCAAAAGCCGCGGGGCTGAAGGTCAC
CTGCGAAGTAACGCCACACCACTTCACCCTGACCGAGCACGATCTGTCGAGCAGCATCGAAAAAGGCAACTTCATCATGA
AGCCCCCGCTCGCTTCGGTGGAAAACCGCGACGCCCTCATCGAAGGACTGCGGGACGGCACCATCGATGCTATCGCCACC
GATCATGCCCCTCATGCCAAGCACGAAAAGGAGTGTCCGCCCGATCAGGCGGCGTTCGGCATCATCGGCCTTGAAACCTC
ACTCGGCCTGACCATCACCGAACTGGTGGACAAAGGAGTCATCACCCTGTCGCAAGCCATCGAGCTGCTTTCAACCAATC
CGAGACGCATCATGGGCCTCGAAACCATCCTTTTCCGGGCGGGTCGCAAAGCCAACCTCACCATCATCGATCCCGACTGC
GAGTGGATAGTCAGCGAATCGGATTTCGGCTCGAAGTCGAGAAACACTCCCTTCATGGGACGCAAGCTCAAAGGCAGAGC
ACTGGGTATCTACCATAACAGCAAGCTCATCATGCGCTGA

Upstream 100 bases:

>100_bases
TCGTCTCGACGTTTCGCTTGAAACTGCCGACGACCATTCGCAGGCAAAAATACTGGTATCGCTCCAGGCGACTGTTTCCT
GAACTATTCATTCCCCGACC

Downstream 100 bases:

>100_bases
ACGTGCCAAATGGAAACAAAGTGTTTTATCTTTTTTCTTTACACTATTTTTCTTACTTTCACTATCTTTTTAGTTGAATT
TGTTGTACAGCATCAACCCA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MSTLFLNARLLNPAENLDTVGSIKIGDDGLIEAVATGGESIPAKAEDNVIDLAGKVLAPGLFDMHCHFREPGQEYKETLE
TGSAAAVAGGFTGVALMPNTRPVIDSPLGVAYIRHHSAGLPIDLEVIGAMTVESRGEALAPYGKYASYSVKAVSDDGTAI
QSSQIMRLAIEYAANFDLLLIQHAEDKHLTAGGIMNDGAVSAMLGLKGIPEVAEPIMIARDLQLIAWLKKHKLNGAVAEP
RYHVAHISTAESVALVRKAKAAGLKVTCEVTPHHFTLTEHDLSSSIEKGNFIMKPPLASVENRDALIEGLRDGTIDAIAT
DHAPHAKHEKECPPDQAAFGIIGLETSLGLTITELVDKGVITLSQAIELLSTNPRRIMGLETILFRAGRKANLTIIDPDC
EWIVSESDFGSKSRNTPFMGRKLKGRALGIYHNSKLIMR

Sequences:

>Translated_439_residues
MSTLFLNARLLNPAENLDTVGSIKIGDDGLIEAVATGGESIPAKAEDNVIDLAGKVLAPGLFDMHCHFREPGQEYKETLE
TGSAAAVAGGFTGVALMPNTRPVIDSPLGVAYIRHHSAGLPIDLEVIGAMTVESRGEALAPYGKYASYSVKAVSDDGTAI
QSSQIMRLAIEYAANFDLLLIQHAEDKHLTAGGIMNDGAVSAMLGLKGIPEVAEPIMIARDLQLIAWLKKHKLNGAVAEP
RYHVAHISTAESVALVRKAKAAGLKVTCEVTPHHFTLTEHDLSSSIEKGNFIMKPPLASVENRDALIEGLRDGTIDAIAT
DHAPHAKHEKECPPDQAAFGIIGLETSLGLTITELVDKGVITLSQAIELLSTNPRRIMGLETILFRAGRKANLTIIDPDC
EWIVSESDFGSKSRNTPFMGRKLKGRALGIYHNSKLIMR
>Mature_438_residues
STLFLNARLLNPAENLDTVGSIKIGDDGLIEAVATGGESIPAKAEDNVIDLAGKVLAPGLFDMHCHFREPGQEYKETLET
GSAAAVAGGFTGVALMPNTRPVIDSPLGVAYIRHHSAGLPIDLEVIGAMTVESRGEALAPYGKYASYSVKAVSDDGTAIQ
SSQIMRLAIEYAANFDLLLIQHAEDKHLTAGGIMNDGAVSAMLGLKGIPEVAEPIMIARDLQLIAWLKKHKLNGAVAEPR
YHVAHISTAESVALVRKAKAAGLKVTCEVTPHHFTLTEHDLSSSIEKGNFIMKPPLASVENRDALIEGLRDGTIDAIATD
HAPHAKHEKECPPDQAAFGIIGLETSLGLTITELVDKGVITLSQAIELLSTNPRRIMGLETILFRAGRKANLTIIDPDCE
WIVSESDFGSKSRNTPFMGRKLKGRALGIYHNSKLIMR

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=405, Percent_Identity=30.3703703703704, Blast_Score=149, Evalue=3e-36,
Organism=Escherichia coli, GI1786722, Length=433, Percent_Identity=27.0207852193995, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI87082175, Length=435, Percent_Identity=26.2068965517241, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193204318, Length=368, Percent_Identity=30.4347826086957, Blast_Score=145, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6322218, Length=405, Percent_Identity=24.9382716049383, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24642586, Length=402, Percent_Identity=31.8407960199005, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_CHLTE (Q8KDK5)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_661933.1
- ProteinModelPortal:   Q8KDK5
- GeneID:   1006973
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1042
- NMPDR:   fig|194439.1.peg.1027
- TIGR:   CT1042
- HOGENOM:   HBG724623
- OMA:   GVMNEGE
- ProtClustDB:   PRK09357
- BioCyc:   CTEP194439:CT_1042-MONOMER
- BRENDA:   3.5.2.3
- HAMAP:   MF_00220_B
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059
- TIGRFAMs:   TIGR00857

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.3

Molecular weight: Translated: 47040; Mature: 46908

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLFLNARLLNPAENLDTVGSIKIGDDGLIEAVATGGESIPAKAEDNVIDLAGKVLAPG
CCEEEEEEEECCCHHCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCC
LFDMHCHFREPGQEYKETLETGSAAAVAGGFTGVALMPNTRPVIDSPLGVAYIRHHSAGL
EEEEEECCCCCCHHHHHHHHCCCCEEEECCCCEEEECCCCCCCCCCCCCEEEEEECCCCC
PIDLEVIGAMTVESRGEALAPYGKYASYSVKAVSDDGTAIQSSQIMRLAIEYAANFDLLL
CEEEEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHHCCCEEEE
IQHAEDKHLTAGGIMNDGAVSAMLGLKGIPEVAEPIMIARDLQLIAWLKKHKLNGAVAEP
EEECCCCEEEECCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RYHVAHISTAESVALVRKAKAAGLKVTCEVTPHHFTLTEHDLSSSIEKGNFIMKPPLASV
CEEEEEECCHHHHHHHHHHHCCCEEEEEEECCCEEEEEHHHHHHHHHCCCEEECCCCCCC
ENRDALIEGLRDGTIDAIATDHAPHAKHEKECPPDQAAFGIIGLETSLGLTITELVDKGV
CCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHEEEEEECCCCCEEHHHHHCCCH
ITLSQAIELLSTNPRRIMGLETILFRAGRKANLTIIDPDCEWIVSESDFGSKSRNTPFMG
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCEEEECCCCCCCCCCCCCCC
RKLKGRALGIYHNSKLIMR
CCCCCCEEEEEECCEEEEC
>Mature Secondary Structure 
STLFLNARLLNPAENLDTVGSIKIGDDGLIEAVATGGESIPAKAEDNVIDLAGKVLAPG
CEEEEEEEECCCHHCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCC
LFDMHCHFREPGQEYKETLETGSAAAVAGGFTGVALMPNTRPVIDSPLGVAYIRHHSAGL
EEEEEECCCCCCHHHHHHHHCCCCEEEECCCCEEEECCCCCCCCCCCCCEEEEEECCCCC
PIDLEVIGAMTVESRGEALAPYGKYASYSVKAVSDDGTAIQSSQIMRLAIEYAANFDLLL
CEEEEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHHCCCEEEE
IQHAEDKHLTAGGIMNDGAVSAMLGLKGIPEVAEPIMIARDLQLIAWLKKHKLNGAVAEP
EEECCCCEEEECCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RYHVAHISTAESVALVRKAKAAGLKVTCEVTPHHFTLTEHDLSSSIEKGNFIMKPPLASV
CEEEEEECCHHHHHHHHHHHCCCEEEEEEECCCEEEEEHHHHHHHHHCCCEEECCCCCCC
ENRDALIEGLRDGTIDAIATDHAPHAKHEKECPPDQAAFGIIGLETSLGLTITELVDKGV
CCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHEEEEEECCCCCEEHHHHHCCCH
ITLSQAIELLSTNPRRIMGLETILFRAGRKANLTIIDPDCEWIVSESDFGSKSRNTPFMG
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCEEEECCCCCCCCCCCCCCC
RKLKGRALGIYHNSKLIMR
CCCCCCEEEEEECCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901