Click here to switch to the map view.

The map label for this gene is hemN [H]

Identifier: 21673211

GI number: 21673211

Start: 382877

End: 384307

Strand: Direct

Name: hemN [H]

Synonym: CT0372

Alternate gene names: 21673211

Gene position: 382877-384307 (Clockwise)

Preceding gene: 21673204

Following gene: 21673212

Centisome position: 17.77

GC content: 58.49

Gene sequence:

>1431_bases
ATGACAACAGATGTCGTCGCGAAGCTGGCTTTGAAGTACAGCAATCCCGGGCCACGTTACACCAGTTACCCCACCATTCC
GTCCTGGAGTGAGGACGGCGTGACTCAGGAGCAGTGGAAAGAGGCTATGGTCAAAGGCTTCAACGAGAGCAACGAGACCA
CGGGTATCAGCATGTATATCCATATCCCGTTCTGCGAGAACTACTGCTACTTCTGCGGCTGCAACGCTCATCGCACCACC
GATCACTCGCTCGAGAAGCCCTACATCGATGCGCTCATCAAGGAGTGGCAGATGTATCTCGACGTTTTCCCCGGCAAGCT
CAACGTCAAGGAGCTGCATATCGGAGGCGGCACACCGACTTTCCTCAGCCCCGAGAACCTTATCCGTCTTGTCGATACCC
TTTTCAGGGATGTCAACAAGATGGACGATTACATGTTCAGTTTCGAAACCAACCCTCGCTCGACCACAAAAGAGCATCTC
GAAGCGCTTTACAGCGTCGGATTCCGCCGCATGAGCTTCGGTATCCAGGACTTCGATCCCGTGGTGCAGGCCGAGATCAA
CCGCCCGCAGTCCTTCGAACTGGTCAAGGAGAAGATCGACATGGCCCGCGAAATCGGCTTCAACTCGGTCAACTTCGATC
TCGTGTACGGCCTGCCGAAGCAGACGCTCGCCACGGTGACCGATACCATCCAGAAAGTGATGGAACTGCGTCCCGACCGC
CTCGCCTTTTACGGCTATGGCCACAACCCGCACCTTTACGAAGGGCAGCGCCGCTTCAAGCTCGAAGACCTGCCGGTGGG
CGACGTCAAGCAGGAGCTGTACGACCAGGGCCGCGCGATGCTCGAATCGATCGGCTATCACGAGGTTGGCATGGACCACT
TCGCCATCGAGGGCGACGCGCTTTACGAGGCGATGAAGAATGGCACCTTGCACCGGAACTTCATGGGCTACACCGAGAAC
ACCACCCAGATGATGCTCGCCCTCGGCGCTTCGTCGATCAGCGACACCTGGTACGCCTTCGCGCAGAACGAGCGCACCGA
CGACCGCTACATGGAGGAGGTCAACAAGGGCCGCTTCCCGATCATGCGCGGTCACCTGCTCAGCGACGAAGACCTTGTGC
TTCGCCGCCATATCCTGAACCTGATGTGCCGCCAGGAGACCTCGTGGGAAGATCCGAAGCTCTACACCGAAGAGCTGGAC
ATCGCCCGCTATCGCCTCGAAGACATGGAGAACGATGGCATCGTGGTGCTTGGCGAGAAGAGTGTGAAGGTCACCGAGAT
CGGCGTGCCCTTCCTCCGCAACGTCTGCATGGCGTTCGACGCGCACCTCTGGCGCTCCGACAGCCTCTCCAAGGCCTACA
ACGTGTCGCGCGACATCCAGAAGGAGTACATCGAAAAGGCCCGCCAGGCCAAGCTCCAGCAGACCTCCTGA

Upstream 100 bases:

>100_bases
AAGGTTAACGCCGTTGCAGTTTGAGGGCTAAAAAATTCGCGGAGTTTTTGTATTTTCATCAGTCTAACAAAAAAAATAAC
ACTTGCCAAGGAAGAATACA

Downstream 100 bases:

>100_bases
GCGGGTGTCTCTTAACGGTTTTGAGGGGTGATCGTTTGGTCACCCTTTTTTTTGGTTAAGATTTCGTATGAACCGCACGA
TGACAAAGTCAATCACACGA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MTTDVVAKLALKYSNPGPRYTSYPTIPSWSEDGVTQEQWKEAMVKGFNESNETTGISMYIHIPFCENYCYFCGCNAHRTT
DHSLEKPYIDALIKEWQMYLDVFPGKLNVKELHIGGGTPTFLSPENLIRLVDTLFRDVNKMDDYMFSFETNPRSTTKEHL
EALYSVGFRRMSFGIQDFDPVVQAEINRPQSFELVKEKIDMAREIGFNSVNFDLVYGLPKQTLATVTDTIQKVMELRPDR
LAFYGYGHNPHLYEGQRRFKLEDLPVGDVKQELYDQGRAMLESIGYHEVGMDHFAIEGDALYEAMKNGTLHRNFMGYTEN
TTQMMLALGASSISDTWYAFAQNERTDDRYMEEVNKGRFPIMRGHLLSDEDLVLRRHILNLMCRQETSWEDPKLYTEELD
IARYRLEDMENDGIVVLGEKSVKVTEIGVPFLRNVCMAFDAHLWRSDSLSKAYNVSRDIQKEYIEKARQAKLQQTS

Sequences:

