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The map label for this gene is uvrD [H]

Identifier: 21673182

GI number: 21673182

Start: 358119

End: 360398

Strand: Direct

Name: uvrD [H]

Synonym: CT0343

Alternate gene names: 21673182

Gene position: 358119-360398 (Clockwise)

Preceding gene: 21673181

Following gene: 21673183

Centisome position: 16.62

GC content: 60.48

Gene sequence:

>2280_bases
GTGTGGGCCGCTAACCTTTTATTTCCAGAAGCTTTGACAGATTTTCTCCAGGGACTCAACGATGTTCAGCGACAGGCCGT
GCTCGCTACCGAAGGCCCCGTGATGGTACTGGCGGGCGCGGGGTCGGGCAAGACTCGCGTCATTACCTACCGCATCGCGC
ACCTCATCCGCAACGTCGGGGTTTTGCCCCAGAACATTCTCGCCCTCACCTTCACCAACAAGGCGGCGGGCGAGATGCGC
CAGCGTATCGACAGCATCCTCGAATATGGCAGCGCCTCCAGCCTCTGGATCGGCACCTTCCACTCGGTGTTCGCGCGGCT
TTTGCGCAGCTACATCCACCTGATCGGCTACGATCGCAACTTCTCGATTTTCGATGCCGACGACAGCAAGAGCCTCATCA
AGCAGTGCATGAAGGAGCTGAACCTGTCGCCCGAAACGCTGCCGGTGAACCTCGTGCACTCGGCCATCAGCAAGGCCAAG
AACAGCTTCGTCCTGCCACCGGAGTTCCATCGCAAGGCGATCGACGACCAGTCGCAGAAGATTTCGCTGGTCTATGAGCG
CTACGTGCACAAGCTGCGCGAGAACAACGCGCTCGATTTCGACGACCTGCTCATCAAGCCTATCGAGCTGTTCACCGAGC
AGCCGCGTGTGCTGGAGCAGTTGCAGGACTATTTCAAGTACCTGCTCATCGACGAGTACCAAGACACCAACCGCGTGCAG
TACCTGGTCGCCAAAATGATCGCCGAAAAGCACCGGAACATCTTCGTCGTTGGCGACGACGCGCAGTCGATCTACTCGTG
GCGCGGGGCGGACATCTCGAACATACTCAACTTCAACGACGATTACGGCGACGCGCAGGTGTTCAAGCTGGTCGATAACT
ACCGCAGCACCAAGACGATTCTGGACGCGGCCAACAGCGTCATCAGCCGCAACACGCACCAGATCAAAAAGGAGCTGGTG
GCCAACGCCGGTATGGGTGAGCCGATCACGCTGATCGAAGCGTTCAACGAAAAGCGCGAGGCCGAAAAGGTGGCCGAGCA
CATCAAGTCGATCCGGCTGTCGAAGGGCGCGCAGTACCGCTCGTTCGCGGTGTTTTACCGCACCAACGCCCAGTCGCGCG
TGATCGAGGACATGATGCGCCAGAACCGCATTCCGTACAAGATTTTCGGCAGCGTGTCGTTCTACAAGCGCAAGGAGATC
AAGGATGCCGTGGCCTACATGCGGCTCGTGCTGAACGACCGTGACAGCGAGTCGCTTCTGCGGGTCATCAACTTTCCGCC
GCGCAAGATTGGCGACGTGAGCATCAACAAGCTCAAGGAGTTCGCCGAGGAACGGAACATTTCGCTCTATGAAGCGGTGA
AGCGCGCGGGTGAGGGGGGCTTCCAGGCGCGGCTCGTCAACGCGCTGACGCAGTTCACTGACCTCATCGAGGCGATGCGG
AAGCAGGCCGAAGAGGGCACCGCCTACGACGTGCTTTCGATGCTCTACGAGACCACCGGCCTGCTCTCGCTCTTGAAGGA
GGAGAACACGCCCGAAGCGCTTGCGCGGCACGAGAACCTTCAGGAGCTGCTCTCGATGACGCGCGACTTTGCCGACCACA
ATCCCAATTCGGCCACGCTCGGCGACTTCCTCTCGACCATCTCGCTCGCCTCGGACTACGACGAAACACAGGAGTCGGAT
AACTACGTCTCGCTCATGACGGTGCACGCGGCGAAGGGTCTTGAATTTCCGGTGGTGTTCGTCACCGGCATGGAGGAGAA
GCTGTTCCCGCTCAACAGCTACGAACCGGGCGAACTGGAGGAGGAGCGGCGGCTCTTCTACGTGGCGATCACCCGAGCGC
GCGAAAAGCTGTTCCTCTCGTGGGCGCAGAGCCGCTATATGTATGGCCAGCCGCAGATGTGCATGCGCTCGACCTTCATC
AACGAAATCAACCCCAACATTATCGTCACCGAAGGGGGGCGCAAGCTCTCCGAAAGCCCGAAAAAGGTCGCTGCGACGGC
GATGGCCGGACGCCCGGTCTTCGGCTCGTCGCTGAGGCCTCAGCCGGGGGGCAGCCCGGCGGCAAAGGTGCCGACCGTCA
AACCCGCCGGATCGGCGCGTCCCACCGGCGCGGCCAAAAGCGAGTACCGCCCGGGCACCAGAGTGCAGCACGCTATCTTC
GGCCCCGGCACCGTGCTCGAAGTGCAGGGCAGTGGGGCGAAGCAGAAGGTCAAGATCAACTTCCGCACCGCCGGCGAAAA
AACGCTGATGGTGCAGTACGCCAATCTGAAGATCGTGTGA

Upstream 100 bases:

>100_bases
GGTTTGAGGACGTTTTTTTCTAATGTCAGCGTTGGTATTCGAGTCCGGATGTGCGAAATTCTTCTGAGCTTTGTGATGGC
TTGCCGATCCCCAGCCGGGA

Downstream 100 bases:

>100_bases
TGAACGCTGCCTGACGGGATGCTTCGCTCTGCTCAGCATGACAAAGGCGCAGCATCCGGGAGCGACGCCGGTTGATTTAT
CCTTCACCCGCTACGTCCAC

Product: DNA helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 759; Mature: 759

Protein sequence:

>759_residues
MWAANLLFPEALTDFLQGLNDVQRQAVLATEGPVMVLAGAGSGKTRVITYRIAHLIRNVGVLPQNILALTFTNKAAGEMR
QRIDSILEYGSASSLWIGTFHSVFARLLRSYIHLIGYDRNFSIFDADDSKSLIKQCMKELNLSPETLPVNLVHSAISKAK
NSFVLPPEFHRKAIDDQSQKISLVYERYVHKLRENNALDFDDLLIKPIELFTEQPRVLEQLQDYFKYLLIDEYQDTNRVQ
YLVAKMIAEKHRNIFVVGDDAQSIYSWRGADISNILNFNDDYGDAQVFKLVDNYRSTKTILDAANSVISRNTHQIKKELV
ANAGMGEPITLIEAFNEKREAEKVAEHIKSIRLSKGAQYRSFAVFYRTNAQSRVIEDMMRQNRIPYKIFGSVSFYKRKEI
KDAVAYMRLVLNDRDSESLLRVINFPPRKIGDVSINKLKEFAEERNISLYEAVKRAGEGGFQARLVNALTQFTDLIEAMR
KQAEEGTAYDVLSMLYETTGLLSLLKEENTPEALARHENLQELLSMTRDFADHNPNSATLGDFLSTISLASDYDETQESD
NYVSLMTVHAAKGLEFPVVFVTGMEEKLFPLNSYEPGELEEERRLFYVAITRAREKLFLSWAQSRYMYGQPQMCMRSTFI
NEINPNIIVTEGGRKLSESPKKVAATAMAGRPVFGSSLRPQPGGSPAAKVPTVKPAGSARPTGAAKSEYRPGTRVQHAIF
GPGTVLEVQGSGAKQKVKINFRTAGEKTLMVQYANLKIV

Sequences:

>Translated_759_residues
MWAANLLFPEALTDFLQGLNDVQRQAVLATEGPVMVLAGAGSGKTRVITYRIAHLIRNVGVLPQNILALTFTNKAAGEMR
QRIDSILEYGSASSLWIGTFHSVFARLLRSYIHLIGYDRNFSIFDADDSKSLIKQCMKELNLSPETLPVNLVHSAISKAK
NSFVLPPEFHRKAIDDQSQKISLVYERYVHKLRENNALDFDDLLIKPIELFTEQPRVLEQLQDYFKYLLIDEYQDTNRVQ
YLVAKMIAEKHRNIFVVGDDAQSIYSWRGADISNILNFNDDYGDAQVFKLVDNYRSTKTILDAANSVISRNTHQIKKELV
ANAGMGEPITLIEAFNEKREAEKVAEHIKSIRLSKGAQYRSFAVFYRTNAQSRVIEDMMRQNRIPYKIFGSVSFYKRKEI
KDAVAYMRLVLNDRDSESLLRVINFPPRKIGDVSINKLKEFAEERNISLYEAVKRAGEGGFQARLVNALTQFTDLIEAMR
KQAEEGTAYDVLSMLYETTGLLSLLKEENTPEALARHENLQELLSMTRDFADHNPNSATLGDFLSTISLASDYDETQESD
NYVSLMTVHAAKGLEFPVVFVTGMEEKLFPLNSYEPGELEEERRLFYVAITRAREKLFLSWAQSRYMYGQPQMCMRSTFI
NEINPNIIVTEGGRKLSESPKKVAATAMAGRPVFGSSLRPQPGGSPAAKVPTVKPAGSARPTGAAKSEYRPGTRVQHAIF
GPGTVLEVQGSGAKQKVKINFRTAGEKTLMVQYANLKIV
>Mature_759_residues
MWAANLLFPEALTDFLQGLNDVQRQAVLATEGPVMVLAGAGSGKTRVITYRIAHLIRNVGVLPQNILALTFTNKAAGEMR
QRIDSILEYGSASSLWIGTFHSVFARLLRSYIHLIGYDRNFSIFDADDSKSLIKQCMKELNLSPETLPVNLVHSAISKAK
NSFVLPPEFHRKAIDDQSQKISLVYERYVHKLRENNALDFDDLLIKPIELFTEQPRVLEQLQDYFKYLLIDEYQDTNRVQ
YLVAKMIAEKHRNIFVVGDDAQSIYSWRGADISNILNFNDDYGDAQVFKLVDNYRSTKTILDAANSVISRNTHQIKKELV
ANAGMGEPITLIEAFNEKREAEKVAEHIKSIRLSKGAQYRSFAVFYRTNAQSRVIEDMMRQNRIPYKIFGSVSFYKRKEI
KDAVAYMRLVLNDRDSESLLRVINFPPRKIGDVSINKLKEFAEERNISLYEAVKRAGEGGFQARLVNALTQFTDLIEAMR
KQAEEGTAYDVLSMLYETTGLLSLLKEENTPEALARHENLQELLSMTRDFADHNPNSATLGDFLSTISLASDYDETQESD
NYVSLMTVHAAKGLEFPVVFVTGMEEKLFPLNSYEPGELEEERRLFYVAITRAREKLFLSWAQSRYMYGQPQMCMRSTFI
NEINPNIIVTEGGRKLSESPKKVAATAMAGRPVFGSSLRPQPGGSPAAKVPTVKPAGSARPTGAAKSEYRPGTRVQHAIF
GPGTVLEVQGSGAKQKVKINFRTAGEKTLMVQYANLKIV

Specific function: Essential helicase. May act as a helicase in plasmid pT181 replication [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=752, Percent_Identity=36.7021276595745, Blast_Score=476, Evalue=1e-135,
Organism=Escherichia coli, GI48994965, Length=663, Percent_Identity=37.8582202111614, Blast_Score=400, Evalue=1e-112,
Organism=Escherichia coli, GI1787196, Length=356, Percent_Identity=25.8426966292135, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6322369, Length=742, Percent_Identity=28.167115902965, Blast_Score=226, Evalue=9e-60,
Organism=Saccharomyces cerevisiae, GI6324477, Length=652, Percent_Identity=22.239263803681, Blast_Score=107, Evalue=8e-24,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 85550; Mature: 85550

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWAANLLFPEALTDFLQGLNDVQRQAVLATEGPVMVLAGAGSGKTRVITYRIAHLIRNVG
CCCCHHCCHHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCCCEEEHHHHHHHHHHHCC
VLPQNILALTFTNKAAGEMRQRIDSILEYGSASSLWIGTFHSVFARLLRSYIHLIGYDRN
CCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCC
FSIFDADDSKSLIKQCMKELNLSPETLPVNLVHSAISKAKNSFVLPPEFHRKAIDDQSQK
CEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCHHH
ISLVYERYVHKLRENNALDFDDLLIKPIELFTEQPRVLEQLQDYFKYLLIDEYQDTNRVQ
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHH
YLVAKMIAEKHRNIFVVGDDAQSIYSWRGADISNILNFNDDYGDAQVFKLVDNYRSTKTI
HHHHHHHHHHCCCEEEEECCHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
LDAANSVISRNTHQIKKELVANAGMGEPITLIEAFNEKREAEKVAEHIKSIRLSKGAQYR
HHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SFAVFYRTNAQSRVIEDMMRQNRIPYKIFGSVSFYKRKEIKDAVAYMRLVLNDRDSESLL
EEEEEEECCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
RVINFPPRKIGDVSINKLKEFAEERNISLYEAVKRAGEGGFQARLVNALTQFTDLIEAMR
HHHCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
KQAEEGTAYDVLSMLYETTGLLSLLKEENTPEALARHENLQELLSMTRDFADHNPNSATL
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
GDFLSTISLASDYDETQESDNYVSLMTVHAAKGLEFPVVFVTGMEEKLFPLNSYEPGELE
HHHHHHHHHHHCCHHHHCCCCEEEEEEEEHHCCCCCCEEEEECCCHHCCCCCCCCCCCCH
EERRLFYVAITRAREKLFLSWAQSRYMYGQPQMCMRSTFINEINPNIIVTEGGRKLSESP
HHCEEEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCH
KKVAATAMAGRPVFGSSLRPQPGGSPAAKVPTVKPAGSARPTGAAKSEYRPGTRVQHAIF
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
GPGTVLEVQGSGAKQKVKINFRTAGEKTLMVQYANLKIV
CCCEEEEEECCCCCEEEEEEEEECCCEEEEEEECCEEEC
>Mature Secondary Structure
MWAANLLFPEALTDFLQGLNDVQRQAVLATEGPVMVLAGAGSGKTRVITYRIAHLIRNVG
CCCCHHCCHHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCCCEEEHHHHHHHHHHHCC
VLPQNILALTFTNKAAGEMRQRIDSILEYGSASSLWIGTFHSVFARLLRSYIHLIGYDRN
CCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCC
FSIFDADDSKSLIKQCMKELNLSPETLPVNLVHSAISKAKNSFVLPPEFHRKAIDDQSQK
CEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCHHH
ISLVYERYVHKLRENNALDFDDLLIKPIELFTEQPRVLEQLQDYFKYLLIDEYQDTNRVQ
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHH
YLVAKMIAEKHRNIFVVGDDAQSIYSWRGADISNILNFNDDYGDAQVFKLVDNYRSTKTI
HHHHHHHHHHCCCEEEEECCHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
LDAANSVISRNTHQIKKELVANAGMGEPITLIEAFNEKREAEKVAEHIKSIRLSKGAQYR
HHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SFAVFYRTNAQSRVIEDMMRQNRIPYKIFGSVSFYKRKEIKDAVAYMRLVLNDRDSESLL
EEEEEEECCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
RVINFPPRKIGDVSINKLKEFAEERNISLYEAVKRAGEGGFQARLVNALTQFTDLIEAMR
HHHCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
KQAEEGTAYDVLSMLYETTGLLSLLKEENTPEALARHENLQELLSMTRDFADHNPNSATL
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
GDFLSTISLASDYDETQESDNYVSLMTVHAAKGLEFPVVFVTGMEEKLFPLNSYEPGELE
HHHHHHHHHHHCCHHHHCCCCEEEEEEEEHHCCCCCCEEEEECCCHHCCCCCCCCCCCCH
EERRLFYVAITRAREKLFLSWAQSRYMYGQPQMCMRSTFINEINPNIIVTEGGRKLSESP
HHCEEEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCH
KKVAATAMAGRPVFGSSLRPQPGGSPAAKVPTVKPAGSARPTGAAKSEYRPGTRVQHAIF
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
GPGTVLEVQGSGAKQKVKINFRTAGEKTLMVQYANLKIV
CCCEEEEEECCCCCEEEEEEEEECCCEEEEEEECCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8232203 [H]