Click here to switch to the map view.

The map label for this gene is mutB [H]

Identifier: 21673629

GI number: 21673629

Start: 764589

End: 765344

Strand: Reverse

Name: mutB [H]

Synonym: CT0799

Alternate gene names: 21673629

Gene position: 765344-764589 (Counterclockwise)

Preceding gene: 21673630

Following gene: 21673628

Centisome position: 35.52

GC content: 60.98

Gene sequence:

>756_bases
GTGCTCTACAGCAAGCTGCTGGCTGACAATTTCGTCTGCGCCACCTGCGGTCACCGCTATGTCCGCCTCAGCGCCCGCGA
TTACATCGAACTGATACTCGACGAGAATGCGTTCACCGAGCACCAGGAAACTCGCTATATCATTGACCGCGATATTCTGA
ATTTCCCCGAATACGCCAACAAACTCCATGAAGAGCGCGTGAAAAACGGCATGACGACGGCACTCATCACGGGCGACGGC
GCGATTGATGGTAAGGAGGTCGTGTTGTGCGCCACGAGCTTCGGCTTCCTCGGTGGCTCGTTCTGCATGTCCACCGGCGA
AAAGGTGTGGCGAGCCGCCAAGATCGCCATAGAGAATCGCCGCCCGCGAATTCTGGTGGCCAAGGTCGGCCAGGATGGGC
ACGATCGCGGCGCGAAGGTGATCGCCGCGGCATTTGCCGACATCGGCTTCGACGTCGATATTTCGCCGCTCTTCCAGACG
CCGGAGGAGATCGTGCAGCAGGCGCTCGACAACGACGTGCATATCGTCGGTATTTCAAGCCTCGCGGGCGGGCACAAAAC
ACTAGTGCCGCAGGTGGTGGAAGGATTGAAGGAGGCGCGGCGCGGCGACATTCTCGTCATCGCAGGCGGCGTCATTCCGG
AGCGCGACTACGACTACCTCTACGAGCGCGGCATCGCGGGCGTCTTCGGCCCCGGCACGGTGATCGCCGAAGCGGCCATC
AAGCTGCTCGCGCTGCTGCTCGAACATCACCAGTGA

Upstream 100 bases:

>100_bases
AAAAAGGTCTCTTTCTTCATCGACAAGCCGAAAAAGAACCTCTTCATCAGCCGCCACAAGCCGCTGCTAAAACGATGATA
AAAGGCATGTCGTCGATCCG

Downstream 100 bases:

>100_bases
GCGGAAACCGGGCGAGGCGATGAGCGGCAGGCATCGGCATGAACCCACGGTTGAGGAGTTCGTCGAAGGCATCAGGAACG
GCGACCGCCGCCTGTTGAGC

Product: acetyl-CoA carboxylase, carboxyl transferase subunit beta/methylmalonyl-CoA mutase, C-terminus

Products: NA

Alternate protein names: MCM-alpha [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MLYSKLLADNFVCATCGHRYVRLSARDYIELILDENAFTEHQETRYIIDRDILNFPEYANKLHEERVKNGMTTALITGDG
AIDGKEVVLCATSFGFLGGSFCMSTGEKVWRAAKIAIENRRPRILVAKVGQDGHDRGAKVIAAAFADIGFDVDISPLFQT
PEEIVQQALDNDVHIVGISSLAGGHKTLVPQVVEGLKEARRGDILVIAGGVIPERDYDYLYERGIAGVFGPGTVIAEAAI
KLLALLLEHHQ

Sequences:

>Translated_251_residues
MLYSKLLADNFVCATCGHRYVRLSARDYIELILDENAFTEHQETRYIIDRDILNFPEYANKLHEERVKNGMTTALITGDG
AIDGKEVVLCATSFGFLGGSFCMSTGEKVWRAAKIAIENRRPRILVAKVGQDGHDRGAKVIAAAFADIGFDVDISPLFQT
PEEIVQQALDNDVHIVGISSLAGGHKTLVPQVVEGLKEARRGDILVIAGGVIPERDYDYLYERGIAGVFGPGTVIAEAAI
KLLALLLEHHQ
>Mature_251_residues
MLYSKLLADNFVCATCGHRYVRLSARDYIELILDENAFTEHQETRYIIDRDILNFPEYANKLHEERVKNGMTTALITGDG
AIDGKEVVLCATSFGFLGGSFCMSTGEKVWRAAKIAIENRRPRILVAKVGQDGHDRGAKVIAAAFADIGFDVDISPLFQT
PEEIVQQALDNDVHIVGISSLAGGHKTLVPQVVEGLKEARRGDILVIAGGVIPERDYDYLYERGIAGVFGPGTVIAEAAI
KLLALLLEHHQ

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG2185

COG function: function code I; Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=126, Percent_Identity=66.6666666666667, Blast_Score=183, Evalue=1e-46,
Organism=Escherichia coli, GI1789284, Length=136, Percent_Identity=61.0294117647059, Blast_Score=185, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI25144500, Length=129, Percent_Identity=62.7906976744186, Blast_Score=171, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 27508; Mature: 27508

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYSKLLADNFVCATCGHRYVRLSARDYIELILDENAFTEHQETRYIIDRDILNFPEYAN
CCHHHHHHCCCEEEECCCEEEEECHHHHHHHHCCCCCCCCCHHHHEEHHHHHCCCHHHHH
KLHEERVKNGMTTALITGDGAIDGKEVVLCATSFGFLGGSFCMSTGEKVWRAAKIAIENR
HHHHHHHHCCCEEEEEECCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RPRILVAKVGQDGHDRGAKVIAAAFADIGFDVDISPLFQTPEEIVQQALDNDVHIVGISS
CCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHCCCEEEEEECC
LAGGHKTLVPQVVEGLKEARRGDILVIAGGVIPERDYDYLYERGIAGVFGPGTVIAEAAI
CCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHH
KLLALLLEHHQ
HHHHHHHHHCC
>Mature Secondary Structure
MLYSKLLADNFVCATCGHRYVRLSARDYIELILDENAFTEHQETRYIIDRDILNFPEYAN
CCHHHHHHCCCEEEECCCEEEEECHHHHHHHHCCCCCCCCCHHHHEEHHHHHCCCHHHHH
KLHEERVKNGMTTALITGDGAIDGKEVVLCATSFGFLGGSFCMSTGEKVWRAAKIAIENR
HHHHHHHHCCCEEEEEECCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RPRILVAKVGQDGHDRGAKVIAAAFADIGFDVDISPLFQTPEEIVQQALDNDVHIVGISS
CCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHCCCEEEEEECC
LAGGHKTLVPQVVEGLKEARRGDILVIAGGVIPERDYDYLYERGIAGVFGPGTVIAEAAI
CCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHH
KLLALLLEHHQ
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8566763; 12949112 [H]