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The map label for this gene is guaA [H]

Identifier: 213692591

GI number: 213692591

Start: 1889657

End: 1891219

Strand: Direct

Name: guaA [H]

Synonym: Blon_1723

Alternate gene names: 213692591

Gene position: 1889657-1891219 (Clockwise)

Preceding gene: 213692571

Following gene: 213692592

Centisome position: 66.71

GC content: 65.2

Gene sequence:

>1563_bases
ATGGCAAACGGTCCTGTGCTTGTCGTCGACTTCGGCGCCCAGTACGCCCAGCTCATCGCCCGCCGCGTGCGCGAAGCAGG
CGTGTACTCCGAGCTGGTCCCTCATTCCATGCCGGTTGACGAGATCCTGGCCAAGGATCCGAAGGCGATTATTCTGTCCG
GCGGCCCGGCCTCTGTGTTCGAGCCCGGCGCGCCGACCATAGATACTAAGGTATTCGAATCCGGTGTTCCTGTGCTTGGT
ATCTGTTACGGCTTCCAGGTCATGGCCTATGAGCTCGGCGGCAAGGTGGATAAGGCCGCTCTCGGCGAATACGGCAAGAC
CTCAGCCACCATCGATGACGCCGACGGCATCCTCGCCGACTCCCCCGCCGAGCAGACCACGTGGATGAGCCACGGTGTGG
CGGTCGAACAGGCCCCGGCCGGCTTCGAAGTGCTGGCCCACACCGAAGGCGCGCCCGTGGCCGCCATGGCGGACGAATCC
CGCAAGCTCTATGGTGTGCAGTGGCACCCGGAAGTCAAGCACTCCCCGCTTGGCCAGAAGCTTATCGAAAACTTCCTGCA
CCGTTGCGCCGCGCTGCCCAACGACTGGGATGCCTCCTCGATTATCGAGGATCAAGTCAAGAAGATCCGCGAGAAGGTCG
GCGACGCCGAGGTGATCTGCGGCCTGTCCGGCGGCGTGGACTCCGCCGTGGCCGCCGCTCTGGTGCACAAGGCCATCGGC
GACCAGCTCACCTGCGTGTTCGTGGACCACGGCCTGCTGCGTAAGGGCGAGGTCGAGCAGGTCAAGCACGACTTCGTTGC
CGCCACCGGCATCAAGCTCATCACCGTGGACGCGGCCGACGACTTCCTTGAGGCCCTGAAGGGAGTCTCCGAGCCGGAGC
GCAAGCGCAAGATCATCGGTGAGAAGTTCATCCGCACGTTCGAGAAGGCCCAGCGCCAAGTGCTTGAAGAGGCCGGCGCG
CGCGGCAAGGAAGTCAAGTTCCTCGTGCAGGGCACCCTCTACCCCGACGTCGTCGAATCCGGCGGCGGCGACGGCGCGGC
CAACATCAAGTCCCACCACAACGTCGGCGGCCTGCCCAAGGACATCAAGTTCCAGCTCATCGAACCGCTGCGCACTCTGT
TCAAGGATGAGGTGCGCGCCATCGGCACCGAGCTCGGTCTGCCCGACGAAATCGTCTGGCGTCAGCCTTTCCCGGGCCCG
GGTCTGGGCATCCGCATCATCGGCGAGATCACCAAGGAGCGCCTCGACCTGCTGCGCGAGGCCGACGCCATCGCCCGCGA
GGAGCTCTCCAAGGCCGGTCTCGACCGCGACATCTGGCAGTGCCCGGTCGTGCTGCTCGCCGACGTTCACTCGGTGGGCG
TCCAGGGTGACGAGCGCACCTACGGCTCCCCCATCGTGCTGCGCCCGGTGAGCTCGGAAGACGCCATGACCGCCGACTGG
TCTCGCGTGCCCTACGACGTGCTCGCCACGATCTCCACGCGCATCACCAACGAGTGCCGCCAGATCAACCGCGTCGTCCT
CGATTGCACGAGCAAGCCGCCGGCCACAATTGAATGGGAGTAA

Upstream 100 bases:

>100_bases
TACGCACATGGTTTCTGCGTGTCGGCCTTGTCGCCTTGACCAGTGATAATCAGTGGTGTTCAGCCCACGTAAAATTCCAA
TGAACGTTAGGGGAATATCA

Downstream 100 bases:

