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The map label for this gene is glmU [H]

Identifier: 21673557

GI number: 21673557

Start: 708532

End: 709509

Strand: Reverse

Name: glmU [H]

Synonym: CT0727

Alternate gene names: 21673557

Gene position: 709509-708532 (Counterclockwise)

Preceding gene: 21673558

Following gene: 21673553

Centisome position: 32.92

GC content: 55.21

Gene sequence:

>978_bases
ATGAAAGCCATCATTCCCGTTGCCGGTGTCGGAAGCCGTCTTCGTCCGCATACCTTTTCCCAACCGAAAGTACTGCTCAA
TGTAGCCGGCAAGCCGATCATCGGGCATATCATGGACAAACTCATCGAATCGGGCATTGATGAGGCCGTGATCATCGTTG
GTTATCTCGGAGGCAAAATCGAGGAGTACCTCACCTCACACTATGCTATCAAACTGACCTTTGTCACCCAGGCCGACCAG
CTCGGTCTCGCCCATGCGGTCCATATGTGCAGACCGCATGTGATCGATGAAGAGCCACTGTTCATCATCCTCGGAGACAC
CATTTTTGATGTCGACCTGAAGCTGGTACTCGGCAGCAGTATTTCGACGCTCGGGGTCAAAGAGGTTGATGATCCGAGAC
GCTTCGGGGTGGTGGTCACCGAGGGCGACAGGATCGTGCGGCTCGTGGAAAAGCCGGAGCAACCGGTGAGCAATCTGGCA
ATCGTCGGACTCTATTTTCTGCACAGGGCAGGCACGCTTTTCAACAGCATTGACTACATCATCACCAACGACATCCGGAC
CAAAGGCGAATTCCAGCTTACCGACGCCCTGCAGCACATGATCGATCTCGGCGAACCATTTTCAACCTTCCCGGTGCAGG
GATGGTACGATTGCGGCAAACCTGAAACGCTTCTCTCAACGAACGAAGTTCTCTTGCAGAGGGATACCCGGCAAAAATCA
CTTCCCGGCTGCATCATCAACCCGCCGGTTTTCATTGCCGACAGCGCCACCGTCACCAACTCCATCATCGGCCCGAACGC
CACCATCGCCGAACATGCGGTCGTCAGGGACTCCATCATCATGAACTCCATCATCGGACGCAAGTCGCAGGTCAGCGAGA
TCATGCTGGACCGGTCGATCGTCGGCAACAACGCCATCGTTTCGGCGATGGGCCACGAGCTGAACATCGGCGACTATTCG
GAAATACGGATGGGCTGA

Upstream 100 bases:

>100_bases
CTGAACGATGTTTTTTCACCGACTTTCAAATCATGATAATCTCCTGCAATTGAAGTAAATTGATGCGCATATTTTCAGTC
AATCAAAAGCGACCCCTGAC

Downstream 100 bases:

>100_bases
GCGGATGATTCGCAACCGGCGGGCAGAGCGGCTTGCTTGCCGGTCAGCTCATGAAGAGGTAGGGCTTCCACTCGTCGGAG
ATCGAGCGGTAGTGCTGGCG

Product: glucose-1-phosphate thymidylyltransferase, putative

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MKAIIPVAGVGSRLRPHTFSQPKVLLNVAGKPIIGHIMDKLIESGIDEAVIIVGYLGGKIEEYLTSHYAIKLTFVTQADQ
LGLAHAVHMCRPHVIDEEPLFIILGDTIFDVDLKLVLGSSISTLGVKEVDDPRRFGVVVTEGDRIVRLVEKPEQPVSNLA
IVGLYFLHRAGTLFNSIDYIITNDIRTKGEFQLTDALQHMIDLGEPFSTFPVQGWYDCGKPETLLSTNEVLLQRDTRQKS
LPGCIINPPVFIADSATVTNSIIGPNATIAEHAVVRDSIIMNSIIGRKSQVSEIMLDRSIVGNNAIVSAMGHELNIGDYS
EIRMG

Sequences:

