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The map label for this gene is cysC

Identifier: 21672679

GI number: 21672679

Start: 458652

End: 459287

Strand: Reverse

Name: cysC

Synonym: BUsg407

Alternate gene names: 21672679

Gene position: 459287-458652 (Counterclockwise)

Preceding gene: 21672680

Following gene: 21672678

Centisome position: 71.6

GC content: 23.11

Gene sequence:

>636_bases
ATGCATAATAATTCAAAAAAAAATATTATTTGGCAAAAACATTCGGTAACACGTATTAAACGTGAGCAAAAAAATGGTCA
TAAATCTATAGTAATATGGTTTACAGGATTATCAGGATCAGGAAAATCTAGTATTGCTAATTCTTTAGAAGAAATACTTT
TTCAAAATAATTTTAATACTTATCTATTAGATGGTGATAATATTAGATCTAGTTTATGTTCTGATTTAAGTTTTAGTATT
TTAGATAGGAATGAAAATATTAGACGTATTGGAGAAGTATCAAAACTTATGATAGATGCAGGAATAATAGTATTAGTTTC
AGTTATTTCTCCTTATAGAAATCAAAGAAAAAAAATTCGTTTAATGTTAGGAAAAATAAATTTTTTGGAAGTTTTCGTTG
ATACTCCATTAAATATATGTGAAGAACGTGATCCTAAAAAATTATATCAAAAATCTCGTCTTGGTAAAATATCTGATTTG
ACTGGTATTCAATCTTTATATGAAATTCCAGAAAAACCAGATTTACATTTAGATGAAACAATATCTTTAAAAAATAATAC
AAAAAAATTAATTCACATATTATGTGATAAAAATATCATATCTTTTCCAAATATTGATGAAACATTTTTATTTTAA

Upstream 100 bases:

>100_bases
AAAAATACAAAAGGTTTCGAATCAGATCTGTATAATTTAATATTAAAATATTTTCCATATTGGCAAATAAAAAAATAAAA
CATAAGGTTCTTTATTAAAA

Downstream 100 bases:

>100_bases
ATAAAACTATTTCGAGTAATATATGAAAATGTTAAAAATATTTTTACTGTTTTTGTTGTTTTGGTTGCAATGCTCTCTTT
GGATTGGAAAAAATGGTATT

Product: adenylylsulfate kinase

Products: NA

Alternate protein names: APS kinase; ATP adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenosine-5'-phosphosulfate kinase

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MHNNSKKNIIWQKHSVTRIKREQKNGHKSIVIWFTGLSGSGKSSIANSLEEILFQNNFNTYLLDGDNIRSSLCSDLSFSI
LDRNENIRRIGEVSKLMIDAGIIVLVSVISPYRNQRKKIRLMLGKINFLEVFVDTPLNICEERDPKKLYQKSRLGKISDL
TGIQSLYEIPEKPDLHLDETISLKNNTKKLIHILCDKNIISFPNIDETFLF

Sequences:

>Translated_211_residues
MHNNSKKNIIWQKHSVTRIKREQKNGHKSIVIWFTGLSGSGKSSIANSLEEILFQNNFNTYLLDGDNIRSSLCSDLSFSI
LDRNENIRRIGEVSKLMIDAGIIVLVSVISPYRNQRKKIRLMLGKINFLEVFVDTPLNICEERDPKKLYQKSRLGKISDL
TGIQSLYEIPEKPDLHLDETISLKNNTKKLIHILCDKNIISFPNIDETFLF
>Mature_211_residues
MHNNSKKNIIWQKHSVTRIKREQKNGHKSIVIWFTGLSGSGKSSIANSLEEILFQNNFNTYLLDGDNIRSSLCSDLSFSI
LDRNENIRRIGEVSKLMIDAGIIVLVSVISPYRNQRKKIRLMLGKINFLEVFVDTPLNICEERDPKKLYQKSRLGKISDL
TGIQSLYEIPEKPDLHLDETISLKNNTKKLIHILCDKNIISFPNIDETFLF

Specific function: Catalyzes the synthesis of activated sulfate

COG id: COG0529

COG function: function code P; Adenylylsulfate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the APS kinase family

Homologues:

Organism=Homo sapiens, GI46094058, Length=200, Percent_Identity=43, Blast_Score=175, Evalue=3e-44,
Organism=Homo sapiens, GI34447231, Length=202, Percent_Identity=43.0693069306931, Blast_Score=173, Evalue=9e-44,
Organism=Homo sapiens, GI62912492, Length=202, Percent_Identity=43.0693069306931, Blast_Score=173, Evalue=9e-44,
Organism=Escherichia coli, GI1789107, Length=194, Percent_Identity=52.0618556701031, Blast_Score=229, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17542422, Length=177, Percent_Identity=46.3276836158192, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6322852, Length=172, Percent_Identity=50.5813953488372, Blast_Score=170, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24667032, Length=200, Percent_Identity=43, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24667028, Length=200, Percent_Identity=43, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24667036, Length=200, Percent_Identity=43, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI116007838, Length=200, Percent_Identity=43, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24667044, Length=200, Percent_Identity=43, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24667040, Length=200, Percent_Identity=43, Blast_Score=166, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYSC_BUCAP (Q8K9D4)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660746.1
- ProteinModelPortal:   Q8K9D4
- SMR:   Q8K9D4
- EnsemblBacteria:   EBBUCT00000000194
- GeneID:   1005753
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg407
- GeneTree:   EBGT00050000007848
- HOGENOM:   HBG309946
- OMA:   ITITAFV
- ProtClustDB:   CLSK341926
- BioCyc:   BAPH198804:BUSG407-MONOMER
- HAMAP:   MF_00065
- InterPro:   IPR002891
- TIGRFAMs:   TIGR00455

Pfam domain/function: PF01583 APS_kinase

EC number: =2.7.1.25

Molecular weight: Translated: 24288; Mature: 24288

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS00761 SPASE_I_3

Important sites: ACT_SITE 110-110

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNNSKKNIIWQKHSVTRIKREQKNGHKSIVIWFTGLSGSGKSSIANSLEEILFQNNFNT
CCCCCCCCEEEECHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCE
YLLDGDNIRSSLCSDLSFSILDRNENIRRIGEVSKLMIDAGIIVLVSVISPYRNQRKKIR
EEEECCHHHHHHHHHCHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMLGKINFLEVFVDTPLNICEERDPKKLYQKSRLGKISDLTGIQSLYEIPEKPDLHLDET
HHHCCCCEEEEEECCCHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCE
ISLKNNTKKLIHILCDKNIISFPNIDETFLF
EECCCCHHHHHHHHHCCCCCCCCCCCHHHCC
>Mature Secondary Structure
MHNNSKKNIIWQKHSVTRIKREQKNGHKSIVIWFTGLSGSGKSSIANSLEEILFQNNFNT
CCCCCCCCEEEECHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCE
YLLDGDNIRSSLCSDLSFSILDRNENIRRIGEVSKLMIDAGIIVLVSVISPYRNQRKKIR
EEEECCHHHHHHHHHCHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMLGKINFLEVFVDTPLNICEERDPKKLYQKSRLGKISDLTGIQSLYEIPEKPDLHLDET
HHHCCCCEEEEEECCCHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCE
ISLKNNTKKLIHILCDKNIISFPNIDETFLF
EECCCCHHHHHHHHHCCCCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438