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The map label for this gene is 21673755

Identifier: 21673755

GI number: 21673755

Start: 875890

End: 876330

Strand: Reverse

Name: 21673755

Synonym: CT0927

Alternate gene names: NA

Gene position: 876330-875890 (Counterclockwise)

Preceding gene: 21673756

Following gene: 21673749

Centisome position: 40.67

GC content: 62.81

Gene sequence:

>441_bases
GTGATCGCGCGGCTCGTGGATCGGGCGGACTTCATGGAGGCTCAGGAGCACTTCGCCCGGAACATCGTGATCGGCTTCGC
CCGCATCCAGGGGCGCTCAGTCGACATCGTGGCTAACCAGCCGGCGGTGATGGCGGGCGAGCTCGACATCGACGCCTCCG
ACAAGACAGCGCGATTCATCCGCTTCTGCAACGCCCTCAACATTCCGCTCGTGACGCTGGTGGACGTGCCCGGATTCCTG
CCTGGCGTCGAGCAGGAGTACGGCGGCATCATTTGCCACGGCGCGAAAATGCTCTTCGCCTACTCGGCGGCCACCGTGCC
GAAATTCACCGTGGTGATGCGCAAGGCCTACGGCGGCGCGTACCTGGCCATGTCGCTCGACATTCTGCATTCAAAACGGG
AGTTCAGGCCACAGAACAAGCATGGCCTGATTCCTCTCTGA

Upstream 100 bases:

>100_bases
GGCTCAACGCCTCTCCCATCACCGGTCGCCAACCTGAAGCGACAAGTACCTGAACACAATCATCCCGGTTGACTCGCGGC
AGAGCTACGATGTACGCGAC

Downstream 100 bases:

>100_bases
ACCTGAAACGAACCTGAATCATGCATGAACGAACAGGAAATAAAAGAGACAGTACGCGAGGCCGAACAGCAAGGAGATCA
CGCCGGAACTGCTCATGATC

Product: propionyl-CoA carboxylase-related protein

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MIARLVDRADFMEAQEHFARNIVIGFARIQGRSVDIVANQPAVMAGELDIDASDKTARFIRFCNALNIPLVTLVDVPGFL
PGVEQEYGGIICHGAKMLFAYSAATVPKFTVVMRKAYGGAYLAMSLDILHSKREFRPQNKHGLIPL

Sequences:

>Translated_146_residues
MIARLVDRADFMEAQEHFARNIVIGFARIQGRSVDIVANQPAVMAGELDIDASDKTARFIRFCNALNIPLVTLVDVPGFL
PGVEQEYGGIICHGAKMLFAYSAATVPKFTVVMRKAYGGAYLAMSLDILHSKREFRPQNKHGLIPL
>Mature_146_residues
MIARLVDRADFMEAQEHFARNIVIGFARIQGRSVDIVANQPAVMAGELDIDASDKTARFIRFCNALNIPLVTLVDVPGFL
PGVEQEYGGIICHGAKMLFAYSAATVPKFTVVMRKAYGGAYLAMSLDILHSKREFRPQNKHGLIPL

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI295821216, Length=125, Percent_Identity=62.4, Blast_Score=169, Evalue=9e-43,
Organism=Homo sapiens, GI119943100, Length=125, Percent_Identity=62.4, Blast_Score=169, Evalue=1e-42,
Organism=Homo sapiens, GI11545863, Length=124, Percent_Identity=38.7096774193548, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25147362, Length=121, Percent_Identity=63.6363636363636, Blast_Score=167, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI25147359, Length=121, Percent_Identity=63.6363636363636, Blast_Score=167, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17552936, Length=124, Percent_Identity=38.7096774193548, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24586065, Length=124, Percent_Identity=39.5161290322581, Blast_Score=88, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 16107; Mature: 16107

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIARLVDRADFMEAQEHFARNIVIGFARIQGRSVDIVANQPAVMAGELDIDASDKTARFI
CCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCEEEEEECCCEEEEEEECCCCCCHHHHHH
RFCNALNIPLVTLVDVPGFLPGVEQEYGGIICHGAKMLFAYSAATVPKFTVVMRKAYGGA
HHHHCCCCCEEEEECCCCCCCCCCHHHCCEEEECHHEEEHHHCCCCCHHHHHHHHHCCCE
YLAMSLDILHSKREFRPQNKHGLIPL
EEEEHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MIARLVDRADFMEAQEHFARNIVIGFARIQGRSVDIVANQPAVMAGELDIDASDKTARFI
CCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCEEEEEECCCEEEEEEECCCCCCHHHHHH
RFCNALNIPLVTLVDVPGFLPGVEQEYGGIICHGAKMLFAYSAATVPKFTVVMRKAYGGA
HHHHCCCCCEEEEECCCCCCCCCCHHHCCEEEECHHEEEHHHCCCCCHHHHHHHHHCCCE
YLAMSLDILHSKREFRPQNKHGLIPL
EEEEHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]