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The map label for this gene is dxs [C]

Identifier: 21673633

GI number: 21673633

Start: 768149

End: 769132

Strand: Direct

Name: dxs [C]

Synonym: CT0804

Alternate gene names: 21673633

Gene position: 768149-769132 (Clockwise)

Preceding gene: 21673627

Following gene: 21673634

Centisome position: 35.65

GC content: 58.64

Gene sequence:

>984_bases
ATGGGAGAGAAAATTACCATCGAACAGACCGCGAAGTATACTTCACGGGGCAACAAGGCTACCCGCACCGGATTTGGCGA
GGCGTTGCTTGAAGCCGGGCGTGAGAACCCGTCTGTTGTCGCTCTCTGTGCTGACCTGACCGGGTCGCTGAACATGCATC
TCTTCCGTAAAGAGTTCCCGGAGCGATTCATCCAGACCGGCATTGCCGAGGCGAACATGATCTCCATGGCCGCCGGCCTG
GCCACTATCGGCAAGATTCCCGTGGCCTCAAGTTTCGCCGTTTTCGCGACTGGCCGCGTCTTCGACCAGATCCGCCAGTC
GGTCTGCTACTCCAATCTCAATGTCAAAATCTGCGCTTCGCACGCCGGCCTTACCCTTGGCGAGGATGGTGCGACGCACC
AGATTCTCGAAGATATCGGTCTGATGCGCAGCCTGCCGCGCATGACCGTCGTCGTACCGTGCGATTACAGCGAAACCAAA
CGCGCCACCAAGGCGATCATCGAGCACGAAGGCCCGGTTTATCTGCGCTTCGGACGTCCAAACGTGCCGGACTTTACCGC
CGATGAGGACGGCTTCGAGATCGGCAAATCCATCGAGCTGCATCCCGGCAAGGACGTCACCGTCATCGCCTGCGGCATCA
TGGTCTGGAAGGCGCTCGAAGCGGCCAGAATCCTTGAAAAAGAGGGGGTGTCGGTGCGCGTTATCAACATGCACACCATC
AAGCCGATCGACACGCTCGCCATCGTGCGCGCGGCCAATGACACCGGCGCGATCGTGACCGCCGAGGAGCACCAGATGTA
CACCGGTCTCGGTGAGGCGGTGGCCAACGTTTGCGCCCGCAACATTCCGGTGCCAATCGAGATGGTTGCCGTCGAGGACA
CCTTCGGTGAATCCGGTAAGCCCGATGACCTGCTCCGCAAATACAAGCTGACTACTGAGGATATTCTGGAGAAAATTTAC
CTCGTACTGCGCAGGAAAGATTGA

Upstream 100 bases:

>100_bases
ACTGGGCTTGGTGGGCGCAACTCAATATCAATGGCGGGGTTAACCCGGCAGGCACTCAGGTCCTGCATAGCTTTTTCAAA
TTTAAGGTATTCTGTCATTA

Downstream 100 bases:

>100_bases
ATTTGAGATCGGTCGGATCAGACAGATCAGTTTGATCCGATTAATCTATACACATTGACCGCAACCCCAAGGAGAACCAC
CACGATGGCAATGCCCAATT

Product: transketolase, C-terminal subunit

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MGEKITIEQTAKYTSRGNKATRTGFGEALLEAGRENPSVVALCADLTGSLNMHLFRKEFPERFIQTGIAEANMISMAAGL
ATIGKIPVASSFAVFATGRVFDQIRQSVCYSNLNVKICASHAGLTLGEDGATHQILEDIGLMRSLPRMTVVVPCDYSETK
RATKAIIEHEGPVYLRFGRPNVPDFTADEDGFEIGKSIELHPGKDVTVIACGIMVWKALEAARILEKEGVSVRVINMHTI
KPIDTLAIVRAANDTGAIVTAEEHQMYTGLGEAVANVCARNIPVPIEMVAVEDTFGESGKPDDLLRKYKLTTEDILEKIY
LVLRRKD

Sequences:

