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The map label for this gene is rnhA [H]

Identifier: 213693043

GI number: 213693043

Start: 2428778

End: 2429668

Strand: Direct

Name: rnhA [H]

Synonym: Blon_2190

Alternate gene names: 213693043

Gene position: 2428778-2429668 (Clockwise)

Preceding gene: 213693041

Following gene: 213693044

Centisome position: 85.74

GC content: 58.7

Gene sequence:

>891_bases
ATGACTATCACAGTATCCACAGACGGTTCCGCATTAGGGAATCCAAACGGGCCAATGGGCTGGGCCTGGGCCGATCATGA
GCCGAACACCGGCGGCAAGCCCGGCCATAAGCACGACGACCACGGCTACGACGCCGGCGGCGCGACCAACGGCACCAACC
AGATTGGCGAACTGTGCGCAGTGTTGGAAGCTTTGCGAGCGCATCCGGGCCCCGAGCCATTGCTCATCGAGTCGGATTCA
CAGTACGCCATCAATTGCTCGACCAAGTGGGTCAAAGGCTGGAAGAAGAACGGCTGGAGAAATTCGCAGAAAAAGCCTGT
GAAGAACAAAGAGCTTATTCAGGCGATCGACCGTGAAATCTCGCAACGCCCTGGCCCGGTGGATTTCCGATGGGTCAAAG
GTCACGCTGGCAACGAGGGCAATGAGTTGGTCGATGAATTGGCACGCACCTATGCGGGCGATTGCCGTTCAGGTGCGCGC
GATGGCTATCTGCCGATTGAAGGCTGGCAGTCGCTGCTGGGCTCCGAATACGCACATGGCACCGATGTGCCTCCAGACGT
GCAGTTGGTATTGGACGGCAAGGCAGATGCGGCAAGTTTGCGCAAACCGGCTGCGGCGACGGATCCGACGGATGTCACAA
GGCCAGAGACCAAGTCTTCGTCACCCTTAGCGGCACAATCAGCGCAACCTGTACAATCAGCGCACCCCGTACACCCCGCA
AAACCCAGTGGGCTGACGGTATCCGGTACGCTGACCTTCTCCCCCGCGCCGAAAACGAGCCCGTATTTCAACGGGCAGCC
GATGCCGATCAAAGGCAGCATCGAAATCGAAGGCTATGTGGACGGCGACGGCAACCTGACCATCACCAACGCACCATTCA
TACGACACTAA

Upstream 100 bases:

>100_bases
AGGTGTGATGTTATTCACACTCTTCACTACGTTGTTTTGCCTCGCACTGGGCAACCCCACTTCAGCAAGAGATTGCACAG
CTTGCGTTAGGGTGGAGAAC

Downstream 100 bases:

>100_bases
CACCCAAACACACGAATATGTACCGCAATCGGACACGATGGCACAAAATCGCTCATTCGCGTTAGGATAGGAGATAAGGC
TTCACGCCGTTGATCCGTGC

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MTITVSTDGSALGNPNGPMGWAWADHEPNTGGKPGHKHDDHGYDAGGATNGTNQIGELCAVLEALRAHPGPEPLLIESDS
QYAINCSTKWVKGWKKNGWRNSQKKPVKNKELIQAIDREISQRPGPVDFRWVKGHAGNEGNELVDELARTYAGDCRSGAR
DGYLPIEGWQSLLGSEYAHGTDVPPDVQLVLDGKADAASLRKPAAATDPTDVTRPETKSSSPLAAQSAQPVQSAHPVHPA
KPSGLTVSGTLTFSPAPKTSPYFNGQPMPIKGSIEIEGYVDGDGNLTITNAPFIRH

Sequences:

>Translated_296_residues
MTITVSTDGSALGNPNGPMGWAWADHEPNTGGKPGHKHDDHGYDAGGATNGTNQIGELCAVLEALRAHPGPEPLLIESDS
QYAINCSTKWVKGWKKNGWRNSQKKPVKNKELIQAIDREISQRPGPVDFRWVKGHAGNEGNELVDELARTYAGDCRSGAR
DGYLPIEGWQSLLGSEYAHGTDVPPDVQLVLDGKADAASLRKPAAATDPTDVTRPETKSSSPLAAQSAQPVQSAHPVHPA
KPSGLTVSGTLTFSPAPKTSPYFNGQPMPIKGSIEIEGYVDGDGNLTITNAPFIRH
>Mature_295_residues
TITVSTDGSALGNPNGPMGWAWADHEPNTGGKPGHKHDDHGYDAGGATNGTNQIGELCAVLEALRAHPGPEPLLIESDSQ
YAINCSTKWVKGWKKNGWRNSQKKPVKNKELIQAIDREISQRPGPVDFRWVKGHAGNEGNELVDELARTYAGDCRSGARD
GYLPIEGWQSLLGSEYAHGTDVPPDVQLVLDGKADAASLRKPAAATDPTDVTRPETKSSSPLAAQSAQPVQSAHPVHPAK
PSGLTVSGTLTFSPAPKTSPYFNGQPMPIKGSIEIEGYVDGDGNLTITNAPFIRH

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids [H]

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Homo sapiens, GI21359816, Length=153, Percent_Identity=35.2941176470588, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1786408, Length=150, Percent_Identity=39.3333333333333, Blast_Score=94, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI115532542, Length=152, Percent_Identity=35.5263157894737, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45552509, Length=151, Percent_Identity=34.4370860927152, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17137476, Length=151, Percent_Identity=34.4370860927152, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00075 RnaseH [H]

EC number: =3.1.26.4 [H]

Molecular weight: Translated: 31507; Mature: 31376

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITVSTDGSALGNPNGPMGWAWADHEPNTGGKPGHKHDDHGYDAGGATNGTNQIGELCA
CEEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
VLEALRAHPGPEPLLIESDSQYAINCSTKWVKGWKKNGWRNSQKKPVKNKELIQAIDREI
HHHHHHCCCCCCCEEEECCCCEEEECCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
SQRPGPVDFRWVKGHAGNEGNELVDELARTYAGDCRSGARDGYLPIEGWQSLLGSEYAHG
HHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCC
TDVPPDVQLVLDGKADAASLRKPAAATDPTDVTRPETKSSSPLAAQSAQPVQSAHPVHPA
CCCCCCEEEEEECCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCC
KPSGLTVSGTLTFSPAPKTSPYFNGQPMPIKGSIEIEGYVDGDGNLTITNAPFIRH
CCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEECCCCCCC
>Mature Secondary Structure 
TITVSTDGSALGNPNGPMGWAWADHEPNTGGKPGHKHDDHGYDAGGATNGTNQIGELCA
EEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
VLEALRAHPGPEPLLIESDSQYAINCSTKWVKGWKKNGWRNSQKKPVKNKELIQAIDREI
HHHHHHCCCCCCCEEEECCCCEEEECCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
SQRPGPVDFRWVKGHAGNEGNELVDELARTYAGDCRSGARDGYLPIEGWQSLLGSEYAHG
HHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCC
TDVPPDVQLVLDGKADAASLRKPAAATDPTDVTRPETKSSSPLAAQSAQPVQSAHPVHPA
CCCCCCEEEEEECCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCC
KPSGLTVSGTLTFSPAPKTSPYFNGQPMPIKGSIEIEGYVDGDGNLTITNAPFIRH
CCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12606174 [H]