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The map label for this gene is argD

Identifier: 21673206

GI number: 21673206

Start: 378743

End: 379945

Strand: Reverse

Name: argD

Synonym: CT0367

Alternate gene names: 21673206

Gene position: 379945-378743 (Counterclockwise)

Preceding gene: 21673207

Following gene: 21673205

Centisome position: 17.63

GC content: 58.69

Gene sequence:

>1203_bases
ATGAACACACCTGCAATAAATCTCGAAACCGAGAAGCAGCTCTTCTTTCATAACTATGCAAGGCTGCCGCTCGACATCGC
CTCTGGCAAAGGCTCGTTCCTCTACACTGCCAGCGGTGAGCGCTACCTCGACATGATCGCCGGCGTCGGCGTCAACGCCA
TCGGCTACGGCGACAAGCGCCTCGAACAGGCAATCACCGAACAGGCTTCGAAATACATCCATGTCTCGAACCTCTTCATG
CAGAAGCCGCAGTTCGACCTGGCTGCGAAGCTGCTTGAAATTTCCAGGATGTCGAAGGTCTTTTTCTGCAACAGCGGCAC
CGAGGCGATCGAGGCGGCCATCAAGCTCGCGAGACGCTTCGCCGCGCGTAACGGAGACACCGACAAAACGCAGGTGCTCT
CACTGACCAACTGCTTCCACGGCAGAACCTACGGCGCGCTCTCGCTGACCGCCAAGCCGAAGTATGTCGACGGCTTCGAG
CCGCTCGTGCCCGAAACCGGCATGATCGATTTCAACGACGTGGAGGATCTGGAACGCAAGGTCTCGAACCGCACGGCAGC
GGTCTTTGTCGAATTCGTGCAGGGCGAGGGCGGCATCCACAAAGTGAGCGAAGCCTTCATTGCAAAGCTGAAAGAGCTGG
CCAAGGAGCACGATTTCCTCATCGTGGCCGATGAAATTCAGGCCGGTTGCGGTCGTACGGGCGCGTTTTTCAGCTACATG
CCGTTCGACATCCAGCCTGATCTGGTCTGCGTGGCCAAGCCGCTTGGCGGCGGACTGCCGCTCGGCGCGATCATCGGCTC
GGAGAAGGTCGCCGAGGTGTTCACCCCCGGTAGCCACGGCACGACTTTCGGCGGCAATCCGGTCGCCTGCGCGGCGGGTC
TCGCCATGATCGAAGCGATCCTGGCGGACGGCCTGATGCAGAACGCACTCGAAGTTGGCTCCATGATGCGTACAGCTTTC
GAGAAAATGGCCGAGAAGCACGCGCAGATTCTCGAAATCCGCCAGTACGGCCTCATGATCGGCGTCACGGTGCACCGCGA
AGCGAAGTACTACGTCGAAGAGGCGTTGAAGAGGGGCGTACTCGTCAATGCCACCAGCAACAACGTCATCAGGCTTCTTC
CACCGCTATCGATCAGCAAAGAGGAGGCGCAACTCTGTCTCGATACACTCGATGCCATCTTCACCGAAGAAGCAAAAGCG
TAA

Upstream 100 bases:

>100_bases
TTCGCTACCGGCAGAAGGACGAGAAGAGCTGACGGACAAGCGCTGATTTCGATGAGAGACAAAAATCACAAACCTGATCT
TTAAAGAACAAACCATGACG

Downstream 100 bases:

>100_bases
GGCTGAAGCGGCGGCAAAGCAACCGCCAGCCGCCGCCAAACCGGCACCAGCCACGATGCCGCTCGGCGCGATGAACTACC
TCTTCATCGCGCTTGGCGCA

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MNTPAINLETEKQLFFHNYARLPLDIASGKGSFLYTASGERYLDMIAGVGVNAIGYGDKRLEQAITEQASKYIHVSNLFM
QKPQFDLAAKLLEISRMSKVFFCNSGTEAIEAAIKLARRFAARNGDTDKTQVLSLTNCFHGRTYGALSLTAKPKYVDGFE
PLVPETGMIDFNDVEDLERKVSNRTAAVFVEFVQGEGGIHKVSEAFIAKLKELAKEHDFLIVADEIQAGCGRTGAFFSYM
PFDIQPDLVCVAKPLGGGLPLGAIIGSEKVAEVFTPGSHGTTFGGNPVACAAGLAMIEAILADGLMQNALEVGSMMRTAF
EKMAEKHAQILEIRQYGLMIGVTVHREAKYYVEEALKRGVLVNATSNNVIRLLPPLSISKEEAQLCLDTLDAIFTEEAKA

Sequences:

>Translated_400_residues
MNTPAINLETEKQLFFHNYARLPLDIASGKGSFLYTASGERYLDMIAGVGVNAIGYGDKRLEQAITEQASKYIHVSNLFM
QKPQFDLAAKLLEISRMSKVFFCNSGTEAIEAAIKLARRFAARNGDTDKTQVLSLTNCFHGRTYGALSLTAKPKYVDGFE
PLVPETGMIDFNDVEDLERKVSNRTAAVFVEFVQGEGGIHKVSEAFIAKLKELAKEHDFLIVADEIQAGCGRTGAFFSYM
PFDIQPDLVCVAKPLGGGLPLGAIIGSEKVAEVFTPGSHGTTFGGNPVACAAGLAMIEAILADGLMQNALEVGSMMRTAF
EKMAEKHAQILEIRQYGLMIGVTVHREAKYYVEEALKRGVLVNATSNNVIRLLPPLSISKEEAQLCLDTLDAIFTEEAKA
>Mature_400_residues
MNTPAINLETEKQLFFHNYARLPLDIASGKGSFLYTASGERYLDMIAGVGVNAIGYGDKRLEQAITEQASKYIHVSNLFM
QKPQFDLAAKLLEISRMSKVFFCNSGTEAIEAAIKLARRFAARNGDTDKTQVLSLTNCFHGRTYGALSLTAKPKYVDGFE
PLVPETGMIDFNDVEDLERKVSNRTAAVFVEFVQGEGGIHKVSEAFIAKLKELAKEHDFLIVADEIQAGCGRTGAFFSYM
PFDIQPDLVCVAKPLGGGLPLGAIIGSEKVAEVFTPGSHGTTFGGNPVACAAGLAMIEAILADGLMQNALEVGSMMRTAF
EKMAEKHAQILEIRQYGLMIGVTVHREAKYYVEEALKRGVLVNATSNNVIRLLPPLSISKEEAQLCLDTLDAIFTEEAKA

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=392, Percent_Identity=29.0816326530612, Blast_Score=198, Evalue=9e-51,
Organism=Homo sapiens, GI284507298, Length=296, Percent_Identity=31.0810810810811, Blast_Score=165, Evalue=8e-41,
Organism=Homo sapiens, GI13994255, Length=434, Percent_Identity=27.1889400921659, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI226442705, Length=421, Percent_Identity=28.7410926365796, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI37574042, Length=423, Percent_Identity=27.8959810874704, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI24119277, Length=429, Percent_Identity=26.5734265734266, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI226442709, Length=353, Percent_Identity=30.028328611898, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI188536080, Length=441, Percent_Identity=23.5827664399093, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI38679950, Length=441, Percent_Identity=23.5827664399093, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI38679946, Length=441, Percent_Identity=23.5827664399093, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788044, Length=396, Percent_Identity=37.3737373737374, Blast_Score=281, Evalue=6e-77,
Organism=Escherichia coli, GI1789759, Length=382, Percent_Identity=34.0314136125654, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI145693181, Length=380, Percent_Identity=33.9473684210526, Blast_Score=211, Evalue=7e-56,
Organism=Escherichia coli, GI1789016, Length=404, Percent_Identity=28.4653465346535, Blast_Score=177, Evalue=9e-46,
Organism=Escherichia coli, GI1787560, Length=394, Percent_Identity=29.9492385786802, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1786991, Length=415, Percent_Identity=27.2289156626506, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786349, Length=347, Percent_Identity=26.5129682997118, Blast_Score=108, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI25144271, Length=398, Percent_Identity=28.894472361809, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI32564660, Length=427, Percent_Identity=29.2740046838407, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI25144274, Length=267, Percent_Identity=29.2134831460674, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71992977, Length=435, Percent_Identity=25.0574712643678, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71981843, Length=170, Percent_Identity=28.8235294117647, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17541228, Length=435, Percent_Identity=22.9885057471264, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324432, Length=398, Percent_Identity=33.1658291457286, Blast_Score=229, Evalue=5e-61,
Organism=Saccharomyces cerevisiae, GI6323470, Length=409, Percent_Identity=33.0073349633252, Blast_Score=206, Evalue=8e-54,
Organism=Saccharomyces cerevisiae, GI6324386, Length=456, Percent_Identity=25.4385964912281, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6321456, Length=445, Percent_Identity=24.2696629213483, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI21357415, Length=382, Percent_Identity=29.0575916230367, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI28574759, Length=429, Percent_Identity=29.1375291375291, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI161085790, Length=427, Percent_Identity=29.03981264637, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI21356575, Length=417, Percent_Identity=28.537170263789, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI281366494, Length=297, Percent_Identity=25.9259259259259, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24667139, Length=297, Percent_Identity=25.9259259259259, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24667143, Length=297, Percent_Identity=25.9259259259259, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGD_CHLTE (P59316)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_661271.1
- ProteinModelPortal:   P59316
- SMR:   P59316
- GeneID:   1008029
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0367
- NMPDR:   fig|194439.1.peg.365
- TIGR:   CT0367
- HOGENOM:   HBG725944
- OMA:   EFVQGEG
- ProtClustDB:   PRK02627
- BioCyc:   CTEP194439:CT_0367-MONOMER
- BRENDA:   2.6.1.11
- GO:   GO:0005737
- HAMAP:   MF_01107
- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF19
- TIGRFAMs:   TIGR00707