>100_bases
TTGCTCTCTGTGACGAATGGGATTCTCCATCGGGGAATCCCTTTTTTGTTGCCGACGATGCCCGGTATAATTTTTCCGCT
TACGACGTCGTCCGGAAAGG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MANGPVLVVDFGAQYAQLIARRVREAGVYSELVPHSMPVDEILAKDPKAIILSGGPASVFEPGAPTIDTKVFESGVPVLG
ICYGFQVMAYELGGKVDKAALGEYGKTSATIDDADGILADSPAEQTTWMSHGVAVEQAPAGFEVLAHTEGAPVAAMADES
RKLYGVQWHPEVKHSPLGQKLIENFLHRCAALPNDWDASSIIEDQVKKIREKVGDAEVICGLSGGVDSAVAAALVHKAIG
DQLTCVFVDHGLLRKGEVEQVKHDFVAATGIKLITVDAADDFLEALKGVSEPERKRKIIGEKFIRTFEKAQRQVLEEAGA
RGKEVKFLVQGTLYPDVVESGGGDGAANIKSHHNVGGLPKDIKFQLIEPLRTLFKDEVRAIGTELGLPDEIVWRQPFPGP
GLGIRIIGEITKERLDLLREADAIAREELSKAGLDRDIWQCPVVLLADVHSVGVQGDERTYGSPIVLRPVSSEDAMTADW
SRVPYDVLATISTRITNECRQINRVVLDCTSKPPATIEWE

Sequences:

>Translated_520_residues
MANGPVLVVDFGAQYAQLIARRVREAGVYSELVPHSMPVDEILAKDPKAIILSGGPASVFEPGAPTIDTKVFESGVPVLG
ICYGFQVMAYELGGKVDKAALGEYGKTSATIDDADGILADSPAEQTTWMSHGVAVEQAPAGFEVLAHTEGAPVAAMADES
RKLYGVQWHPEVKHSPLGQKLIENFLHRCAALPNDWDASSIIEDQVKKIREKVGDAEVICGLSGGVDSAVAAALVHKAIG
DQLTCVFVDHGLLRKGEVEQVKHDFVAATGIKLITVDAADDFLEALKGVSEPERKRKIIGEKFIRTFEKAQRQVLEEAGA
RGKEVKFLVQGTLYPDVVESGGGDGAANIKSHHNVGGLPKDIKFQLIEPLRTLFKDEVRAIGTELGLPDEIVWRQPFPGP
GLGIRIIGEITKERLDLLREADAIAREELSKAGLDRDIWQCPVVLLADVHSVGVQGDERTYGSPIVLRPVSSEDAMTADW
SRVPYDVLATISTRITNECRQINRVVLDCTSKPPATIEWE
>Mature_519_residues
ANGPVLVVDFGAQYAQLIARRVREAGVYSELVPHSMPVDEILAKDPKAIILSGGPASVFEPGAPTIDTKVFESGVPVLGI
CYGFQVMAYELGGKVDKAALGEYGKTSATIDDADGILADSPAEQTTWMSHGVAVEQAPAGFEVLAHTEGAPVAAMADESR
KLYGVQWHPEVKHSPLGQKLIENFLHRCAALPNDWDASSIIEDQVKKIREKVGDAEVICGLSGGVDSAVAAALVHKAIGD
QLTCVFVDHGLLRKGEVEQVKHDFVAATGIKLITVDAADDFLEALKGVSEPERKRKIIGEKFIRTFEKAQRQVLEEAGAR
GKEVKFLVQGTLYPDVVESGGGDGAANIKSHHNVGGLPKDIKFQLIEPLRTLFKDEVRAIGTELGLPDEIVWRQPFPGPG
LGIRIIGEITKERLDLLREADAIAREELSKAGLDRDIWQCPVVLLADVHSVGVQGDERTYGSPIVLRPVSSEDAMTADWS
RVPYDVLATISTRITNECRQINRVVLDCTSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=553, Percent_Identity=35.9855334538879, Blast_Score=295, Evalue=8e-80,
Organism=Escherichia coli, GI1788854, Length=528, Percent_Identity=50.3787878787879, Blast_Score=493, Evalue=1e-140,
Organism=Escherichia coli, GI1789760, Length=155, Percent_Identity=34.1935483870968, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1787517, Length=186, Percent_Identity=26.3440860215054, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71992710, Length=572, Percent_Identity=34.4405594405594, Blast_Score=284, Evalue=9e-77,
Organism=Caenorhabditis elegans, GI71992717, Length=572, Percent_Identity=34.2657342657343, Blast_Score=284, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI133901714, Length=572, Percent_Identity=34.4405594405594, Blast_Score=283, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6323873, Length=517, Percent_Identity=46.2282398452611, Blast_Score=479, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6322638, Length=161, Percent_Identity=30.4347826086957, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281365319, Length=547, Percent_Identity=34.3692870201097, Blast_Score=268, Evalue=5e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 56239; Mature: 56108