>Translated_476_residues
MTTDVVAKLALKYSNPGPRYTSYPTIPSWSEDGVTQEQWKEAMVKGFNESNETTGISMYIHIPFCENYCYFCGCNAHRTT
DHSLEKPYIDALIKEWQMYLDVFPGKLNVKELHIGGGTPTFLSPENLIRLVDTLFRDVNKMDDYMFSFETNPRSTTKEHL
EALYSVGFRRMSFGIQDFDPVVQAEINRPQSFELVKEKIDMAREIGFNSVNFDLVYGLPKQTLATVTDTIQKVMELRPDR
LAFYGYGHNPHLYEGQRRFKLEDLPVGDVKQELYDQGRAMLESIGYHEVGMDHFAIEGDALYEAMKNGTLHRNFMGYTEN
TTQMMLALGASSISDTWYAFAQNERTDDRYMEEVNKGRFPIMRGHLLSDEDLVLRRHILNLMCRQETSWEDPKLYTEELD
IARYRLEDMENDGIVVLGEKSVKVTEIGVPFLRNVCMAFDAHLWRSDSLSKAYNVSRDIQKEYIEKARQAKLQQTS
>Mature_475_residues
TTDVVAKLALKYSNPGPRYTSYPTIPSWSEDGVTQEQWKEAMVKGFNESNETTGISMYIHIPFCENYCYFCGCNAHRTTD
HSLEKPYIDALIKEWQMYLDVFPGKLNVKELHIGGGTPTFLSPENLIRLVDTLFRDVNKMDDYMFSFETNPRSTTKEHLE
ALYSVGFRRMSFGIQDFDPVVQAEINRPQSFELVKEKIDMAREIGFNSVNFDLVYGLPKQTLATVTDTIQKVMELRPDRL
AFYGYGHNPHLYEGQRRFKLEDLPVGDVKQELYDQGRAMLESIGYHEVGMDHFAIEGDALYEAMKNGTLHRNFMGYTENT
TQMMLALGASSISDTWYAFAQNERTDDRYMEEVNKGRFPIMRGHLLSDEDLVLRRHILNLMCRQETSWEDPKLYTEELDI
ARYRLEDMENDGIVVLGEKSVKVTEIGVPFLRNVCMAFDAHLWRSDSLSKAYNVSRDIQKEYIEKARQAKLQQTS

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=260, Percent_Identity=26.5384615384615, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI87082341, Length=441, Percent_Identity=38.5487528344671, Blast_Score=297, Evalue=1e-81,
Organism=Escherichia coli, GI1789325, Length=243, Percent_Identity=27.5720164609054, Blast_Score=110, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 55090; Mature: 54959

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTDVVAKLALKYSNPGPRYTSYPTIPSWSEDGVTQEQWKEAMVKGFNESNETTGISMYI
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEE
HIPFCENYCYFCGCNAHRTTDHSLEKPYIDALIKEWQMYLDVFPGKLNVKELHIGGGTPT
EEEEECCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
FLSPENLIRLVDTLFRDVNKMDDYMFSFETNPRSTTKEHLEALYSVGFRRMSFGIQDFDP
CCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCH
VVQAEINRPQSFELVKEKIDMAREIGFNSVNFDLVYGLPKQTLATVTDTIQKVMELRPDR
HHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCC
LAFYGYGHNPHLYEGQRRFKLEDLPVGDVKQELYDQGRAMLESIGYHEVGMDHFAIEGDA
EEEEECCCCCCCCCCCHHCEECCCCCCHHHHHHHHHHHHHHHHCCCHHCCCCCEEECHHH
LYEAMKNGTLHRNFMGYTENTTQMMLALGASSISDTWYAFAQNERTDDRYMEEVNKGRFP
HHHHHHCCCEECCCCCCCCCHHHHHHHHCCCHHCHHHHHHHCCCCCHHHHHHHHHCCCCC
IMRGHLLSDEDLVLRRHILNLMCRQETSWEDPKLYTEELDIARYRLEDMENDGIVVLGEK
EEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCC
SVKVTEIGVPFLRNVCMAFDAHLWRSDSLSKAYNVSRDIQKEYIEKARQAKLQQTS
CEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TTDVVAKLALKYSNPGPRYTSYPTIPSWSEDGVTQEQWKEAMVKGFNESNETTGISMYI
CHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEE
HIPFCENYCYFCGCNAHRTTDHSLEKPYIDALIKEWQMYLDVFPGKLNVKELHIGGGTPT
EEEEECCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
FLSPENLIRLVDTLFRDVNKMDDYMFSFETNPRSTTKEHLEALYSVGFRRMSFGIQDFDP
CCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCH
VVQAEINRPQSFELVKEKIDMAREIGFNSVNFDLVYGLPKQTLATVTDTIQKVMELRPDR
HHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCC
LAFYGYGHNPHLYEGQRRFKLEDLPVGDVKQELYDQGRAMLESIGYHEVGMDHFAIEGDA
EEEEECCCCCCCCCCCHHCEECCCCCCHHHHHHHHHHHHHHHHCCCHHCCCCCEEECHHH
LYEAMKNGTLHRNFMGYTENTTQMMLALGASSISDTWYAFAQNERTDDRYMEEVNKGRFP
HHHHHHCCCEECCCCCCCCCHHHHHHHHCCCHHCHHHHHHHCCCCCHHHHHHHHHCCCCC
IMRGHLLSDEDLVLRRHILNLMCRQETSWEDPKLYTEELDIARYRLEDMENDGIVVLGEK
EEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCC
SVKVTEIGVPFLRNVCMAFDAHLWRSDSLSKAYNVSRDIQKEYIEKARQAKLQQTS
CEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]