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The map label for this gene is nadA

Identifier: 21673405

GI number: 21673405

Start: 577864

End: 578832

Strand: Direct

Name: nadA

Synonym: CT0570

Alternate gene names: 21673405

Gene position: 577864-578832 (Clockwise)

Preceding gene: 21673404

Following gene: 21673406

Centisome position: 26.82

GC content: 60.99

Gene sequence:

>969_bases
ATGACCATAGCGACCGATATGCACAAAGAGGCGGCGGGCCTTTCGACCGAAGCGCTGCTCCGGCGGGTGCAGGCTCTCAA
GAAGGAGATGAACGCGATTATCCTTGCCCACTACTACACCCTGCCGGAAATCCAGCAGGCGGCGGACATCGTGGGCGACA
GCCTCGCCCTGGCGCGGGCGGCGGAGAAGACGTCGGCGGACGTGATCGTTTTCGCCGGGGTGTACTTCATGGCCGAGACC
GCCAAGATTCTCAATCCTGGCAAGATGGTGCTCATGCCCGATCCGGGCGCGGGCTGCCCGCTGGCCGACAGTTGCCCGGA
GGAGGAGTTCCGCGCCTTCCGCCAGGCGCATCCCGACGCCATTGCCATTACCTACGTCAACTCGTCGGCGGCGATCAAGA
AGCTTTCGGACATCATCTGCACCTCGTCGAACGCCGAGCATATCGTGCGGCAGATTCCGCCGGAGCAGCAGATCATCTTC
GGTCCTGACCGCAACCTCGGCGCATGGGTGATGAAGCGCACCGGGCGCGACATGCTGCTCTGGCAGGGCTTCTGCTATGT
GCACGACGCCTACTCCGAGGTTTACATGATCCAAGCCAAGGCGATGTATCCGGATGCGGAATTGATCGCTCATCCCGAGT
GCCGCGAGGAGGTGCTGCGTCAGGCTTCGTTCGTTGGCTCGACCTCGGCCCTGCTCGATTACACCGAAAAGAGTCCGCGC
AAAAGCTTCATCGTGGCAACCGAGCCGGGCATTCTTTACGAAATGGAGAAACGCTCGCCGGGCAAGGTTTTCATTCCTGC
GCCCAAAGACCCGGCCAATCCGCGCAGCGTCTGCAAGCAGATGAAGCAGAACACGCTTGACAAGCTCTATCTCTGCATGG
TGAACCGCTCGCCCGAGATCACCGTTGACGAGAGCCTGCGCGAAGGGGCGCTGAAGTCGATCAAAAGAATGCTCGAAATG
TCCGCCTGA

Upstream 100 bases:

>100_bases
TCGTCGGAGGGAGTCGGATTTGTTTCCGGCTTTCACTCCGGCCTACGCTCCTCTTCAACCGTCGAGGAGTTTTTTTATTT
CATTATTTTGACAGATCGAT

Downstream 100 bases:

>100_bases
CCTGCCGTCGCCGGGCGCCACTCCGCTCACCGGAAGTCGCGGCCCGGCAAAATCTCTGACCGTTCAGCCCTCCGCTGTTG
CCGCTCATCCCCGTTTCTGC

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MTIATDMHKEAAGLSTEALLRRVQALKKEMNAIILAHYYTLPEIQQAADIVGDSLALARAAEKTSADVIVFAGVYFMAET
AKILNPGKMVLMPDPGAGCPLADSCPEEEFRAFRQAHPDAIAITYVNSSAAIKKLSDIICTSSNAEHIVRQIPPEQQIIF
GPDRNLGAWVMKRTGRDMLLWQGFCYVHDAYSEVYMIQAKAMYPDAELIAHPECREEVLRQASFVGSTSALLDYTEKSPR
KSFIVATEPGILYEMEKRSPGKVFIPAPKDPANPRSVCKQMKQNTLDKLYLCMVNRSPEITVDESLREGALKSIKRMLEM
SA

Sequences:

>Translated_322_residues
MTIATDMHKEAAGLSTEALLRRVQALKKEMNAIILAHYYTLPEIQQAADIVGDSLALARAAEKTSADVIVFAGVYFMAET
AKILNPGKMVLMPDPGAGCPLADSCPEEEFRAFRQAHPDAIAITYVNSSAAIKKLSDIICTSSNAEHIVRQIPPEQQIIF
GPDRNLGAWVMKRTGRDMLLWQGFCYVHDAYSEVYMIQAKAMYPDAELIAHPECREEVLRQASFVGSTSALLDYTEKSPR
KSFIVATEPGILYEMEKRSPGKVFIPAPKDPANPRSVCKQMKQNTLDKLYLCMVNRSPEITVDESLREGALKSIKRMLEM
SA
>Mature_321_residues
TIATDMHKEAAGLSTEALLRRVQALKKEMNAIILAHYYTLPEIQQAADIVGDSLALARAAEKTSADVIVFAGVYFMAETA
KILNPGKMVLMPDPGAGCPLADSCPEEEFRAFRQAHPDAIAITYVNSSAAIKKLSDIICTSSNAEHIVRQIPPEQQIIFG
PDRNLGAWVMKRTGRDMLLWQGFCYVHDAYSEVYMIQAKAMYPDAELIAHPECREEVLRQASFVGSTSALLDYTEKSPRK
SFIVATEPGILYEMEKRSPGKVFIPAPKDPANPRSVCKQMKQNTLDKLYLCMVNRSPEITVDESLREGALKSIKRMLEMS
A

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 2 subfamily

Homologues:

Organism=Escherichia coli, GI1786964, Length=312, Percent_Identity=42.3076923076923, Blast_Score=231, Evalue=7e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NADA_CHLTE (Q8KEW2)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_661470.1
- ProteinModelPortal:   Q8KEW2
- SMR:   Q8KEW2
- GeneID:   1006225
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0570
- NMPDR:   fig|194439.1.peg.564
- TIGR:   CT0570
- HOGENOM:   HBG291157
- OMA:   IAHPECE
- ProtClustDB:   PRK09375
- BioCyc:   CTEP194439:CT_0570-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00568
- InterPro:   IPR003473
- InterPro:   IPR023066
- TIGRFAMs:   TIGR00550

Pfam domain/function: PF02445 NadA

EC number: =2.5.1.72

Molecular weight: Translated: 35719; Mature: 35588

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: BINDING 37-37 BINDING 54-54 BINDING 125-125 BINDING 142-142 BINDING 211-211 BINDING 228-228

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIATDMHKEAAGLSTEALLRRVQALKKEMNAIILAHYYTLPEIQQAADIVGDSLALARA
CCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCEEEEEEECCCHHHHHHHHHHCCHHHHHHH
AEKTSADVIVFAGVYFMAETAKILNPGKMVLMPDPGAGCPLADSCPEEEFRAFRQAHPDA
HHCCCCCEEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCE
IAITYVNSSAAIKKLSDIICTSSNAEHIVRQIPPEQQIIFGPDRNLGAWVMKRTGRDMLL
EEEEEECCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEECCCCCCHHHHHHHCCCCEEE
WQGFCYVHDAYSEVYMIQAKAMYPDAELIAHPECREEVLRQASFVGSTSALLDYTEKSPR
ECCHHHEEHHCCCEEEEEEECCCCCHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCC
KSFIVATEPGILYEMEKRSPGKVFIPAPKDPANPRSVCKQMKQNTLDKLYLCMVNRSPEI
CEEEEEECCCEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCE
TVDESLREGALKSIKRMLEMSA
EEHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TIATDMHKEAAGLSTEALLRRVQALKKEMNAIILAHYYTLPEIQQAADIVGDSLALARA
CCCCCCHHHHCCCCHHHHHHHHHHHHHHHCEEEEEEECCCHHHHHHHHHHCCHHHHHHH
AEKTSADVIVFAGVYFMAETAKILNPGKMVLMPDPGAGCPLADSCPEEEFRAFRQAHPDA
HHCCCCCEEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCE
IAITYVNSSAAIKKLSDIICTSSNAEHIVRQIPPEQQIIFGPDRNLGAWVMKRTGRDMLL
EEEEEECCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEECCCCCCHHHHHHHCCCCEEE
WQGFCYVHDAYSEVYMIQAKAMYPDAELIAHPECREEVLRQASFVGSTSALLDYTEKSPR
ECCHHHEEHHCCCEEEEEEECCCCCHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCC
KSFIVATEPGILYEMEKRSPGKVFIPAPKDPANPRSVCKQMKQNTLDKLYLCMVNRSPEI
CEEEEEECCCEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCE
TVDESLREGALKSIKRMLEMSA
EEHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901