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The map label for this gene is cbs [H]

Identifier: 213692863

GI number: 213692863

Start: 2188251

End: 2188889

Strand: Reverse

Name: cbs [H]

Synonym: Blon_2004

Alternate gene names: 213692863

Gene position: 2188889-2188251 (Counterclockwise)

Preceding gene: 213692864

Following gene: 213692862

Centisome position: 77.27

GC content: 61.19

Gene sequence:

>639_bases
ATGACCATCCACAACAGCCTCGCAGAACTCATCGGCAACACCCCACTCGTCAAACTCAACCACATCCCGCAGGTGGCCGG
CGTCAAATCCACCATCGCCGTCAAAGTCGAATACTTCAACCCCGGCGGCACCATCTCCGGCACCGGCAAGTACCTCAAGG
AAGCCTCCAACGGCGCGGTCAAAGTCATCGGCTCCGACCCGGAAGGCTCCATCTACTCCGCTTCCTCACGCGATGAAGTC
CACCAGTACGACATCGAGGGCGTGGGGGAGGACTTCTACCCCAAGGCCTTCAACCGGAATATCACCGACGACATCGTGCG
CGTATCCGACGCCGAAGCCTTTGAAATGACCCGCCGTCTGGCCGGCGAGGAGGCGCTGCTGGTCGGCGGCTCGTCCGGCA
TGGCCGTGGCCAGCGCCATCAAGTACGCGCTCGCCAATGATTTGGACGAGAACCAGATCGTGGTGGTGCTCGCCCCTGAT
TCCGGCCGCAGCTATCTGGAGAAGATCTTCAATGACGACTGGATGCGCGCCAACGGCTACGGCGATATTGTGGAGCGCAC
CAGCAAACCCTCCCTCGCCGAGCAGTACCTTGACGGAGCTCCCTCTGATGAGGGAGCTGGGGACGGACTCCATAACTAG

Upstream 100 bases:

>100_bases
ACTCGATTTCAAACCAAAGCCACAGTCCATTCGTCTGGGAACGTCGGTTCACGAACGCAACGCAGCAAAACGCCACAACC
CCAGCAACGAAGGACTTCAC

Downstream 100 bases:

>100_bases
CTATCAAAAGAATCAATACCAATATCCGCACTGGCCTCCAAGCACTACCAGTATGTGTGGGTCGAGACCCCGTCCAACCC
GCTGCTCAACATCACCGACA

Product: cystathionine beta-synthase

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MTIHNSLAELIGNTPLVKLNHIPQVAGVKSTIAVKVEYFNPGGTISGTGKYLKEASNGAVKVIGSDPEGSIYSASSRDEV
HQYDIEGVGEDFYPKAFNRNITDDIVRVSDAEAFEMTRRLAGEEALLVGGSSGMAVASAIKYALANDLDENQIVVVLAPD
SGRSYLEKIFNDDWMRANGYGDIVERTSKPSLAEQYLDGAPSDEGAGDGLHN

Sequences:

>Translated_212_residues
MTIHNSLAELIGNTPLVKLNHIPQVAGVKSTIAVKVEYFNPGGTISGTGKYLKEASNGAVKVIGSDPEGSIYSASSRDEV
HQYDIEGVGEDFYPKAFNRNITDDIVRVSDAEAFEMTRRLAGEEALLVGGSSGMAVASAIKYALANDLDENQIVVVLAPD
SGRSYLEKIFNDDWMRANGYGDIVERTSKPSLAEQYLDGAPSDEGAGDGLHN
>Mature_211_residues
TIHNSLAELIGNTPLVKLNHIPQVAGVKSTIAVKVEYFNPGGTISGTGKYLKEASNGAVKVIGSDPEGSIYSASSRDEVH
QYDIEGVGEDFYPKAFNRNITDDIVRVSDAEAFEMTRRLAGEEALLVGGSSGMAVASAIKYALANDLDENQIVVVLAPDS
GRSYLEKIFNDDWMRANGYGDIVERTSKPSLAEQYLDGAPSDEGAGDGLHN

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=142, Percent_Identity=42.2535211267606, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI295821200, Length=142, Percent_Identity=42.2535211267606, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI4557415, Length=142, Percent_Identity=42.2535211267606, Blast_Score=116, Evalue=1e-26,
Organism=Escherichia coli, GI1788754, Length=91, Percent_Identity=37.3626373626374, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17534315, Length=120, Percent_Identity=40.8333333333333, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25147552, Length=122, Percent_Identity=38.5245901639344, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI32566672, Length=131, Percent_Identity=31.2977099236641, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562970, Length=131, Percent_Identity=31.2977099236641, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115535073, Length=124, Percent_Identity=33.8709677419355, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI32566674, Length=102, Percent_Identity=36.2745098039216, Blast_Score=63, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=145, Percent_Identity=39.3103448275862, Blast_Score=115, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24643623, Length=146, Percent_Identity=38.3561643835616, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI20129101, Length=146, Percent_Identity=38.3561643835616, Blast_Score=94, Evalue=5e-20,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 22670; Mature: 22539

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIHNSLAELIGNTPLVKLNHIPQVAGVKSTIAVKVEYFNPGGTISGTGKYLKEASNGAV
CCCHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHCCCCEE
KVIGSDPEGSIYSASSRDEVHQYDIEGVGEDFYPKAFNRNITDDIVRVSDAEAFEMTRRL
EEEECCCCCCEEECCCCCCHHCCCCCCCCCCCCCHHHCCCCCHHHEECCCCHHHHHHHHH
AGEEALLVGGSSGMAVASAIKYALANDLDENQIVVVLAPDSGRSYLEKIFNDDWMRANGY
CCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHCCCCEEECCC
GDIVERTSKPSLAEQYLDGAPSDEGAGDGLHN
HHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TIHNSLAELIGNTPLVKLNHIPQVAGVKSTIAVKVEYFNPGGTISGTGKYLKEASNGAV
CCHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHCCCCEE
KVIGSDPEGSIYSASSRDEVHQYDIEGVGEDFYPKAFNRNITDDIVRVSDAEAFEMTRRL
EEEECCCCCCEEECCCCCCHHCCCCCCCCCCCCCHHHCCCCCHHHEECCCCHHHHHHHHH
AGEEALLVGGSSGMAVASAIKYALANDLDENQIVVVLAPDSGRSYLEKIFNDDWMRANGY
CCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHCCCCEEECCC
GDIVERTSKPSLAEQYLDGAPSDEGAGDGLHN
HHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]