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANGPVLVVDFGAQYAQLIARRVREAGVYSELVPHSMPVDEILAKDPKAIILSGGPASVF
CCCCCEEEEECCHHHHHHHHHHHHHHCHHHHHCCCCCCHHHHHHCCCCEEEECCCCCCCC
EPGAPTIDTKVFESGVPVLGICYGFQVMAYELGGKVDKAALGEYGKTSATIDDADGILAD
CCCCCCCCHHHHHCCCCCEEHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCC
SPAEQTTWMSHGVAVEQAPAGFEVLAHTEGAPVAAMADESRKLYGVQWHPEVKHSPLGQK
CCCHHHHHHHCCEEEECCCCCCEEEEECCCCCEEEECCCCCCEEEEEECCCCCCCCCHHH
LIENFLHRCAALPNDWDASSIIEDQVKKIREKVGDAEVICGLSGGVDSAVAAALVHKAIG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHC
DQLTCVFVDHGLLRKGEVEQVKHDFVAATGIKLITVDAADDFLEALKGVSEPERKRKIIG
CCEEEEEECCCCCCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHCCCCHHHHHHHHH
EKFIRTFEKAQRQVLEEAGARGKEVKFLVQGTLYPDVVESGGGDGAANIKSHHNVGGLPK
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCH
DIKFQLIEPLRTLFKDEVRAIGTELGLPDEIVWRQPFPGPGLGIRIIGEITKERLDLLRE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
ADAIAREELSKAGLDRDIWQCPVVLLADVHSVGVQGDERTYGSPIVLRPVSSEDAMTADW
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCC
SRVPYDVLATISTRITNECRQINRVVLDCTSKPPATIEWE
CCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCC
>Mature Secondary Structure 
ANGPVLVVDFGAQYAQLIARRVREAGVYSELVPHSMPVDEILAKDPKAIILSGGPASVF
CCCCEEEEECCHHHHHHHHHHHHHHCHHHHHCCCCCCHHHHHHCCCCEEEECCCCCCCC
EPGAPTIDTKVFESGVPVLGICYGFQVMAYELGGKVDKAALGEYGKTSATIDDADGILAD
CCCCCCCCHHHHHCCCCCEEHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCC
SPAEQTTWMSHGVAVEQAPAGFEVLAHTEGAPVAAMADESRKLYGVQWHPEVKHSPLGQK
CCCHHHHHHHCCEEEECCCCCCEEEEECCCCCEEEECCCCCCEEEEEECCCCCCCCCHHH
LIENFLHRCAALPNDWDASSIIEDQVKKIREKVGDAEVICGLSGGVDSAVAAALVHKAIG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHC
DQLTCVFVDHGLLRKGEVEQVKHDFVAATGIKLITVDAADDFLEALKGVSEPERKRKIIG
CCEEEEEECCCCCCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHCCCCHHHHHHHHH
EKFIRTFEKAQRQVLEEAGARGKEVKFLVQGTLYPDVVESGGGDGAANIKSHHNVGGLPK
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCH
DIKFQLIEPLRTLFKDEVRAIGTELGLPDEIVWRQPFPGPGLGIRIIGEITKERLDLLRE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
ADAIAREELSKAGLDRDIWQCPVVLLADVHSVGVQGDERTYGSPIVLRPVSSEDAMTADW
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCC
SRVPYDVLATISTRITNECRQINRVVLDCTSKPPATIEWE
CCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12381787 [H]