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.11

Molecular weight: Translated: 43549; Mature: 43549

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 139-139 BINDING 142-142 BINDING 281-281 BINDING 282-282

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPAINLETEKQLFFHNYARLPLDIASGKGSFLYTASGERYLDMIAGVGVNAIGYGDKR
CCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCEEEEECCCHHHHHHHCCCCCEECCCHHH
LEQAITEQASKYIHVSNLFMQKPQFDLAAKLLEISRMSKVFFCNSGTEAIEAAIKLARRF
HHHHHHHHHHHEEEHHHHHHCCCCHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHH
AARNGDTDKTQVLSLTNCFHGRTYGALSLTAKPKYVDGFEPLVPETGMIDFNDVEDLERK
HHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
VSNRTAAVFVEFVQGEGGIHKVSEAFIAKLKELAKEHDFLIVADEIQAGCGRTGAFFSYM
HHCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEHHHCCCCCCCCCCCEEC
PFDIQPDLVCVAKPLGGGLPLGAIIGSEKVAEVFTPGSHGTTFGGNPVACAAGLAMIEAI
CCCCCCCEEEEECCCCCCCCHHHHHCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
LADGLMQNALEVGSMMRTAFEKMAEKHAQILEIRQYGLMIGVTVHREAKYYVEEALKRGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEHHHHHHHHHHHHCCE
LVNATSNNVIRLLPPLSISKEEAQLCLDTLDAIFTEEAKA
EEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNTPAINLETEKQLFFHNYARLPLDIASGKGSFLYTASGERYLDMIAGVGVNAIGYGDKR
CCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCEEEEECCCHHHHHHHCCCCCEECCCHHH
LEQAITEQASKYIHVSNLFMQKPQFDLAAKLLEISRMSKVFFCNSGTEAIEAAIKLARRF
HHHHHHHHHHHEEEHHHHHHCCCCHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHH
AARNGDTDKTQVLSLTNCFHGRTYGALSLTAKPKYVDGFEPLVPETGMIDFNDVEDLERK
HHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
VSNRTAAVFVEFVQGEGGIHKVSEAFIAKLKELAKEHDFLIVADEIQAGCGRTGAFFSYM
HHCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEHHHCCCCCCCCCCCEEC
PFDIQPDLVCVAKPLGGGLPLGAIIGSEKVAEVFTPGSHGTTFGGNPVACAAGLAMIEAI
CCCCCCCEEEEECCCCCCCCHHHHHCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
LADGLMQNALEVGSMMRTAFEKMAEKHAQILEIRQYGLMIGVTVHREAKYYVEEALKRGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEHHHHHHHHHHHHCCE
LVNATSNNVIRLLPPLSISKEEAQLCLDTLDAIFTEEAKA
EEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901