>Translated_327_residues
MGEKITIEQTAKYTSRGNKATRTGFGEALLEAGRENPSVVALCADLTGSLNMHLFRKEFPERFIQTGIAEANMISMAAGL
ATIGKIPVASSFAVFATGRVFDQIRQSVCYSNLNVKICASHAGLTLGEDGATHQILEDIGLMRSLPRMTVVVPCDYSETK
RATKAIIEHEGPVYLRFGRPNVPDFTADEDGFEIGKSIELHPGKDVTVIACGIMVWKALEAARILEKEGVSVRVINMHTI
KPIDTLAIVRAANDTGAIVTAEEHQMYTGLGEAVANVCARNIPVPIEMVAVEDTFGESGKPDDLLRKYKLTTEDILEKIY
LVLRRKD
>Mature_326_residues
GEKITIEQTAKYTSRGNKATRTGFGEALLEAGRENPSVVALCADLTGSLNMHLFRKEFPERFIQTGIAEANMISMAAGLA
TIGKIPVASSFAVFATGRVFDQIRQSVCYSNLNVKICASHAGLTLGEDGATHQILEDIGLMRSLPRMTVVVPCDYSETKR
ATKAIIEHEGPVYLRFGRPNVPDFTADEDGFEIGKSIELHPGKDVTVIACGIMVWKALEAARILEKEGVSVRVINMHTIK
PIDTLAIVRAANDTGAIVTAEEHQMYTGLGEAVANVCARNIPVPIEMVAVEDTFGESGKPDDLLRKYKLTTEDILEKIYL
VLRRKD

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=309, Percent_Identity=37.5404530744337, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI4507521, Length=309, Percent_Identity=37.5404530744337, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI225637463, Length=313, Percent_Identity=38.9776357827476, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI225637459, Length=313, Percent_Identity=38.9776357827476, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI225637461, Length=313, Percent_Identity=38.9776357827476, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI133778974, Length=313, Percent_Identity=36.1022364217252, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI291084858, Length=234, Percent_Identity=28.2051282051282, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI156564403, Length=239, Percent_Identity=27.6150627615063, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786622, Length=299, Percent_Identity=27.7591973244147, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788808, Length=336, Percent_Identity=27.3809523809524, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI48994911, Length=314, Percent_Identity=25.4777070063694, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17539652, Length=319, Percent_Identity=34.1692789968652, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17538422, Length=234, Percent_Identity=25.6410256410256, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6325331, Length=337, Percent_Identity=23.7388724035608, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45551847, Length=328, Percent_Identity=33.2317073170732, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI45550715, Length=328, Percent_Identity=33.2317073170732, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24645119, Length=328, Percent_Identity=33.2317073170732, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24666278, Length=313, Percent_Identity=34.185303514377, Blast_Score=157, Evalue=7e-39,
Organism=Drosophila melanogaster, GI21358145, Length=239, Percent_Identity=28.8702928870293, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24650940, Length=239, Percent_Identity=28.8702928870293, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 35682; Mature: 35550

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEKITIEQTAKYTSRGNKATRTGFGEALLEAGRENPSVVALCADLTGSLNMHLFRKEFP
CCCEEEHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHH
ERFIQTGIAEANMISMAAGLATIGKIPVASSFAVFATGRVFDQIRQSVCYSNLNVKICAS
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCEEEEEC
HAGLTLGEDGATHQILEDIGLMRSLPRMTVVVPCDYSETKRATKAIIEHEGPVYLRFGRP
CCCCEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCC
NVPDFTADEDGFEIGKSIELHPGKDVTVIACGIMVWKALEAARILEKEGVSVRVINMHTI
CCCCCCCCCCCHHCCCEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEC
KPIDTLAIVRAANDTGAIVTAEEHQMYTGLGEAVANVCARNIPVPIEMVAVEDTFGESGK
CCHHHEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCC
PDDLLRKYKLTTEDILEKIYLVLRRKD
CHHHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GEKITIEQTAKYTSRGNKATRTGFGEALLEAGRENPSVVALCADLTGSLNMHLFRKEFP
CCEEEHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHH
ERFIQTGIAEANMISMAAGLATIGKIPVASSFAVFATGRVFDQIRQSVCYSNLNVKICAS
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCEEEEEC
HAGLTLGEDGATHQILEDIGLMRSLPRMTVVVPCDYSETKRATKAIIEHEGPVYLRFGRP
CCCCEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCC
NVPDFTADEDGFEIGKSIELHPGKDVTVIACGIMVWKALEAARILEKEGVSVRVINMHTI
CCCCCCCCCCCHHCCCEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEC
KPIDTLAIVRAANDTGAIVTAEEHQMYTGLGEAVANVCARNIPVPIEMVAVEDTFGESGK
CCHHHEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCC
PDDLLRKYKLTTEDILEKIYLVLRRKD
CHHHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]