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The map label for this gene is coaBC [H]

Identifier: 213692872

GI number: 213692872

Start: 2197818

End: 2199131

Strand: Direct

Name: coaBC [H]

Synonym: Blon_2013

Alternate gene names: 213692872

Gene position: 2197818-2199131 (Clockwise)

Preceding gene: 213692861

Following gene: 213692873

Centisome position: 77.59

GC content: 63.01

Gene sequence:

>1314_bases
ATGGCACATATTCTTCTGGGCGTCACCGGCAGCATCGCTGCATTCAAGGCCTGTCATCTGGCATCCGATTGGACCAAGGC
CGGCCACGAGGTGCGGGTTATCGAAACCACAGCGGCCGAAGGTTTCGTCACTCCCCTGACCTTCACCTCGCTGACCCATC
AGCCCACCCGTACCACGATGTTCCCCGCTTATCCGGCCGCGCACGGCGACGTGACGGCCAATCCGACCGTGCCAACGACC
ATCAATCATGTGGCCGATGCGGCCTGGGCCAATCTGCTGGTGGTGGCCCCGGCGAGCGCCGACGTCATCGCCCGCATCGC
CTGTGGATTGGCGAACGATACGCTGACGTCCACCATTCTGGCCTATGAGGGGCCGAAGATCCTATGCCCGTCGATGAACG
TGCATATGTACAACAATCCGGCCACGCAGCGCAATCTGAAAACCTGCGCCGAATTGGGCTGGCAGATTGTGGAGCCGGAG
GAAGGCAATCTGGCTTGCGGCGACGTGGGACGAGGCCGTATGGAAGAGCCGGCGCGCATCGAGGAAGTGGCCGCTCGGCT
GCTGGCGGATGCGCAGGATGACCAGGCTCCCTCATCTTCCCCGCTCAAGGGGCTGCGCGTGCTGGTCACTGCCGGGCCAA
CGCAGGAGCCGCTAGACCCGGTCCGCTATCTGACGAACCATTCCACCGGCAAGATGGGGTATGCGATTGCCTCGGCCGCA
GCCGAATTTGGTGCCGACGTAACGTTGGTCTCCGGTCCAGTCGCCTTGACCGCGCCCGATGCGGTGGATGTGGTGCGCGT
CATGACCGCGCAGGATATGTTCGATGCGGTGGCCGACGCCTTCCCGGCGGCGGATATCACGATTATGGCCGCCGCCGTGG
GCGATTTCCGCGTGGCCGAGATTGCGCCGGAGAAAATCAAGAAGGCCGGCCGCAGCAGCATCACCGTGGAGCTGGTTTCC
AACCCGGATATTCTGGCGTGGGCCGGCGAACGCAAGCGCGACGACGGCTCGCAGATCCTGTGCGGATTCGCGATGGAGAC
CGAGCATCTGATTCGTAATGCGGAGAAGAAGCTGACGTCCAAGTATTGCGACATGCTGGTGGCCAACAATCTGCGCGACG
CCGGTGCCGGGTTCGGCACCGACACCAACGTTGTCACCGTGCTCACGTCCGGAGCGGAGGATGCCGGTACCCCGAAGATC
GAGCATTGGGACAAGATGGACAAAACCGTGCTTGCGCAACGACTGTTGCTGCGGCTCGCAGCGTTGCGTTCCGGCGGCGC
GAGCAATGTCGATGACGAGAACAAGGAGGCCTGA

Upstream 100 bases:

>100_bases
GTCCGCGGCGACCACAGCACGCGGCGCATCGTCGGGCAACAACGCGGGAAGCGCTGGCGTGGGCACATGTGCGGCCTTGG
CATAAGGCCGGGAGGCAGCT

Downstream 100 bases:

>100_bases
CCCATGCTGATGGCGGTCGATATCGGCAATACGAATATCGTGATCGGTTTTCTGGAGGGCGACCGCATCGTCGGCTCCTA
CCGCATCACCACCAAGGCGA

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MAHILLGVTGSIAAFKACHLASDWTKAGHEVRVIETTAAEGFVTPLTFTSLTHQPTRTTMFPAYPAAHGDVTANPTVPTT
INHVADAAWANLLVVAPASADVIARIACGLANDTLTSTILAYEGPKILCPSMNVHMYNNPATQRNLKTCAELGWQIVEPE
EGNLACGDVGRGRMEEPARIEEVAARLLADAQDDQAPSSSPLKGLRVLVTAGPTQEPLDPVRYLTNHSTGKMGYAIASAA
AEFGADVTLVSGPVALTAPDAVDVVRVMTAQDMFDAVADAFPAADITIMAAAVGDFRVAEIAPEKIKKAGRSSITVELVS
NPDILAWAGERKRDDGSQILCGFAMETEHLIRNAEKKLTSKYCDMLVANNLRDAGAGFGTDTNVVTVLTSGAEDAGTPKI
EHWDKMDKTVLAQRLLLRLAALRSGGASNVDDENKEA

Sequences:

>Translated_437_residues
MAHILLGVTGSIAAFKACHLASDWTKAGHEVRVIETTAAEGFVTPLTFTSLTHQPTRTTMFPAYPAAHGDVTANPTVPTT
INHVADAAWANLLVVAPASADVIARIACGLANDTLTSTILAYEGPKILCPSMNVHMYNNPATQRNLKTCAELGWQIVEPE
EGNLACGDVGRGRMEEPARIEEVAARLLADAQDDQAPSSSPLKGLRVLVTAGPTQEPLDPVRYLTNHSTGKMGYAIASAA
AEFGADVTLVSGPVALTAPDAVDVVRVMTAQDMFDAVADAFPAADITIMAAAVGDFRVAEIAPEKIKKAGRSSITVELVS
NPDILAWAGERKRDDGSQILCGFAMETEHLIRNAEKKLTSKYCDMLVANNLRDAGAGFGTDTNVVTVLTSGAEDAGTPKI
EHWDKMDKTVLAQRLLLRLAALRSGGASNVDDENKEA
>Mature_436_residues
AHILLGVTGSIAAFKACHLASDWTKAGHEVRVIETTAAEGFVTPLTFTSLTHQPTRTTMFPAYPAAHGDVTANPTVPTTI
NHVADAAWANLLVVAPASADVIARIACGLANDTLTSTILAYEGPKILCPSMNVHMYNNPATQRNLKTCAELGWQIVEPEE
GNLACGDVGRGRMEEPARIEEVAARLLADAQDDQAPSSSPLKGLRVLVTAGPTQEPLDPVRYLTNHSTGKMGYAIASAAA
EFGADVTLVSGPVALTAPDAVDVVRVMTAQDMFDAVADAFPAADITIMAAAVGDFRVAEIAPEKIKKAGRSSITVELVSN
PDILAWAGERKRDDGSQILCGFAMETEHLIRNAEKKLTSKYCDMLVANNLRDAGAGFGTDTNVVTVLTSGAEDAGTPKIE
HWDKMDKTVLAQRLLLRLAALRSGGASNVDDENKEA

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=189, Percent_Identity=30.1587301587302, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI87082301, Length=436, Percent_Identity=39.2201834862385, Blast_Score=266, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17560194, Length=200, Percent_Identity=29.5, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322762, Length=199, Percent_Identity=30.1507537688442, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24657262, Length=188, Percent_Identity=27.1276595744681, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 46210; Mature: 46079

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHILLGVTGSIAAFKACHLASDWTKAGHEVRVIETTAAEGFVTPLTFTSLTHQPTRTTM
CCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEECCCCCCCCCEE
FPAYPAAHGDVTANPTVPTTINHVADAAWANLLVVAPASADVIARIACGLANDTLTSTIL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHCCCCCHHHHHHE
AYEGPKILCPSMNVHMYNNPATQRNLKTCAELGWQIVEPEEGNLACGDVGRGRMEEPARI
EECCCEEECCCCCEEEECCCCHHHHHHHHHHCCCEEECCCCCCEEECCCCCCCCCCCHHH
EEVAARLLADAQDDQAPSSSPLKGLRVLVTAGPTQEPLDPVRYLTNHSTGKMGYAIASAA
HHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHH
AEFGADVTLVSGPVALTAPDAVDVVRVMTAQDMFDAVADAFPAADITIMAAAVGDFRVAE
HHHCCCEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEHHH
IAPEKIKKAGRSSITVELVSNPDILAWAGERKRDDGSQILCGFAMETEHLIRNAEKKLTS
CCHHHHHHCCCCEEEEEEECCCCEEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHH
KYCDMLVANNLRDAGAGFGTDTNVVTVLTSGAEDAGTPKIEHWDKMDKTVLAQRLLLRLA
HHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ALRSGGASNVDDENKEA
HHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
AHILLGVTGSIAAFKACHLASDWTKAGHEVRVIETTAAEGFVTPLTFTSLTHQPTRTTM
CEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEECCCCCCCCCEE
FPAYPAAHGDVTANPTVPTTINHVADAAWANLLVVAPASADVIARIACGLANDTLTSTIL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHCCCCCHHHHHHE
AYEGPKILCPSMNVHMYNNPATQRNLKTCAELGWQIVEPEEGNLACGDVGRGRMEEPARI
EECCCEEECCCCCEEEECCCCHHHHHHHHHHCCCEEECCCCCCEEECCCCCCCCCCCHHH
EEVAARLLADAQDDQAPSSSPLKGLRVLVTAGPTQEPLDPVRYLTNHSTGKMGYAIASAA
HHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHH
AEFGADVTLVSGPVALTAPDAVDVVRVMTAQDMFDAVADAFPAADITIMAAAVGDFRVAE
HHHCCCEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEHHH
IAPEKIKKAGRSSITVELVSNPDILAWAGERKRDDGSQILCGFAMETEHLIRNAEKKLTS
CCHHHHHHCCCCEEEEEEECCCCEEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHH
KYCDMLVANNLRDAGAGFGTDTNVVTVLTSGAEDAGTPKIEHWDKMDKTVLAQRLLLRLA
HHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ALRSGGASNVDDENKEA
HHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]