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The map label for this gene is proA [H]

Identifier: 213692713

GI number: 213692713

Start: 2013331

End: 2014596

Strand: Reverse

Name: proA [H]

Synonym: Blon_1846

Alternate gene names: 213692713

Gene position: 2014596-2013331 (Counterclockwise)

Preceding gene: 213692714

Following gene: 213692712

Centisome position: 71.12

GC content: 62.56

Gene sequence:

>1266_bases
ATGAGCGATGAATTGAGTCCTGAGGTGTTCGACGCGGTGTGCCGCCAGGCCGATCAGGCCGCACGCGCACAGGAGCGTCT
TGCACAGGCAAATACCGAAGCCAAGAACGAACTGCTGCTCGCCATTGCGGACGCGCTGGACGAGCACGCCGCGGACATCG
AAGCCGCCAACGCGCTGGACATGCTCGAATCCAAGGAAAACGGCATGGACGCGGGCAAGCTCGACCGCCTGCTGTTCGAC
GTGCCGCGCGTGGCCACCCTGCCCGATCCGGTCGGTGAAATCGTGCGCGGATACAACCTGCCCAACGGTCTGCGCCTTAC
CCAAACGCGCGTACCGATGGGCGTCATCGGCATGATCTATGAGGCCCGGCCGAACGTCACTGTGGACGTGTCCAGCCTGT
GCCTCAAGTCCGGCAATGCCGCGCTGCTGCGAGGCGGCCACGCCGCCGAACGCACCAATGCCGCCACGCTGGGCGTCATC
GCCCCGGTGCTTGAAGCCCACGGTTTCGAATCCACACTGGTGCAGTCCGTCGACCAGTACGGACGCGCCGGTGCTACCGC
CATGATGGAGGCGCGAGGCCATATCGACGTGCTCGTGCCGCGAGGAGGAGCGGGTCTAATCCAAGCCGTCGTGCGCAACT
CCAAAGTGCCGGTCATCGAAACCGGCGCCGGCAACGTGCATATCTACATCGACAAGTCCGGTGATCTCGCCAAGGCCATC
CCGATCATCATCAACGCCAAAACCCAGCGCGTGGGCGTGTGCAACGCCGCCGAAAAGCTATTGGTTCATAAGGATGTCGC
CGCCGAATTCCTGCCGCAGATCGCCGCCGCGTTGGCCGAGGCGAACGTTGTACTGCAGACCGACACCACGTCGTACGACA
TCATCTCCGGCGCGGCAATCGAGGGCCTTGACCTCAACCACGCCACTGAAGAGGATTGGGACACTGAATACCTGGCCCTC
AAAATGGGCATCAAGGTGGTGCCGGACCTGGACACGGCCATCGACCACATCAACACGCATTCCACAGGCCACACCGAATC
CATCATCGCCGAGGATTATGCGGCCATCGAGGAATTCACCAAGCGCATCGACTCGGCCGTGGTCGTGGTCAACGCCTCCA
CCCGCTTCACCGACGGCGGCGTGTTTGGCTTTGGTGCTGAGCTTGGCATCTCTACGCAGAAGATGCACGCACGCGGTCCC
ATGGGATTGCGGGAGATGACCACCACCAAGTGGATCGGTTACGGAACAGGACAGGTGCGCGCATGA

Upstream 100 bases:

>100_bases
GAGGGGAGCCGGTTCTGTTTGCGATTCAAAACGTCAGACATCCCATAACAAGCGGGTCGGAGTAAGCAATCAGCCGCGTT
GTGAGTTACGCTTGACTGTT

Downstream 100 bases:

>100_bases
ACGAGGACGGCAACATGAACATCACGGCTGACACGGCAAACAAGGCAAGCGAACTGCGGCCCGACATCGACCTCAACGAT
CCCAAGCTCGGCCTGAAGAT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MSDELSPEVFDAVCRQADQAARAQERLAQANTEAKNELLLAIADALDEHAADIEAANALDMLESKENGMDAGKLDRLLFD
VPRVATLPDPVGEIVRGYNLPNGLRLTQTRVPMGVIGMIYEARPNVTVDVSSLCLKSGNAALLRGGHAAERTNAATLGVI
APVLEAHGFESTLVQSVDQYGRAGATAMMEARGHIDVLVPRGGAGLIQAVVRNSKVPVIETGAGNVHIYIDKSGDLAKAI
PIIINAKTQRVGVCNAAEKLLVHKDVAAEFLPQIAAALAEANVVLQTDTTSYDIISGAAIEGLDLNHATEEDWDTEYLAL
KMGIKVVPDLDTAIDHINTHSTGHTESIIAEDYAAIEEFTKRIDSAVVVVNASTRFTDGGVFGFGAELGISTQKMHARGP
MGLREMTTTKWIGYGTGQVRA

Sequences:

>Translated_421_residues
MSDELSPEVFDAVCRQADQAARAQERLAQANTEAKNELLLAIADALDEHAADIEAANALDMLESKENGMDAGKLDRLLFD
VPRVATLPDPVGEIVRGYNLPNGLRLTQTRVPMGVIGMIYEARPNVTVDVSSLCLKSGNAALLRGGHAAERTNAATLGVI
APVLEAHGFESTLVQSVDQYGRAGATAMMEARGHIDVLVPRGGAGLIQAVVRNSKVPVIETGAGNVHIYIDKSGDLAKAI
PIIINAKTQRVGVCNAAEKLLVHKDVAAEFLPQIAAALAEANVVLQTDTTSYDIISGAAIEGLDLNHATEEDWDTEYLAL
KMGIKVVPDLDTAIDHINTHSTGHTESIIAEDYAAIEEFTKRIDSAVVVVNASTRFTDGGVFGFGAELGISTQKMHARGP
MGLREMTTTKWIGYGTGQVRA
>Mature_420_residues
SDELSPEVFDAVCRQADQAARAQERLAQANTEAKNELLLAIADALDEHAADIEAANALDMLESKENGMDAGKLDRLLFDV
PRVATLPDPVGEIVRGYNLPNGLRLTQTRVPMGVIGMIYEARPNVTVDVSSLCLKSGNAALLRGGHAAERTNAATLGVIA
PVLEAHGFESTLVQSVDQYGRAGATAMMEARGHIDVLVPRGGAGLIQAVVRNSKVPVIETGAGNVHIYIDKSGDLAKAIP
IIINAKTQRVGVCNAAEKLLVHKDVAAEFLPQIAAALAEANVVLQTDTTSYDIISGAAIEGLDLNHATEEDWDTEYLALK
MGIKVVPDLDTAIDHINTHSTGHTESIIAEDYAAIEEFTKRIDSAVVVVNASTRFTDGGVFGFGAELGISTQKMHARGPM
GLREMTTTKWIGYGTGQVRA

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=420, Percent_Identity=32.8571428571429, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI21361368, Length=420, Percent_Identity=32.8571428571429, Blast_Score=207, Evalue=1e-53,
Organism=Escherichia coli, GI1786438, Length=412, Percent_Identity=46.1165048543689, Blast_Score=363, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17569967, Length=420, Percent_Identity=34.5238095238095, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17569969, Length=420, Percent_Identity=34.5238095238095, Blast_Score=229, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6324899, Length=427, Percent_Identity=34.8946135831382, Blast_Score=236, Evalue=4e-63,
Organism=Drosophila melanogaster, GI21357643, Length=411, Percent_Identity=34.5498783454988, Blast_Score=217, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 44752; Mature: 44621

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDELSPEVFDAVCRQADQAARAQERLAQANTEAKNELLLAIADALDEHAADIEAANALD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLESKENGMDAGKLDRLLFDVPRVATLPDPVGEIVRGYNLPNGLRLTQTRVPMGVIGMIY
HHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCEEEECCCCHHHHHHEE
EARPNVTVDVSSLCLKSGNAALLRGGHAAERTNAATLGVIAPVLEAHGFESTLVQSVDQY
ECCCCCEEEHHHHHHCCCCEEEEECCCCHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
GRAGATAMMEARGHIDVLVPRGGAGLIQAVVRNSKVPVIETGAGNVHIYIDKSGDLAKAI
CCCCCHHHHCCCCCEEEEEECCCHHHHHHHHCCCCCCEEEECCCEEEEEEECCCCCHHCC
PIIINAKTQRVGVCNAAEKLLVHKDVAAEFLPQIAAALAEANVVLQTDTTSYDIISGAAI
EEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEECCCEE
EGLDLNHATEEDWDTEYLALKMGIKVVPDLDTAIDHINTHSTGHTESIIAEDYAAIEEFT
CCCCCCCCCCCCCCCCEEEEEECCEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
KRIDSAVVVVNASTRFTDGGVFGFGAELGISTQKMHARGPMGLREMTTTKWIGYGTGQVR
HHHCCEEEEEECCCEECCCCEEECCHHCCCCHHHHHCCCCCCHHHHHHHEEEECCCCCCC
A
C
>Mature Secondary Structure 
SDELSPEVFDAVCRQADQAARAQERLAQANTEAKNELLLAIADALDEHAADIEAANALD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLESKENGMDAGKLDRLLFDVPRVATLPDPVGEIVRGYNLPNGLRLTQTRVPMGVIGMIY
HHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCEEEECCCCHHHHHHEE
EARPNVTVDVSSLCLKSGNAALLRGGHAAERTNAATLGVIAPVLEAHGFESTLVQSVDQY
ECCCCCEEEHHHHHHCCCCEEEEECCCCHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
GRAGATAMMEARGHIDVLVPRGGAGLIQAVVRNSKVPVIETGAGNVHIYIDKSGDLAKAI
CCCCCHHHHCCCCCEEEEEECCCHHHHHHHHCCCCCCEEEECCCEEEEEEECCCCCHHCC
PIIINAKTQRVGVCNAAEKLLVHKDVAAEFLPQIAAALAEANVVLQTDTTSYDIISGAAI
EEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEECCCEE
EGLDLNHATEEDWDTEYLALKMGIKVVPDLDTAIDHINTHSTGHTESIIAEDYAAIEEFT
CCCCCCCCCCCCCCCCEEEEEECCEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
KRIDSAVVVVNASTRFTDGGVFGFGAELGISTQKMHARGPMGLREMTTTKWIGYGTGQVR
HHHCCEEEEEECCCEECCCCEEECCHHCCCCHHHHHCCCCCCHHHHHHHEEEECCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12381787 [H]