>Translated_325_residues
MKAIIPVAGVGSRLRPHTFSQPKVLLNVAGKPIIGHIMDKLIESGIDEAVIIVGYLGGKIEEYLTSHYAIKLTFVTQADQ
LGLAHAVHMCRPHVIDEEPLFIILGDTIFDVDLKLVLGSSISTLGVKEVDDPRRFGVVVTEGDRIVRLVEKPEQPVSNLA
IVGLYFLHRAGTLFNSIDYIITNDIRTKGEFQLTDALQHMIDLGEPFSTFPVQGWYDCGKPETLLSTNEVLLQRDTRQKS
LPGCIINPPVFIADSATVTNSIIGPNATIAEHAVVRDSIIMNSIIGRKSQVSEIMLDRSIVGNNAIVSAMGHELNIGDYS
EIRMG
>Mature_325_residues
MKAIIPVAGVGSRLRPHTFSQPKVLLNVAGKPIIGHIMDKLIESGIDEAVIIVGYLGGKIEEYLTSHYAIKLTFVTQADQ
LGLAHAVHMCRPHVIDEEPLFIILGDTIFDVDLKLVLGSSISTLGVKEVDDPRRFGVVVTEGDRIVRLVEKPEQPVSNLA
IVGLYFLHRAGTLFNSIDYIITNDIRTKGEFQLTDALQHMIDLGEPFSTFPVQGWYDCGKPETLLSTNEVLLQRDTRQKS
LPGCIINPPVFIADSATVTNSIIGPNATIAEHAVVRDSIIMNSIIGRKSQVSEIMLDRSIVGNNAIVSAMGHELNIGDYS
EIRMG

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=324, Percent_Identity=30.5555555555556, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI11761621, Length=324, Percent_Identity=30.5555555555556, Blast_Score=111, Evalue=8e-25,
Organism=Escherichia coli, GI1790224, Length=259, Percent_Identity=30.1158301158301, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788355, Length=272, Percent_Identity=26.4705882352941, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1787488, Length=266, Percent_Identity=29.6992481203008, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788351, Length=256, Percent_Identity=27.734375, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1790168, Length=318, Percent_Identity=25.7861635220126, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI133931050, Length=342, Percent_Identity=29.8245614035088, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17509979, Length=349, Percent_Identity=25.5014326647564, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17509981, Length=336, Percent_Identity=25, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=328, Percent_Identity=26.8292682926829, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21355443, Length=323, Percent_Identity=27.5541795665635, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24644084, Length=323, Percent_Identity=27.5541795665635, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 35574; Mature: 35574

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIIPVAGVGSRLRPHTFSQPKVLLNVAGKPIIGHIMDKLIESGIDEAVIIVGYLGGKI
CCCEEECCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEECCCHH
EEYLTSHYAIKLTFVTQADQLGLAHAVHMCRPHVIDEEPLFIILGDTIFDVDLKLVLGSS
HHHHCCCEEEEEEEEECCHHHHHHHHHHHHCCCCCCCCCEEEEECCEEEEEEEEEEECCC
ISTLGVKEVDDPRRFGVVVTEGDRIVRLVEKPEQPVSNLAIVGLYFLHRAGTLFNSIDYI
CCCCCCCCCCCCHHEEEEEECCCCEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEE
ITNDIRTKGEFQLTDALQHMIDLGEPFSTFPVQGWYDCGKPETLLSTNEVLLQRDTRQKS
EECCCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCCHHHHCCCCHHHC
LPGCIINPPVFIADSATVTNSIIGPNATIAEHAVVRDSIIMNSIIGRKSQVSEIMLDRSI
CCCEEECCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
VGNNAIVSAMGHELNIGDYSEIRMG
CCCCCEEEECCCCCCCCCCHHHCCC
>Mature Secondary Structure
MKAIIPVAGVGSRLRPHTFSQPKVLLNVAGKPIIGHIMDKLIESGIDEAVIIVGYLGGKI
CCCEEECCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEECCCHH
EEYLTSHYAIKLTFVTQADQLGLAHAVHMCRPHVIDEEPLFIILGDTIFDVDLKLVLGSS
HHHHCCCEEEEEEEEECCHHHHHHHHHHHHCCCCCCCCCEEEEECCEEEEEEEEEEECCC
ISTLGVKEVDDPRRFGVVVTEGDRIVRLVEKPEQPVSNLAIVGLYFLHRAGTLFNSIDYI
CCCCCCCCCCCCHHEEEEEECCCCEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEE
ITNDIRTKGEFQLTDALQHMIDLGEPFSTFPVQGWYDCGKPETLLSTNEVLLQRDTRQKS
EECCCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCCHHHHCCCCHHHC
LPGCIINPPVFIADSATVTNSIIGPNATIAEHAVVRDSIIMNSIIGRKSQVSEIMLDRSI
CCCEEECCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
VGNNAIVSAMGHELNIGDYSEIRMG
CCCCCEEEECCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]