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The map label for this gene is phr [H]

Identifier: 21673346

GI number: 21673346

Start: 519982

End: 521361

Strand: Reverse

Name: phr [H]

Synonym: CT0511

Alternate gene names: 21673346

Gene position: 521361-519982 (Counterclockwise)

Preceding gene: 21673347

Following gene: 21673345

Centisome position: 24.19

GC content: 61.59

Gene sequence:

>1380_bases
ATGGCCAAAGCAATAACAATCGACGAGCGCCGGATACTCCGCCTGAACCAGCGCGAGGATCGACAAGGCCCGGTAATCTA
TTGGATGTCGCGCGACCAGCGCGTGCGCCACAACTGGGCGCTGCTTTTTGCCTGCCAGAAGGCGAACCAGCTCGGCCAGC
CGCTCGAAGTGGTATTCACCCTTTCACCCAGCTTTCTCGGTGCGCCGATGCGCCACTACGACTTCATGTTCCGGGGACTT
CGCGAGGTGGAAACGAGACTGCGTGAGCTGGGCGTACCGTTCACTGTACTCTACGGCGAACCGGGCGAAACACTGCCGAA
GTATACTGAAAAGCGAAACGCCGGGGTGGTGGTGGCGGACTTCTCGCCGCTAAAGCTGGTGCGCGGCTGGAAGCTGGCTG
TTGCACAGCAGCTTTCGTGCGCATTTTATGAAGTCGATGCGCACAACATCGTGCCATGCTGGCTGGCTTCGCCCAAGCAG
GAGTACGCCGCGCGCACGATCAGGCCGAAGCTCAATGCCCTGCAAGGTGAGTTCCTGACCGGCTTCCCCGAACCGGAACT
CCGGCATCAGCCCGACACATTGCCACCCCCGGTGCAGTGGAATGCGATGGAAACGCTACTCAAGGTTGACCGTTCAATCA
AGGCAGTACCCGGTCTGGAACCGGGCGAAACGGCAGCGGAAGCGCGTCTGCGCAGCTTCGTCACTGGCCGCCTGAGCCGC
TACGCCGACGAGCGCAACGATCCCAACTCCGGCGCAGTCTCGGGCCTCTCGCCCTACCTGCACTTCGGCCAGCTCAGCGC
CCAGCACGCCACCTTCGAGGCCGCCCGGAGCAAAGCTTCAGAGGTCAACCGCGAGGCCTTCGTCGAAGAGCTGTTCATCC
GCCGGGAGCTGTCGGAGAACTACTGCTACTACAACGAGCGCTACGACTCGTTCGACGGCATTCCGGAGTGGGCAAAAAAG
ACGCTGATGGAGCACGCTGGCGACCACCGCGACGCCATCTACACGCCGGAGCAGTTCGAGCGGGCGCAAACGCACGATCC
GCTCTGGAACGCCGCCCAGACCCAGTTGCTCGAAACCGGCATCATCCACGGATATATGCGCATGTACTGGGCAAAAAAGA
TTCTCGAATGGAGCGCAACCCCGGCGGCAGCCTTCGATATCGCGCTCATGCTCAACGACCGCTACGCCCTTGACGGGCGC
GACCCCAACGGCTACGTCGGCGTCGCCTGGTCAATCGGCGGCCTCCACGACCGCCCATGGACCGAGCGTCCGGTCTATGG
CACCATCCGCTACATGAACTCAAACGGCTGCAAACGAAAATTCGACGTCCCCCGATATATCGCCGAAATGACCGGCAAGT
CGCAGGCTACACTGTTCTGA

Upstream 100 bases:

>100_bases
AATCGACGTCAAAAAAAGAGATTGGGCTAAAACCTTTATTTTATATTGTTTTATCCGTATACCCCGGGCTAAAGTCCGGG
GCAATTGTTTAAGCATTTTA

Downstream 100 bases:

>100_bases
GAGAAGAGGACAATTGGCGGTATCGAATATTTTCCGCTATTTTTACTTAGAAACTATAAAAGCCACAACTGGAAAGAGAA
AAAATCGCTTGTAAGCCGTT

Product: DNA deoxyribodipyrimidine photolyase, class II

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MAKAITIDERRILRLNQREDRQGPVIYWMSRDQRVRHNWALLFACQKANQLGQPLEVVFTLSPSFLGAPMRHYDFMFRGL
REVETRLRELGVPFTVLYGEPGETLPKYTEKRNAGVVVADFSPLKLVRGWKLAVAQQLSCAFYEVDAHNIVPCWLASPKQ
EYAARTIRPKLNALQGEFLTGFPEPELRHQPDTLPPPVQWNAMETLLKVDRSIKAVPGLEPGETAAEARLRSFVTGRLSR
YADERNDPNSGAVSGLSPYLHFGQLSAQHATFEAARSKASEVNREAFVEELFIRRELSENYCYYNERYDSFDGIPEWAKK
TLMEHAGDHRDAIYTPEQFERAQTHDPLWNAAQTQLLETGIIHGYMRMYWAKKILEWSATPAAAFDIALMLNDRYALDGR
DPNGYVGVAWSIGGLHDRPWTERPVYGTIRYMNSNGCKRKFDVPRYIAEMTGKSQATLF

Sequences:

>Translated_459_residues
MAKAITIDERRILRLNQREDRQGPVIYWMSRDQRVRHNWALLFACQKANQLGQPLEVVFTLSPSFLGAPMRHYDFMFRGL
REVETRLRELGVPFTVLYGEPGETLPKYTEKRNAGVVVADFSPLKLVRGWKLAVAQQLSCAFYEVDAHNIVPCWLASPKQ
EYAARTIRPKLNALQGEFLTGFPEPELRHQPDTLPPPVQWNAMETLLKVDRSIKAVPGLEPGETAAEARLRSFVTGRLSR
YADERNDPNSGAVSGLSPYLHFGQLSAQHATFEAARSKASEVNREAFVEELFIRRELSENYCYYNERYDSFDGIPEWAKK
TLMEHAGDHRDAIYTPEQFERAQTHDPLWNAAQTQLLETGIIHGYMRMYWAKKILEWSATPAAAFDIALMLNDRYALDGR
DPNGYVGVAWSIGGLHDRPWTERPVYGTIRYMNSNGCKRKFDVPRYIAEMTGKSQATLF
>Mature_458_residues
AKAITIDERRILRLNQREDRQGPVIYWMSRDQRVRHNWALLFACQKANQLGQPLEVVFTLSPSFLGAPMRHYDFMFRGLR
EVETRLRELGVPFTVLYGEPGETLPKYTEKRNAGVVVADFSPLKLVRGWKLAVAQQLSCAFYEVDAHNIVPCWLASPKQE
YAARTIRPKLNALQGEFLTGFPEPELRHQPDTLPPPVQWNAMETLLKVDRSIKAVPGLEPGETAAEARLRSFVTGRLSRY
ADERNDPNSGAVSGLSPYLHFGQLSAQHATFEAARSKASEVNREAFVEELFIRRELSENYCYYNERYDSFDGIPEWAKKT
LMEHAGDHRDAIYTPEQFERAQTHDPLWNAAQTQLLETGIIHGYMRMYWAKKILEWSATPAAAFDIALMLNDRYALDGRD
PNGYVGVAWSIGGLHDRPWTERPVYGTIRYMNSNGCKRKFDVPRYIAEMTGKSQATLF

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Drosophila melanogaster, GI24586396, Length=459, Percent_Identity=49.0196078431373, Blast_Score=459, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24586398, Length=459, Percent_Identity=49.0196078431373, Blast_Score=458, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24586404, Length=156, Percent_Identity=55.7692307692308, Blast_Score=209, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008148
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 52541; Mature: 52410

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKAITIDERRILRLNQREDRQGPVIYWMSRDQRVRHNWALLFACQKANQLGQPLEVVFT
CCCEEEECCHHHHCCCCCCCCCCCEEEEECCCCHHHHCEEEEEEEHHHHHCCCCEEEEEE
LSPSFLGAPMRHYDFMFRGLREVETRLRELGVPFTVLYGEPGETLPKYTEKRNAGVVVAD
ECHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHCCCCCEEEEC
FSPLKLVRGWKLAVAQQLSCAFYEVDAHNIVPCWLASPKQEYAARTIRPKLNALQGEFLT
CCHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEECCCCHHHHHHHHHCHHHHHHCCCHHC
GFPEPELRHQPDTLPPPVQWNAMETLLKVDRSIKAVPGLEPGETAAEARLRSFVTGRLSR
CCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
YADERNDPNSGAVSGLSPYLHFGQLSAQHATFEAARSKASEVNREAFVEELFIRRELSEN
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YCYYNERYDSFDGIPEWAKKTLMEHAGDHRDAIYTPEQFERAQTHDPLWNAAQTQLLETG
CEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
IIHGYMRMYWAKKILEWSATPAAAFDIALMLNDRYALDGRDPNGYVGVAWSIGGLHDRPW
HHHHHHHHHHHHHHHHCCCCCHHHEEEEEEECCEEEECCCCCCCEEEEEEEECCCCCCCC
TERPVYGTIRYMNSNGCKRKFDVPRYIAEMTGKSQATLF
CCCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AKAITIDERRILRLNQREDRQGPVIYWMSRDQRVRHNWALLFACQKANQLGQPLEVVFT
CCEEEECCHHHHCCCCCCCCCCCEEEEECCCCHHHHCEEEEEEEHHHHHCCCCEEEEEE
LSPSFLGAPMRHYDFMFRGLREVETRLRELGVPFTVLYGEPGETLPKYTEKRNAGVVVAD
ECHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHCCCCCEEEEC
FSPLKLVRGWKLAVAQQLSCAFYEVDAHNIVPCWLASPKQEYAARTIRPKLNALQGEFLT
CCHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEECCCCHHHHHHHHHCHHHHHHCCCHHC
GFPEPELRHQPDTLPPPVQWNAMETLLKVDRSIKAVPGLEPGETAAEARLRSFVTGRLSR
CCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
YADERNDPNSGAVSGLSPYLHFGQLSAQHATFEAARSKASEVNREAFVEELFIRRELSEN
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YCYYNERYDSFDGIPEWAKKTLMEHAGDHRDAIYTPEQFERAQTHDPLWNAAQTQLLETG
CEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
IIHGYMRMYWAKKILEWSATPAAAFDIALMLNDRYALDGRDPNGYVGVAWSIGGLHDRPW
HHHHHHHHHHHHHHHHCCCCCHHHEEEEEEECCEEEECCCCCCCEEEEEEEECCCCCCCC
TERPVYGTIRYMNSNGCKRKFDVPRYIAEMTGKSQATLF
CCCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2668276 [H]