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The map label for this gene is galK [H]

Identifier: 213692918

GI number: 213692918

Start: 2274249

End: 2275499

Strand: Reverse

Name: galK [H]

Synonym: Blon_2062

Alternate gene names: 213692918

Gene position: 2275499-2274249 (Counterclockwise)

Preceding gene: 213692919

Following gene: 213692917

Centisome position: 80.33

GC content: 65.23

Gene sequence:

>1251_bases
ATGACTGCTGTTGAATTCATTGAGCCGCTGACCCATGAGGAAGGCGTCTCGCAAGCCACCAAGCTGTTCGTCGACACCTA
CGGCGCTGCGCCCGAGGGCGTGTGGGCTGCTCCGGGCCGTGTGAACCTGATCGGTGAGCACACCGATTACAACGCCGGCC
TGTGCCTGCCGATCGCTCTGCCGCATCGCACCTTCATCGCCCTGAAGCCGCGCGAAGACACCAAGGTTCGCGTCGTCTCC
GGCGTGGCTCCCGACAAGGTCGCCGAAGCTGATCTCGATGGCCTCAAGGCCCGTGGCGTGGACGGCTGGTCCGCCTACCC
GACCGGTGTGGCCTGGGCGCTGCGTCAGGCTGGTTTCGACAAGGTCAAGGGCTTTGATGCCGCCTTCGTCTCCTGCGTGC
CGCTGGGCTCCGGCCTGAGCTCCTCCGCCGCCATGACCTGCTCCACCGCTCTGGCTCTGGACGACGTGTACGGCCTTGGC
TACGGTGATTCCGACGCCGGCCGTGTGACCCTCATCAACGCCGCCATCAAGTCCGAGAACGAGATGGCCGGCGCCTCCAC
CGGCGGTCTTGACCAGAACGCTTCCATGCGTTGCACCGAAGGCCACGCGCTGCTGCTTGACTGCCGTCCGGAGCTGACCC
CGCTGGAGAACGTCTCCCAGCAGGAGTTCGACCTCGACAAGTACAACCTCGAGCTGCTTGTGGTCGATACCCAGGCTCCG
CACCAGCTCAACGATGGCCAGTACGCTCAGCGTCGCGCCACCTGCGAGGAAGCCGCCAAGATTCTCGGTGTGGCCAACCT
GCGTGTGACCGCCGACGGCATCTCCAAGGCCGATGACCAGTTCCAGGCCCTCAAGGAAACGCTTGACGCCCTGCCTGACG
AGACCATGAAGAAGCGCGTGCGCCACGTCGTCACCGAAATCGAGCGCGTGCGTTCCTTCGTGCGTGCCTTCGCTCAGGGC
GACATCAAGGCTGCGGGCCGTCTGTTCAACGCTTCCCACGATTCGCTGGCCGCCGACTACGAGGTCACCGTCCCCGAGCT
GGACATCGCCGTAGACGTGGCCCGCAAGAACGGCGCCTACGGTGCGCGTATGACCGGCGGCGGCTTCGGCGGCTCCATCA
TCGCCCTGGTCGACAAGGGCCAGGGCCACGAGATTGCACAGAAGATTGCTGACCGCTTCGAAAAGGAAGGTTTCAACGCA
CCTCGCGCCTTGCCGGCGTTCGCTGCGGCTTCCGCGAGCCGCGAGGCCTGA

Upstream 100 bases:

>100_bases
ATGGCCGCCTGGATCTCCGACACCACGCCGGAACTCATCGCCAAGCGCTTCCATGAGCTCGGCTCCATCGACATCGCCGA
CTGATAGAAAGAAAACACCA

Downstream 100 bases:

>100_bases
TCTCGGAAGCTGATGCAAAAACGCGCGTTGGCGCACGTCCTTTTTCATGGACGTGCGCCAACGCGCGTTTTTGCATGATT
TACTTGTGGGCCAGATGGTG

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MTAVEFIEPLTHEEGVSQATKLFVDTYGAAPEGVWAAPGRVNLIGEHTDYNAGLCLPIALPHRTFIALKPREDTKVRVVS
GVAPDKVAEADLDGLKARGVDGWSAYPTGVAWALRQAGFDKVKGFDAAFVSCVPLGSGLSSSAAMTCSTALALDDVYGLG
YGDSDAGRVTLINAAIKSENEMAGASTGGLDQNASMRCTEGHALLLDCRPELTPLENVSQQEFDLDKYNLELLVVDTQAP
HQLNDGQYAQRRATCEEAAKILGVANLRVTADGISKADDQFQALKETLDALPDETMKKRVRHVVTEIERVRSFVRAFAQG
DIKAAGRLFNASHDSLAADYEVTVPELDIAVDVARKNGAYGARMTGGGFGGSIIALVDKGQGHEIAQKIADRFEKEGFNA
PRALPAFAAASASREA

Sequences:

>Translated_416_residues
MTAVEFIEPLTHEEGVSQATKLFVDTYGAAPEGVWAAPGRVNLIGEHTDYNAGLCLPIALPHRTFIALKPREDTKVRVVS
GVAPDKVAEADLDGLKARGVDGWSAYPTGVAWALRQAGFDKVKGFDAAFVSCVPLGSGLSSSAAMTCSTALALDDVYGLG
YGDSDAGRVTLINAAIKSENEMAGASTGGLDQNASMRCTEGHALLLDCRPELTPLENVSQQEFDLDKYNLELLVVDTQAP
HQLNDGQYAQRRATCEEAAKILGVANLRVTADGISKADDQFQALKETLDALPDETMKKRVRHVVTEIERVRSFVRAFAQG
DIKAAGRLFNASHDSLAADYEVTVPELDIAVDVARKNGAYGARMTGGGFGGSIIALVDKGQGHEIAQKIADRFEKEGFNA
PRALPAFAAASASREA
>Mature_415_residues
TAVEFIEPLTHEEGVSQATKLFVDTYGAAPEGVWAAPGRVNLIGEHTDYNAGLCLPIALPHRTFIALKPREDTKVRVVSG
VAPDKVAEADLDGLKARGVDGWSAYPTGVAWALRQAGFDKVKGFDAAFVSCVPLGSGLSSSAAMTCSTALALDDVYGLGY
GDSDAGRVTLINAAIKSENEMAGASTGGLDQNASMRCTEGHALLLDCRPELTPLENVSQQEFDLDKYNLELLVVDTQAPH
QLNDGQYAQRRATCEEAAKILGVANLRVTADGISKADDQFQALKETLDALPDETMKKRVRHVVTEIERVRSFVRAFAQGD
IKAAGRLFNASHDSLAADYEVTVPELDIAVDVARKNGAYGARMTGGGFGGSIIALVDKGQGHEIAQKIADRFEKEGFNAP
RALPAFAAASASREA

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=392, Percent_Identity=35.969387755102, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI4503897, Length=407, Percent_Identity=27.5184275184275, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI48527957, Length=407, Percent_Identity=27.5184275184275, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1786972, Length=377, Percent_Identity=33.9522546419098, Blast_Score=192, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI71989053, Length=406, Percent_Identity=29.064039408867, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6319494, Length=490, Percent_Identity=28.3673469387755, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320212, Length=230, Percent_Identity=30.4347826086957, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24661292, Length=423, Percent_Identity=26.241134751773, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21355577, Length=423, Percent_Identity=26.241134751773, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24661285, Length=423, Percent_Identity=26.241134751773, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 44239; Mature: 44108

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAVEFIEPLTHEEGVSQATKLFVDTYGAAPEGVWAAPGRVNLIGEHTDYNAGLCLPIAL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCEEEEEECCCCCCCCEEEEEEC
PHRTFIALKPREDTKVRVVSGVAPDKVAEADLDGLKARGVDGWSAYPTGVAWALRQAGFD
CCCEEEEECCCCCCEEEEEECCCCCHHHHHCCCCHHCCCCCCCCCCCHHHHHHHHHCCHH
KVKGFDAAFVSCVPLGSGLSSSAAMTCSTALALDDVYGLGYGDSDAGRVTLINAAIKSEN
HHCCCCHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCC
EMAGASTGGLDQNASMRCTEGHALLLDCRPELTPLENVSQQEFDLDKYNLELLVVDTQAP
CCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCHHCCCHHHCCCCCCCEEEEEEECCCC
HQLNDGQYAQRRATCEEAAKILGVANLRVTADGISKADDQFQALKETLDALPDETMKKRV
CCCCCCHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHH
RHVVTEIERVRSFVRAFAQGDIKAAGRLFNASHDSLAADYEVTVPELDIAVDVARKNGAY
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEECCCEEEEEEEECCCCCC
GARMTGGGFGGSIIALVDKGQGHEIAQKIADRFEKEGFNAPRALPAFAAASASREA
CCEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure 
TAVEFIEPLTHEEGVSQATKLFVDTYGAAPEGVWAAPGRVNLIGEHTDYNAGLCLPIAL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCEEEEEECCCCCCCCEEEEEEC
PHRTFIALKPREDTKVRVVSGVAPDKVAEADLDGLKARGVDGWSAYPTGVAWALRQAGFD
CCCEEEEECCCCCCEEEEEECCCCCHHHHHCCCCHHCCCCCCCCCCCHHHHHHHHHCCHH
KVKGFDAAFVSCVPLGSGLSSSAAMTCSTALALDDVYGLGYGDSDAGRVTLINAAIKSEN
HHCCCCHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCC
EMAGASTGGLDQNASMRCTEGHALLLDCRPELTPLENVSQQEFDLDKYNLELLVVDTQAP
CCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCHHCCCHHHCCCCCCCEEEEEEECCCC
HQLNDGQYAQRRATCEEAAKILGVANLRVTADGISKADDQFQALKETLDALPDETMKKRV
CCCCCCHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHH
RHVVTEIERVRSFVRAFAQGDIKAAGRLFNASHDSLAADYEVTVPELDIAVDVARKNGAY
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEECCCEEEEEEEECCCCCC
GARMTGGGFGGSIIALVDKGQGHEIAQKIADRFEKEGFNAPRALPAFAAASASREA
CCEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]