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The map label for this gene is pyrE [H]

Identifier: 21672924

GI number: 21672924

Start: 78362

End: 78919

Strand: Direct

Name: pyrE [H]

Synonym: CT0083

Alternate gene names: 21672924

Gene position: 78362-78919 (Clockwise)

Preceding gene: 21672923

Following gene: 21672925

Centisome position: 3.64

GC content: 62.01

Gene sequence:

>558_bases
ATGTTCAAGTCGAGCGGCGCCTTGCTCGATGGCCATTTCCGGCTCACTTCTGGCCGCCACAGCAACTCCTATTTCCAGTG
CGCCAAGGTGCTGCAATACCCGGAATATCTTTCGGCGATCTGCGGCCAAATCGCCGGATTTTTCAGGGAGAGCGGCATCA
CGACGGTCATTTCGCCCGCCATTGGCGGCATCGTCGTCGGCACGGAGGTCGGTCGGCAGCTTGGCGTCAAGACTATCTTC
GCCGAACGCAAAGAGGGTGCGATGATGATCCGGCGCGGCTTCTCCATCGATCCCTCCGAGCAGGTGCTGGTGGTCGAGGA
TGTAATCACCACCGGTGGCTCCGTCGCCGAGGTGATCGAGCTGGTCAAGGCCGCCGGAGCGACTGTGGCCGGAGTCGCCT
CGGTAGTTGACCGTAGCAACGGCAAGGTACGGCTGGCGGACAAGCAGTTCTCGCTGCTCACGATGGAGGTGGTCAGCTAC
GCGCCGGAGGAGTGCCCGCTCTGCAAGGAGGAAATCCCGATTTACGCGCCGGGCAGCCGAACCAATCCCCAGTGCTGA

Upstream 100 bases:

>100_bases
TCTTTATCGTTAGGTGTCTGGTGTTTGCGGATACCCGGAATTTCCTTTTTCACGCATCATTGACCGATTTTTCCTCATGA
CCAATTCGGAAACCCTCGCG

Downstream 100 bases:

>100_bases
GCAGCCAGATGCAGCAGGGCATCCACACCATTTCGTTCGTCGGACTCGGGCTTATCGGCGCCTCGCTGATGCAGGCGCTC
AAGCGCGCTGCCGGGGCGAC

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MFKSSGALLDGHFRLTSGRHSNSYFQCAKVLQYPEYLSAICGQIAGFFRESGITTVISPAIGGIVVGTEVGRQLGVKTIF
AERKEGAMMIRRGFSIDPSEQVLVVEDVITTGGSVAEVIELVKAAGATVAGVASVVDRSNGKVRLADKQFSLLTMEVVSY
APEECPLCKEEIPIYAPGSRTNPQC

Sequences:

>Translated_185_residues
MFKSSGALLDGHFRLTSGRHSNSYFQCAKVLQYPEYLSAICGQIAGFFRESGITTVISPAIGGIVVGTEVGRQLGVKTIF
AERKEGAMMIRRGFSIDPSEQVLVVEDVITTGGSVAEVIELVKAAGATVAGVASVVDRSNGKVRLADKQFSLLTMEVVSY
APEECPLCKEEIPIYAPGSRTNPQC
>Mature_185_residues
MFKSSGALLDGHFRLTSGRHSNSYFQCAKVLQYPEYLSAICGQIAGFFRESGITTVISPAIGGIVVGTEVGRQLGVKTIF
AERKEGAMMIRRGFSIDPSEQVLVVEDVITTGGSVAEVIELVKAAGATVAGVASVVDRSNGKVRLADKQFSLLTMEVVSY
APEECPLCKEEIPIYAPGSRTNPQC

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 19750; Mature: 19750

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKSSGALLDGHFRLTSGRHSNSYFQCAKVLQYPEYLSAICGQIAGFFRESGITTVISPA
CCCCCCCEEECEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEHHC
IGGIVVGTEVGRQLGVKTIFAERKEGAMMIRRGFSIDPSEQVLVVEDVITTGGSVAEVIE
CCCEEECHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCEEEEEHHHHCCCCHHHHHH
LVKAAGATVAGVASVVDRSNGKVRLADKQFSLLTMEVVSYAPEECPLCKEEIPIYAPGSR
HHHHCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCHHCCCEECCCCC
TNPQC
CCCCC
>Mature Secondary Structure
MFKSSGALLDGHFRLTSGRHSNSYFQCAKVLQYPEYLSAICGQIAGFFRESGITTVISPA
CCCCCCCEEECEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEHHC
IGGIVVGTEVGRQLGVKTIFAERKEGAMMIRRGFSIDPSEQVLVVEDVITTGGSVAEVIE
CCCEEECHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCEEEEEHHHHCCCCHHHHHH
LVKAAGATVAGVASVVDRSNGKVRLADKQFSLLTMEVVSYAPEECPLCKEEIPIYAPGSR
HHHHCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCHHCCCEECCCCC
TNPQC
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA