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The map label for this gene is atpB

Identifier: 21672296

GI number: 21672296

Start: 2026

End: 2844

Strand: Direct

Name: atpB

Synonym: BUsg002

Alternate gene names: 21672296

Gene position: 2026-2844 (Clockwise)

Preceding gene: 21672295

Following gene: 21672297

Centisome position: 0.32

GC content: 26.37

Gene sequence:

>819_bases
ATGTCTTTAGAGAAAATATCTAATCCTCAAAAATATATCAGTCATCATTTAAATCATTTGCAAATAGATTTATGTAATTT
TAAGTTTGTTGAACCAGGAAAAATTGTTTCTCATTTTTGGGTTTTAAATATTGATTCAATCATATTTTCTCTTGTATTAG
GATGTTTTTTTTTGAGCATCTTTTACACAGTGGCAAAAAAAATTACGACTGGTGTTCCAAATGGATTACAAGCTTCTATT
GAATTAATTTTTGATTTTATCCGTTCTAATGTTAAGAGTATGTATCAAGGAAAAAATCCTCTTATTGCACCTTTATCGTT
AACAGTTTTTGTTTGGGTTTTTTTAATGAATCTTATGGATTTAATTCCAATTGATTTTTTTCCATTTATTTCTGAGAGGT
TTTTTCATTTTCCAGCAATGCGTATTGTGCCGTCCGCTGATATTAATATTACATTGTCAATGTCATTGGGTGTTTTTATT
TTAATTTTATTTTATAGTGTAAAGATGAAGGGATTAATTGGTTTTTGTAAAGAACTTACTTTACAACCTTTTAATCATCC
TGTATTTTTTATTTTTAATTTTTTATTAGAATTAGTTTCTTTATTATCAAAACCAATTTCTTTGGGATTAAGACTTTTTG
GAAATATGTATTCTGGTGAAATGATTTTTATTTTAATTGCTGGTTTACTCCCATGGTGGTCACAGTTTTTTTTAAATGTT
CCATGGGCTATTTTTCATATTTTAATAATTTCTCTACAGGCTTTTATTTTTATGGTATTGACGATTGTTTATTTGTCAAT
GGCTTCTCAATCTCATTAA

Upstream 100 bases:

>100_bases
GTAATAATTTTTCTTGATTTTATTAATTTAGTAATTTTTAAAATTAGTTATTTTATTTGTCTTGTTTTTATTTATTTATA
AAATAAATGAGAAAAAAATT

Downstream 100 bases:

>100_bases
GATGAAAATTGACCATAATTGTATTGAAAACTGGAGTTTGTAATGGAAAGTTTAAATGTTGATATGTTGTATATAGCGGT
TGCTATTATGATTGGATTAG

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MSLEKISNPQKYISHHLNHLQIDLCNFKFVEPGKIVSHFWVLNIDSIIFSLVLGCFFLSIFYTVAKKITTGVPNGLQASI
ELIFDFIRSNVKSMYQGKNPLIAPLSLTVFVWVFLMNLMDLIPIDFFPFISERFFHFPAMRIVPSADINITLSMSLGVFI
LILFYSVKMKGLIGFCKELTLQPFNHPVFFIFNFLLELVSLLSKPISLGLRLFGNMYSGEMIFILIAGLLPWWSQFFLNV
PWAIFHILIISLQAFIFMVLTIVYLSMASQSH

Sequences:

>Translated_272_residues
MSLEKISNPQKYISHHLNHLQIDLCNFKFVEPGKIVSHFWVLNIDSIIFSLVLGCFFLSIFYTVAKKITTGVPNGLQASI
ELIFDFIRSNVKSMYQGKNPLIAPLSLTVFVWVFLMNLMDLIPIDFFPFISERFFHFPAMRIVPSADINITLSMSLGVFI
LILFYSVKMKGLIGFCKELTLQPFNHPVFFIFNFLLELVSLLSKPISLGLRLFGNMYSGEMIFILIAGLLPWWSQFFLNV
PWAIFHILIISLQAFIFMVLTIVYLSMASQSH
>Mature_271_residues
SLEKISNPQKYISHHLNHLQIDLCNFKFVEPGKIVSHFWVLNIDSIIFSLVLGCFFLSIFYTVAKKITTGVPNGLQASIE
LIFDFIRSNVKSMYQGKNPLIAPLSLTVFVWVFLMNLMDLIPIDFFPFISERFFHFPAMRIVPSADINITLSMSLGVFIL
ILFYSVKMKGLIGFCKELTLQPFNHPVFFIFNFLLELVSLLSKPISLGLRLFGNMYSGEMIFILIAGLLPWWSQFFLNVP
WAIFHILIISLQAFIFMVLTIVYLSMASQSH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=272, Percent_Identity=68.0147058823529, Blast_Score=364, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_BUCAP (O51878)

Other databases:

- EMBL:   AF008210
- EMBL:   AE013218
- RefSeq:   NP_660363.1
- ProteinModelPortal:   O51878
- SMR:   O51878
- EnsemblBacteria:   EBBUCT00000000267
- GeneID:   1005812
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg002
- GeneTree:   EBGT00050000007817
- HOGENOM:   HBG734175
- OMA:   LPWWSQF
- ProtClustDB:   PRK05815
- BioCyc:   BAPH198804:BUSG002-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 31254; Mature: 31123

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x91f9ed4)-; HASH(0xadfe408)-; HASH(0xadfcea8)-; HASH(0xadfe4c8)-; HASH(0xadfcc8c)-; HASH(0xadfe70c)-;

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLEKISNPQKYISHHLNHLQIDLCNFKFVEPGKIVSHFWVLNIDSIIFSLVLGCFFLSI
CCCHHCCCHHHHHHHHHHHEEEEEECCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYTVAKKITTGVPNGLQASIELIFDFIRSNVKSMYQGKNPLIAPLSLTVFVWVFLMNLMD
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
LIPIDFFPFISERFFHFPAMRIVPSADINITLSMSLGVFILILFYSVKMKGLIGFCKELT
HHCCHHHHHHHHHHHHCCHHHEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHC
LQPFNHPVFFIFNFLLELVSLLSKPISLGLRLFGNMYSGEMIFILIAGLLPWWSQFFLNV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
PWAIFHILIISLQAFIFMVLTIVYLSMASQSH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
SLEKISNPQKYISHHLNHLQIDLCNFKFVEPGKIVSHFWVLNIDSIIFSLVLGCFFLSI
CCHHCCCHHHHHHHHHHHEEEEEECCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYTVAKKITTGVPNGLQASIELIFDFIRSNVKSMYQGKNPLIAPLSLTVFVWVFLMNLMD
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
LIPIDFFPFISERFFHFPAMRIVPSADINITLSMSLGVFILILFYSVKMKGLIGFCKELT
HHCCHHHHHHHHHHHHCCHHHEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHC
LQPFNHPVFFIFNFLLELVSLLSKPISLGLRLFGNMYSGEMIFILIAGLLPWWSQFFLNV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
PWAIFHILIISLQAFIFMVLTIVYLSMASQSH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9216881; 9516544; 12089438