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The map label for this gene is pepA

Identifier: 21672630

GI number: 21672630

Start: 405137

End: 406645

Strand: Reverse

Name: pepA

Synonym: BUsg355

Alternate gene names: 21672630

Gene position: 406645-405137 (Counterclockwise)

Preceding gene: 21672635

Following gene: 21672629

Centisome position: 63.39

GC content: 26.57

Gene sequence:

>1509_bases
ATGAAATTTTTTATAAAAAATGTTCTTTTAGAAGAAGAAAAAAGTGATTGTATTGTAATTGGCGTTTTTGAATTTTGTGA
ATTTAAATATTCAAACAATTATTTAAATAAATCTATTTGTAGTTATATTAATAATTTTATTAAAAAAGGTGATATGCAAG
GAAAAGTAGGTGAAACACTTTTATTGTATGATGTTCCTAATGTTGTTTCTAAAAGAATACTACTCGTAGGATGCGGTAAA
AAAAATAGATTAAATAGATATTATCTTGATAAGATCATAAATAAAAGTATGAAAATTTTAAATAAATTTTCTATTAAAAA
TATTATTTTTTCTTTAACTGAAATAAATATTGAAAATTATGATATATATTGGTCGATTAGGACAATAGTTAATTCTATCA
ATAAATATTTATATAAAAATTTTAAGATAAATGCTTTTTTAAAAAAAGAGGTTTATTTAAATTCAATTTCATTTCATATA
ATAGAAAAAAAAGATTTTCATATAGCAAATAATTCTTTAAAACATGCTTTAGCAATTAATTCTGGCATTACAGCTGCAAA
AAATTTAGCTGATTTACCACCTAATATTTGTAATCCATTATACTTATCTTTACAAGCTCAAAAATTATCTGAAAAATATA
AAGATAAAATCCATGTTACATCTATTGACATTAAAGAAATGAATAATTTAGGTATGAACGCCTATGTGGCAGTTGGAAAG
GGATCTAAAAATAAACCGTATATGTCTGTAATCAAATATTCTGGAATAAATAATACTGAACAAGAAAAAATTATTGTATT
AATAGGAAAGGGATTAACATTTGATTCTGGAGGTATATCTATTAAACCGTCTAACAATATGAATGAAATGAAGTATGACA
TGTGCGGTGCTGCGGCAGTATATGGCACTTTAATTGCTGCAGCTAAATTAAATTTACCACTAACTATTATAGGTATTTTA
GCAGGTTGTGAAAATATGCCAGGAGGAAATGCATTTAGACCTGGTGATATTATAACTACGATGTCAGGTAAAACAGTAGA
AATATTAAATACTGATGCTGAAGGACGTTTAGTTTTATGTGATGTTTTAACATATGTACAGCGTTTTTCTCCAAACATAG
TTATTGATATTGCTACCTTAACTGGAGCATGTGTTGTCGCATTAGGAAATCATTTTAGCGGTCTTTTTTCAAACGATGAT
CAACTTGCTTATGCATTAGAAAAATCATCAAGACAAACTAACGATAAAATATGGCGTTTGCCTCTATCTTTAGAATATGA
AAAAGAGTTACATTCTAATTTTGCGGATCTTTCAAATGTTGGAAGAGGTAAAGCAGGTGCAATAACTGCTTCTTGTTTTC
TTGCTCAATTTTCGAAAAAATATACTTGGGCTCATTTAGATATTGCTGGAACTGCTTGGAAATCTGGTAAAAATCACGGT
GCAACAGGTCGTCCTGTTGAACTATTAAGTCAATTTTTATTAAATGAATCTAATTTTTTAAAATTTTAA

Upstream 100 bases:

>100_bases
TTATATAGTATATAATATTTTTTTATATTTTATTTATTTTTTTAATAAATAAAAAGTATAATTAACTAACAACTTTGATT
ATGTTTTTTGAGAAAAAATT

Downstream 100 bases:

>100_bases
ATAATATAAAAAAATTTATTTTTTTGATGCAGCAATATTGCTATTTTTTAAATCATAAATACAGTTGAATATAATGAAAA
AAAATTATAACCCTAAAGAT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MKFFIKNVLLEEEKSDCIVIGVFEFCEFKYSNNYLNKSICSYINNFIKKGDMQGKVGETLLLYDVPNVVSKRILLVGCGK
KNRLNRYYLDKIINKSMKILNKFSIKNIIFSLTEINIENYDIYWSIRTIVNSINKYLYKNFKINAFLKKEVYLNSISFHI
IEKKDFHIANNSLKHALAINSGITAAKNLADLPPNICNPLYLSLQAQKLSEKYKDKIHVTSIDIKEMNNLGMNAYVAVGK
GSKNKPYMSVIKYSGINNTEQEKIIVLIGKGLTFDSGGISIKPSNNMNEMKYDMCGAAAVYGTLIAAAKLNLPLTIIGIL
AGCENMPGGNAFRPGDIITTMSGKTVEILNTDAEGRLVLCDVLTYVQRFSPNIVIDIATLTGACVVALGNHFSGLFSNDD
QLAYALEKSSRQTNDKIWRLPLSLEYEKELHSNFADLSNVGRGKAGAITASCFLAQFSKKYTWAHLDIAGTAWKSGKNHG
ATGRPVELLSQFLLNESNFLKF

Sequences:

>Translated_502_residues
MKFFIKNVLLEEEKSDCIVIGVFEFCEFKYSNNYLNKSICSYINNFIKKGDMQGKVGETLLLYDVPNVVSKRILLVGCGK
KNRLNRYYLDKIINKSMKILNKFSIKNIIFSLTEINIENYDIYWSIRTIVNSINKYLYKNFKINAFLKKEVYLNSISFHI
IEKKDFHIANNSLKHALAINSGITAAKNLADLPPNICNPLYLSLQAQKLSEKYKDKIHVTSIDIKEMNNLGMNAYVAVGK
GSKNKPYMSVIKYSGINNTEQEKIIVLIGKGLTFDSGGISIKPSNNMNEMKYDMCGAAAVYGTLIAAAKLNLPLTIIGIL
AGCENMPGGNAFRPGDIITTMSGKTVEILNTDAEGRLVLCDVLTYVQRFSPNIVIDIATLTGACVVALGNHFSGLFSNDD
QLAYALEKSSRQTNDKIWRLPLSLEYEKELHSNFADLSNVGRGKAGAITASCFLAQFSKKYTWAHLDIAGTAWKSGKNHG
ATGRPVELLSQFLLNESNFLKF
>Mature_502_residues
MKFFIKNVLLEEEKSDCIVIGVFEFCEFKYSNNYLNKSICSYINNFIKKGDMQGKVGETLLLYDVPNVVSKRILLVGCGK
KNRLNRYYLDKIINKSMKILNKFSIKNIIFSLTEINIENYDIYWSIRTIVNSINKYLYKNFKINAFLKKEVYLNSISFHI
IEKKDFHIANNSLKHALAINSGITAAKNLADLPPNICNPLYLSLQAQKLSEKYKDKIHVTSIDIKEMNNLGMNAYVAVGK
GSKNKPYMSVIKYSGINNTEQEKIIVLIGKGLTFDSGGISIKPSNNMNEMKYDMCGAAAVYGTLIAAAKLNLPLTIIGIL
AGCENMPGGNAFRPGDIITTMSGKTVEILNTDAEGRLVLCDVLTYVQRFSPNIVIDIATLTGACVVALGNHFSGLFSNDD
QLAYALEKSSRQTNDKIWRLPLSLEYEKELHSNFADLSNVGRGKAGAITASCFLAQFSKKYTWAHLDIAGTAWKSGKNHG
ATGRPVELLSQFLLNESNFLKF

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=326, Percent_Identity=41.7177914110429, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI47155554, Length=384, Percent_Identity=30.46875, Blast_Score=146, Evalue=5e-35,
Organism=Escherichia coli, GI1790710, Length=501, Percent_Identity=51.8962075848303, Blast_Score=546, Evalue=1e-156,
Organism=Escherichia coli, GI87082123, Length=278, Percent_Identity=43.1654676258993, Blast_Score=199, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17556903, Length=310, Percent_Identity=32.258064516129, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17565172, Length=176, Percent_Identity=30.1136363636364, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24661038, Length=499, Percent_Identity=28.8577154308617, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI21355725, Length=367, Percent_Identity=31.8801089918256, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI161077148, Length=318, Percent_Identity=34.9056603773585, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI20130057, Length=318, Percent_Identity=34.9056603773585, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI20129969, Length=317, Percent_Identity=33.1230283911672, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI20129963, Length=317, Percent_Identity=34.0694006309148, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24662227, Length=319, Percent_Identity=31.974921630094, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI21355645, Length=319, Percent_Identity=30.7210031347962, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24662223, Length=319, Percent_Identity=30.7210031347962, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI19922386, Length=319, Percent_Identity=32.2884012539185, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI221379063, Length=319, Percent_Identity=34.7962382445141, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI221379062, Length=319, Percent_Identity=34.7962382445141, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI21357381, Length=320, Percent_Identity=34.6875, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646701, Length=363, Percent_Identity=24.2424242424242, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24646703, Length=363, Percent_Identity=24.2424242424242, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21358201, Length=363, Percent_Identity=24.2424242424242, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_BUCAP (Q8K9I0)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660697.1
- ProteinModelPortal:   Q8K9I0
- SMR:   Q8K9I0
- MEROPS:   M17.003
- EnsemblBacteria:   EBBUCT00000000382
- GeneID:   1005800
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg355
- GeneTree:   EBGT00050000008030
- HOGENOM:   HBG742580
- OMA:   LGHHISG
- ProtClustDB:   PRK00913
- BioCyc:   BAPH198804:BUSG355-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 56042; Mature: 56042

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 282-282 ACT_SITE 356-356

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFFIKNVLLEEEKSDCIVIGVFEFCEFKYSNNYLNKSICSYINNFIKKGDMQGKVGETL
CCHHHHHHHHCCCCCCEEEEEEHHHHEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEE
LLYDVPNVVSKRILLVGCGKKNRLNRYYLDKIINKSMKILNKFSIKNIIFSLTEINIENY
EEEECCHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEHEEECEECE
DIYWSIRTIVNSINKYLYKNFKINAFLKKEVYLNSISFHIIEKKDFHIANNSLKHALAIN
EEEEEHHHHHHHHHHHHHHCCEEEEEEEEEEEEEEEEEEEEECCCEEECCCCCCEEEEEC
SGITAAKNLADLPPNICNPLYLSLQAQKLSEKYKDKIHVTSIDIKEMNNLGMNAYVAVGK
CCCCHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHCEEEEEEEEHHHHCCCCCEEEEEECC
GSKNKPYMSVIKYSGINNTEQEKIIVLIGKGLTFDSGGISIKPSNNMNEMKYDMCGAAAV
CCCCCCCEEEEEECCCCCCCCCEEEEEEECCEEECCCCEEECCCCCCCHHHHHHHHHHHH
YGTLIAAAKLNLPLTIIGILAGCENMPGGNAFRPGDIITTMSGKTVEILNTDAEGRLVLC
HHHHHHHHHCCCCCEEEHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEHH
DVLTYVQRFSPNIVIDIATLTGACVVALGNHFSGLFSNDDQLAYALEKSSRQTNDKIWRL
HHHHHHHHCCCCEEEEEEHHHCCHHEECCCCCCCCCCCCCCEEEEEHHHCCCCCCCEEEE
PLSLEYEKELHSNFADLSNVGRGKAGAITASCFLAQFSKKYTWAHLDIAGTAWKSGKNHG
CCCEEHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCC
ATGRPVELLSQFLLNESNFLKF
CCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKFFIKNVLLEEEKSDCIVIGVFEFCEFKYSNNYLNKSICSYINNFIKKGDMQGKVGETL
CCHHHHHHHHCCCCCCEEEEEEHHHHEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEE
LLYDVPNVVSKRILLVGCGKKNRLNRYYLDKIINKSMKILNKFSIKNIIFSLTEINIENY
EEEECCHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEHEEECEECE
DIYWSIRTIVNSINKYLYKNFKINAFLKKEVYLNSISFHIIEKKDFHIANNSLKHALAIN
EEEEEHHHHHHHHHHHHHHCCEEEEEEEEEEEEEEEEEEEEECCCEEECCCCCCEEEEEC
SGITAAKNLADLPPNICNPLYLSLQAQKLSEKYKDKIHVTSIDIKEMNNLGMNAYVAVGK
CCCCHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHCEEEEEEEEHHHHCCCCCEEEEEECC
GSKNKPYMSVIKYSGINNTEQEKIIVLIGKGLTFDSGGISIKPSNNMNEMKYDMCGAAAV
CCCCCCCEEEEEECCCCCCCCCEEEEEEECCEEECCCCEEECCCCCCCHHHHHHHHHHHH
YGTLIAAAKLNLPLTIIGILAGCENMPGGNAFRPGDIITTMSGKTVEILNTDAEGRLVLC
HHHHHHHHHCCCCCEEEHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEHH
DVLTYVQRFSPNIVIDIATLTGACVVALGNHFSGLFSNDDQLAYALEKSSRQTNDKIWRL
HHHHHHHHCCCCEEEEEEHHHCCHHEECCCCCCCCCCCCCCEEEEEHHHCCCCCCCEEEE
PLSLEYEKELHSNFADLSNVGRGKAGAITASCFLAQFSKKYTWAHLDIAGTAWKSGKNHG
CCCEEHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCC
ATGRPVELLSQFLLNESNFLKF
CCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438