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The map label for this gene is tetA [H]

Identifier: 21673820

GI number: 21673820

Start: 941090

End: 942358

Strand: Reverse

Name: tetA [H]

Synonym: CT0992

Alternate gene names: 21673820

Gene position: 942358-941090 (Counterclockwise)

Preceding gene: 21673823

Following gene: 21673819

Centisome position: 43.73

GC content: 56.74

Gene sequence:

>1269_bases
ATGAAGAAATCTCCGTTGGCCATTCTGTTCCTGACAGTTCTGCTCGATCTGATCGGCTTCGGTATCGTACTGCCGCTGCT
GCCGACCTACGCCAAGGAGCTTGGCGCGTCGCCCTTCATGATCGGCCTGATCGCGTCGATCTACTCGACGATGCAGTTCA
TCTTTTCGCCGATCTGGGGCAAGCTGAGCGACAAGATCGGACGGCGTCCGGTGATGCTGTCGAGCATCTTTCTGACCTTG
GTCTCTTACGTCTTCTTCTCGAAGGCGGTCACCATTCCACTACTGATTCTTGCCCGTTCGCTCTCCGGCATCGGCTCGGC
CAACATCGCTGCGGCGCAGGCGGCCATCACCGACGTGACCGACTCGAAAAGCCGTTCCGGCGCGATGGGCATGCTCGGCG
CGGCCTTCGGCATCGGCTTCATCATCGGCCCGCTCGTCGGCGGCGTCCTGATGACCAACTTCGGCATCTCGATGGTCGGT
CTGTTCGCCGCCGGACTCAACTTCATCAACTTCACCCTGGCACTCTTCCTGCTGAACGAAACCAATCCTCACACCGAGGG
CTTCCTGTCGCTTTTCAGAAAAAACCCGGAATCGGTGGTTCATACCAACAACTCGCTGTTCGCCTCGCTCGCCCACAAAA
GCAGCGCCTACGCCGACAAGATTCACGAGGTCTTCAGCTCGCGCCCCGTCGCGCTGTTGATGATTATAAACTTCATCTAT
ACGCTGGCTATCGTGAACATGCAGGTCTCGGCCATTCTTCTCTGGAGCGATGTCTATCATGCCACCGAGCAGCAGGTCGG
CTATCTGTTCGCCTACGTAGGTTTCTTTACCGTTATCGTGCAAGGGGTGATGCTGCCGAAGATGACCCGCAACTATGGAG
AACACAAGCTGATGGTTTTGGGTCACATCACCTCGTTCATTGGCGTGTTTTTCATTCCGTTCATCCCGGTCACCTCGCTC
TTCACGGTCGGCCTCGCCATCCTGCTCTTCTTCGCCATCGGCACCAGCCTGGTCAATCCGCTCAACATTTCAATGATCTC
GCTTTACAGCTACAAGCAGAAGCAGGGGCAGATCATGGGGTTCGCGCAGTCGGTCAACGCACTGGCCCGAATCCTCGGCC
CGTTCAGCGGCAGCATTCTGTACGGATATGACCACCGCATGCCGTACTACGTGGCCGGTGCGCTGACCGTGGTCGGCACG
TTCATTTCGATGACCCTGTTCAAGTATGAAATCGAGGCTTTCGAGCCGACTACGGAAATGGCTGAATAA

Upstream 100 bases:

>100_bases
GACTCCCCTATCCCTTCCACAATCTTGACGCCGCGTTTCAACATGGCTGGCGTTTTTTGTATTTTGAATTTTTTCAGCTT
CACCTAACGGCTTGCCTTTC

Downstream 100 bases:

>100_bases
ACTCCCTGAATTGAAAAGGAGAACCCTATGCGCATAGGCGTTGCTGGCGTCGGCAAGCTCGGCGAGTTCCATACCAACCT
GTTGAAGCAGATTGCAGCCG

Product: drug resistance protein, putative

Products: NA

Alternate protein names: TetA(E) [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MKKSPLAILFLTVLLDLIGFGIVLPLLPTYAKELGASPFMIGLIASIYSTMQFIFSPIWGKLSDKIGRRPVMLSSIFLTL
VSYVFFSKAVTIPLLILARSLSGIGSANIAAAQAAITDVTDSKSRSGAMGMLGAAFGIGFIIGPLVGGVLMTNFGISMVG
LFAAGLNFINFTLALFLLNETNPHTEGFLSLFRKNPESVVHTNNSLFASLAHKSSAYADKIHEVFSSRPVALLMIINFIY
TLAIVNMQVSAILLWSDVYHATEQQVGYLFAYVGFFTVIVQGVMLPKMTRNYGEHKLMVLGHITSFIGVFFIPFIPVTSL
FTVGLAILLFFAIGTSLVNPLNISMISLYSYKQKQGQIMGFAQSVNALARILGPFSGSILYGYDHRMPYYVAGALTVVGT
FISMTLFKYEIEAFEPTTEMAE

Sequences:

>Translated_422_residues
MKKSPLAILFLTVLLDLIGFGIVLPLLPTYAKELGASPFMIGLIASIYSTMQFIFSPIWGKLSDKIGRRPVMLSSIFLTL
VSYVFFSKAVTIPLLILARSLSGIGSANIAAAQAAITDVTDSKSRSGAMGMLGAAFGIGFIIGPLVGGVLMTNFGISMVG
LFAAGLNFINFTLALFLLNETNPHTEGFLSLFRKNPESVVHTNNSLFASLAHKSSAYADKIHEVFSSRPVALLMIINFIY
TLAIVNMQVSAILLWSDVYHATEQQVGYLFAYVGFFTVIVQGVMLPKMTRNYGEHKLMVLGHITSFIGVFFIPFIPVTSL
FTVGLAILLFFAIGTSLVNPLNISMISLYSYKQKQGQIMGFAQSVNALARILGPFSGSILYGYDHRMPYYVAGALTVVGT
FISMTLFKYEIEAFEPTTEMAE
>Mature_422_residues
MKKSPLAILFLTVLLDLIGFGIVLPLLPTYAKELGASPFMIGLIASIYSTMQFIFSPIWGKLSDKIGRRPVMLSSIFLTL
VSYVFFSKAVTIPLLILARSLSGIGSANIAAAQAAITDVTDSKSRSGAMGMLGAAFGIGFIIGPLVGGVLMTNFGISMVG
LFAAGLNFINFTLALFLLNETNPHTEGFLSLFRKNPESVVHTNNSLFASLAHKSSAYADKIHEVFSSRPVALLMIINFIY
TLAIVNMQVSAILLWSDVYHATEQQVGYLFAYVGFFTVIVQGVMLPKMTRNYGEHKLMVLGHITSFIGVFFIPFIPVTSL
FTVGLAILLFFAIGTSLVNPLNISMISLYSYKQKQGQIMGFAQSVNALARILGPFSGSILYGYDHRMPYYVAGALTVVGT
FISMTLFKYEIEAFEPTTEMAE

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI217416366, Length=428, Percent_Identity=27.803738317757, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI225703104, Length=364, Percent_Identity=23.9010989010989, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI225703102, Length=364, Percent_Identity=23.9010989010989, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI166064062, Length=362, Percent_Identity=24.8618784530387, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI166064060, Length=362, Percent_Identity=24.8618784530387, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI39753965, Length=356, Percent_Identity=21.9101123595506, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI94721311, Length=387, Percent_Identity=22.7390180878553, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI87081738, Length=171, Percent_Identity=32.1637426900585, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1790146, Length=235, Percent_Identity=28.0851063829787, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17551570, Length=428, Percent_Identity=24.5327102803738, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71996331, Length=389, Percent_Identity=22.879177377892, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25146993, Length=401, Percent_Identity=21.4463840399002, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI193210343, Length=401, Percent_Identity=21.4463840399002, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI17738085, Length=372, Percent_Identity=26.6129032258064, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005828
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1; PF00083 Sugar_tr [H]

EC number: NA

Molecular weight: Translated: 45938; Mature: 45938

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CC
>Mature Secondary Structure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CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8331085 [H]